Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0108 | 0.088 | 0.2225 |
Loa Loa (eye worm) | RNA binding protein | 0.0265 | 0.3352 | 0.4302 |
Brugia malayi | TAR-binding protein | 0.0265 | 0.3352 | 0.4479 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0263 | 0.3322 | 0.4435 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0144 | 0.1442 | 0.1825 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.0805 | 0.033 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0265 | 0.3352 | 0.4479 |
Schistosoma mansoni | tar DNA-binding protein | 0.0265 | 0.3352 | 0.3009 |
Loa Loa (eye worm) | TAR-binding protein | 0.0265 | 0.3352 | 0.4302 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 0.1296 | 0.121 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0108 | 0.088 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0265 | 0.3352 | 0.3009 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0144 | 0.1442 | 0.1825 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0263 | 0.3322 | 0.4256 |
Brugia malayi | MH2 domain containing protein | 0.0134 | 0.1296 | 0.1483 |
Schistosoma mansoni | tar DNA-binding protein | 0.0265 | 0.3352 | 0.3009 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0687 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.2012 | 0.2286 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0234 | 0.2863 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0265 | 0.3352 | 0.4302 |
Mycobacterium ulcerans | hypothetical protein | 0.016 | 0.1697 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0265 | 0.3352 | 0.3009 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0108 | 0.088 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0103 | 0.0805 | 0.033 |
Echinococcus multilocularis | tar DNA binding protein | 0.0265 | 0.3352 | 0.3009 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0103 | 0.0805 | 0.0768 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0144 | 0.1442 | 0.3643 |
Onchocerca volvulus | 0.0103 | 0.0805 | 0.5 | |
Brugia malayi | RNA binding protein | 0.0265 | 0.3352 | 0.4479 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.088 | 0.0585 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0506 | 0.7141 | 0.6993 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0687 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0108 | 0.088 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0083 | 0.0492 | 0.0311 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 0.1296 | 0.121 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0506 | 0.7141 | 0.6993 |
Brugia malayi | hypothetical protein | 0.0506 | 0.7141 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0337 | 0.4479 | 0.4193 |
Echinococcus multilocularis | tumor protein p63 | 0.0337 | 0.4479 | 0.4193 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0303 | 0.3958 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0303 | 0.3958 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0265 | 0.3352 | 0.3009 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0263 | 0.3322 | 0.4435 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.2012 | 0.1599 |
Echinococcus granulosus | tar DNA binding protein | 0.0265 | 0.3352 | 0.3009 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0303 | 0.3958 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0108 | 0.088 | 0.5 |
Brugia malayi | hypothetical protein | 0.0108 | 0.088 | 0.0877 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.018 | 0.2012 | 0.2526 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0083 | 0.0492 | 0.0311 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0108 | 0.088 | 0.2225 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0303 | 0.3958 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.7141 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 0.3322 | 0.4256 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.