Detailed information for compound 727064

Basic information

Technical information
  • TDR Targets ID: 727064
  • Name: 9-[2-(3-methoxypropylamino)ethyl]purin-6-amin e
  • MW: 250.3 | Formula: C11H18N6O
  • H donors: 2 H acceptors: 3 LogP: -0.58 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCCNCCn1cnc2c1ncnc2N
  • InChi: 1S/C11H18N6O/c1-18-6-2-3-13-4-5-17-8-16-9-10(12)14-7-15-11(9)17/h7-8,13H,2-6H2,1H3,(H2,12,14,15)
  • InChiKey: MRICYUQVBIGGOL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-[2-(3-methoxypropylamino)ethyl]-6-purinamine
  • 2-(6-aminopurin-9-yl)ethyl-(3-methoxypropyl)amine
  • TULIP028934
  • CBKinase1_012323
  • CBKinase1_024723

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0598 0.1577
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0057 0.0051
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0016 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0028 0.0408 0.0408
Brugia malayi MH2 domain containing protein 0.013 0.2486 0.2486
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0161 0.021
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0598 0.129
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0598 0.0113
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0057 0.0051
Loa Loa (eye worm) hypothetical protein 0.0049 0.0835 0.0835
Onchocerca volvulus 0.0101 0.1901 0.3754
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0831 0.0831
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0057 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.1402 0.2784
Loa Loa (eye worm) hypothetical protein 0.0098 0.1826 0.1826
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0016 0.0161 0.0319
Loa Loa (eye worm) hypothetical protein 0.0029 0.0427 0.0427
Mycobacterium ulcerans lipase LipD 0.0037 0.0578 0.2498
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0007 0.0007
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.042 0.2707
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0891 0.0885
Echinococcus granulosus geminin 0.0167 0.3244 0.324
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0057 0.0051
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.1551 0.6698
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0016 0.0161 0.0161
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0513 0.0513
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0057 0.0057
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.3244 0.6408
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0057 0.0057
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0057 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0381 0.763 1
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0578 0.1247
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0161 0.021
Onchocerca volvulus 0.0011 0.0057 0.0113
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.1551 0.5966
Echinococcus multilocularis cpg binding protein 0.003 0.0447 0.0441
Entamoeba histolytica heat shock transcription factor, putative 0.0098 0.1826 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0408 0.081
Trichomonas vaginalis cation chloride cotransporter, putative 0.0028 0.0408 0.081
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.1551 1
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.2486 0.2486
Brugia malayi ecdysteroid receptor 0.0011 0.0057 0.0057
Echinococcus multilocularis geminin 0.0167 0.3244 0.324
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0408 0.081
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0005 0.0005
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0161 0.0319
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0057 0.0075
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.5036 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0057 0.0057
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0891 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0057
Echinococcus multilocularis GPCR, family 2 0.0016 0.0144 0.0137
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0144 0.0137
Schistosoma mansoni tar DNA-binding protein 0.0138 0.2648 0.347
Brugia malayi RNA recognition motif domain containing protein 0.0138 0.2648 0.2648
Onchocerca volvulus 0.0037 0.0578 0.1143
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0057 0.0113
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3244 0.6442
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0956 0.095
Echinococcus multilocularis cation chloride cotransporter 0.0028 0.0408 0.0401
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0016 0.0161 0.0161
Mycobacterium tuberculosis Conserved protein 0.0037 0.0578 0.1247
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0161 0.0161
Schistosoma mansoni ap endonuclease 0.0038 0.0598 0.0784
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0112
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.5036 1
Brugia malayi GH09271p 0.002 0.0233 0.0233
Brugia malayi TAR-binding protein 0.0138 0.2648 0.2648
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0057 0.0057
Mycobacterium tuberculosis Conserved protein 0.0037 0.0578 0.1247
Brugia malayi nuclear receptor NHR-88 0.0011 0.0057 0.0057
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0578 0.1149
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0381 0.763 0.763
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.2316 0.3035
Brugia malayi HSF-type DNA-binding domain containing protein 0.0098 0.1826 0.1826
Brugia malayi CXXC zinc finger family protein 0.0029 0.0413 0.0413
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0161 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0057 0.0057
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0598 0.0592
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0161 0.021
Onchocerca volvulus 0.0037 0.0578 0.1143
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0831 0.0831
Brugia malayi hypothetical protein 0.015 0.2896 0.2896
Brugia malayi hypothetical protein 0.0016 0.0161 0.0161
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0598 0.0598
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0233 0.0463
Loa Loa (eye worm) TAR-binding protein 0.0138 0.2648 0.2648
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0381 0.763 1
Schistosoma mansoni smad1 5 8 and 0.0009 0.0007 0.0009
Onchocerca volvulus Huntingtin homolog 0.0256 0.5063 1
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0057 0.0057
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0578 0.1247
Loa Loa (eye worm) hypothetical protein 0.0038 0.0602 0.0602
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0057 0.0057
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0016 0.0161 0.0161
Schistosoma mansoni smad 0.0009 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0057
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.1551 0.2033
Loa Loa (eye worm) hypothetical protein 0.0049 0.0831 0.0831
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0057 0.0057
Echinococcus granulosus lamin 0.003 0.0444 0.0437
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0057 0.0075
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.1551 0.1545
Loa Loa (eye worm) hypothetical protein 0.0294 0.5844 0.5844
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0578 0.0578
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0891 0.177
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0578 0.1247
Echinococcus multilocularis musashi 0.003 0.0444 0.0437
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0161 0.021
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0161
Schistosoma mansoni solute carrier family 12 electroneutral k-cl cotransporter 0.0058 0.101 0.1323
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0956 0.2062
Brugia malayi MH1 domain containing protein 0.0009 0.0007 0.0007
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0891 1
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.5036 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0144 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0057 0.0057
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0057 0.0075
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0578 0.1403
Onchocerca volvulus Huntingtin homolog 0.0256 0.5063 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0413 0.0413
Echinococcus multilocularis survival motor neuron protein 1 0.0497 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0578 0.0578
Loa Loa (eye worm) solute carrier family 12 member 1 0.0057 0.0994 0.0994
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0016 0.0161 0.0319
Schistosoma mansoni cpg binding protein 0.003 0.0447 0.0586
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0057 0.0051
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0057 0.0057
Brugia malayi hypothetical protein 0.0256 0.5063 0.5063
Schistosoma mansoni hypothetical protein 0.0016 0.0144 0.0188
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0444 0.0444
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0578 0.1149
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1072 0.1405
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0016 0.0161 0.0154
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0891 0.2486
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0161 0.0154
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0891 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0058 0.101 0.101
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0598 0.0598
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3428 0.6808
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0016 0.0161 0.0319
Echinococcus granulosus cation chloride cotransporter 0.0028 0.0408 0.0401
Schistosoma mansoni hypothetical protein 0.0034 0.0513 0.0672
Brugia malayi beta-lactamase family protein 0.0037 0.0578 0.0578
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.5036 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0408 0.081
Brugia malayi MAP kinase sur-1 0.0052 0.0891 0.0891
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.2486 0.2486
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0057 0.0051
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0161 0.0154
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.2316 0.2311
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0057 0.0075
Brugia malayi Amino acid permease family protein 0.0058 0.101 0.101
Schistosoma mansoni cpg binding protein 0.0029 0.0413 0.0542
Schistosoma mansoni smad1 5 8 and 0.0009 0.0007 0.0009
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0161 0.0154
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0598 0.1577
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0891 0.0891
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0157 0.0157
Entamoeba histolytica heat shock transcription factor, putative 0.0098 0.1826 1
Echinococcus multilocularis tar DNA binding protein 0.0138 0.2648 0.2643
Brugia malayi hypothetical protein 0.002 0.0233 0.0233
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0098 0.1826 0.3606
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.5036 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0161
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0161 0.0154
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0956 0.2062
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0891 1
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3428 0.6808
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0891 0.18
Schistosoma mansoni hypothetical protein 0.0167 0.3244 0.4252
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0057 0.0057
Schistosoma mansoni lamin 0.003 0.0444 0.0582
Echinococcus multilocularis solute carrier family 12 0.0058 0.101 0.1004
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0578 0.1247
Entamoeba histolytica heat shock transcription factor, putative 0.0098 0.1826 1
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0161 0.0154
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0161
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0016 0.0161 0.0161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0057 0.0057
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.1551 1
Brugia malayi MH2 domain containing protein 0.0009 0.0007 0.0007
Toxoplasma gondii exonuclease III APE 0.0038 0.0598 0.0941
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0057 0.0051
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.2316 1
Mycobacterium ulcerans hypothetical protein 0.0037 0.0578 0.2498
Loa Loa (eye worm) hypothetical protein 0.0497 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0891 0.0885
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0598 0.1577
Echinococcus granulosus expressed protein 0.0016 0.0161 0.0154
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0578 0.2498
Loa Loa (eye worm) hypothetical protein 0.0038 0.0602 0.0602
Echinococcus multilocularis expressed protein 0.0016 0.0161 0.0154
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0578 0.0758
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0057 0.0057
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0578 0.1149
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0161 0.0161
Echinococcus multilocularis muscleblind protein 0.0294 0.5844 0.5841
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0057 0.0057
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0161 0.0154
Brugia malayi beta-lactamase family protein 0.0037 0.0578 0.0578
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0891 0.177
Toxoplasma gondii ABC1 family protein 0.0037 0.0578 0.0837
Schistosoma mansoni lamin 0.003 0.0444 0.0582
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0381 0.763 0.7629
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.2316 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0578 0.1149
Schistosoma mansoni tar DNA-binding protein 0.0138 0.2648 0.347
Brugia malayi steroid hormone receptor 0.0011 0.0057 0.0057
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0598 0.0592
Loa Loa (eye worm) hypothetical protein 0.0256 0.5063 0.5063
Echinococcus granulosus cpg binding protein 0.003 0.0447 0.0441
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0057
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0578 0.0578
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.2316 1
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0598 0.1188
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0381 0.763 0.763
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.5036 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0408 0.081
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0598 0.2628
Onchocerca volvulus 0.0049 0.0819 0.1619
Loa Loa (eye worm) hypothetical protein 0.0058 0.101 0.101
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.1551 0.1545
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.1551 0.5
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0161 0.0319
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0007 0.0007
Brugia malayi Smad1 0.0009 0.0007 0.0007
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0161 0.0154
Echinococcus granulosus solute carrier family 12 0.0058 0.101 0.1004
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0007 0.0009
Onchocerca volvulus 0.0029 0.0413 0.0816
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0016 0.0161 0.0161
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0007 0.0007
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0057 0.0075
Loa Loa (eye worm) hypothetical protein 0.0084 0.1551 0.1551
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0939 0.274
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0057 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.1402 0.2784
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0578 0.1247
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0891 1
Brugia malayi Probable ClpP-like protease 0.0084 0.1551 0.1551
Loa Loa (eye worm) hypothetical protein 0.0037 0.0578 0.0578
Schistosoma mansoni hypothetical protein 0.0016 0.0144 0.0188
Schistosoma mansoni tar DNA-binding protein 0.0138 0.2648 0.347
Loa Loa (eye worm) Smad1 0.0009 0.0007 0.0007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0598 0.063
Loa Loa (eye worm) RNA binding protein 0.0138 0.2648 0.2648
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0891 0.0885
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0057
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0007 0.0001
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0016 0.0161 0.0161
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0101 0.1901 0.1901
Loa Loa (eye worm) hypothetical protein 0.002 0.0233 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0057 0.0057
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0144 0.0144
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3244 0.6442
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0381 0.763 0.7629
Schistosoma mansoni survival motor neuron protein 0.0101 0.1901 0.2491
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.1551 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0057 0.0051
Schistosoma mansoni coup transcription factor 0.0011 0.0057 0.0075
Brugia malayi intermediate filament protein 0.003 0.0444 0.0444
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3244 0.6442
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.2316 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0427 0.0427
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0057 0.0051
Loa Loa (eye worm) hypothetical protein 0.003 0.0444 0.0444
Brugia malayi nuclear hormone receptor 0.0011 0.0057 0.0057
Schistosoma mansoni smad1 5 8 and 0.0009 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0578 0.0578
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0016 0.0161 0.0319
Onchocerca volvulus 0.0016 0.0161 0.0317
Trichomonas vaginalis esterase, putative 0.0037 0.0578 0.1149
Loa Loa (eye worm) hypothetical protein 0.0016 0.0161 0.0161
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0891 0.177
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0381 0.763 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0144 0.0137
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.1551 1
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0161 0.021
Schistosoma mansoni ap endonuclease 0.0038 0.0598 0.0784
Loa Loa (eye worm) amino acid permease 0.0038 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0037 0.0578 0.0578
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0016 0.0161 0.0161
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0016 0.0161 0.0154
Schistosoma mansoni cpg binding protein 0.003 0.0447 0.0586
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0598 0.2583
Loa Loa (eye worm) hypothetical protein 0.002 0.0233 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0057 0.0057
Schistosoma mansoni cation chloride cotransporter 0.0028 0.0408 0.0534
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0057 0.0057
Mycobacterium tuberculosis Conserved protein 0.0037 0.0578 0.1247
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0161 0.021
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0057 0.0075
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0161 0.021
Onchocerca volvulus 0.003 0.0444 0.0876
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0112
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0255 0.5036 0.5036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0057 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3244 0.6442
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0161 0.021
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.2316 0.3035
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0057 0.0075
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0161 0.0161
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0144 0.0144
Onchocerca volvulus 0.0016 0.0161 0.0317
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0956 0.095
Loa Loa (eye worm) hypothetical protein 0.0256 0.5063 0.5063
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.1227 0.2437
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0891 0.1168
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0294 0.5844 0.5844
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0578 0.1149
Loa Loa (eye worm) hypothetical protein 0.0034 0.0513 0.0513
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0138 0.2648 0.2648
Echinococcus granulosus survival motor neuron protein 1 0.0497 1 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0578 0.0572
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.1551 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0057
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0057 0.0051
Brugia malayi MH1 domain containing protein 0.0009 0.0007 0.0007
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0057 0.0075
Echinococcus multilocularis lamin dm0 0.003 0.0444 0.0437
Brugia malayi Muscleblind-like protein 0.0294 0.5844 0.5844
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0057 0.0051
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0144 0.0137
Schistosoma mansoni hypothetical protein 0.0101 0.1901 0.2491
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0124 0.0117
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.2316 1
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0057 0.0051
Onchocerca volvulus 0.015 0.2896 0.572
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0057
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0578 0.1247
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0891 0.177
Mycobacterium ulcerans beta-lactamase 0.0037 0.0578 0.2498
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0233 0.0463
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0161 0.021
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0016 0.0161 0.021
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0444 0.0444
Brugia malayi beta-lactamase 0.0037 0.0578 0.0578
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3244 0.6442
Loa Loa (eye worm) hypothetical protein 0.0038 0.0602 0.0602
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0891 0.18
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0161 0.0319
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0124 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0057 0.0057
Schistosoma mansoni intermediate filament proteins 0.003 0.0444 0.0582
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3244 0.6442
Onchocerca volvulus 0.003 0.0444 0.0876
Loa Loa (eye worm) hypothetical protein 0.015 0.2896 0.2896
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0956 0.6167
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0057 0.0051
Echinococcus granulosus GPCR family 2 0.0016 0.0144 0.0137
Loa Loa (eye worm) hypothetical protein 0.0058 0.101 0.101
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0057 0.0051
Brugia malayi G-protein alpha subunit 0.0016 0.0161 0.0161
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0057 0.0051
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0161 0.021
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0016 0.0161 0.021
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.1551 0.5966
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.2316 0.2311
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0161 0.0319
Loa Loa (eye worm) hypothetical protein 0.003 0.0432 0.0432
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.1551 1
Onchocerca volvulus 0.0016 0.0161 0.0317
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0007 0.0001
Echinococcus granulosus lamin dm0 0.003 0.0444 0.0437
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0057 0.0051
Trypanosoma brucei protein kinase, putative 0.0052 0.0891 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0891 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0578 0.0758
Brugia malayi RNA binding protein 0.0138 0.2648 0.2648
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0161 0.021
Loa Loa (eye worm) intermediate filament protein 0.003 0.0444 0.0444
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0057 0.0051
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0057 0.0113
Loa Loa (eye worm) hypothetical protein 0.0037 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.0049 0.0835 0.0835
Brugia malayi Hypothetical 112.3 kDa protein K02A2.3 in chromosome II 0.0058 0.101 0.101
Trichomonas vaginalis cation chloride cotransporter, putative 0.0028 0.0408 0.081
Echinococcus granulosus tar DNA binding protein 0.0138 0.2648 0.2643
Loa Loa (eye worm) hypothetical protein 0.0049 0.0835 0.0835
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0891 0.0885
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0578 0.2498
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0598 0.1188
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0381 0.763 0.7629
Schistosoma mansoni hypothetical protein 0.0167 0.3244 0.4252
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0381 0.763 0.7629
Echinococcus multilocularis muscleblind protein 1 0.0294 0.5844 0.5841
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0578 0.0572
Schistosoma mansoni hypothetical protein 0.0016 0.0144 0.0188
Loa Loa (eye worm) hypothetical protein 0.0016 0.0144 0.0144
Schistosoma mansoni Smad4 0.0009 0.0007 0.0009
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0578 0.1247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0057 0.0057
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0057 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0057 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0138 0.2648 0.347
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.1402 0.2784
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0016 0.0161 0.0161
Echinococcus granulosus intermediate filament protein 0.003 0.0444 0.0437
Loa Loa (eye worm) hypothetical protein 0.0038 0.0602 0.0602
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.2316 0.4994
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3244 0.6442
Loa Loa (eye worm) G protein alpha subunit 3 0.0016 0.0161 0.0161
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0144 0.0144
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0598 0.063
Echinococcus granulosus muscleblind protein 0.0294 0.5844 0.5841
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0831 0.0831
Loa Loa (eye worm) hypothetical protein 0.0015 0.0124 0.0124
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0016 0.0161 0.0161
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0057 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0029 0.0427 0.0427
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.1551 0.6698
Schistosoma mansoni tar DNA-binding protein 0.0138 0.2648 0.347
Onchocerca volvulus 0.0037 0.0578 0.1143
Brugia malayi MH2 domain containing protein 0.0009 0.0007 0.0007
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0255 0.5036 0.5036
Loa Loa (eye worm) beta-lactamase 0.0037 0.0578 0.0578
Schistosoma mansoni hypothetical protein 0.0016 0.0144 0.0188
Brugia malayi solute carrier family 12 member 1 0.0077 0.1402 0.1402
Echinococcus multilocularis lamin 0.003 0.0444 0.0437
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0057 0.0075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0057 0.0051
Mycobacterium leprae Probable lipase LipE 0.0037 0.0578 0.373
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0578 0.373
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.4637 1
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0157 0.0157
Brugia malayi Amino acid permease family protein 0.0028 0.0408 0.0408
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0598 0.063
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0233 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0408 0.081

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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