Detailed information for compound 725817

Basic information

Technical information
  • TDR Targets ID: 725817
  • Name: 2-(2-chlorophenoxy)-1-(4-prop-2-enylpiperazin -1-yl)ethanone
  • MW: 294.777 | Formula: C15H19ClN2O2
  • H donors: 0 H acceptors: 1 LogP: 2.5 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCN1CCN(CC1)C(=O)COc1ccccc1Cl
  • InChi: 1S/C15H19ClN2O2/c1-2-7-17-8-10-18(11-9-17)15(19)12-20-14-6-4-3-5-13(14)16/h2-6H,1,7-12H2
  • InChiKey: MRQXFGBHVFRRSX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-allylpiperazin-1-yl)-2-(2-chlorophenoxy)ethanone
  • 1-(4-allyl-1-piperazinyl)-2-(2-chlorophenoxy)ethanone
  • IVK/0015856

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0748 0.0721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0123 0.0561
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.1376 0.6974
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0261 0.1193
Echinococcus multilocularis histone acetyltransferase MYST2 0.0166 0.1286 0.2519
Schistosoma mansoni cpg binding protein 0.0037 0.015 0.0191
Schistosoma mansoni inositol transporter 0.0038 0.0161 0.0204
Schistosoma mansoni hypothetical protein 0.0165 0.1283 0.1632
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0067 0.0084
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0024 0.0029 0.0133
Mycobacterium tuberculosis Probable lipase LipD 0.018 0.1413 0.1388
Schistosoma mansoni hypothetical protein 0.0193 0.1525 0.1941
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0067 0.0084
Leishmania major hypothetical protein, conserved 0.0062 0.0372 0.0466
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0227 0.1037
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0096 0.0122
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0117 0.0857 0.1074
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0227 0.1605
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0334 0.0419
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0117 0.0857 0.1644
Schistosoma mansoni tar DNA-binding protein 0.033 0.2745 0.3493
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.018 0.1413 0.1388
Echinococcus multilocularis high affinity choline transporter 1 0.0349 0.2908 0.5698
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0024 0.0029 0.0037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0334 0.0419
Trypanosoma brucei glycosyl hydrolase-like protein 0.0027 0.0059 0.0074
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0921 0.7978 1
Schistosoma mansoni carbon catabolite repressor protein 0.0024 0.0029 0.0037
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.0059 0.0114
Leishmania major pantothenate kinase subunit, putative 0.0024 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0027 0.0059 0.0114
Trypanosoma brucei C-8 sterol isomerase, putative 0.038 0.3186 0.3993
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0261 0.1193
Brugia malayi RNA recognition motif domain containing protein 0.033 0.2745 0.5268
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0144 0.0181
Echinococcus multilocularis neutral alpha glucosidase AB 0.0073 0.0463 0.0907
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0024 0.0029 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0334 0.0419
Schistosoma mansoni tar DNA-binding protein 0.033 0.2745 0.3493
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0024 0.0029 0.0056
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0334 0.0419
Loa Loa (eye worm) MBCTL1 0.0166 0.1286 0.2468
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0063 0.0289
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0059 0.0271
Entamoeba histolytica deoxycytidyl transferase, putative 0.0058 0.0334 0.2971
Loa Loa (eye worm) hypothetical protein 0.0088 0.0597 0.1145
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0227 0.0285
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0292 0.2407 0.462
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0609 0.521 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0117 0.0857 0.1074
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0067 0.0129
Trypanosoma brucei protein kinase, putative 0.005 0.0261 0.0328
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0348 0.0436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0123 0.0561
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0067 0.0307
Brugia malayi Pre-SET motif family protein 0.0031 0.0096 0.0184
Echinococcus multilocularis lysosomal alpha glucosidase 0.0327 0.2718 0.5326
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0024 0.0029 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.004 0.018
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0261 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0093 0.0425
Echinococcus granulosus histone acetyltransferase KAT2B 0.0424 0.3578 0.7011
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0166 0.1286 0.2519
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0261 0.0512
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0024 0.0029 0.0259
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0059 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.004 0.0182
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0117 0.0857 0.761
Trypanosoma cruzi DNA polymerase eta, putative 0.0058 0.0334 0.0419
Loa Loa (eye worm) hypothetical protein 0.018 0.1413 0.2713
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0024 0.0029 0.0037
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0022 0.0014 0.0063
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0024 0.0029 0.0206
Plasmodium falciparum ataxin-2 like protein, putative 0.0153 0.1172 1
Echinococcus granulosus polycomb protein SCMH1 0.0145 0.1108 0.217
Echinococcus granulosus neutral alpha glucosidase AB 0.0073 0.0463 0.0907
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0024 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.018 0.1413 0.2713
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0067 0.0476
Leishmania major hypothetical protein, conserved 0.0024 0.0029 0.0037
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0436 0.3681 0.4614
Entamoeba histolytica hypothetical protein 0.0147 0.1126 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0024 0.0029 0.0056
Schistosoma mansoni synaptojanin 0.0024 0.0029 0.0037
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0144 0.0181
Leishmania major trypanothione reductase 0.0046 0.0227 0.0284
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0261 0.0512
Echinococcus granulosus solute carrier family 5 0.0038 0.0161 0.0315
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0058 0.0334 0.0655
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0117 0.0857 0.1678
Plasmodium falciparum DNase I-like protein, putative 0.0024 0.0029 0.0249
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0024 0.0029 0.0056
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0436 0.3681 0.4614
Loa Loa (eye worm) hypothetical protein 0.018 0.1413 0.2713
Loa Loa (eye worm) hypothetical protein 0.0038 0.0161 0.0308
Trichomonas vaginalis D-aminoacylase, putative 0.018 0.1413 0.645
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0161 0.0315
Plasmodium vivax SET domain protein, putative 0.0031 0.0096 0.0679
Leishmania major cathepsin L-like protease 0.0065 0.0398 0.0499
Brugia malayi Flap endonuclease-1 0.0028 0.0067 0.0129
Trypanosoma cruzi PAB1-binding protein , putative 0.0153 0.1172 0.1468
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0161 0.0315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.004 0.0182
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0067 0.0084
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0292 0.2407 0.4716
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0463 0.2113
Brugia malayi PHD-finger family protein 0.0114 0.0827 0.1587
Onchocerca volvulus 0.0038 0.0161 0.0814
Echinococcus granulosus methyl CpG binding domain protein 2 0.0069 0.0435 0.0852
Echinococcus granulosus histone acetyltransferase MYST2 0.0166 0.1286 0.2519
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0059 0.0074
Echinococcus multilocularis solute carrier family 5 0.0038 0.0161 0.0315
Loa Loa (eye worm) PHD-finger family protein 0.0084 0.0564 0.1082
Plasmodium vivax SET domain containing protein 0.0022 0.0015 0.0109
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0024 0.0029 0.0259
Mycobacterium leprae Probable lipase LipE 0.018 0.1413 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.018 0.1413 0.1388
Brugia malayi ERG2 and Sigma1 receptor like protein 0.038 0.3186 0.6115
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0073 0.0463 0.3276
Schistosoma mansoni DNA polymerase eta 0.0058 0.0334 0.0426
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0852 0.0825
Plasmodium vivax hypothetical protein, conserved 0.018 0.1413 1
Echinococcus granulosus tumor protein p63 0.0356 0.2971 0.5821
Trichomonas vaginalis D-aminoacylase, putative 0.018 0.1413 0.645
Loa Loa (eye worm) hypothetical protein 0.0349 0.2908 0.5582
Brugia malayi ImpB/MucB/SamB family protein 0.0058 0.0334 0.0642
Brugia malayi hypothetical protein 0.0088 0.0597 0.1145
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0255 0.2082 0.4079
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0354 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0168 0.0765
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0161 0.0315
Mycobacterium tuberculosis Probable esterase LipL 0.018 0.1413 0.1388
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0334 0.0419
Loa Loa (eye worm) hypothetical protein 0.0288 0.237 0.4549
Schistosoma mansoni hypothetical protein 0.0165 0.1283 0.1632
Brugia malayi hypothetical protein 0.0153 0.1172 0.2249
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0158 0.1218 0.1527
Brugia malayi Bromodomain containing protein 0.0167 0.1296 0.2487
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0398 0.0499
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0261 0.1849
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0024 0.0029 0.0057
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0398 0.0499
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0146 0.1116 0.2186
Mycobacterium tuberculosis Probable lipase LipE 0.018 0.1413 0.1388
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.013 0.0967 0.1212
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0261 0.0328
Plasmodium falciparum glutathione reductase 0.0046 0.0227 0.1937
Plasmodium falciparum histone acetyltransferase GCN5 0.0118 0.0862 0.736
Loa Loa (eye worm) hypothetical protein 0.0024 0.0029 0.0056
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0024 0.0029 0.0249
Trypanosoma cruzi C-8 sterol isomerase, putative 0.038 0.3186 0.3993
Entamoeba histolytica hypothetical protein 0.0147 0.1126 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0101 0.0711 0.0905
Trypanosoma brucei hypothetical protein, conserved 0.018 0.1413 0.1771
Leishmania major cathepsin L-like protease 0.0065 0.0398 0.0499
Echinococcus granulosus beta LACTamase domain containing family member 0.018 0.1413 0.2769
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0193 0.1525 0.2989
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0227 0.2019
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0463 0.2113
Schistosoma mansoni sodium/solute symporter 0.0038 0.0161 0.0204
Schistosoma mansoni synaptojanin 0.0024 0.0029 0.0037
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0227 0.0436
Trichomonas vaginalis ap endonuclease, putative 0.0117 0.0857 0.391
Schistosoma mansoni nocturnin 0.0024 0.0029 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0334 0.0419
Onchocerca volvulus 0.0052 0.0281 0.1425
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0024 0.0029 0.0259
Schistosoma mansoni hypothetical protein 0.0193 0.1525 0.1941
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0398 0.0499
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0024 0.0029 0.0037
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.018 0.1413 0.2713
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0059 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0123 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.004 0.0182
Giardia lamblia GTOR 0.0046 0.0227 0.2636
Echinococcus granulosus lysosomal alpha glucosidase 0.0327 0.2718 0.5326
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0227 0.0289
Loa Loa (eye worm) hypothetical protein 0.0088 0.0597 0.1145
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0093 0.0647 0.0823
Brugia malayi RNA binding protein 0.033 0.2745 0.5268
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0013 0.0016
Schistosoma mansoni terminal deoxycytidyl transferase 0.0058 0.0334 0.0426
Schistosoma mansoni tar DNA-binding protein 0.033 0.2745 0.3493
Entamoeba histolytica acetyltransferase, GNAT family 0.0118 0.0862 0.7661
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.2191 1
Schistosoma mansoni hypothetical protein 0.0193 0.1525 0.1941
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0852 0.0825
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0117 0.0857 0.1074
Brugia malayi glutathione reductase 0.0046 0.0227 0.0435
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0068 0.0426 0.0835
Plasmodium falciparum ataxin-2 like protein, putative 0.0153 0.1172 1
Onchocerca volvulus 0.018 0.1413 0.7165
Trypanosoma brucei ISWI complex protein 0.0062 0.0372 0.0466
Loa Loa (eye worm) beta-lactamase 0.018 0.1413 0.2713
Onchocerca volvulus 0.018 0.1413 0.7165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.004 0.0182
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0334 0.0419
Brugia malayi Calcitonin receptor-like protein seb-1 0.0609 0.521 1
Echinococcus granulosus GPCR family 2 0.0193 0.1525 0.2989
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0024 0.0029 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0144 0.0657
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0398 0.0499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0063 0.0289
Trypanosoma cruzi ISWI complex protein 0.0062 0.0372 0.0466
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0748 0.0721
Echinococcus granulosus zinc finger protein 0.0092 0.0635 0.1244
Mycobacterium ulcerans esterase/lipase LipP 0.018 0.1413 0.2852
Loa Loa (eye worm) mbt repeat family protein 0.0145 0.1108 0.2126
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0274 0.0344
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0334 0.0419
Schistosoma mansoni cpg binding protein 0.0028 0.0067 0.0085
Schistosoma mansoni hypothetical protein 0.0416 0.3505 0.446
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0117 0.0857 0.083
Leishmania major cathepsin L-like protease 0.0065 0.0398 0.0499
Brugia malayi GH02984p 0.0349 0.2908 0.5582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0144 0.0657
Schistosoma mansoni alpha glucosidase 0.0073 0.0463 0.0589
Echinococcus granulosus traf and tnf receptor associated protein 0.0024 0.0029 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1459 0.6661
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0024 0.0029 0.0259
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0024 0.0029 0.0206
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0463 0.2113
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0161 0.0315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0123 0.0561
Plasmodium vivax hypothetical protein, conserved 0.002 0.000000011335 0.000000080203
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0227 0.0285
Onchocerca volvulus 0.018 0.1413 0.7165
Mycobacterium tuberculosis Conserved hypothetical protein 0.0485 0.4117 0.41
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.013 0.0967 0.1212
Brugia malayi Bromodomain containing protein 0.0318 0.2633 0.5054
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0024 0.0029 0.0259
Leishmania major DNA polymerase eta, putative 0.0058 0.0334 0.0419
Echinococcus granulosus cpg binding protein 0.0037 0.015 0.0294
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0117 0.0857 0.9934
Schistosoma mansoni methyl-cpg binding protein mbd 0.0069 0.0435 0.0553
Mycobacterium tuberculosis Conserved protein 0.018 0.1413 0.1388
Schistosoma mansoni bromodomain containing protein 0.003 0.0083 0.0106
Echinococcus multilocularis polycomb protein SCMH1 0.0145 0.1108 0.217
Trypanosoma cruzi PAB1-binding protein , putative 0.0153 0.1172 0.1468
Echinococcus multilocularis deoxyribonuclease 1 2 0.0024 0.0029 0.0057
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0227 0.0285
Echinococcus granulosus fetal alzheimer antigen falz 0.0093 0.0647 0.1268
Echinococcus multilocularis traf and tnf receptor associated protein 0.0024 0.0029 0.0057
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0024 0.0029 0.0206
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1376 0.6279
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0398 0.0499
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0024 0.0029 0.0259
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0024 0.0029 0.0056
Brugia malayi beta-lactamase family protein 0.018 0.1413 0.2713
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0117 0.0857 0.7312
Echinococcus granulosus neutral sphingomyelinase 0.0024 0.0029 0.0057
Schistosoma mansoni ap endonuclease 0.0117 0.0857 0.109
Schistosoma mansoni tar DNA-binding protein 0.033 0.2745 0.3493
Trichomonas vaginalis penicillin-binding protein, putative 0.018 0.1413 0.645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0227 0.1037
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0334 0.0419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0398 0.0499
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0024 0.0029 0.0133
Brugia malayi Glycosyl hydrolases family 31 protein 0.0073 0.0463 0.0889
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0117 0.0857 0.6061
Schistosoma mansoni hypothetical protein 0.0193 0.1525 0.1941
Loa Loa (eye worm) hypothetical protein 0.0024 0.0029 0.0056
Trypanosoma brucei unspecified product 0.004 0.0175 0.0219
Mycobacterium ulcerans beta-lactamase 0.018 0.1413 0.2852
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.018 0.1413 0.2852
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0117 0.0857 0.1678
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0281 0.0358
Echinococcus granulosus dna polymerase kappa 0.0058 0.0334 0.0655
Giardia lamblia hypothetical protein 0.0024 0.0029 0.0338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0398 0.0499
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0022 0.0014 0.0063
Echinococcus granulosus histone lysine methyltransferase setb 0.0101 0.0711 0.1393
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0292 0.2407 0.4716
Loa Loa (eye worm) hypothetical protein 0.018 0.1413 0.2713
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0081 0.0158
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0024 0.0029 0.0037
Brugia malayi CXXC zinc finger family protein 0.0028 0.0067 0.0129
Schistosoma mansoni transcription factor LCR-F1 0.0147 0.1126 0.1433
Loa Loa (eye worm) hypothetical protein 0.0024 0.0029 0.0056
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1376 0.6279
Schistosoma mansoni tar DNA-binding protein 0.033 0.2745 0.3493
Schistosoma mansoni hypothetical protein 0.0907 0.7858 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0138 0.1042 0.4758
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0261 0.0328
Echinococcus multilocularis neutral sphingomyelinase 0.0024 0.0029 0.0057
Schistosoma mansoni methyl-cpg binding protein mbd 0.0069 0.0435 0.0553
Brugia malayi Glycosyl hydrolases family 31 protein 0.0327 0.2718 0.5217
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0334 0.0419
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0024 0.0029 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0463 0.058
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0024 0.0029 0.0259
Schistosoma mansoni hypothetical protein 0.0084 0.0564 0.0718
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0024 0.0029 0.0206
Onchocerca volvulus 0.0024 0.0029 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.004 0.018
Toxoplasma gondii histone lysine methyltransferase SET1 0.0074 0.0478 0.3384
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0024 0.0029 0.0259
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0024 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.018 0.1413 0.2713
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0327 0.2718 0.5217
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0138 0.1042 0.7376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.004 0.018
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0024 0.0029 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0334 0.0419
Toxoplasma gondii thioredoxin reductase 0.0046 0.0227 0.1605
Schistosoma mansoni hypothetical protein 0.0397 0.3341 0.4251
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0147 0.1126 0.2205
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0024 0.0029 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0334 0.0419
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1459 0.6661
Schistosoma mansoni hypothetical protein 0.0147 0.1126 0.1433
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0147 0.1126 0.2205
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0024 0.0029 0.0056
Loa Loa (eye worm) hypothetical protein 0.038 0.3186 0.6115
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0024 0.0029 0.0206
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0058 0.0334 0.0655
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0093 0.0647 0.1268
Loa Loa (eye worm) hypothetical protein 0.0166 0.1286 0.2468
Schistosoma mansoni cpg binding protein 0.0037 0.015 0.0191
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0073 0.0463 0.4113
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0067 0.0597
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0292 0.2407 0.3063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0398 0.0499
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.2191 1
Trypanosoma brucei RNA editing exonuclease 2 0.0024 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0052 0.0281 0.054
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.1818 0.3489
Loa Loa (eye worm) hypothetical protein 0.018 0.1413 0.2713
Entamoeba histolytica hypothetical protein 0.0147 0.1126 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0024 0.0029 0.0056
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.013 0.0967 0.1212
Loa Loa (eye worm) glutathione reductase 0.0046 0.0227 0.0435
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0067 0.078
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0463 0.058
Loa Loa (eye worm) latrophilin receptor protein 2 0.0193 0.1525 0.2928
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0067 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0227 0.1037
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0227 0.2019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0398 0.0499
Echinococcus multilocularis GPCR, family 2 0.0193 0.1525 0.2989
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0852 0.0825
Trypanosoma cruzi mitochondrial protein 99, putative 0.0024 0.0029 0.0037
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.1042 0.2042
Brugia malayi follicle stimulating hormone receptor 0.0226 0.1818 0.3489
Mycobacterium tuberculosis Probable reductase 0.0105 0.0748 0.0721
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0292 0.2407 0.462
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0058 0.0334 0.0306
Loa Loa (eye worm) RNA binding protein 0.033 0.2745 0.5268
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0101 0.0711 0.1393
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0193 0.1525 0.2989
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0748 0.0721
Giardia lamblia Inositol 5-phosphatase 4 0.0024 0.0029 0.0338
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0175 0.0219
Leishmania major glycosyl hydrolase-like protein 0.0027 0.0059 0.0074
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0024 0.0029 0.0037
Plasmodium vivax exodeoxyribonuclease III, putative 0.0024 0.0029 0.0206
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.1413 0.1771
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0334 0.0419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0398 0.0499
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0398 0.0499
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0227 0.0436
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0138 0.1042 0.7376
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0024 0.0029 0.0056
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0144 0.0181
Echinococcus granulosus SAM and MBT domain containing protein 0.0145 0.1108 0.217
Echinococcus multilocularis tar DNA binding protein 0.033 0.2745 0.5378
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.018 0.1413 0.1799
Loa Loa (eye worm) hypothetical protein 0.0101 0.0711 0.1364
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0058 0.0334 0.0642
Entamoeba histolytica ankyrin repeat protein, putative 0.002 0.000000011335 0.0000001007
Echinococcus granulosus dnaJ subfamily B 0.0397 0.3341 0.6545
Schistosoma mansoni sex comb on midleg homolog 0.0145 0.1108 0.141
Schistosoma mansoni neutral sphingomyelinase 0.0024 0.0029 0.0037
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0261 0.0502
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0268 0.2191 0.4205
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0059 0.0271
Onchocerca volvulus Putative neutral sphingomyelinase 0.0024 0.0029 0.0148
Plasmodium vivax ataxin-2 like protein, putative 0.0153 0.1172 0.829
Trichomonas vaginalis DNA polymerase eta, putative 0.0058 0.0334 0.1527
Onchocerca volvulus 0.0243 0.1973 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0029 0.0056
Loa Loa (eye worm) hypothetical protein 0.0177 0.1384 0.2656
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0024 0.0029 0.0037
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0024 0.0029 0.0056
Brugia malayi mbt repeat family protein 0.0145 0.1108 0.2126
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0463 0.2113
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1376 0.6279
Echinococcus multilocularis beta LACTamase domain containing family member 0.018 0.1413 0.2769
Echinococcus granulosus tar DNA binding protein 0.033 0.2745 0.5378
Leishmania major hypothetical protein, conserved 0.0024 0.0029 0.0037
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0024 0.0029 0.0056
Echinococcus multilocularis zinc finger protein 0.0092 0.0635 0.1244
Plasmodium falciparum thioredoxin reductase 0.0046 0.0227 0.1937
Loa Loa (eye worm) hypothetical protein 0.0609 0.521 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0145 0.1108 0.5615
Trypanosoma brucei unspecified product 0.004 0.0175 0.0219
Schistosoma mansoni eyes absent homolog 0.0088 0.0597 0.0759
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0227 0.0445
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0193 0.1525 0.2989
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0096 0.0188
Echinococcus granulosus dna polymerase eta 0.0058 0.0334 0.0655
Mycobacterium ulcerans lipase LipD 0.018 0.1413 0.2852
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0024 0.0029 0.0133
Leishmania major endonuclease/exonuclease protein-like protein 0.0024 0.0029 0.0037
Brugia malayi Latrophilin receptor protein 2 0.0193 0.1525 0.2928
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0144 0.0657
Loa Loa (eye worm) acetyltransferase 0.0446 0.3772 0.724
Trichomonas vaginalis ap endonuclease, putative 0.0117 0.0857 0.391
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0024 0.0029 0.0037
Trypanosoma brucei DNA polymerase eta, putative 0.0058 0.0334 0.0419
Plasmodium vivax glutathione reductase, putative 0.0046 0.0227 0.1605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0123 0.0561
Leishmania major C-8 sterol isomerase-like protein 0.038 0.3186 0.3993
Trichomonas vaginalis esterase, putative 0.018 0.1413 0.645
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0024 0.0029 0.0037
Trichomonas vaginalis D-aminoacylase, putative 0.018 0.1413 0.645
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0024 0.0029 0.0133
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0073 0.0463 0.2113
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0227 0.0285
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0921 0.7978 1
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.1413 0.1771
Loa Loa (eye worm) hypothetical protein 0.0145 0.1108 0.2126
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0024 0.0029 0.0037
Schistosoma mansoni zinc finger protein 0.0062 0.0372 0.0473
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0117 0.0857 0.138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0398 0.0499
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0117 0.0857 0.5
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0024 0.0029 0.0056
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0073 0.0463 0.0889
Toxoplasma gondii LsmAD domain-containing protein 0.0153 0.1172 0.829
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0398 0.0499
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0117 0.0857 0.1074
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0463 0.2113
Leishmania major hypothetical protein, conserved 0.018 0.1413 0.1771
Echinococcus multilocularis synaptojanin 1 0.0024 0.0029 0.0057
Toxoplasma gondii ABC1 family protein 0.018 0.1413 1
Toxoplasma gondii bromodomain-containing protein 0.002 0.000000011335 0.000000080203
Echinococcus multilocularis geminin 0.0165 0.1283 0.2513
Echinococcus multilocularis tumor protein p63 0.0356 0.2971 0.5821
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0144 0.0657
Brugia malayi hypothetical protein 0.0099 0.0693 0.1329
Trypanosoma brucei DNA polymerase beta thumb, putative 0.013 0.0967 0.1212
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.3341 0.6545
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0748 0.0721
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0261 0.1193
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0123 0.0869
Onchocerca volvulus 0.0031 0.0096 0.0486
Leishmania major hypothetical protein, conserved 0.0153 0.1172 0.1468
Mycobacterium tuberculosis Conserved protein 0.018 0.1413 0.1388
Trichomonas vaginalis Phospholipase C precursor, putative 0.0024 0.0029 0.0133
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.2191 1
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0261 0.3031
Mycobacterium tuberculosis Conserved hypothetical protein 0.0058 0.0334 0.0306
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0024 0.0029 0.0206
Brugia malayi beta-lactamase 0.018 0.1413 0.2713
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0161 0.0315
Trichomonas vaginalis set domain proteins, putative 0.0243 0.1973 0.9003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0292 0.2407 0.3063
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0255 0.2082 0.4079
Schistosoma mansoni zinc finger protein 0.0092 0.0635 0.0808
Mycobacterium ulcerans hypothetical protein 0.018 0.1413 0.2852
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0227 0.0435
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0138 0.1042 0.4758
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0024 0.0029 0.0037
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0024 0.0029 0.0206
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0193 0.1525 0.2928
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0261 0.1193
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0024 0.0029 0.0056
Leishmania major mitochondrial DNA polymerase beta 0.0921 0.7978 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0166 0.1286 0.1636
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0084 0.0385
Trypanosoma cruzi ISWI complex protein 0.0062 0.0372 0.0466
Loa Loa (eye worm) hypothetical protein 0.003 0.0083 0.0159
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0166 0.1286 0.2468
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0096 0.0122
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0261 0.0328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0061 0.0278
Loa Loa (eye worm) hypothetical protein 0.0156 0.1204 0.231
Trichomonas vaginalis maltase-glucoamylase, putative 0.0073 0.0463 0.2113
Trypanosoma brucei PAB1-binding protein , putative 0.0153 0.1172 0.1468
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0446 0.3772 0.4801
Loa Loa (eye worm) TAR-binding protein 0.033 0.2745 0.5268
Entamoeba histolytica hypothetical protein 0.0147 0.1126 1
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.2191 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0609 0.521 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0096 0.0679
Loa Loa (eye worm) hypothetical protein 0.0416 0.3505 0.6727
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1376 0.6279
Echinococcus granulosus flap endonuclease 1 0.0028 0.0067 0.0132
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0597 0.5104 1
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0161 0.1136
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0268 0.2191 0.4205
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1376 0.6279
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0024 0.0029 0.0133
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1376 0.6279
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0161 0.0308
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0024 0.0029 0.0133
Loa Loa (eye worm) hypothetical protein 0.0193 0.1525 0.2928
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0227 0.0445
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.018 0.1413 0.2713
Brugia malayi Pre-SET motif family protein 0.0214 0.1712 0.3286
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0227 0.0445
Loa Loa (eye worm) bromodomain containing protein 0.0083 0.0552 0.1059
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0024 0.0029 0.0259
Onchocerca volvulus 0.0189 0.1496 0.7585
Schistosoma mansoni sex comb on midleg homolog 0.0145 0.1108 0.141
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0024 0.0029 0.0037
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.018 0.1413 0.1799
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0138 0.1042 0.7376
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0024 0.0029 0.0056
Echinococcus granulosus geminin 0.0165 0.1283 0.2513
Echinococcus multilocularis lysosomal alpha glucosidase 0.0327 0.2718 0.5326
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0024 0.0029 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0175 0.0219
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0073 0.0463 0.4113
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.2191 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0059 0.0271
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0059 0.0271
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.018 0.1413 0.1388
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0227 0.0285
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0597 0.5104 1
Leishmania major RNA-editing complex protein MP100, putative 0.0024 0.0029 0.0037
Leishmania major DNA polymerase kappa, putative 0.0058 0.0334 0.0419
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0292 0.2407 0.3063
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0024 0.0029 0.0056
Brugia malayi MAP kinase sur-1 0.005 0.0261 0.0502
Trichomonas vaginalis sucrase-isomaltase, putative 0.0073 0.0463 0.2113
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0175 0.0219
Toxoplasma gondii hypothetical protein 0.0149 0.1136 0.8036
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0073 0.0463 0.2113
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0024 0.0029 0.0133
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0161 0.0315
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0145 0.1108 0.141
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0261 0.0328
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0059 0.0528
Schistosoma mansoni ap endonuclease 0.0117 0.0857 0.109
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0227 0.0284
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0068 0.0426 0.0835
Schistosoma mansoni cript-related 0.0024 0.0029 0.0037
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0024 0.0029 0.0037
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0027 0.0059 0.0301
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0261 0.0328
Onchocerca volvulus 0.0024 0.0029 0.0148
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0334 0.0419
Schistosoma mansoni alpha-glucosidase 0.0282 0.2315 0.2946
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0227 0.0445
Trypanosoma brucei glucosidase, putative 0.0073 0.0463 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0061 0.0278
Mycobacterium leprae conserved hypothetical protein 0.018 0.1413 1
Brugia malayi latrophilin 2 splice variant baaae 0.0416 0.3505 0.6727
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0146 0.1116 0.2186
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0921 0.7978 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0123 0.0561
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0193 0.1525 0.2989
Echinococcus multilocularis SAM and MBT domain containing protein 0.0145 0.1108 0.217
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0029 0.0206
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0261 0.0512
Schistosoma mansoni flap endonuclease-1 0.0025 0.0043 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0063 0.0289
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0161 0.0315
Loa Loa (eye worm) hypothetical protein 0.0058 0.0334 0.0642
Brugia malayi Thioredoxin reductase 0.0046 0.0227 0.0435
Trypanosoma brucei trypanothione reductase 0.0046 0.0227 0.0284
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0058 0.0334 0.0426
Brugia malayi acetyltransferase, GNAT family protein 0.0446 0.3772 0.724
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.2191 1
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0024 0.0029 0.0037
Echinococcus multilocularis dna polymerase kappa 0.0058 0.0334 0.0655
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0292 0.2407 0.4716
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0334 0.0419
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.033 0.2745 0.5268
Echinococcus granulosus synaptojanin 1 0.0024 0.0029 0.0057
Brugia malayi CCR4 0.0024 0.0029 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0398 0.0499
Leishmania major hypothetical protein, conserved 0.0024 0.0029 0.0037
Plasmodium falciparum flap endonuclease 1 0.0028 0.0067 0.0574
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0123 0.0561
Loa Loa (eye worm) hypothetical protein 0.0153 0.1172 0.2249
Schistosoma mansoni high-affinity choline transporter 0.0349 0.2908 0.3701
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0024 0.0029 0.0206
Giardia lamblia Histone acetyltransferase GCN5 0.0118 0.0862 1
Schistosoma mansoni hypothetical protein 0.0068 0.0426 0.0542
Echinococcus granulosus high affinity choline transporter 1 0.0349 0.2908 0.5698
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0334 0.0419
Echinococcus multilocularis dna polymerase eta 0.0058 0.0334 0.0655
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0067 0.0476
Trichomonas vaginalis penicillin-binding protein, putative 0.018 0.1413 0.645
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0024 0.0029 0.0249
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0261 0.0512
Schistosoma mansoni hypothetical protein 0.0062 0.0372 0.0473
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0334 0.0419
Echinococcus multilocularis cpg binding protein 0.0037 0.015 0.0294
Leishmania major alpha glucosidase II subunit, putative 0.0073 0.0463 0.058
Loa Loa (eye worm) hypothetical protein 0.0194 0.154 0.2956
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0059 0.0271
Schistosoma mansoni bromodomain containing protein 0.027 0.2211 0.2814
Giardia lamblia DINP protein human, muc B family 0.0058 0.0334 0.3879
Onchocerca volvulus 0.0028 0.0067 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0144 0.0657
Brugia malayi exodeoxyribonuclease III family protein 0.0117 0.0857 0.1644
Trypanosoma brucei unspecified product 0.0058 0.0334 0.0419
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0292 0.2407 0.4716
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0024 0.0029 0.0057
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0024 0.0029 0.0259
Brugia malayi mbt repeat family protein 0.0145 0.1108 0.2126
Trichomonas vaginalis maltase-glucoamylase, putative 0.0027 0.0059 0.0271
Mycobacterium tuberculosis Conserved protein 0.018 0.1413 0.1388
Brugia malayi beta-lactamase family protein 0.018 0.1413 0.2713
Brugia malayi hypothetical protein 0.0147 0.1126 0.216
Mycobacterium tuberculosis Probable hydrolase 0.018 0.1413 0.1388
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0024 0.0029 0.0037
Schistosoma mansoni inositol transporter 0.0038 0.0161 0.0204
Onchocerca volvulus 0.0145 0.1108 0.5615
Mycobacterium ulcerans hypothetical protein 0.0485 0.4117 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0436 0.3681 0.4614
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0024 0.0029 0.0057
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0227 0.0285
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0058 0.0334 0.1527
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0227 0.0198
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0024 0.0029 0.0057
Loa Loa (eye worm) hypothetical protein 0.0186 0.1467 0.2815
Plasmodium falciparum bromodomain protein 1 0.002 0.000000011335 0.00000009675
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0067 0.0132
Schistosoma mansoni alpha-glucosidase 0.0282 0.2315 0.2946
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0024 0.0029 0.0037
Treponema pallidum exodeoxyribonuclease (exoA) 0.0117 0.0857 1
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1376 0.6279
Brugia malayi TAR-binding protein 0.033 0.2745 0.5268
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0024 0.0029 0.0259
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0261 0.0328
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0166 0.1286 0.2519
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0446 0.3772 0.7391
Trypanosoma cruzi mitochondrial protein 99, putative 0.0024 0.0029 0.0037
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0069 0.0435 0.0852
Brugia malayi ImpB/MucB/SamB family protein 0.0058 0.0334 0.0642
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0024 0.0029 0.0037
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0261 0.0328
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0024 0.0029 0.0037
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.1712 0.3286
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0852 0.1558
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0398 0.0499
Toxoplasma gondii exonuclease III APE 0.0117 0.0857 0.6061
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0059 0.0271
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0058 0.0334 0.0419
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0024 0.0029 0.0249
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0748 0.0721
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0024 0.0029 0.0249
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0101 0.0711 0.0905

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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