Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | metacaspase, putative | 0.0137 | 0.0431 | 0.0018 |
Trypanosoma brucei | metacaspase MCA3 | 0.0137 | 0.0431 | 0.0005 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.0137 | 0.0426 | 0.0015 |
Onchocerca volvulus | 0.1692 | 1 | 1 | |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0137 | 0.0426 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0518 | 0.2777 | 0.2811 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0514 | 0.2747 | 0.2747 |
Brugia malayi | Hexokinase family protein | 0.1692 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.1692 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.1692 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.1692 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0518 | 0.2777 | 0.2811 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0514 | 0.2747 | 0.2747 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0694 | 0.3855 | 0.3578 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0079 | 0.007 | 0.007 |
Treponema pallidum | hexokinase (hxk) | 0.1692 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0518 | 0.2777 | 0.2811 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0518 | 0.2777 | 0.2465 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0284 | 0.1337 | 0.1098 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0694 | 0.3855 | 0.4094 |
Trypanosoma brucei | metacaspase 5, putative | 0.0137 | 0.0431 | 0.0005 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0137 | 0.0431 | 0.0021 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0079 | 0.007 | 0.007 |
Trypanosoma brucei | hexokinase, putative | 0.1692 | 1 | 1 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0137 | 0.0431 | 0.0431 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0137 | 0.0431 | 0.0431 |
Loa Loa (eye worm) | hexokinase | 0.1692 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.1168 | 0.6772 | 0.6633 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0137 | 0.0431 | 0.0021 |
Leishmania major | hexokinase, putative | 0.1692 | 1 | 1 |
Schistosoma mansoni | glutaminase | 0.15 | 0.882 | 0.882 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0527 | 0.2832 | 0.2832 |
Trypanosoma brucei | metacaspase | 0.0137 | 0.0431 | 0.0005 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0518 | 0.2777 | 0.2777 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.1108 | 0.6403 | 0.6241 |
Echinococcus granulosus | caspase 8 | 0.0137 | 0.0431 | 0.0431 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.1062 | 0.6123 | 0.6791 |
Echinococcus granulosus | hexokinase | 0.1692 | 1 | 1 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.1062 | 0.6123 | 0.6123 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.1062 | 0.6123 | 0.6123 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1168 | 0.6772 | 0.6633 |
Onchocerca volvulus | 0.1692 | 1 | 1 | |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0137 | 0.0431 | 0.0431 |
Echinococcus granulosus | caspase 2 | 0.0137 | 0.0431 | 0.0431 |
Entamoeba histolytica | hexokinase 2 | 0.1692 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.1692 | 1 | 1 |
Echinococcus granulosus | citrate lyase subunit beta protein | 0.0134 | 0.0413 | 0.0413 |
Brugia malayi | MH2 domain containing protein | 0.0527 | 0.2832 | 0.2832 |
Brugia malayi | Cell death protein 3 precursor | 0.0137 | 0.0431 | 0.0431 |
Mycobacterium ulcerans | glutaminase | 0.15 | 0.882 | 1 |
Onchocerca volvulus | 0.1061 | 0.6119 | 0.5944 | |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0518 | 0.2777 | 0.2777 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.007 | 0.007 |
Echinococcus granulosus | hexokinase | 0.1692 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.1692 | 1 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0518 | 0.2777 | 0.2726 |
Trypanosoma cruzi | hexokinase, putative | 0.1692 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0518 | 0.2777 | 0.2777 |
Loa Loa (eye worm) | hexokinase | 0.0524 | 0.2808 | 0.2808 |
Brugia malayi | Hexokinase family protein | 0.0524 | 0.2808 | 0.2808 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.1062 | 0.6123 | 0.5956 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0518 | 0.2777 | 0.2777 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.1062 | 0.6123 | 0.5956 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0431 | 0.0431 |
Loa Loa (eye worm) | hexokinase type II | 0.1692 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.1692 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1154 | 0.6689 | 0.6689 |
Trypanosoma brucei | hexokinase | 0.1692 | 1 | 1 |
Brugia malayi | hexokinase type II | 0.0538 | 0.2897 | 0.2897 |
Entamoeba histolytica | hexokinase 1 | 0.1692 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0079 | 0.007 | 0.007 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.1108 | 0.6403 | 0.6241 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0514 | 0.2747 | 0.2747 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0518 | 0.2777 | 0.2811 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0137 | 0.0431 | 0.0021 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.1062 | 0.6123 | 0.595 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0079 | 0.007 | 0.007 |
Trypanosoma brucei | hypothetical protein, conserved | 0.1168 | 0.6772 | 0.6629 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.1062 | 0.6123 | 0.6123 |
Trypanosoma cruzi | metacaspase, putative | 0.0137 | 0.0431 | 0.0018 |
Toxoplasma gondii | hexokinase | 0.1692 | 1 | 1 |
Trypanosoma brucei | metacaspase MCA2 | 0.0137 | 0.0431 | 0.0005 |
Trichomonas vaginalis | glutaminase, putative | 0.15 | 0.882 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0137 | 0.0431 | 0.0021 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0137 | 0.0426 | 0.0089 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0514 | 0.2747 | 0.2747 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0137 | 0.0431 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0431 | 0.0431 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.1062 | 0.6123 | 0.6123 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0137 | 0.0431 | 0.0021 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.1108 | 0.6403 | 0.6241 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0368 | 0.1853 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0518 | 0.2777 | 0.2455 |
Echinococcus multilocularis | hexokinase | 0.1692 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0527 | 0.2832 | 0.2832 |
Loa Loa (eye worm) | hexokinase | 0.1692 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0538 | 0.2897 | 0.2897 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1168 | 0.6772 | 0.6633 |
Echinococcus multilocularis | citrate lyase subunit beta protein | 0.0134 | 0.0413 | 0.0413 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0137 | 0.0431 | 0.0021 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.1108 | 0.6403 | 0.7125 |
Onchocerca volvulus | 0.1692 | 1 | 1 | |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0518 | 0.2777 | 0.2451 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0518 | 0.2777 | 0.2811 |
Trypanosoma cruzi | metacaspase, putative | 0.0137 | 0.0431 | 0.0018 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0257 | 0.1165 | 0.0895 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0137 | 0.0431 | 0.0021 |
Echinococcus multilocularis | caspase | 0.0514 | 0.2747 | 0.2747 |
Echinococcus multilocularis | caspase 8 | 0.0137 | 0.0431 | 0.0431 |
Echinococcus granulosus | caspase | 0.0514 | 0.2747 | 0.2747 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0518 | 0.2777 | 0.2465 |
Echinococcus multilocularis | caspase 2 | 0.0137 | 0.0431 | 0.0431 |
Schistosoma mansoni | kinase | 0.0263 | 0.1207 | 0.1207 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0352 | 0.1752 | 0.1396 |
Trypanosoma brucei | Metacaspase-4 | 0.0137 | 0.0431 | 0.0005 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0518 | 0.2777 | 0.2465 |
Loa Loa (eye worm) | hypothetical protein | 0.0538 | 0.2897 | 0.2897 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.1108 | 0.6403 | 0.7125 |
Onchocerca volvulus | Hexokinase homolog | 0.1061 | 0.6119 | 0.5944 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0137 | 0.0431 | 0.0018 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0257 | 0.1165 | 0.0895 |
Echinococcus granulosus | caspase 3 | 0.0376 | 0.1902 | 0.1902 |
Echinococcus granulosus | hexokinase | 0.1692 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.1692 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0137 | 0.0431 | 0.0021 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0518 | 0.2777 | 0.2811 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0518 | 0.2777 | 0.2777 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.0284 | 0.1337 | 0.6412 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.1108 | 0.6403 | 0.7125 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.1108 | 0.6403 | 1 |
Trypanosoma cruzi | Glucose-6-phosphate dehydrogenase, putative | 0.0342 | 0.1689 | 0.1331 |
Echinococcus multilocularis | caspase 3 | 0.0376 | 0.1902 | 0.1902 |
Leishmania major | metacaspase, putative | 0.0137 | 0.0431 | 0.0018 |
Plasmodium falciparum | hexokinase | 0.1692 | 1 | 1 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.1062 | 0.6123 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.15 | 0.882 | 0.882 |
Loa Loa (eye worm) | hexokinase | 0.1061 | 0.6119 | 0.6119 |
Brugia malayi | Hexokinase family protein | 0.1061 | 0.6119 | 0.6119 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0137 | 0.0431 | 0.0021 |
Trypanosoma cruzi | metacaspase, putative | 0.0137 | 0.0431 | 0.0018 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0137 | 0.0431 | 0.0021 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0518 | 0.2777 | 0.2811 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0137 | 0.0431 | 0.0021 |
Echinococcus multilocularis | hexokinase | 0.1692 | 1 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.15 | 0.882 | 0.882 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0137 | 0.0431 | 0.0021 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0137 | 0.0431 | 0.0021 |
Brugia malayi | glutaminase DH11.1 | 0.15 | 0.882 | 0.882 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.1062 | 0.6123 | 0.6123 |
Trypanosoma cruzi | hexokinase, putative | 0.1692 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0137 | 0.0431 | 0.0021 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0137 | 0.0431 | 0.0018 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.