Detailed information for compound 727547

Basic information

Technical information
  • TDR Targets ID: 727547
  • Name: 2-iodo-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl ]benzamide
  • MW: 485.319 | Formula: C16H12IN3O3S2
  • H donors: 2 H acceptors: 4 LogP: 3.29 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1I)Nc1ccc(cc1)S(=O)(=O)Nc1nccs1
  • InChi: 1S/C16H12IN3O3S2/c17-14-4-2-1-3-13(14)15(21)19-11-5-7-12(8-6-11)25(22,23)20-16-18-9-10-24-16/h1-10H,(H,18,20)(H,19,21)
  • InChiKey: IRDROAQAELEVLG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-iodo-N-[4-(thiazol-2-ylsulfamoyl)phenyl]benzamide
  • 2-iodo-N-[4-(2-thiazolylsulfamoyl)phenyl]benzamide
  • ZINC00705497
  • CBDivE_011048
  • AG-205/10459001
  • 2-Iodo-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-benzamide
  • BAS 00850779
  • A1159/0054164

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0859 0.7759 1
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0891 0.8092 1
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0859 0.7759 1
Mycobacterium ulcerans glutaminase 0.1079 1 1
Trypanosoma brucei hypothetical protein, conserved 0.084 0.7564 0.974
Trypanosoma brucei hexokinase 0.0789 0.7047 0.9049
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0373 0.2811 0.1542
Echinococcus granulosus hexokinase type 2 0.0789 0.7047 0.9083
Echinococcus granulosus hexokinase 0.0789 0.7047 0.9083
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0891 0.8092 0.8092
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0197 0.1018 0.1312
Leishmania major hexokinase, putative 0.0789 0.7047 0.9083
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0859 0.7759 0.7363
Trypanosoma cruzi hexokinase, putative 0.0789 0.7047 0.9083
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0124 0.0275 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0373 0.2811 0.2811
Loa Loa (eye worm) hypothetical protein 0.0251 0.1569 0.008
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0859 0.7759 1
Trypanosoma cruzi hypothetical protein, conserved 0.084 0.7564 0.9749
Onchocerca volvulus Hexokinase homolog 0.0495 0.4054 0.2935
Schistosoma mansoni caspase-3 (C14 family) 0.0197 0.1018 0.0081
Onchocerca volvulus 0.0789 0.7047 1
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0258 0.1638 0.7998
Trichomonas vaginalis CAMK family protein kinase 0.0373 0.2811 0.2811
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0859 0.7759 0.7759
Echinococcus granulosus caspase 0.0197 0.1018 0.1312
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0373 0.2811 0.3623
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0891 0.8092 1
Trypanosoma brucei polo-like protein kinase 0.0373 0.2811 0.3389
Echinococcus multilocularis hexokinase type 2 0.0789 0.7047 0.9083
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0859 0.7759 1
Brugia malayi Hexokinase family protein 0.0495 0.4054 0.3004
Trichomonas vaginalis CAMK family protein kinase 0.0185 0.0895 0.0895
Brugia malayi serine/threonine-protein kinase plk-2 0.0373 0.2811 0.1542
Trypanosoma brucei hexokinase 0.0789 0.7047 0.9049
Mycobacterium ulcerans lipoprotein LpqF 0.0124 0.0275 0.0275
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0891 0.8092 1
Loa Loa (eye worm) glutaminase 0.1079 1 1
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0859 0.7759 1
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0561 0.4726 0.4726
Echinococcus multilocularis hexokinase 0.0789 0.7047 0.9083
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0258 0.1638 0.1638
Trichomonas vaginalis CAMK family protein kinase 0.0373 0.2811 0.2811
Echinococcus granulosus caspase 3 0.0144 0.0482 0.0622
Schistosoma mansoni serine/threonine protein kinase 0.0373 0.2811 0.2061
Brugia malayi glucose-6-phosphate dehydrogenase 0.0859 0.7759 0.7363
Brugia malayi hexokinase 0.0789 0.7047 0.6526
Brugia malayi MH2 domain containing protein 0.0355 0.2634 0.1333
Loa Loa (eye worm) hypothetical protein 0.0538 0.4494 0.3521
Loa Loa (eye worm) MH2 domain-containing protein 0.0355 0.2634 0.1333
Trypanosoma cruzi polo-like protein kinase, putative 0.0373 0.2811 0.3623
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0276 0.1829 0.2357
Echinococcus granulosus hexokinase 0.0789 0.7047 0.9083
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0859 0.7759 0.7525
Trypanosoma brucei hexokinase, putative 0.0789 0.7047 0.9049
Trichomonas vaginalis CAMK family protein kinase 0.0373 0.2811 0.2811
Echinococcus granulosus hexokinase 0.0789 0.7047 0.9083
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0124 0.0275 0.134
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0373 0.2811 0.3623
Brugia malayi Hexokinase family protein 0.0789 0.7047 0.6526
Onchocerca volvulus 0.0789 0.7047 1
Loa Loa (eye worm) glutaminase 2 0.1079 1 1
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0891 0.8092 0.8092
Trichomonas vaginalis CAMK family protein kinase 0.0373 0.2811 0.2811
Loa Loa (eye worm) hexokinase type II 0.0789 0.7047 0.6526
Loa Loa (eye worm) hexokinase 0.0789 0.7047 0.6526
Schistosoma mansoni glutaminase 0.1079 1 1
Echinococcus multilocularis hexokinase 0.0789 0.7047 0.9083
Onchocerca volvulus 0.0495 0.4054 0.2935
Loa Loa (eye worm) hypothetical protein 0.0251 0.1569 0.008
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0197 0.1018 0.1312
Trypanosoma cruzi hexokinase, putative 0.0789 0.7047 0.9083
Loa Loa (eye worm) hexokinase 0.0789 0.7047 0.6526
Trichomonas vaginalis CAMK family protein kinase 0.0185 0.0895 0.0895
Echinococcus multilocularis caspase 0.0197 0.1018 0.1312
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0859 0.7759 1
Toxoplasma gondii hexokinase 0.0789 0.7047 0.6896
Leishmania major hexokinase, putative 0.0789 0.7047 0.9083
Schistosoma mansoni hexokinase 0.0789 0.7047 0.6739
Trichomonas vaginalis CAMK family protein kinase 0.0373 0.2811 0.2811
Leishmania major hypothetical protein, conserved 0.084 0.7564 0.9749
Echinococcus multilocularis hexokinase 0.0789 0.7047 0.9083
Trichomonas vaginalis glutaminase, putative 0.1079 1 1
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0285 0.1913 0.2465
Onchocerca volvulus 0.0789 0.7047 1
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0859 0.7759 0.5
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0298 0.2048 1
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0891 0.8092 1
Brugia malayi hexokinase type II 0.0251 0.1569 0.008
Entamoeba histolytica hexokinase 2 0.0789 0.7047 1
Loa Loa (eye worm) hexokinase 0.0495 0.4054 0.3004
Entamoeba histolytica hexokinase 1 0.0789 0.7047 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0373 0.2811 0.3623
Loa Loa (eye worm) transcription factor SMAD2 0.0355 0.2634 0.1333
Schistosoma mansoni caspase-7 (C14 family) 0.0197 0.1018 0.0081
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0891 0.8092 0.8092
Trypanosoma cruzi hypothetical protein, conserved 0.084 0.7564 0.9749
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0373 0.2811 0.3623
Trichomonas vaginalis CAMK family protein kinase 0.0373 0.2811 0.2811
Echinococcus multilocularis caspase 3 0.0144 0.0482 0.0622

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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