Detailed information for compound 726845

Basic information

Technical information
  • TDR Targets ID: 726845
  • Name: 2-[2-(3-chlorophenoxy)propanoylamino]benzoic acid
  • MW: 319.74 | Formula: C16H14ClNO4
  • H donors: 2 H acceptors: 3 LogP: 3.9 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)OC(C(=O)Nc1ccccc1C(=O)O)C
  • InChi: 1S/C16H14ClNO4/c1-10(22-12-6-4-5-11(17)9-12)15(19)18-14-8-3-2-7-13(14)16(20)21/h2-10H,1H3,(H,18,19)(H,20,21)
  • InChiKey: BFARJUBDWYUUHV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[2-(3-chlorophenoxy)-1-oxopropyl]amino]benzoic acid
  • STK284272
  • CBKinase1_011213
  • CBKinase1_023613

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0523 0.5
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0163 0.2389 0.3163
Loa Loa (eye worm) hypothetical protein 0.0114 0.1287 0.3098
Brugia malayi TAR-binding protein 0.0211 0.3453 0.8186
Echinococcus granulosus tumor protein p63 0.0386 0.7333 1
Brugia malayi MH2 domain containing protein 0.0126 0.1561 0.2962
Toxoplasma gondii ABC1 family protein 0.0079 0.0523 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0523 0.0096
Loa Loa (eye worm) RNA binding protein 0.0211 0.3453 0.8394
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0523 0.0703
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0114 0.1287 0.3098
Schistosoma mansoni alpha-glucosidase 0.0157 0.2257 0.6517
Schistosoma mansoni alpha-glucosidase 0.0157 0.2257 0.6517
Brugia malayi Pre-SET motif family protein 0.0241 0.411 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0523 0.1233
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0345 0.6423 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0523 0.1233
Loa Loa (eye worm) hypothetical protein 0.0078 0.0489 0.1148
Onchocerca volvulus 0.0106 0.1111 0.2262
Echinococcus multilocularis lysosomal alpha glucosidase 0.0183 0.2822 0.3375
Brugia malayi beta-lactamase family protein 0.0079 0.0523 0.0096
Loa Loa (eye worm) hypothetical protein 0.0079 0.0523 0.1233
Loa Loa (eye worm) hypothetical protein 0.0079 0.0523 0.1233
Mycobacterium ulcerans hypothetical protein 0.0182 0.2799 1
Onchocerca volvulus 0.0274 0.4848 1
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0523 0.0703
Loa Loa (eye worm) hypothetical protein 0.0079 0.0523 0.1233
Onchocerca volvulus 0.0079 0.0523 0.1044
Loa Loa (eye worm) beta-lactamase 0.0079 0.0523 0.1233
Mycobacterium tuberculosis Conserved hypothetical protein 0.0182 0.2799 0.2401
Brugia malayi beta-lactamase family protein 0.0079 0.0523 0.0096
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0211 0.3453 0.8394
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1561 0.377
Leishmania major mitochondrial DNA polymerase beta 0.0345 0.6423 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0114 0.1287 0.2203
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0163 0.2389 0.3163
Schistosoma mansoni tar DNA-binding protein 0.0211 0.3453 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0183 0.2822 0.3375
Brugia malayi Glycosyl hydrolases family 31 protein 0.0183 0.2822 0.6443
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0523 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1561 0.377
Loa Loa (eye worm) hypothetical protein 0.0079 0.0523 0.1233
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0345 0.6423 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0241 0.411 1
Schistosoma mansoni hypothetical protein 0.0078 0.0489 0.1368
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0114 0.1287 0.2203
Brugia malayi RNA binding protein 0.0211 0.3453 0.8186
Schistosoma mansoni tar DNA-binding protein 0.0211 0.3453 1
Schistosoma mansoni tar DNA-binding protein 0.0211 0.3453 1
Schistosoma mansoni tar DNA-binding protein 0.0211 0.3453 1
Mycobacterium leprae Probable lipase LipE 0.0079 0.0523 0.5
Echinococcus multilocularis tumor protein p63 0.0386 0.7333 1
Onchocerca volvulus 0.0079 0.0523 0.1044
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0523 0.1469
Onchocerca volvulus 0.0079 0.0523 0.1044
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0345 0.6423 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0523 0.1469
Echinococcus granulosus lysosomal alpha glucosidase 0.0183 0.2822 0.3375
Brugia malayi RNA recognition motif domain containing protein 0.0211 0.3453 0.8186
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0183 0.2822 0.6851
Echinococcus multilocularis tar DNA binding protein 0.0211 0.3453 0.4302
Schistosoma mansoni tar DNA-binding protein 0.0211 0.3453 1
Trichomonas vaginalis set domain proteins, putative 0.0274 0.4848 1
Loa Loa (eye worm) TAR-binding protein 0.0211 0.3453 0.8394
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0163 0.2389 0.3643
Brugia malayi beta-lactamase 0.0079 0.0523 0.0096
Loa Loa (eye worm) hypothetical protein 0.0079 0.0523 0.1233
Echinococcus granulosus tar DNA binding protein 0.0211 0.3453 0.4302

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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