Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1374 | 0.1552 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3072 | 0.3155 |
Schistosoma mansoni | chromobox protein | 0.0067 | 0.3469 | 0.3563 |
Onchocerca volvulus | 0.0032 | 0.1184 | 0.0286 | |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0015 | 0.0086 | 0.5 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0067 | 0.3469 | 0.3976 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.1411 | 0.145 |
Echinococcus granulosus | peregrin | 0.003 | 0.105 | 0.1079 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0028 | 0.0924 | 0.095 |
Trichomonas vaginalis | set domain proteins, putative | 0.0166 | 1 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0039 | 0.1641 | 0.1686 |
Brugia malayi | Heterochromatin protein 1 | 0.0067 | 0.3469 | 0.3938 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2232 | 0.2545 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0086 | 0.0088 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0015 | 0.0086 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0058 | 0.2874 | 0.3287 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0018 | 0.0292 | 0.03 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1259 | 0.1419 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.3072 | 0.3476 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3072 | 0.3155 |
Brugia malayi | Pre-SET motif family protein | 0.0021 | 0.0468 | 0.0445 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0924 | 0.1032 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0018 | 0.0292 | 0.03 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0015 | 0.0086 | 0.0088 |
Echinococcus granulosus | zinc finger protein | 0.0016 | 0.0134 | 0.0138 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0663 | 0.0681 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0015 | 0.0086 | 0.0088 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0028 | 0.0924 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0021 | 0.0468 | 0.0481 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0024 | 0.0663 | 0.0672 |
Echinococcus multilocularis | peregrin | 0.003 | 0.105 | 0.1079 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0015 | 0.0086 | 0.0061 |
Echinococcus multilocularis | chromobox protein 1 | 0.0067 | 0.3469 | 0.3563 |
Schistosoma mansoni | zinc finger protein | 0.0016 | 0.0134 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.2853 | 0.3263 |
Brugia malayi | Pre-SET motif family protein | 0.0146 | 0.8676 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0086 | 0.0088 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0146 | 0.8676 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0091 | 0.509 | 0.5826 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.9735 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0091 | 0.509 | 0.5229 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.1411 | 0.1543 |
Echinococcus multilocularis | zinc finger protein | 0.0016 | 0.0134 | 0.0138 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0028 | 0.0924 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0015 | 0.0086 | 0.0088 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.0924 | 0.0976 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.3072 | 0.3516 |
Plasmodium falciparum | phd finger protein, putative | 0.0028 | 0.0924 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.002 | 0.0417 | 0.0429 |
Brugia malayi | Bromodomain containing protein | 0.0031 | 0.1129 | 0.1215 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0029 | 0.1004 | 0.1031 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0028 | 0.0924 | 0.095 |
Plasmodium vivax | SET domain protein, putative | 0.0021 | 0.0468 | 0.4558 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.1546 | 0.0781 |
Schistosoma mansoni | jumonji domain containing protein | 0.0072 | 0.3858 | 0.3963 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.1411 | 0.145 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.1374 | 0.1412 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1389 | 0.1569 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3072 | 0.3155 |
Schistosoma mansoni | chromobox protein | 0.0067 | 0.3469 | 0.3563 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0015 | 0.0086 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0035 | 0.1389 | 0.1569 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0029 | 0.1004 | 0.1031 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.1546 | 0.0781 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.3072 | 0.3155 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0037 | 0.1546 | 0.0685 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1133 | 0.1273 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3072 | 0.3155 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0468 | 0.0481 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0032 | 0.1184 | 0.1216 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0086 | 0.0088 |
Plasmodium vivax | hypothetical protein, conserved | 0.0028 | 0.0924 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0067 | 0.3469 | 0.3563 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.1374 | 0.1412 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0028 | 0.0924 | 0.095 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0015 | 0.0086 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.1411 | 0.1595 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.3072 | 0.3516 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0048 | 0.2267 | 0.2329 |
Brugia malayi | Bromodomain containing protein | 0.003 | 0.105 | 0.1123 |
Brugia malayi | chromobox protein homolog 3 | 0.0037 | 0.1546 | 0.17 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0663 | 0.0729 |
Trichomonas vaginalis | chromobox protein, putative | 0.004 | 0.1732 | 0.0984 |
Brugia malayi | RNA binding protein | 0.0061 | 0.3072 | 0.3476 |
Trichomonas vaginalis | chromobox protein, putative | 0.0067 | 0.3469 | 0.2878 |
Brugia malayi | Bromodomain containing protein | 0.0061 | 0.308 | 0.3486 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1546 | 0.1751 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.3072 | 0.3155 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0028 | 0.0924 | 0.1032 |
Echinococcus multilocularis | geminin | 0.0162 | 0.9735 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0034 | 0.131 | 0.1345 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0035 | 0.1374 | 0.1412 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0015 | 0.0086 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0048 | 0.2267 | 0.2329 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0017 | 0.019 | 0.0182 |
Schistosoma mansoni | bromodomain containing protein | 0.0051 | 0.2457 | 0.2524 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0035 | 0.1389 | 0.1517 |
Echinococcus granulosus | geminin | 0.0162 | 0.9735 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0021 | 0.0468 | 0.4558 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.019 | 0.0195 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0035 | 0.1389 | 0.1517 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0039 | 0.1641 | 0.1686 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0035 | 0.1374 | 0.1412 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.136 | 0.1536 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1016 | 0.1138 |
Echinococcus granulosus | chromobox protein 1 | 0.0067 | 0.3469 | 0.3563 |
Trichomonas vaginalis | chromobox protein, putative | 0.0067 | 0.3469 | 0.2878 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0086 | 0.0088 |
Onchocerca volvulus | 0.0029 | 0.1016 | 0.0101 | |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0015 | 0.0086 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3072 | 0.3155 |
Echinococcus granulosus | chromobox protein 1 | 0.0067 | 0.3469 | 0.3563 |
Brugia malayi | PHD-finger family protein | 0.002 | 0.0418 | 0.0386 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0091 | 0.509 | 0.5229 |
Giardia lamblia | PHD finger protein 15 | 0.0028 | 0.0924 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.3072 | 0.3476 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.9735 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0924 | 0.095 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.004 | 0.1732 | 0.089 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.1411 | 0.145 |
Trichomonas vaginalis | chromobox protein, putative | 0.004 | 0.1732 | 0.0984 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.3072 | 0.3516 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0018 | 0.0292 | 0.03 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.