Detailed information for compound 725724

Basic information

Technical information
  • TDR Targets ID: 725724
  • Name: 1-methyl-4-[4-[3-(trifluoromethyl)phenoxy]but yl]piperazine
  • MW: 316.362 | Formula: C16H23F3N2O
  • H donors: 0 H acceptors: 0 LogP: 3.34 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)CCCCOc1cccc(c1)C(F)(F)F
  • InChi: 1S/C16H23F3N2O/c1-20-8-10-21(11-9-20)7-2-3-12-22-15-6-4-5-14(13-15)16(17,18)19/h4-6,13H,2-3,7-12H2,1H3
  • InChiKey: USUGCRJQJJHDFJ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0464 0.1988
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0334 0.1151
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.1425 0.1739
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.212 0.3376
Loa Loa (eye worm) hypothetical protein 0.0088 0.1647 0.202
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0043 0.0595 0.2622
Mycobacterium ulcerans beta-lactamase 0.007 0.1209 0.3591
Onchocerca volvulus 0.007 0.1209 0.204
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0282 0.6177 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0249 0.5418 0.6796
Leishmania major cathepsin L-like protease 0.0062 0.1021 0.1227
Schistosoma mansoni tar DNA-binding protein 0.013 0.2622 0.3748
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.1209 0.3591
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.5503 0.6904
Leishmania major hypothetical protein, conserved 0.005 0.0754 0.0889
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.1209 0.3591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1021 0.1285
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.3465 0.6262
Mycobacterium tuberculosis Conserved protein 0.007 0.1209 0.1162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1021 0.1285
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0754 0.4621
Schistosoma mansoni hypothetical protein 0.0313 0.6909 1
Echinococcus multilocularis tar DNA binding protein 0.013 0.2622 0.4196
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0407 0.1715
Loa Loa (eye worm) hypothetical protein 0.0063 0.1049 0.1262
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0407 0.065
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0282 0.6177 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.1209 0.1888
Schistosoma mansoni alpha glucosidase 0.0035 0.0407 0.0517
Mycobacterium leprae conserved hypothetical protein 0.007 0.1209 0.5
Loa Loa (eye worm) hypothetical protein 0.007 0.1209 0.1465
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.1049 0.1626
Treponema pallidum exodeoxyribonuclease (exoA) 0.0078 0.1406 0.5
Toxoplasma gondii ABC1 family protein 0.007 0.1209 0.8371
Leishmania major C-8 sterol isomerase-like protein 0.0357 0.7947 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0334 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0127 0.0136
Mycobacterium tuberculosis Conserved protein 0.007 0.1209 0.1162
Schistosoma mansoni alpha-glucosidase 0.0137 0.2795 0.4
Loa Loa (eye worm) hypothetical protein 0.007 0.1209 0.1465
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.212 0.3376
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0194 0.018
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0564 0.0648
Schistosoma mansoni tar DNA-binding protein 0.013 0.2622 0.3748
Schistosoma mansoni hypothetical protein 0.003 0.0291 0.0348
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0723 0.0978
Schistosoma mansoni hypothetical protein 0.0079 0.1425 0.2002
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.078 0.0921
Onchocerca volvulus 0.0229 0.4939 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0078 0.1406 0.1715
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.4288 0.5365
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0078 0.1406 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0078 0.1406 0.1361
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0249 0.5418 0.6796
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0407 0.0449
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0228 0.0287
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.2622 0.3255
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.2975 0.4772
Schistosoma mansoni tar DNA-binding protein 0.013 0.2622 0.3748
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0043 0.0595 0.0687
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0078 0.1406 0.5
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0564 0.071
Trypanosoma brucei glucosidase, putative 0.0035 0.0407 0.0512
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.1209 0.1162
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0045 0.0629 0.0841
Schistosoma mansoni hypothetical protein 0.0079 0.1425 0.2002
Echinococcus granulosus tar DNA binding protein 0.013 0.2622 0.4196
Schistosoma mansoni hypothetical protein 0.0023 0.0105 0.0077
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.2898 0.3647
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0407 0.065
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0078 0.1406 0.221
Plasmodium vivax hypothetical protein, conserved 0.007 0.1209 0.8371
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.5503 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0043 0.0595 0.0748
Loa Loa (eye worm) hypothetical protein 0.007 0.1209 0.1465
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0043 0.0595 0.0687
Brugia malayi hypothetical protein 0.005 0.0754 0.0889
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0407 0.0579
Loa Loa (eye worm) beta-lactamase 0.007 0.1209 0.1465
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0208 0.446 0.7197
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.1406 0.2484
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0655 0.0983
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0387 0.0487
Brugia malayi beta-lactamase 0.007 0.1209 0.1465
Schistosoma mansoni ap endonuclease 0.0078 0.1406 0.1974
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0407 0.1715
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.1209 0.1465
Echinococcus granulosus GPCR family 2 0.0079 0.1425 0.2242
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0387 0.0424
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0712 0.0836
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0373 0.0523
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.6177 0.8931
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0059 0.0074
Toxoplasma gondii exonuclease III APE 0.0078 0.1406 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0655 0.1105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1021 0.1285
Trypanosoma brucei C-8 sterol isomerase, putative 0.0357 0.7947 1
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0723 0.0978
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0334 0.0516
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.5503 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1021 0.1285
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0387 0.0613
Loa Loa (eye worm) hypothetical protein 0.0249 0.5418 0.6796
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0078 0.1406 0.1715
Schistosoma mansoni hypothetical protein 0.0079 0.1425 0.2002
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.1406 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0253 0.0293
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0464 0.3037
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0881 0.1209
Brugia malayi mbt repeat family protein 0.0049 0.0723 0.0849
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.1254 0.1961
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0282 0.6177 1
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.1209 0.1162
Brugia malayi Bromodomain containing protein 0.008 0.1444 0.1763
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0052 0.0066
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0723 0.1095
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.1209 0.1888
Trypanosoma brucei unspecified product 0.002 0.0052 0.0066
Echinococcus multilocularis zinc finger protein 0.0042 0.0571 0.0847
Entamoeba histolytica hypothetical protein 0.0109 0.212 1
Mycobacterium ulcerans hypothetical protein 0.007 0.1209 0.3591
Loa Loa (eye worm) hypothetical protein 0.0056 0.0881 0.105
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0299 0.6594 0.8297
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.5503 0.6904
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.3316 0.4134
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0595 0.0687
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0446 0.0722
Trypanosoma brucei hypothetical protein, conserved 0.007 0.1209 0.1521
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.1209 0.1686
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.3465 0.6262
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1021 0.1227
Trypanosoma cruzi ISWI complex protein 0.003 0.0291 0.0302
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1209 0.2122
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0655 0.1105
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0253 0.0484
Loa Loa (eye worm) TAR-binding protein 0.013 0.2622 0.3255
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.6594 0.8286
Brugia malayi RNA binding protein 0.013 0.2622 0.3255
Loa Loa (eye worm) hypothetical protein 0.007 0.1209 0.1465
Loa Loa (eye worm) MBCTL1 0.0056 0.0881 0.105
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.2975 0.3702
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0179 0.0233
Echinococcus granulosus zinc finger protein 0.0042 0.0571 0.0847
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.5503 1
Mycobacterium tuberculosis Conserved protein 0.007 0.1209 0.1162
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0253 0.0328
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1021 0.1285
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.1406 0.2484
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.3465 0.6262
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0043 0.0595 0.0748
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0238 0.034
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0194 0.0687
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0881 0.1354
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.3316 0.5328
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.3465 0.6856
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0334 0.0516
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0464 0.2221
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0249 0.5418 0.6796
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0078 0.1406 0.1715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0334 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0126 0.0135
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0043 0.0595 0.0687
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.2898 0.3604
Loa Loa (eye worm) hypothetical protein 0.017 0.357 0.4455
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0066
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0595 0.0687
Onchocerca volvulus 0.0092 0.174 0.3172
Schistosoma mansoni bromodomain containing protein 0.0129 0.261 0.3729
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0043 0.0595 0.0687
Entamoeba histolytica hypothetical protein 0.0109 0.212 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0066
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0407 0.0449
Brugia malayi mbt repeat family protein 0.0049 0.0723 0.0849
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0357 0.7947 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0881 0.105
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0754 0.0889
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0208 0.446 0.7197
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0407 0.1754
Brugia malayi hypothetical protein 0.0109 0.212 0.2619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0127 0.0136
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1209 0.2122
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.3675 0.6646
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0655 0.3797
Echinococcus granulosus fetal alzheimer antigen falz 0.0045 0.0629 0.0941
Leishmania major cathepsin L-like protease 0.0062 0.1021 0.1227
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0122 0.2443 0.3903
Loa Loa (eye worm) hypothetical protein 0.0079 0.1425 0.1739
Schistosoma mansoni zinc finger protein 0.003 0.0291 0.0348
Mycobacterium tuberculosis Probable hydrolase 0.007 0.1209 0.1162
Brugia malayi TAR-binding protein 0.013 0.2622 0.3255
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0066
Brugia malayi beta-lactamase family protein 0.007 0.1209 0.1465
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1209 0.1465
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.1209 0.1162
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.2975 0.4262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0334 0.0516
Giardia lamblia GTOR 0.0043 0.0595 0.4005
Mycobacterium leprae Probable lipase LipE 0.007 0.1209 0.5
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.054 0.0617
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0066
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0043 0.0595 0.0885
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0043 0.0595 0.0791
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.1209 0.1162
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0045 0.0629 0.0941
Plasmodium vivax SET domain protein, putative 0.0029 0.0253 0.0484
Trichomonas vaginalis set domain proteins, putative 0.0229 0.4939 0.8965
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.1049 0.1453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0185 0.0244
Leishmania major cathepsin L-like protease 0.0062 0.1021 0.1227
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0194 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0334 0.0516
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0723 0.1095
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.1425 0.1739
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.5503 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1021 0.1285
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.3316 0.5328
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0881 0.1354
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0194 0.018
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0655 0.3797
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0122 0.2443 0.3903
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0407 0.065
Brugia malayi Flap endonuclease-1 0.0026 0.0194 0.018
Onchocerca volvulus 0.007 0.1209 0.204
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0564 0.0648
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1209 0.1465
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.6177 0.8931
Schistosoma mansoni hypothetical protein 0.0041 0.054 0.0711
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.357 0.4455
Schistosoma mansoni alpha-glucosidase 0.0137 0.2795 0.4
Loa Loa (eye worm) hypothetical protein 0.0049 0.0723 0.0849
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0407 0.0579
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.1209 0.1686
Schistosoma mansoni flap endonuclease-1 0.0024 0.0135 0.0121
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.3316 0.5328
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.1425 0.2242
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0881 0.1354
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0066
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0194 0.018
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0407 0.0449
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1021 0.1227
Schistosoma mansoni hypothetical protein 0.017 0.357 0.513
Mycobacterium ulcerans lipase LipD 0.007 0.1209 0.3591
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1021 0.1227
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0282 0.6177 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0282 0.6177 0.7758
Loa Loa (eye worm) hypothetical protein 0.0357 0.7947 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0078 0.1406 0.6547
Brugia malayi beta-lactamase family protein 0.007 0.1209 0.1465
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0043 0.0595 0.2622
Brugia malayi Bromodomain containing protein 0.0153 0.3156 0.3932
Leishmania major hypothetical protein, conserved 0.007 0.1209 0.1465
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0078 0.1406 0.4203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1021 0.1285
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0066
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0723 0.1003
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0194 0.0245
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0373 0.0523
Loa Loa (eye worm) acetyltransferase 0.0145 0.2975 0.3702
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1021 0.1285
Onchocerca volvulus 0.0049 0.0723 0.1003
Brugia malayi exodeoxyribonuclease III family protein 0.0078 0.1406 0.1715
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0052 0.0066
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.1254 0.1961
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0407 0.065
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0723 0.1095
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.1425 0.2242
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.212 0.3016
Schistosoma mansoni tar DNA-binding protein 0.013 0.2622 0.3748
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0387 0.0424
Brugia malayi Pre-SET motif family protein 0.0029 0.0253 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0185 0.0244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.026 0.038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0387 0.0613
Echinococcus multilocularis GPCR, family 2 0.0079 0.1425 0.2242
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0052 0.0066
Leishmania major hypothetical protein, conserved 0.003 0.0291 0.0302
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.1406 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0754 0.0889
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.3465 0.6262
Brugia malayi Pre-SET motif family protein 0.0201 0.4288 0.5365
Echinococcus granulosus flap endonuclease 1 0.0026 0.0194 0.0232
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0105 0.0086
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0723 0.0978
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0407 0.065
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0078 0.1406 0.221
Loa Loa (eye worm) hypothetical protein 0.007 0.1209 0.1465
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.3675 0.6646
Trichomonas vaginalis esterase, putative 0.007 0.1209 0.2122
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0373 0.0467
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0754 0.0949
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0595 0.0995
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0373 0.0467
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.1209 0.2122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1021 0.1285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.1049 0.1453
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.2898 0.3604
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.3465 0.6262
Loa Loa (eye worm) RNA binding protein 0.013 0.2622 0.3255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0185 0.0244
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0407 0.065
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0282 0.6177 0.7758
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0126 0.0135
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0723 0.0849
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0105 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0126 0.0135
Schistosoma mansoni hypothetical protein 0.0109 0.212 0.3016
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.1021 0.1227
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0754 0.4621
Mycobacterium ulcerans hypothetical protein 0.0158 0.3273 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0357 0.7947 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.1367 0.1665
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.6177 0.8931
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1021 0.1285
Schistosoma mansoni hypothetical protein 0.0079 0.1425 0.2002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0078 0.1406 0.1715
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0407 0.065
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.5503 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0387 0.0613
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0407 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0334 0.0516
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.2772 0.4441
Loa Loa (eye worm) hypothetical protein 0.0183 0.3855 0.4817
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.5503 1
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0723 0.1095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0179 0.0233
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0253 0.0293
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0407 0.0449
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0896 0.1069
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0754 0.4621
Trypanosoma brucei ISWI complex protein 0.003 0.0291 0.0366
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.1209 0.1162
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0043 0.0595 0.0885
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0595 0.0995
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0407 0.0449
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1021 0.1285
Trypanosoma cruzi ISWI complex protein 0.003 0.0291 0.0302
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.1209 0.1162
Onchocerca volvulus 0.007 0.1209 0.204
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.6594 0.8286
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0194 0.0232
Entamoeba histolytica hypothetical protein 0.0109 0.212 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.1049 0.1626
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0482 0.0544
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1209 0.2122
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0407 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0387 0.0613
Loa Loa (eye worm) hypothetical protein 0.007 0.1209 0.1465
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0052 0.0066
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0754 0.4621
Toxoplasma gondii hypothetical protein 0.0048 0.0709 0.4247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0127 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0127 0.0136
Loa Loa (eye worm) hypothetical protein 0.0141 0.2876 0.3577
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.3465 0.6262
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0754 0.0889
Schistosoma mansoni tar DNA-binding protein 0.013 0.2622 0.3748
Loa Loa (eye worm) hypothetical protein 0.0085 0.1558 0.1907
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.3465 0.6262
Leishmania major mitochondrial DNA polymerase beta 0.0299 0.6594 0.8286
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0564 0.0648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0595 0.0995
Brugia malayi RNA recognition motif domain containing protein 0.013 0.2622 0.3255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0387 0.0613
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0078 0.1406 0.177
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.1209 0.1465
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.3273 0.3238
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.3316 0.4134
Brugia malayi PHD-finger family protein 0.0053 0.082 0.0972
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.1425 0.2242
Brugia malayi hypothetical protein 0.0032 0.0337 0.0361
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.1209 0.2122
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0052 0.0066
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.1425 0.2242
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0881 0.1354
Schistosoma mansoni ap endonuclease 0.0078 0.1406 0.1974
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0194 0.1049
Entamoeba histolytica hypothetical protein 0.0109 0.212 1
Schistosoma mansoni zinc finger protein 0.0042 0.0571 0.0756
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0655 0.3797
Brugia malayi Latrophilin receptor protein 2 0.0079 0.1425 0.1739

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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