Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.9497 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0958 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0958 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.9497 | 0.9444 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0958 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0958 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.9497 | 0.9444 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.0958 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0958 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0958 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.9497 | 0.9444 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0958 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0958 | 1 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0958 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0958 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.9497 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0958 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0958 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.9497 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0958 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0958 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0958 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0958 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.9497 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.9497 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0958 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0958 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0958 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0958 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.9497 | 0.9444 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0958 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0958 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0958 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.9497 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.