Detailed information for compound 725715

Basic information

Technical information
  • TDR Targets ID: 725715
  • Name: 3-[4-(ethylsulfamoyl)phenyl]-N-(3-fluoropheny l)propanamide
  • MW: 350.408 | Formula: C17H19FN2O3S
  • H donors: 2 H acceptors: 3 LogP: 2.42 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNS(=O)(=O)c1ccc(cc1)CCC(=O)Nc1cccc(c1)F
  • InChi: 1S/C17H19FN2O3S/c1-2-19-24(22,23)16-9-6-13(7-10-16)8-11-17(21)20-15-5-3-4-14(18)12-15/h3-7,9-10,12,19H,2,8,11H2,1H3,(H,20,21)
  • InChiKey: HHQUGWMZHOYYJY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[4-(ethylsulfamoyl)phenyl]-N-(3-fluorophenyl)propionamide
  • ZINC04868169

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0 0.0001
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0063 0.0203
Brugia malayi mbt repeat family protein 0.0047 0.063 0.0742
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.5651 0.9301
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0117 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0636 0.1282
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0447 0.3293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0447 0.0715
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0636 0.1282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0228 0.046
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.1247 0.1469
Onchocerca volvulus 0.0031 0.0296 0.0595
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.5651 0.9301
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.1247 0.2513
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.1247 0.1997
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0301 0.6076 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0636 0.0955
Echinococcus granulosus tar DNA binding protein 0.0196 0.3826 0.5329
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0166 0.1222
Loa Loa (eye worm) hypothetical protein 0.0131 0.2427 0.286
Plasmodium vivax SET domain protein, putative 0.0031 0.0296 0.1855
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Schistosoma mansoni hypothetical protein 0.0031 0.0291 0.0479
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0063 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0063 0.0074
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.063 0.1037
Schistosoma mansoni hypothetical protein 0.0131 0.2427 0.3995
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0413 0.8485 1
Entamoeba histolytica hypothetical protein 0.0081 0.1356 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0636 0.0955
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0131 0.2427 0.3381
Echinococcus granulosus dna polymerase kappa 0.0021 0.0063 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0196 0.3826 0.6297
Onchocerca volvulus 0.0076 0.1247 0.2512
Echinococcus multilocularis zinc finger protein 0.0047 0.0633 0.0882
Onchocerca volvulus 0.0052 0.0729 0.1468
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0554 0.0887
Brugia malayi latrophilin 2 splice variant baaae 0.0282 0.5681 0.6695
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0063 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0222 0.0448
Trichomonas vaginalis bromodomain-containing protein, putative 0.0092 0.1594 0.3211
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0063 0.0462
Mycobacterium ulcerans lipase LipD 0.0076 0.1247 0.4009
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0 0.0001
Trichomonas vaginalis esterase, putative 0.0076 0.1247 0.2513
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0636 0.4689
Loa Loa (eye worm) hypothetical protein 0.0076 0.1247 0.1469
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.1247 0.2053
Brugia malayi mbt repeat family protein 0.0047 0.063 0.0742
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0166 0.1039
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.1247 0.2513
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0447 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0376 0.0759
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0063 0.0074
Schistosoma mansoni transcription factor LCR-F1 0.0081 0.1356 0.2232
Leishmania major hypothetical protein, conserved 0.0076 0.1247 0.1997
Echinococcus granulosus histone acetyltransferase KAT2B 0.0092 0.1594 0.222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0303 0.061
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.2757 0.4414
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0936 0.1499
Schistosoma mansoni bromodomain containing protein 0.0136 0.2541 0.4182
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0092 0.1594 0.3211
Plasmodium falciparum histone acetyltransferase GCN5 0.008 0.1335 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Trypanosoma brucei unspecified product 0.0021 0.0063 0.0031
Echinococcus multilocularis tar DNA binding protein 0.0196 0.3826 0.5329
Echinococcus granulosus GPCR family 2 0.0131 0.2427 0.3381
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0636 0.0749
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0429 0.0864
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0047 0.063 0.0742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0429 0.0864
Echinococcus multilocularis cysteine protease 0.0018 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0376 0.0759
Schistosoma mansoni tar DNA-binding protein 0.0196 0.3826 0.6297
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 0.6245 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.6245 1
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0063 0.0088
Schistosoma mansoni hypothetical protein 0.0081 0.1356 0.2232
Schistosoma mansoni flap endonuclease-1 0.0023 0.0114 0.0187
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.063 0.1037
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0166 0.081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0169 0.0341
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0769 0.1266
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0296 0.0487
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0724 0.1097
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0376 0.236
Onchocerca volvulus 0.0076 0.1247 0.2512
Leishmania major cathepsin L-like protease 0.0067 0.1061 0.1698
Loa Loa (eye worm) acetyltransferase 0.0301 0.6076 0.716
Loa Loa (eye worm) RNA binding protein 0.0196 0.3826 0.4508
Brugia malayi hypothetical protein 0.0051 0.0724 0.0853
Echinococcus multilocularis tumor protein p63 0.0352 0.7179 1
Loa Loa (eye worm) hypothetical protein 0.0282 0.5681 0.6695
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0636 0.1018
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0063 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0222 0.0448
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.063 0.1268
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0 0.0001
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.043 0.0687
Loa Loa (eye worm) latrophilin receptor protein 2 0.0131 0.2427 0.286
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.1247 0.1997
Mycobacterium tuberculosis Conserved protein 0.0076 0.1247 0.1247
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0 0.0001
Loa Loa (eye worm) TAR-binding protein 0.0196 0.3826 0.4508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0376 0.0759
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.104 0.1449
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0376 0.0759
Echinococcus granulosus histone acetyltransferase KAT2B 0.0288 0.5794 0.8072
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0063 0.0127
Loa Loa (eye worm) hypothetical protein 0.0144 0.271 0.3193
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.1247 0.1737
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0296 0.1855
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0488 0.0983
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0131 0.2427 0.3381
Leishmania major hypothetical protein, conserved 0.0051 0.0724 0.1159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.5651 0.9301
Echinococcus granulosus flap endonuclease 1 0.0025 0.0166 0.0231
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.1247 0.2513
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0554 0.0887
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0063 0.0031
Leishmania major cathepsin L-like protease 0.0067 0.1061 0.1698
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0228 0.046
Brugia malayi Bromodomain containing protein 0.0085 0.145 0.1709
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0447 0.09
Leishmania major DNA polymerase eta, putative 0.0021 0.0063 0.01
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0 0.0001
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.2757 0.4414
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0636 0.0749
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0063 0.0088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0447 0.0715
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0447 0.09
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0447 0.2802
Schistosoma mansoni DNA polymerase eta 0.0021 0.0063 0.0104
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0724 0.4541
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0724 0.1159
Onchocerca volvulus 0.0249 0.4963 1
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0166 0.0231
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.063 0.1037
Loa Loa (eye worm) MBCTL1 0.0053 0.0769 0.0906
Schistosoma mansoni tar DNA-binding protein 0.0196 0.3826 0.6297
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.017 0.0343
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0447 0.3018
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0636 0.0886
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.3757 0.5233
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.1247 0.1247
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0102 0.0094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Echinococcus multilocularis cysteine protease 0.0018 0 0.0001
Plasmodium vivax hypothetical protein, conserved 0.0076 0.1247 0.7826
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.1247 0.1247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0228 0.046
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0063 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0636 0.1018
Brugia malayi TAR-binding protein 0.0196 0.3826 0.4508
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0063 0.0203
Brugia malayi hypothetical protein 0.0081 0.1356 0.1598
Schistosoma mansoni hypothetical protein 0.0131 0.2427 0.3995
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.017 0.0343
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0046 0.0607 0.0999
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.1247 0.2513
Trypanosoma cruzi ISWI complex protein 0.0031 0.0291 0.0465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0281 0.0565
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0063 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Plasmodium falciparum flap endonuclease 1 0.0025 0.0166 0.1241
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0046 0.0607 0.0846
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0063 0.0127
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0724 0.5423
Loa Loa (eye worm) hypothetical protein 0.0076 0.1247 0.1469
Mycobacterium leprae conserved hypothetical protein 0.0076 0.1247 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Schistosoma mansoni hypothetical protein 0.0042 0.0524 0.0862
Onchocerca volvulus 0.0076 0.1247 0.2512
Loa Loa (eye worm) hypothetical protein 0.0076 0.1247 0.1469
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.063 0.0877
Brugia malayi Latrophilin receptor protein 2 0.0131 0.2427 0.286
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0281 0.5651 0.7872
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0447 0.0622
Brugia malayi Bromodomain containing protein 0.016 0.3052 0.3597
Echinococcus granulosus zinc finger protein 0.0047 0.0633 0.0882
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0063 0.0104
Brugia malayi RNA binding protein 0.0196 0.3826 0.4508
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.1247 0.1247
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0063 0.0104
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0447 0.3346
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.063 0.0877
Schistosoma mansoni eyes absent homolog 0.009 0.1555 0.256
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0447 0.0526
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Leishmania major cathepsin L-like protease 0.0067 0.1061 0.1698
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0 0.0001
Schistosoma mansoni hypothetical protein 0.0131 0.2427 0.3995
Giardia lamblia GTOR 0.0047 0.0636 0.4506
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0769 0.1071
Leishmania major mitochondrial DNA polymerase beta 0.0309 0.6245 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.164 0.1932
Toxoplasma gondii exonuclease III APE 0.0038 0.0447 0.2802
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.2757 0.4375
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.6245 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0281 0.5651 0.7872
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0 0.0001
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0063 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0636 0.1282
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.1191 0.166
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.3757 0.5233
Brugia malayi hypothetical protein 0.0033 0.0334 0.0393
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.1061 0.1698
Echinococcus granulosus dna polymerase eta 0.0021 0.0063 0.0088
Loa Loa (eye worm) hypothetical protein 0.0076 0.1247 0.1469
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0063 0.0063
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0554 0.0887
Loa Loa (eye worm) hypothetical protein 0.0078 0.1298 0.1529
Schistosoma mansoni hypothetical protein 0.0293 0.591 0.9727
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0769 0.1071
Mycobacterium tuberculosis Conserved protein 0.0076 0.1247 0.1247
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0636 0.4689
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0 0.0001
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0367 0.0605
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0 0.0001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0081 0.1356 0.1889
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0758 0.1213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0076 0.1247 0.1469
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0092 0.1594 1
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0376 0.0759
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.1061 0.1698
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.043 0.0622
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0131 0.2427 0.286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0169 0.0341
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.104 0.1449
Brugia malayi beta-lactamase 0.0076 0.1247 0.1469
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0447 0.0526
Schistosoma mansoni tar DNA-binding protein 0.0196 0.3826 0.6297
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0063 0.0063
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0296 0.0412
Entamoeba histolytica hypothetical protein 0.0081 0.1356 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0636 0.1047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0196 0.3826 0.4508
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Loa Loa (eye worm) hypothetical protein 0.009 0.1557 0.1834
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.1247 0.1737
Schistosoma mansoni hypothetical protein 0.0023 0.0117 0.0192
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0447 1
Toxoplasma gondii hypothetical protein 0.005 0.0691 0.4335
Loa Loa (eye worm) hypothetical protein 0.009 0.1555 0.1832
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0447 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0429 0.0864
Giardia lamblia Histone acetyltransferase GCN5 0.008 0.1335 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0131 0.2427 0.3381
Brugia malayi RNA recognition motif domain containing protein 0.0196 0.3826 0.4508
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0063 0.01
Loa Loa (eye worm) hypothetical protein 0.0413 0.8485 1
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.063 0.0742
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0063 0.01
Entamoeba histolytica hypothetical protein 0.0081 0.1356 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0166 0.0265
Echinococcus granulosus fetal alzheimer antigen falz 0.0046 0.0607 0.0846
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0063 0.0074
Brugia malayi Flap endonuclease-1 0.0025 0.0166 0.0195
Brugia malayi follicle stimulating hormone receptor 0.0261 0.5231 0.6165
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.1247 0.4009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0 0.0001
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0367 0.0512
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.3111 0.3111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0169 0.0341
Schistosoma mansoni ap endonuclease 0.0038 0.0447 0.0735
Mycobacterium ulcerans beta-lactamase 0.0076 0.1247 0.4009
Brugia malayi Pre-SET motif family protein 0.0219 0.4315 0.5084
Schistosoma mansoni tar DNA-binding protein 0.0196 0.3826 0.6297
Loa Loa (eye worm) bromodomain containing protein 0.0043 0.055 0.0647
Brugia malayi beta-lactamase family protein 0.0076 0.1247 0.1469
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.063 0.0877
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0092 0.1594 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0063 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0376 0.0759
Mycobacterium ulcerans hypothetical protein 0.0076 0.1247 0.4009
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0367 0.0512
Brugia malayi hypothetical protein 0.009 0.1555 0.1832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0429 0.0864
Schistosoma mansoni hypothetical protein 0.0131 0.2427 0.3995
Loa Loa (eye worm) hypothetical protein 0.009 0.1555 0.1832
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0261 0.5231 0.6165
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0296 0.0487
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0063 0.01
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.1247 0.4009
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.1247 0.1247
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0729 0.12
Leishmania major hypothetical protein, conserved 0.0031 0.0291 0.0465
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0753 0.1206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0769 0.1071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0081 0.1356 0.1889
Leishmania major DNA polymerase kappa, putative 0.0021 0.0063 0.01
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.104 0.1712
Loa Loa (eye worm) hypothetical protein 0.0053 0.0769 0.0906
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0131 0.2427 0.3381
Loa Loa (eye worm) hypothetical protein 0.0066 0.104 0.1226
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0413 0.8485 1
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.1247 0.1941
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0117 0.0163
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1061 0.164
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0281 0.5651 0.7872
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0636 0.1018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0092 0.1594 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0724 0.0853
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.1061 0.1698
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0301 0.6076 0.8464
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0281 0.5651 0.7872
Brugia malayi acetyltransferase, GNAT family protein 0.0301 0.6076 0.716
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0166 0.0195
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0 0.0001
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0166 0.0197
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0724 0.5423
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0724 0.4541
Loa Loa (eye worm) beta-lactamase 0.0076 0.1247 0.1469
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0636 0.0886
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0129 0.2384 0.3322
Echinococcus granulosus tumor protein p63 0.0352 0.7179 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.063 0.0877
Mycobacterium ulcerans hypothetical protein 0.0163 0.3111 1
Entamoeba histolytica hypothetical protein 0.0081 0.1356 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.1247 0.1469
Entamoeba histolytica acetyltransferase, GNAT family 0.008 0.1335 0.9843
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0166 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0376 0.0759
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0447 0.0447
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.1061 0.1698
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.1191 0.166
Mycobacterium leprae Probable lipase LipE 0.0076 0.1247 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.1247 0.1247
Trichomonas vaginalis set domain proteins, putative 0.0249 0.4963 1
Mycobacterium tuberculosis Conserved protein 0.0076 0.1247 0.1247
Trypanosoma brucei ISWI complex protein 0.0031 0.0291 0.0398
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0 0.0001
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0724 0.1159
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0281 0.5651 0.666
Schistosoma mansoni zinc finger protein 0.0047 0.0633 0.1042
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0554 0.0823
Echinococcus multilocularis dna polymerase eta 0.0021 0.0063 0.0088
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0367 0.0605
Loa Loa (eye worm) hypothetical protein 0.0052 0.0729 0.0859
Toxoplasma gondii ABC1 family protein 0.0076 0.1247 0.7826
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.017 0.0343
Schistosoma mansoni zinc finger protein 0.0031 0.0291 0.0479
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.1247 0.1247
Brugia malayi beta-lactamase family protein 0.0076 0.1247 0.1469
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0447 0.1436
Trypanosoma cruzi ISWI complex protein 0.0031 0.0291 0.0465
Brugia malayi Calcitonin receptor-like protein seb-1 0.0413 0.8485 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0636 0.1018
Schistosoma mansoni ap endonuclease 0.0038 0.0447 0.0735
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.1247 0.1247
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0524 0.0617
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.017 0.0343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0063 0.01
Schistosoma mansoni hypothetical protein 0.0282 0.5681 0.9351
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0166 0.0335
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0447 0.0715
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0166 0.1039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0429 0.0864
Onchocerca volvulus 0.0047 0.063 0.1268
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0769 0.0906
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0769 0.1071
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0281 0.5651 0.666
Echinococcus granulosus cathepsin l1 0.0018 0 0.0001
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0447 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.1247 0.2053
Brugia malayi PHD-finger family protein 0.0058 0.0866 0.102
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.4315 0.5084
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.1247 0.2513
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.043 0.0687
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0271 0.0378
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.104 0.1712
Loa Loa (eye worm) hypothetical protein 0.0076 0.1247 0.1469
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.0074
Echinococcus multilocularis GPCR, family 2 0.0131 0.2427 0.3381
Brugia malayi Pre-SET motif family protein 0.0031 0.0296 0.0348
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0129 0.2384 0.3322
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0 0.0001

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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