Detailed information for compound 725720

Basic information

Technical information
  • TDR Targets ID: 725720
  • Name: 1-[2-(3-butan-2-yloxyphenoxy)ethyl]-4-methylp iperazine
  • MW: 292.416 | Formula: C17H28N2O2
  • H donors: 0 H acceptors: 0 LogP: 3.04 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(Oc1cccc(c1)OCCN1CCN(CC1)C)C
  • InChi: 1S/C17H28N2O2/c1-4-15(2)21-17-7-5-6-16(14-17)20-13-12-19-10-8-18(3)9-11-19/h5-7,14-15H,4,8-13H2,1-3H3
  • InChiKey: REIFQNWEKTVAPJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-methyl-4-[2-(3-sec-butoxyphenoxy)ethyl]piperazine
  • 1-[2-(3-butan-2-yloxyphenoxy)ethyl]-4-methyl-piperazine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RNA recognition motif domain containing protein 0.0198 0.2725 0.4674
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.3178 0.6372
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0081 0.0768 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.01 0.023
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0081 0.0768 0.5
Echinococcus multilocularis lysosomal alpha glucosidase 0.0186 0.2517 0.4317
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0292 0.4292 0.7363
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0035 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0292 0.4292 0.7363
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0035 0.0004 0.0008
Schistosoma mansoni hypothetical protein 0.0075 0.0665 0.1142
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1764 0.3027
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.4334 1
Schistosoma mansoni eyes absent homolog 0.0096 0.1025 0.1758
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0081 0.0768 0.1317
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.01 0.0171
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.0057
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0042 0.0118 0.0203
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0665 0.1142
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0081 0.0768 0.1317
Trichomonas vaginalis ap endonuclease, putative 0.0081 0.0768 0.1771
Schistosoma mansoni hypothetical protein 0.0099 0.1073 0.1841
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0035 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0004 0.0004
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0035 0.0004 0.0008
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.01 0.0232
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.001
Brugia malayi Pre-SET motif family protein 0.0204 0.2819 0.4837
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0035 0.0004 0.0004
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0035 0.0004 0.0008
Toxoplasma gondii hypothetical protein 0.0102 0.1118 0.2605
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.0203
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0004 0.0004
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0035 0.0004 0.0008
Plasmodium vivax phosphodiesterase gamma, putative 0.0035 0.0004 0.0057
Brugia malayi hypothetical protein 0.0096 0.1025 0.1758
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0081 0.0768 0.0768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1764 0.3027
Loa Loa (eye worm) TAR-binding protein 0.0198 0.2725 0.4674
Loa Loa (eye worm) hypothetical protein 0.0215 0.3002 0.5151
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0081 0.0768 0.0768
Loa Loa (eye worm) RNA binding protein 0.0198 0.2725 0.4674
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.4334 1
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0042 0.0118 0.0275
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.2641 0.6093
Entamoeba histolytica hypothetical protein 0.0075 0.0665 0.847
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0256 0.3698 0.6343
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0314 0.4665 0.8003
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Schistosoma mansoni inositol transporter 0.0042 0.0118 0.0203
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0004 0.0004
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0035 0.0004 0.0008
Schistosoma mansoni alpha glucosidase 0.0041 0.01 0.0171
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.2641 0.6093
Brugia malayi TAR-binding protein 0.0198 0.2725 0.4674
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0035 0.0004 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0004 0.001
Brugia malayi Sodium:solute symporter family protein 0.0042 0.0118 0.0203
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0383 0.5829 1
Schistosoma mansoni alpha-glucosidase 0.016 0.2084 0.3575
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.01 0.0171
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0081 0.0768 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0256 0.3698 0.6343
Mycobacterium leprae conserved hypothetical protein 0.0035 0 0.5
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0294 0.4334 0.7436
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.01 0.0171
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0633 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0099 0.1073 0.1841
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0089 0.0899 0.0899
Echinococcus multilocularis GPCR, family 2 0.0099 0.1073 0.1841
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0035 0.0004 0.0008
Echinococcus multilocularis solute carrier family 5 0.0042 0.0118 0.0203
Leishmania major hypothetical protein, conserved 0.0035 0.0004 0.0004
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0035 0.0004 0.0004
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0665 0.1142
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0035 0.0004 0.0008
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0035 0.0004 0.0004
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.0004
Onchocerca volvulus 0.0042 0.0118 0.0359
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.4334 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0314 0.4665 0.8003
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0035 0.0004 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.2641 0.6093
Toxoplasma gondii exonuclease III APE 0.0081 0.0768 0.1789
Mycobacterium tuberculosis Conserved hypothetical protein 0.0333 0.4988 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0299 0.4422 0.4422
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0004 0.001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0099 0.1073 0.1841
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0089 0.0899 0.0899
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Echinococcus multilocularis tar DNA binding protein 0.0198 0.2725 0.4674
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.01 0.023
Schistosoma mansoni hypothetical protein 0.0099 0.1073 0.1841
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0099 0.1073 0.1841
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0035 0.0004 0.0008
Schistosoma mansoni ap endonuclease 0.0081 0.0768 0.1317
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0633 1 1
Schistosoma mansoni ap endonuclease 0.0081 0.0768 0.1317
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0004 0.001
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0042 0.0118 0.0203
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0004 0.0004
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0035 0.0004 0.0008
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.001
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0035 0.0004 0.0008
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.01 0.01
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0292 0.4292 0.7363
Loa Loa (eye worm) latrophilin receptor protein 2 0.0099 0.1073 0.1841
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0081 0.0768 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.01 0.023
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0035 0.0004 0.0004
Schistosoma mansoni high-affinity choline transporter 0.0383 0.5829 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0004 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.2815 0.6495
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0004 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0004 0.001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.1764 0.3027
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0081 0.0768 0.0768
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.01 0.023
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0081 0.0768 0.1317
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0035 0.0004 0.0008
Echinococcus multilocularis lysosomal alpha glucosidase 0.0186 0.2517 0.4317
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0035 0.0004 0.0008
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0299 0.4422 0.4422
Mycobacterium ulcerans hypothetical protein 0.0333 0.4988 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0035 0.0004 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0004 0.0004
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.001
Schistosoma mansoni tar DNA-binding protein 0.0198 0.2725 0.4674
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.01 0.023
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Schistosoma mansoni inositol transporter 0.0042 0.0118 0.0203
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0081 0.0768 0.0768
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0089 0.0899 0.0899
Brugia malayi GH02984p 0.0383 0.5829 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.1073 0.1841
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0004 0.001
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0292 0.4292 0.7363
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0035 0.0004 0.0004
Onchocerca volvulus Glucosylceramidase homolog 0.0193 0.2641 0.8027
Loa Loa (eye worm) hypothetical protein 0.0096 0.1025 0.1758
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.1764 0.3027
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.01 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0004 0.0004
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0035 0.0004 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0198 0.2725 0.4674
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0035 0.0004 0.0008
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0004 0.001
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0299 0.4422 0.4422
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0256 0.3698 0.6343
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0099 0.1073 0.1841
Brugia malayi hypothetical protein 0.0075 0.0665 0.1142
Brugia malayi latrophilin 2 splice variant baaae 0.0215 0.3002 0.5151
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.0004
Onchocerca volvulus 0.0232 0.329 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0081 0.0768 0.1539
Echinococcus granulosus sodium:glucose cotransporter 2 0.0042 0.0118 0.0203
Leishmania major hypothetical protein, conserved 0.0035 0.0004 0.0004
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0035 0.0004 0.0008
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0035 0.0004 0.0008
Echinococcus granulosus high affinity choline transporter 1 0.0383 0.5829 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.01 0.01
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0035 0.0004 0.0008
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.001
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0004 0.001
Mycobacterium leprae Probable lipase LipE 0.0035 0 0.5
Loa Loa (eye worm) PDE1B protein 0.0035 0.0004 0.0008
Trichomonas vaginalis ap endonuclease, putative 0.0081 0.0768 0.1771
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0004 0.001
Schistosoma mansoni tar DNA-binding protein 0.0198 0.2725 0.4674
Echinococcus granulosus sodium:myo inositol cotransporter 0.0042 0.0118 0.0203
Brugia malayi Calcitonin receptor-like protein seb-1 0.0314 0.4665 0.8003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0099 0.1073 0.1841
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0004 0.001
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0292 0.4292 0.7363
Schistosoma mansoni sodium/solute symporter 0.0042 0.0118 0.0203
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1764 0.3027
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.2641 0.6093
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0035 0.0004 0.0004
Entamoeba histolytica hypothetical protein 0.0075 0.0665 0.847
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0035 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0099 0.1073 0.1841
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.2641 0.6093
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.0057
Echinococcus granulosus GPCR family 2 0.0099 0.1073 0.1841
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0035 0.0004 0.0008
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Schistosoma mansoni tar DNA-binding protein 0.0198 0.2725 0.4674
Brugia malayi Latrophilin receptor protein 2 0.0099 0.1073 0.1841
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.01 0.023
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.2819 0.4837
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0035 0.0004 0.001
Echinococcus multilocularis high affinity choline transporter 1 0.0383 0.5829 1
Echinococcus granulosus sodium:glucose cotransporter 0.0042 0.0118 0.0203
Schistosoma mansoni alpha-glucosidase 0.016 0.2084 0.3575
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0186 0.2517 0.4317
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0292 0.4292 0.7363
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.01 0.023
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0294 0.4334 0.7436
Echinococcus granulosus lysosomal alpha glucosidase 0.0186 0.2517 0.4317
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0108 0.1225 0.1225
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0042 0.0118 0.0203
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0035 0.0004 0.001
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0035 0.0004 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.2641 0.6093
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Trypanosoma brucei glucosidase, putative 0.0041 0.01 0.01
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0004 0.001
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0035 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0096 0.1025 0.1758
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.4334 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.01 0.023
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0035 0.0004 0.0004
Echinococcus granulosus tar DNA binding protein 0.0198 0.2725 0.4674
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0004 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0004 0.001
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0292 0.4292 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0035 0.0004 0.0004
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0089 0.0899 0.0899
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0042 0.0118 0.0203
Schistosoma mansoni hypothetical protein 0.0215 0.3002 0.5151
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0035 0.0004 0.0008
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.01 0.023
Onchocerca volvulus 0.0107 0.1207 0.3668
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0035 0.0004 0.0008
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0004 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0004 0.001
Trichomonas vaginalis set domain proteins, putative 0.0232 0.329 0.7591
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.4334 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Echinococcus granulosus solute carrier family 5 0.0042 0.0118 0.0203
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0004 0.0008
Brugia malayi exodeoxyribonuclease III family protein 0.0081 0.0768 0.1317
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0035 0.0004 0.0004
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0035 0.0004 0.0008
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0633 1 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0081 0.0768 0.1539
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0004 0.001
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0035 0.0004 0.0008
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0198 0.2725 0.4674
Entamoeba histolytica hypothetical protein 0.0075 0.0665 0.847
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.001
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0035 0.0004 0.0008
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.001
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0256 0.3698 0.6343
Schistosoma mansoni tar DNA-binding protein 0.0198 0.2725 0.4674
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0665 0.1142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1764 0.3027
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.01 0.0171
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0004 0.001
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0035 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0004 0.0008
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0004 0.001
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.0057
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0004 0.001
Treponema pallidum exodeoxyribonuclease (exoA) 0.0081 0.0768 0.5
Leishmania major cAMP-specific phosphodiesterase, putative 0.0035 0.0004 0.0004
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0081 0.0768 0.178
Loa Loa (eye worm) hypothetical protein 0.0314 0.4665 0.8003
Brugia malayi RNA binding protein 0.0198 0.2725 0.4674
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.2641 0.6093
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.2815 0.6495
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0292 0.4292 1
Schistosoma mansoni hypothetical protein 0.0099 0.1073 0.1841
Brugia malayi Glycosyl hydrolases family 31 protein 0.0186 0.2517 0.4317
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0035 0.0004 0.0008
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0004 0.001
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0004 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1764 0.3027
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0035 0.0004 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.4334 1
Entamoeba histolytica hypothetical protein 0.0075 0.0665 0.847
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1764 0.3027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1764 0.3027
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0004 0.001

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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