Detailed information for compound 725842

Basic information

Technical information
  • TDR Targets ID: 725842
  • Name: 1-[2-(2-methoxyphenyl)ethyl]-3-(2-methylpheny l)urea
  • MW: 284.353 | Formula: C17H20N2O2
  • H donors: 2 H acceptors: 1 LogP: 3.22 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1CCNC(=O)Nc1ccccc1C
  • InChi: 1S/C17H20N2O2/c1-13-7-3-5-9-15(13)19-17(20)18-12-11-14-8-4-6-10-16(14)21-2/h3-10H,11-12H2,1-2H3,(H2,18,19,20)
  • InChiKey: NQUCNYXAUVQSNG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC06725527
  • IVK/0014699

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus zinc finger protein 0.005 0.0671 0.0735
Echinococcus granulosus transient receptor potential ion channel A 0.0093 0.1603 0.1789
Loa Loa (eye worm) hypothetical protein 0.0075 0.121 0.1309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0218
Echinococcus multilocularis transient receptor potential ion channel A 0.0093 0.1603 0.1717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0596 0.1169
Brugia malayi beta-lactamase family protein 0.0075 0.121 0.129
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0514 0.0823
Onchocerca volvulus 0.0075 0.121 0.2039
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.2051 0.2202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0388 0.0746
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0357 0.0381
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0131 0.243 0.2613
Loa Loa (eye worm) hypothetical protein 0.0075 0.121 0.1309
Schistosoma mansoni bromodomain containing protein 0.0138 0.2587 0.2799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1023 0.164
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.2727 0.4358
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0589 0.0617
Brugia malayi Latrophilin receptor protein 2 0.0132 0.2457 0.2643
Echinococcus multilocularis tar DNA binding protein 0.0194 0.38 0.4099
Schistosoma mansoni transient receptor potential channel 4 0.0096 0.1673 0.181
Loa Loa (eye worm) hypothetical protein 0.0132 0.2457 0.2659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0596 0.1169
Onchocerca volvulus 0.0047 0.0589 0.0716
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0406 0.0418
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0406 0.0436
Echinococcus multilocularis tumor protein p63 0.0349 0.7167 0.7751
Schistosoma mansoni tar DNA-binding protein 0.0194 0.38 0.4112
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.121 0.1192
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.1153 0.1229
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0074 0.0061
Entamoeba histolytica hypothetical protein 0.0114 0.2051 0.9513
Loa Loa (eye worm) hypothetical protein 0.0419 0.8676 0.9389
Trypanosoma brucei unspecified product 0.002 0.002 0.0031
Schistosoma mansoni hypothetical protein 0.0031 0.0249 0.0269
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0684 0.1096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0335 0.0639
Trypanosoma cruzi ISWI complex protein 0.0031 0.0249 0.0368
Schistosoma mansoni transient receptor potential channel 0.0064 0.0964 0.1043
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.121 0.1915
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0388 0.0593
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0729 0.0801
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0031
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0285 0.5766 0.624
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0031
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0589 0.0643
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.121 0.194
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0447 0.0867
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0406 0.0783
Schistosoma mansoni hypothetical protein 0.0023 0.0074 0.008
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0596 0.0955
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0254 0.0275
Echinococcus multilocularis zinc finger protein 0.005 0.0671 0.0705
Mycobacterium tuberculosis Conserved protein 0.0075 0.121 0.1192
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0285 0.5766 0.6493
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0335 0.0639
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.121 0.2417
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0684 0.192
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0306 0.6232 1
Mycobacterium leprae conserved hypothetical protein 0.0075 0.121 0.5
Schistosoma mansoni hypothetical protein 0.0132 0.2457 0.2659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0218
Schistosoma mansoni tar DNA-binding protein 0.0194 0.38 0.4112
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0326 0.0345
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0326 0.0353
Loa Loa (eye worm) acetyltransferase 0.0445 0.9241 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0134 0.2493 0.5025
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0596 0.0645
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0689 0.0746
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.2051 0.222
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0897 0.1412
Toxoplasma gondii ABC1 family protein 0.0075 0.121 0.4267
Onchocerca volvulus 0.0051 0.0689 0.0928
Echinococcus granulosus tar DNA binding protein 0.0194 0.38 0.4271
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0132 0.2457 0.2643
Loa Loa (eye worm) hypothetical protein 0.0286 0.5798 0.6274
Brugia malayi mbt repeat family protein 0.0047 0.0589 0.0617
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0031
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0131 0.243 0.2723
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0254 0.0254
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1023 0.164
Schistosoma mansoni tar DNA-binding protein 0.0194 0.38 0.4112
Schistosoma mansoni transient receptor potential channel 0.0064 0.0964 0.1043
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0596 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0186 0.0337
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0229 0.0236
Schistosoma mansoni ap endonuclease 0.0038 0.0406 0.0439
Loa Loa (eye worm) beta-lactamase 0.0075 0.121 0.1309
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.373 0.4023
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0589 0.0617
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.121 0.1309
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0059 0.0094
Leishmania major hypothetical protein, conserved 0.0031 0.0249 0.0368
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.121 0.2417
Loa Loa (eye worm) TAR-binding protein 0.0194 0.38 0.4112
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0596 0.0926
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0261 0.0489
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0132 0.2457 0.2754
Entamoeba histolytica hypothetical protein 0.0114 0.2051 0.9513
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.002 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0335 0.0639
Echinococcus granulosus transient receptor potential gamma protein 0.0096 0.1673 0.1868
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0596 0.2695
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0031
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0326 0.0331
Giardia lamblia GTOR 0.0047 0.0596 0.2695
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0186 0.0337
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.121 0.1192
Mycobacterium leprae Probable lipase LipE 0.0075 0.121 0.5
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0729 0.0789
Mycobacterium tuberculosis Conserved protein 0.0075 0.121 0.1192
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0596 0.065
Mycobacterium ulcerans hypothetical protein 0.0075 0.121 0.3883
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0134 0.2493 1
Brugia malayi hypothetical protein 0.0051 0.0684 0.072
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0684 0.1068
Schistosoma mansoni hypothetical protein 0.0286 0.5798 0.6274
Echinococcus granulosus histone acetyltransferase KAT2B 0.0428 0.8869 1
Leishmania major mitochondrial DNA polymerase beta 0.0306 0.6232 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1023 0.164
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0713 0.1116
Brugia malayi RNA binding protein 0.0194 0.38 0.4099
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0589 0.0638
Loa Loa (eye worm) hypothetical protein 0.0033 0.0288 0.0311
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.002 0.0031
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0406 0.5
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0134 0.2493 0.5025
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.121 0.3883
Brugia malayi beta-lactamase 0.0075 0.121 0.129
Schistosoma mansoni tar DNA-binding protein 0.0194 0.38 0.4112
Schistosoma mansoni hypothetical protein 0.0291 0.5892 0.6377
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1023 0.164
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0388 0.0593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0388 0.0746
Brugia malayi Bromodomain containing protein 0.0088 0.1491 0.1596
Loa Loa (eye worm) hypothetical protein 0.0143 0.2679 0.2899
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0132 0.2457 0.2754
Leishmania major cathepsin L-like protease 0.0066 0.1023 0.1614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0335 0.0639
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0596 0.1169
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0718 0.1124
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0285 0.5766 0.6493
Loa Loa (eye worm) hypothetical protein 0.0077 0.126 0.1364
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0589 0.0643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0127 0.0216
Trypanosoma brucei ISWI complex protein 0.0031 0.0249 0.0398
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0031
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.121 0.129
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0596 0.2695
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.2727 0.4375
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0045 0.0567 0.0592
Brugia malayi hypothetical protein 0.0114 0.2051 0.2202
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0031
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0483 0.0522
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0406 0.1806
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0406 0.0418
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.1023 0.1614
Loa Loa (eye worm) MBCTL1 0.0053 0.0729 0.0789
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0729 0.0769
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.458 0.4956
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1023 0.164
Loa Loa (eye worm) latrophilin receptor protein 2 0.0132 0.2457 0.2659
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.121 0.1915
Schistosoma mansoni hypothetical protein 0.0042 0.0483 0.0522
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1023 0.164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0388 0.0746
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.1023 0.1614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0218
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0134 0.2493 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0045 0.0567 0.0617
Schistosoma mansoni tar DNA-binding protein 0.0194 0.38 0.4112
Mycobacterium tuberculosis Conserved protein 0.0075 0.121 0.1192
Loa Loa (eye worm) RNA binding protein 0.0194 0.38 0.4112
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0589 0.0638
Loa Loa (eye worm) hypothetical protein 0.0097 0.1682 0.182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0335 0.0639
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0074 0.0058
Giardia lamblia Histone acetyltransferase GCN5 0.0119 0.2155 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.1598 0.173
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.121 0.1192
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0684 0.159
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0514 0.0795
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0406 0.0386
Entamoeba histolytica acetyltransferase, GNAT family 0.0119 0.2155 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0194 0.38 0.4112
Schistosoma mansoni hypothetical protein 0.0132 0.2457 0.2659
Loa Loa (eye worm) hypothetical protein 0.0096 0.1673 0.181
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0406 0.1259
Loa Loa (eye worm) hypothetical protein 0.0047 0.0589 0.0638
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.2051 0.2295
Trypanosoma cruzi ISWI complex protein 0.0031 0.0249 0.0368
Toxoplasma gondii hypothetical protein 0.0049 0.0651 0.1775
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0445 0.9241 1
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.121 0.2417
Trichomonas vaginalis set domain proteins, putative 0.0247 0.4941 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0127 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.018 0.0325
Brugia malayi Bromodomain containing protein 0.0162 0.31 0.334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0388 0.0746
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0406 0.0439
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.1023 0.1614
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.002 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0285 0.5766 0.624
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0406 0.065
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0031
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0589 0.0638
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.3083 0.3069
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0684 0.192
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.002 0.0031
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0406 0.1806
Brugia malayi TAR-binding protein 0.0194 0.38 0.4099
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.121 0.2417
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0031
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0045 0.0567 0.0613
Brugia malayi MH2 domain containing protein 0.0119 0.2155 0.2315
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.1153 0.1281
Leishmania major hypothetical protein, conserved 0.0051 0.0684 0.1068
Echinococcus granulosus histone acetyltransferase KAT2B 0.0134 0.2493 0.2794
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0132 0.2457 0.2643
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0419 0.8676 0.9389
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0964 0.1066
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.2727 0.4358
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0406 0.0678
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0285 0.5766 0.6231
Brugia malayi Calcitonin receptor-like protein seb-1 0.0419 0.8676 0.9388
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0684 0.1068
Schistosoma mansoni DNA polymerase eta 0.002 0.002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0066 0.1002 0.1084
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0357 0.0366
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.373 0.4193
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.121 0.1344
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0596 0.0926
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.121 0.1192
Leishmania major hypothetical protein, conserved 0.0075 0.121 0.1915
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.6232 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0964 0.1023
Schistosoma mansoni transient receptor potential channel 0.0096 0.1673 0.181
Loa Loa (eye worm) hypothetical protein 0.0051 0.0689 0.0746
Leishmania major cathepsin L-like protease 0.0066 0.1023 0.1614
Schistosoma mansoni hypothetical protein 0.0114 0.2051 0.222
Toxoplasma gondii exonuclease III APE 0.0038 0.0406 0.0678
Mycobacterium ulcerans lipase LipD 0.0075 0.121 0.3883
Brugia malayi follicle stimulating hormone receptor 0.023 0.458 0.4945
Loa Loa (eye worm) hypothetical protein 0.0075 0.121 0.1309
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.121 0.1309
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0285 0.5766 0.624
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0729 0.0769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0335 0.0639
Brugia malayi mbt repeat family protein 0.0047 0.0589 0.0617
Schistosoma mansoni zinc finger protein 0.005 0.0671 0.0726
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0388 0.0622
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0031
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.121 0.3883
Loa Loa (eye worm) hypothetical protein 0.0036 0.0357 0.0387
Brugia malayi Pre-SET motif family protein 0.0031 0.0254 0.0254
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.121 0.2417
Brugia malayi PHD-finger family protein 0.0061 0.0905 0.0959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0335 0.0639
Loa Loa (eye worm) bromodomain containing protein 0.0046 0.0587 0.0635
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.121 0.1192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0127 0.0216
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0596 0.0955
Loa Loa (eye worm) hypothetical protein 0.0051 0.0684 0.074
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.121 0.1192
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0445 0.9241 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0514 0.0795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0186 0.0337
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0596 0.0624
Brugia malayi latrophilin 2 splice variant baaae 0.0286 0.5798 0.6266
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0596 0.0645
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0406 0.5
Schistosoma mansoni zinc finger protein 0.0031 0.0249 0.0269
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0406 0.0621
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0964 0.1023
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0285 0.5766 0.6231
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0964 0.1066
Onchocerca volvulus 0.0075 0.121 0.2039
Brugia malayi Pre-SET motif family protein 0.0217 0.429 0.4631
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1023 0.164
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0514 0.0795
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.121 0.1192
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1023 0.164
Brugia malayi hypothetical protein 0.0033 0.0292 0.0295
Trichomonas vaginalis esterase, putative 0.0075 0.121 0.2417
Schistosoma mansoni hypothetical protein 0.0132 0.2457 0.2659
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0335 0.0361
Echinococcus granulosus GPCR family 2 0.0132 0.2457 0.2754
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0596 0.0926
Onchocerca volvulus 0.0075 0.121 0.2039
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0596 0.0926
Brugia malayi RNA recognition motif domain containing protein 0.0194 0.38 0.4099
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.429 0.4643
Loa Loa (eye worm) hypothetical protein 0.0075 0.121 0.1309
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0406 0.0621
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.002 0.0022
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.002 0.0022
Plasmodium falciparum histone acetyltransferase GCN5 0.0119 0.2155 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0134 0.2493 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.2155 0.2332
Schistosoma mansoni ap endonuclease 0.0038 0.0406 0.0439
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.2155 0.2332
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.121 0.1309
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0406 0.0783
Mycobacterium ulcerans beta-lactamase 0.0075 0.121 0.3883
Loa Loa (eye worm) hypothetical protein 0.0075 0.121 0.1309
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.002 0.0031
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0326 0.0353
Onchocerca volvulus 0.0247 0.4941 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0894 0.0967
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.1002 0.1084
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.1023 0.1614
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1023 0.164
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0357 0.0366
Entamoeba histolytica hypothetical protein 0.0114 0.2051 0.9513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0218
Loa Loa (eye worm) hypothetical protein 0.0075 0.121 0.1309
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1023 0.164
Brugia malayi acetyltransferase, GNAT family protein 0.0445 0.9241 1
Schistosoma mansoni hypothetical protein 0.0132 0.2457 0.2659
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.1002 0.1084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1023 0.164
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.1002 0.1064
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0589 0.0638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0285 0.5766 0.6231
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0285 0.5766 0.624
Echinococcus granulosus tumor protein p63 0.0349 0.7167 0.8077
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.1002 0.1109
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0729 0.0769
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0132 0.2457 0.2643
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0729 0.0801
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0254 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0239 0.0444
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.6232 1
Mycobacterium ulcerans hypothetical protein 0.0161 0.3083 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0684 0.159
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0419 0.8676 0.9388
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0589 0.0716
Echinococcus multilocularis GPCR, family 2 0.0132 0.2457 0.2643
Loa Loa (eye worm) hypothetical protein 0.0053 0.0729 0.0789
Plasmodium vivax hypothetical protein, conserved 0.0075 0.121 0.4267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.018 0.0325
Echinococcus multilocularis transient receptor potential gamma protein 0.0096 0.1673 0.1792
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.121 0.129
Entamoeba histolytica hypothetical protein 0.0114 0.2051 0.9513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0388 0.0746
Brugia malayi beta-lactamase family protein 0.0075 0.121 0.129
Leishmania major cathepsin L-like protease 0.0066 0.1023 0.1614
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0406 0.0621

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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