Detailed information for compound 727545

Basic information

Technical information
  • TDR Targets ID: 727545
  • Name: N,N-diethyl-4-[2-(naphthalen-1-ylamino)-1,3-t hiazol-4-yl]benzenesulfonamide
  • MW: 437.578 | Formula: C23H23N3O2S2
  • H donors: 1 H acceptors: 3 LogP: 5.62 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1ccc(cc1)c1csc(n1)Nc1cccc2c1cccc2)CC
  • InChi: 1S/C23H23N3O2S2/c1-3-26(4-2)30(27,28)19-14-12-18(13-15-19)22-16-29-23(25-22)24-21-11-7-9-17-8-5-6-10-20(17)21/h5-16H,3-4H2,1-2H3,(H,24,25)
  • InChiKey: GLXSTUSVNSLLGW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N,N-diethyl-4-[2-(1-naphthylamino)thiazol-4-yl]benzenesulfonamide
  • N,N-diethyl-4-[2-(1-naphthylamino)-4-thiazolyl]benzenesulfonamide
  • ZINC01226768
  • CBDivE_008546
  • Oprea1_434427

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0234 0.1377 0.1377
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0123 0.053 0.0689
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0312 0.1967 0.2557
Echinococcus multilocularis hexokinase 0.1049 0.7559 1
Echinococcus granulosus hexokinase 0.1049 0.7559 1
Onchocerca volvulus 0.1049 0.7559 1
Echinococcus granulosus caspase 3 0.0145 0.07 0.0926
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0473 0.3192 0.4223
Leishmania major hexokinase, putative 0.1049 0.7559 0.9826
Onchocerca volvulus 0.1049 0.7559 1
Brugia malayi Hexokinase family protein 0.1049 0.7559 0.7559
Trypanosoma cruzi hypothetical protein, conserved 0.1066 0.7693 1
Loa Loa (eye worm) hypothetical protein 0.0333 0.2129 0.2129
Trichomonas vaginalis CAMK family protein kinase 0.0473 0.3192 0.3192
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.097 0.6962 0.905
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.097 0.6962 0.6962
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.1011 0.7278 0.7278
Onchocerca volvulus 0.1049 0.7559 1
Echinococcus multilocularis caspase 3 0.0145 0.07 0.0926
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0268 0.1635 0.1166
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.097 0.6962 0.921
Trichomonas vaginalis CAMK family protein kinase 0.0473 0.3192 0.3192
Trichomonas vaginalis CAMK family protein kinase 0.0473 0.3192 0.3192
Loa Loa (eye worm) glutaminase 0.137 1 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0064 0.0064
Trypanosoma cruzi hexokinase, putative 0.1049 0.7559 0.9826
Loa Loa (eye worm) glutaminase 2 0.137 1 1
Entamoeba histolytica hexokinase 1 0.1049 0.7559 1
Plasmodium falciparum hexokinase 0.1049 0.7559 1
Brugia malayi RNA binding protein 0.0061 0.0064 0.0064
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.1011 0.7278 0.7278
Echinococcus granulosus hexokinase 0.1049 0.7559 1
Mycobacterium ulcerans lipoprotein LpqF 0.0129 0.0576 0.0048
Entamoeba histolytica serine/threonine protein kinase, putative 0.0473 0.3192 0.4112
Brugia malayi TAR-binding protein 0.0061 0.0064 0.0064
Loa Loa (eye worm) hexokinase 0.0658 0.4593 0.4593
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0473 0.3192 0.4223
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0633 0.4408 0.4094
Trypanosoma brucei polo-like protein kinase 0.0473 0.3192 0.415
Echinococcus granulosus hexokinase 0.1049 0.7559 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0064 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0064 0.0064
Echinococcus granulosus tar DNA binding protein 0.0061 0.0064 0.0085
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0123 0.053 0.053
Echinococcus multilocularis citrate lyase subunit beta protein 0.0123 0.053 0.0701
Loa Loa (eye worm) RNA binding protein 0.0061 0.0064 0.0064
Loa Loa (eye worm) transcription factor SMAD2 0.0474 0.3195 0.3195
Onchocerca volvulus 0.0658 0.4593 0.6075
Trypanosoma cruzi polo-like protein kinase, putative 0.0473 0.3192 0.415
Trypanosoma cruzi polo-like protein kinase, putative 0.0473 0.3192 0.415
Loa Loa (eye worm) hypothetical protein 0.0333 0.2129 0.2129
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0198 0.1102 0.1457
Trypanosoma brucei hexokinase 0.1049 0.7559 0.9826
Echinococcus granulosus citrate lyase subunit beta protein 0.0123 0.053 0.0701
Trypanosoma cruzi hexokinase, putative 0.1049 0.7559 0.9826
Brugia malayi glucose-6-phosphate dehydrogenase 0.097 0.6962 0.6962
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0129 0.0576 0.5
Brugia malayi hypothetical protein 0.0072 0.0142 0.0142
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0064 0.0064
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0123 0.053 0.0689
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0142 0.0188
Schistosoma mansoni glutaminase 0.137 1 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0064 0.0064
Toxoplasma gondii hexokinase 0.1049 0.7559 1
Echinococcus multilocularis hexokinase 0.1049 0.7559 1
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0142 0.0142
Trypanosoma brucei beta lactamase 0.0129 0.0576 0.0748
Echinococcus granulosus hexokinase type 2 0.1049 0.7559 1
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0064 0.0085
Schistosoma mansoni hexokinase 0.1049 0.7559 0.7559
Plasmodium vivax hexokinase, putative 0.1049 0.7559 1
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.097 0.6962 0.6962
Brugia malayi MH2 domain containing protein 0.0474 0.3195 0.3195
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0198 0.1102 0.1457
Loa Loa (eye worm) hexokinase 0.1049 0.7559 0.7559
Trypanosoma brucei hexokinase, putative 0.1049 0.7559 0.9826
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0321 0.2038 0.2649
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0473 0.3192 0.3192
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.097 0.6962 0.5
Loa Loa (eye worm) hexokinase 0.1049 0.7559 0.7559
Leishmania major hypothetical protein, conserved 0.1066 0.7693 1
Trichomonas vaginalis glutaminase, putative 0.137 1 1
Brugia malayi Hexokinase family protein 0.0658 0.4593 0.4593
Loa Loa (eye worm) hexokinase 0.0324 0.2061 0.2061
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.097 0.6962 0.905
Loa Loa (eye worm) hexokinase type II 0.1049 0.7559 0.7559
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0142 0.0188
Brugia malayi serine/threonine-protein kinase plk-2 0.0473 0.3192 0.3192
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0129 0.0576 0.028
Brugia malayi hexokinase 0.1049 0.7559 0.7559
Echinococcus multilocularis hexokinase 0.1049 0.7559 1
Onchocerca volvulus Hexokinase homolog 0.0658 0.4593 0.6075
Schistosoma mansoni serine/threonine protein kinase 0.0473 0.3192 0.3192
Trichomonas vaginalis CAMK family protein kinase 0.0473 0.3192 0.3192
Trypanosoma cruzi hypothetical protein, conserved 0.1066 0.7693 1
Leishmania major hexokinase, putative 0.1049 0.7559 0.9826
Echinococcus multilocularis hexokinase type 2 0.1049 0.7559 1
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.097 0.6962 0.905
Schistosoma mansoni hypothetical protein 0.0072 0.0142 0.0142
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.1011 0.7278 0.9628
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0268 0.1635 0.6809
Trypanosoma brucei hypothetical protein, conserved 0.1066 0.7693 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0064 0.0064
Entamoeba histolytica hexokinase 2 0.1049 0.7559 1
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.097 0.6962 0.921
Echinococcus granulosus caspase 0.0198 0.1102 0.1457
Trichomonas vaginalis CAMK family protein kinase 0.0473 0.3192 0.3192
Trichomonas vaginalis CAMK family protein kinase 0.0473 0.3192 0.3192
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.1011 0.7278 1
Trichomonas vaginalis CAMK family protein kinase 0.0473 0.3192 0.3192
Trichomonas vaginalis CAMK family protein kinase 0.0234 0.1377 0.1377
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.1011 0.7278 0.9628
Loa Loa (eye worm) MH2 domain-containing protein 0.0474 0.3195 0.3195
Trypanosoma brucei hexokinase 0.1049 0.7559 0.9826
Mycobacterium ulcerans glutaminase 0.137 1 1
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.1011 0.7278 0.9628
Brugia malayi Hexokinase family protein 0.0324 0.2061 0.2061
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0064 0.0064
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.1011 0.7278 0.7278
Onchocerca volvulus Serine\/threonine kinase homolog 0.0473 0.3192 0.4223
Schistosoma mansoni kinase 0.0241 0.1425 0.1425
Treponema pallidum hexokinase (hxk) 0.1049 0.7559 1
Schistosoma mansoni caspase-7 (C14 family) 0.0198 0.1102 0.1102
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0336 0.2152 1
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.097 0.6962 0.6792
Loa Loa (eye worm) hypothetical protein 0.0715 0.5028 0.5028
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0064 0.0064
Echinococcus multilocularis caspase 0.0198 0.1102 0.1457
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0473 0.3192 0.415
Schistosoma mansoni caspase-3 (C14 family) 0.0198 0.1102 0.1102
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0123 0.053 0.0689
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0633 0.4408 0.5831
Brugia malayi hexokinase type II 0.0333 0.2129 0.2129

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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