Detailed information for compound 727091

Basic information

Technical information
  • TDR Targets ID: 727091
  • Name: N-[4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]p henyl]-3,5,6-trimethyl-1-benzofuran-2-carboxa mide
  • MW: 464.537 | Formula: C24H24N4O4S
  • H donors: 2 H acceptors: 5 LogP: 4.53 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc(C)nc(c1)NS(=O)(=O)c1ccc(cc1)NC(=O)c1oc2c(c1C)cc(c(c2)C)C
  • InChi: 1S/C24H24N4O4S/c1-13-10-20-16(4)23(32-21(20)11-14(13)2)24(29)27-18-6-8-19(9-7-18)33(30,31)28-22-12-15(3)25-17(5)26-22/h6-12H,1-5H3,(H,27,29)(H,25,26,28)
  • InChiKey: NNXPXNYRISBKPY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl]-3,5,6-trimethyl-benzofuran-2-carboxamide
  • N-[4-[(2,6-dimethyl-4-pyrimidinyl)sulfamoyl]phenyl]-3,5,6-trimethyl-2-benzofurancarboxamide
  • ZINC01115154

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0639 0.6299
Loa Loa (eye worm) TAR-binding protein 0.0335 0.4053 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0059 0.0091
Schistosoma mansoni hypothetical protein 0.0048 0.0422 0.0655
Schistosoma mansoni hypothetical protein 0.0048 0.0422 0.0655
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0113 0.1119
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0318 0.4985
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0113 0.1236
Echinococcus granulosus endoplasmin 0.0028 0.0169 0.0262
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0307 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0192 0.0474
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.046 0.0712
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0318 0.314
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0192 0.0474
Echinococcus multilocularis calpain 0.0061 0.0589 0.0589
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1014 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0178 0.2064 0.3199
Giardia lamblia Kinase, PLK 0.0094 0.1014 1
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0258 0.2549
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0059 0.0146
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0059 0.0582
Leishmania major heat shock protein 83-1 0.0035 0.0258 0.2549
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0258 0.2549
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0059 0.0091
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0006 0.0059
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0258 0.2549
Trypanosoma brucei heat shock protein, putative 0.0035 0.0258 0.2549
Schistosoma mansoni tar DNA-binding protein 0.0335 0.4053 0.6282
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.2064 0.2064
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0589 0.5811
Echinococcus granulosus lamin dm0 0.0029 0.0192 0.0297
Trypanosoma brucei polo-like protein kinase 0.0094 0.1014 1
Loa Loa (eye worm) hypothetical protein 0.0144 0.1635 0.4034
Echinococcus multilocularis calpain family protein 1, d 0.0144 0.1635 0.1635
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0307 0.0758
Trypanosoma brucei calpain-like protein, putative 0.0061 0.0589 0.5811
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0307 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0059 0.0582
Schistosoma mansoni calpain (C02 family) 0.0061 0.0589 0.0913
Trypanosoma cruzi kinesin, putative 0.0061 0.0589 0.5811
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0113 0.1119
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0284 0.0441
Schistosoma mansoni calpain-7 (C02 family) 0.0061 0.0589 0.0913
Trypanosoma brucei antigen, putative 0.0061 0.0589 0.5811
Leishmania major heat shock protein 83-1 0.0035 0.0258 0.2549
Trypanosoma brucei heat shock protein, putative 0.0035 0.0258 0.2549
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0639 0.0639
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0582
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0006 0.0059
Schistosoma mansoni alpha-glucosidase 0.0153 0.1752 0.2715
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0146
Schistosoma mansoni hypothetical protein 0.0103 0.1121 0.1737
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0318 0.314
Loa Loa (eye worm) hypothetical protein 0.0053 0.0487 0.1201
Schistosoma mansoni ap endonuclease 0.0039 0.0307 0.0476
Leishmania major heat shock protein 83-1 0.0035 0.0258 0.2549
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0059 0.0582
Schistosoma mansoni tar DNA-binding protein 0.0335 0.4053 0.6282
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0169 0.167
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0582
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.1014 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0059 0.0582
Trypanosoma brucei unspecified product 0.0019 0.0059 0.0582
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0006 0.0059
Echinococcus multilocularis geminin 0.0525 0.6452 0.6452
Entamoeba histolytica hypothetical protein 0.0037 0.0284 0.2803
Loa Loa (eye worm) hypothetical protein 0.0125 0.1399 0.3453
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0639 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0307 0.3031
Loa Loa (eye worm) hypothetical protein 0.0321 0.3874 0.9557
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0589 0.5811
Onchocerca volvulus 0.0029 0.0192 0.1174
Echinococcus granulosus calpain 7 C02 family 0.0061 0.0589 0.0913
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0318 0.314
Schistosoma mansoni tar DNA-binding protein 0.0335 0.4053 0.6282
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0589 0.5811
Loa Loa (eye worm) calpain family protein 1 0.0204 0.2404 0.593
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1014 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0113 0.028
Echinococcus multilocularis endoplasmin 0.0028 0.0169 0.0169
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0028 0.0169 0.232
Plasmodium falciparum endoplasmin, putative 0.0021 0.0089 0.2902
Echinococcus granulosus dna polymerase eta 0.0019 0.0059 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0582
Plasmodium falciparum heat shock protein 90 0.0035 0.0258 0.8411
Brugia malayi Muscleblind-like protein 0.0321 0.3874 0.9557
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0019 0.0048
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0258 0.2549
Trypanosoma brucei heat shock protein, putative 0.0035 0.0258 0.2549
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0422 0.0655
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0006 0.0059
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0113 0.1119
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0258 0.2549
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0006 0.0059
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0307 0.4579
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.0169 0.167
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0113 0.1236
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0059 0.0582
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0059 0.0582
Brugia malayi heat shock protein 90 0.0035 0.0258 0.0638
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0307 0.0476
Echinococcus multilocularis hypothetical protein 0.0061 0.0589 0.0589
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.046 0.1134
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0589 0.5811
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0059 0.0582
Brugia malayi calpain 5 0.0061 0.0589 0.1454
Leishmania major heat shock protein 83-1 0.0035 0.0258 0.2549
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0307 0.0758
Onchocerca volvulus Huntingtin homolog 0.0125 0.1399 0.856
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0089 0.088
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1014 1
Echinococcus granulosus heat shock protein 90 0.0028 0.0169 0.0262
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0639 1
Trypanosoma brucei calpain-like protein, putative 0.0061 0.0589 0.5811
Trypanosoma cruzi Heat shock protein 83, putative 0.0035 0.0258 0.2549
Schistosoma mansoni intermediate filament proteins 0.0029 0.0192 0.0297
Giardia lamblia Heat shock protein HSP 90-alpha 0.0028 0.0169 0.1155
Trichomonas vaginalis endoplasmin, putative 0.0021 0.0089 0.088
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0582
Schistosoma mansoni alpha-glucosidase 0.0153 0.1752 0.2715
Leishmania major heat shock protein 83-1 0.0035 0.0258 0.2549
Trypanosoma brucei kinesin, putative 0.0061 0.0589 0.5811
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0113 0.1236
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0097
Trypanosoma brucei calpain-like protein, putative 0.0061 0.0589 0.5811
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0589 0.5811
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0028 0.0169 0.167
Brugia malayi Endoplasmin precursor 0.0035 0.0258 0.0638
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0582
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0059 0.0146
Loa Loa (eye worm) hypothetical protein 0.0204 0.2404 0.593
Echinococcus multilocularis heat shock protein 0.0035 0.0258 0.0258
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0113 0.1119
Schistosoma mansoni kinase 0.0048 0.0427 0.0662
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0204 0.2404 0.3725
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0318 0.314
Loa Loa (eye worm) hypothetical protein 0.0023 0.0113 0.028
Toxoplasma gondii heat shock protein 90, putative 0.0035 0.0258 0.4047
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0059 0.0516
Leishmania major heat shock protein 83-1 0.0035 0.0258 0.2549
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0411 0.4057
Toxoplasma gondii heat shock protein HSP90 0.0035 0.0258 0.4047
Schistosoma mansoni heat shock protein 0.0035 0.0258 0.0401
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0318 0.314
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0582
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0307 0.3031
Echinococcus granulosus calpain A 0.0215 0.2535 0.3929
Echinococcus granulosus muscleblind protein 0.0321 0.3874 0.6003
Schistosoma mansoni alpha glucosidase 0.0039 0.0318 0.0493
Entamoeba histolytica protein kinase, putative 0.0061 0.0593 0.5849
Leishmania major heat shock protein 83-1 0.0035 0.0258 0.2549
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0113 0.028
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0059 0.0327
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.046 0.0712
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0059 0.0582
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0028 0.0169 0.0262
Leishmania major heat shock protein 83-1 0.0035 0.0258 0.2549
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0582
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0006 0.0059
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0639 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0144 0.1635 0.4034
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0006 0.0059
Brugia malayi calpain family protein 1 0.0204 0.2404 0.593
Echinococcus granulosus lamin 0.0029 0.0192 0.0297
Brugia malayi TAR-binding protein 0.0335 0.4053 1
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0411 0.4057
Trypanosoma brucei heat shock protein, putative 0.0035 0.0258 0.2549
Brugia malayi calpain 7 0.0061 0.0589 0.1454
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0059 0.0059
Onchocerca volvulus 0.0144 0.1635 1
Schistosoma mansoni hypothetical protein 0.0048 0.0422 0.0655
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0169 0.167
Echinococcus multilocularis heat shock protein 90 0.0035 0.0258 0.0258
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1014 1
Echinococcus granulosus tumor protein p63 0.036 0.4373 0.6778
Brugia malayi RNA recognition motif domain containing protein 0.0335 0.4053 1
Trypanosoma brucei glucosidase, putative 0.0039 0.0318 0.314
Brugia malayi RNA binding protein 0.0335 0.4053 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0422 0.1042
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0178 0.2064 0.5093
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0318 0.314
Giardia lamblia Grp94/Hsp90 0.0028 0.0169 0.1155
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0582
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0039 0.0196
Brugia malayi hypothetical protein 0.0037 0.0284 0.0701
Loa Loa (eye worm) hypothetical protein 0.0125 0.1399 0.3453
Schistosoma mansoni heat shock protein 0.0035 0.0258 0.0401
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0589 0.5811
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.046 0.1134
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0059 0.0582
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0113 0.1407
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0097
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0589 0.5811
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0215 0.2535 0.3929
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0006 0.0059
Schistosoma mansoni lamin 0.0029 0.0192 0.0297
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0113 0.1236
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.1723 0.425
Trypanosoma brucei heat shock protein, putative 0.0035 0.0258 0.2549
Echinococcus granulosus heat shock protein 0.0035 0.0258 0.0401
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1014 1
Schistosoma mansoni Mername-AA248 (C02 family) 0.0061 0.0589 0.0913
Schistosoma mansoni endoplasmin 0.0035 0.0258 0.0401
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0059 0.0582
Brugia malayi Glycosyl hydrolases family 31 protein 0.0178 0.2064 0.5093
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.1121 0.2765
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0318 0.0786
Echinococcus granulosus geminin 0.0525 0.6452 1
Loa Loa (eye worm) heat shock protein 90 0.0035 0.0258 0.0638
Schistosoma mansoni DNA polymerase eta 0.0019 0.0059 0.0091
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0639 0.099
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0169 0.167
Onchocerca volvulus 0.0053 0.0487 0.2978
Trypanosoma cruzi heat shock protein 90, putative 0.0035 0.0258 0.2549
Loa Loa (eye worm) hypothetical protein 0.0204 0.2404 0.593
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0059 0.0582
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0192 0.0474
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0639 0.099
Echinococcus multilocularis calpain A 0.0215 0.2535 0.2535
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0006 0.0059
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0284 0.0441
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.046 0.0712
Onchocerca volvulus 0.0023 0.0113 0.0694
Echinococcus multilocularis calpain 7 (C02 family) 0.0061 0.0589 0.0589
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.1014 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0307 0.5217
Leishmania major heat shock protein 83-1 0.0035 0.0258 0.2549
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0318 0.0786
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.046 0.046
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0059 0.0091
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.1014 0.2501
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0422 0.0422
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0059 0.0327
Echinococcus multilocularis lamin 0.0029 0.0192 0.0192
Leishmania major heat shock protein 83-1 0.0035 0.0258 0.2549
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0113 0.1119
Loa Loa (eye worm) hypothetical protein 0.0103 0.1121 0.2765
Onchocerca volvulus 0.0047 0.0416 0.2547
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.046 0.046
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0059 0.0146
Leishmania major DNA polymerase kappa, putative 0.0019 0.0059 0.0582
Leishmania major heat shock protein 83-1 0.0035 0.0258 0.2549
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0307 0.3031
Echinococcus granulosus calpain 5 0.0061 0.0589 0.0913
Schistosoma mansoni tar DNA-binding protein 0.0335 0.4053 0.6282
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0061 0.0589 0.5811
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0097
Schistosoma mansoni ap endonuclease 0.0039 0.0307 0.0476
Echinococcus granulosus GPCR family 2 0.0048 0.0422 0.0655
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0639 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0006 0.0059
Trypanosoma brucei heat shock protein, putative 0.0035 0.0258 0.2549
Trypanosoma brucei heat shock protein, putative 0.0035 0.0258 0.2549
Loa Loa (eye worm) calpain family protein 1 0.0144 0.1635 0.4034
Echinococcus multilocularis muscleblind protein 0.0321 0.3874 0.3874
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0335 0.4053 1
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0039 0.1283
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0113 0.1236
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0318 0.314
Loa Loa (eye worm) hypothetical protein 0.0151 0.1723 0.425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.046 0.0712
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0422 0.0422
Schistosoma mansoni lamin 0.0029 0.0192 0.0297
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.1014 0.6201
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0113 0.028
Loa Loa (eye worm) endoplasmin 0.0035 0.0258 0.0638
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0006 0.0059
Schistosoma mansoni hypothetical protein 0.0048 0.0422 0.0655
Brugia malayi hypothetical protein 0.0125 0.1399 0.3453
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0039 0.5
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0307 0.3031
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0307 0.3031
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1014 1
Loa Loa (eye worm) RNA binding protein 0.0335 0.4053 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0582
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0422 0.0655
Loa Loa (eye worm) hypothetical protein 0.0231 0.2742 0.6766
Plasmodium vivax heat shock protein 86, putative 0.0035 0.0258 0.4388
Echinococcus multilocularis dna polymerase eta 0.0019 0.0059 0.0059
Entamoeba histolytica hypothetical protein 0.0037 0.0284 0.2803
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.1723 0.425
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0059 0.0582
Echinococcus granulosus heat shock protein 90 0.0035 0.0258 0.0401
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0059 0.0059
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.2064 0.2064
Trypanosoma cruzi kinesin, putative 0.0061 0.0589 0.5811
Toxoplasma gondii exonuclease III APE 0.0039 0.0307 0.4812
Schistosoma mansoni calpain-7 (C02 family) 0.0061 0.0589 0.0913
Leishmania major heat shock protein 83-1 0.0035 0.0258 0.2549
Schistosoma mansoni survival motor neuron protein 0.0047 0.0416 0.0645
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0028 0.0169 1
Schistosoma mansoni calpain C (C02 family) 0.0061 0.0589 0.0913
Onchocerca volvulus 0.0029 0.0192 0.1174
Onchocerca volvulus 0.0103 0.1118 0.684
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0582
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0039 0.0669
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1014 1
Echinococcus multilocularis heat shock protein 90 0.0028 0.0169 0.0169
Entamoeba histolytica hypothetical protein 0.0037 0.0284 0.2803
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0258 0.2549
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0318 0.314
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0318 0.314
Giardia lamblia Heat shock protein HSP 90-alpha 0.0035 0.0258 0.2089
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.2742 0.425
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0097
Loa Loa (eye worm) calpain 0.0061 0.0589 0.1454
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0215 0.2535 0.2535
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0318 0.0318
Plasmodium vivax calpain, putative 0.0061 0.0589 1
Mycobacterium ulcerans heat shock protein 90 0.0028 0.0169 0.2167
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0318 0.314
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0589 0.5811
Echinococcus granulosus intermediate filament protein 0.0029 0.0192 0.0297
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0589 0.5811
Brugia malayi intermediate filament protein 0.0029 0.0192 0.0474
Leishmania major heat shock protein 83-1 0.0035 0.0258 0.2549
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0113 0.1119
Leishmania major heat shock protein 83-1 0.0035 0.0258 0.2549
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0307 0.3031
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0589 0.5811
Leishmania major heat shock protein 83-1 0.0035 0.0258 0.2549
Schistosoma mansoni hypothetical protein 0.0525 0.6452 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0015
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0059 0.0582
Echinococcus granulosus tar DNA binding protein 0.0335 0.4053 0.6282
Trypanosoma brucei Heat shock protein 83, putative 0.0035 0.0258 0.2549
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0113 0.1236
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0589 0.5811
Echinococcus granulosus calpain A 0.0061 0.0589 0.0913
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0215 0.2535 0.3929
Echinococcus granulosus calpain 0.0061 0.0589 0.0913
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0006 0.0059
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0097
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0192 0.0474
Loa Loa (eye worm) hypothetical protein 0.0321 0.3874 0.9557
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0318 0.0493
Leishmania major heat shock protein 83-1 0.0035 0.0258 0.2549
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0307 1
Echinococcus multilocularis musashi 0.0029 0.0192 0.0192
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0079 0.078
Entamoeba histolytica calpain large subunit domain III containing protein 0.0061 0.0589 0.5811
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0639 0.099
Leishmania major kinesin, putative 0.0061 0.0589 0.5811
Loa Loa (eye worm) hypothetical protein 0.0023 0.0113 0.028
Loa Loa (eye worm) hypothetical protein 0.0029 0.0185 0.0457
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0422 0.1042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.046 0.0712
Plasmodium vivax endoplasmin, putative 0.0035 0.0258 0.4388
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0422 0.1042
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0258 0.2549
Echinococcus multilocularis muscleblind protein 1 0.0321 0.3874 0.3874
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0048 0.0422 0.1042
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0318 0.314
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.1014 0.1571
Brugia malayi hypothetical protein 0.0231 0.2742 0.6766
Echinococcus multilocularis tar DNA binding protein 0.0335 0.4053 0.4053
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0113 0.1236
Schistosoma mansoni tar DNA-binding protein 0.0335 0.4053 0.6282
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0318 0.314
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0019 0.0048
Mycobacterium ulcerans hypothetical protein 0.0023 0.0113 0.1236
Echinococcus multilocularis tumor protein p63 0.036 0.4373 0.4373
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1014 1
Schistosoma mansoni hypothetical protein 0.0037 0.0284 0.0441
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0487 0.0755
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0318 0.314
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.1723 0.425
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0307 0.3031
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0318 0.314
Echinococcus multilocularis lamin dm0 0.0029 0.0192 0.0192
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0307 0.0307
Echinococcus multilocularis GPCR, family 2 0.0048 0.0422 0.0422
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0006 0.0037
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0307 0.447
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0006 0.0059
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0639 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0307 0.2601
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1014 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0416 0.1028
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0059 0.0582
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0113 0.028
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0061 0.0589 0.5811
Schistosoma mansoni hypothetical protein 0.0525 0.6452 1
Schistosoma mansoni hypothetical protein 0.0047 0.0416 0.0645
Brugia malayi calpain family protein 1 0.0204 0.2404 0.593
Echinococcus multilocularis calpain 5 0.0061 0.0589 0.0589
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0215 0.2535 0.3929
Entamoeba histolytica hypothetical protein 0.0037 0.0284 0.2803
Trypanosoma brucei calpain-like protein, putative 0.0061 0.0589 0.5811
Leishmania major heat shock protein 83-1 0.0035 0.0258 0.2549
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1014 0.1571
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0113 0.1407
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0258 0.2549
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0059 0.0091
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0589 0.5811
Schistosoma mansoni endoplasmin 0.0035 0.0258 0.0401
Onchocerca volvulus Huntingtin homolog 0.0125 0.1399 0.856
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.1014 0.1014
Trypanosoma brucei heat shock protein, putative 0.0035 0.0258 0.2549
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.1014 0.2501
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0059 0.0516
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.2742 0.2742
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.0169 0.167
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0589 0.5811
Loa Loa (eye worm) calpain 5 0.0061 0.0589 0.1454

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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