Detailed information for compound 727614

Basic information

Technical information
  • TDR Targets ID: 727614
  • Name: 1-[2-(4-bromophenyl)-6-phenylpyrimidin-4-yl]- 1-methylhydrazine
  • MW: 355.232 | Formula: C17H15BrN4
  • H donors: 1 H acceptors: 2 LogP: 3.93 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)c1nc(cc(n1)c1ccccc1)N(N)C
  • InChi: 1S/C17H15BrN4/c1-22(19)16-11-15(12-5-3-2-4-6-12)20-17(21-16)13-7-9-14(18)10-8-13/h2-11H,19H2,1H3
  • InChiKey: AGCDSXRPEZRTFJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-(4-bromophenyl)-6-phenyl-pyrimidin-4-yl]-1-methyl-hydrazine
  • 1-[2-(4-bromophenyl)-6-phenyl-4-pyrimidinyl]-1-methylhydrazine
  • CBDivE_016242
  • ZINC00825592

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi polo-like protein kinase, putative 0.0188 0.2676 0.2672
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0433 0.6492 0.6492
Treponema pallidum hexokinase (hxk) 0.0659 1 1
Echinococcus granulosus hexokinase 0.0659 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.3448 0.3448
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0433 0.6492 0.6492
Schistosoma mansoni caspase-3 (C14 family) 0.0197 0.2813 0.2813
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.2676 0.325
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.015 0.2087 1
Brugia malayi MH2 domain containing protein 0.0238 0.3448 0.3448
Loa Loa (eye worm) hypothetical protein 0.0449 0.674 0.674
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0188 0.2676 0.2676
Schistosoma mansoni 6-phosphogluconolactonase 0.0017 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0567 0.0684
Loa Loa (eye worm) glutaminase 0.0544 0.8221 0.8221
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0567 0.0684
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0523 0.0523
Trypanosoma cruzi metacaspase, putative 0.0053 0.0567 0.0562
Entamoeba histolytica hexokinase 1 0.0659 1 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0188 0.2676 0.2676
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0433 0.6492 0.6492
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0735 0.0888
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0049 0.0507 0.0611
Entamoeba histolytica hypothetical protein 0.0036 0.0307 0.0302
Giardia lamblia Kinase, PLK 0.0188 0.2676 0.396
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0283 0.4152 0.5048
Schistosoma mansoni kinase 0.0096 0.1236 0.1236
Echinococcus multilocularis caspase 8 0.0053 0.0567 0.0567
Brugia malayi hypothetical protein 0.0036 0.0307 0.0307
Echinococcus multilocularis caspase 3 0.0144 0.1993 0.1993
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0197 0.2813 0.2813
Echinococcus granulosus caspase 8 0.0053 0.0567 0.0567
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0567 0.0684
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0139 0.1918 0.1914
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0188 0.2676 0.2672
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0567 0.0684
Entamoeba histolytica hypothetical protein 0.0036 0.0307 0.0302
Leishmania major hypothetical protein, conserved 0.0424 0.6341 0.634
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0433 0.6492 0.649
Schistosoma mansoni caspase-7 (C14 family) 0.0197 0.2813 0.2813
Echinococcus granulosus caspase 2 0.0053 0.0567 0.0567
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.045 0.6749 0.6553
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.0567 0.0562
Trichomonas vaginalis glutaminase, putative 0.0544 0.8221 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0188 0.2676 0.2676
Onchocerca volvulus 0.0659 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0424 0.6341 0.634
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0049 0.0507 0.0502
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.0567 0.0562
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0433 0.6492 0.649
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.2676 0.325
Trypanosoma brucei hypothetical protein, conserved 0.0424 0.6341 0.634
Trypanosoma cruzi hexokinase, putative 0.0659 1 1
Echinococcus multilocularis hexokinase 0.0659 1 1
Leishmania major hexokinase, putative 0.0659 1 1
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0049 0.0507 0.0502
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.2676 0.325
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0188 0.2676 0.2676
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0567 0.0684
Brugia malayi 6-phosphogluconolactonase family protein 0.0017 0.0005 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.3448 0.3448
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0567 0.0684
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0433 0.6492 0.7896
Trypanosoma cruzi metacaspase, putative 0.0053 0.0567 0.0562
Schistosoma mansoni hexokinase 0.0659 1 1
Echinococcus granulosus caspase 3 0.0144 0.1993 0.1993
Echinococcus multilocularis 6 phosphogluconolactonase 0.0017 0.0005 0.0005
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0433 0.6492 0.649
Loa Loa (eye worm) hypothetical protein 0.005 0.0523 0.0523
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0433 0.6492 1
Leishmania major metacaspase, putative 0.0053 0.0567 0.0562
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0049 0.0507 0.0611
Onchocerca volvulus 0.0659 1 1
Plasmodium falciparum hexokinase 0.0659 1 1
Brugia malayi hexokinase type II 0.0209 0.3007 0.3007
Brugia malayi Hexokinase family protein 0.0413 0.618 0.618
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.045 0.6749 0.8209
Entamoeba histolytica hexokinase 2 0.0659 1 1
Echinococcus granulosus caspase 0.0197 0.2813 0.2813
Schistosoma mansoni 6-phosphogluconolactonase 0.0017 0.0005 0.0005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0735 0.0888
Trypanosoma brucei metacaspase 5, putative 0.0053 0.0567 0.0562
Trypanosoma brucei polo-like protein kinase 0.0188 0.2676 0.2672
Echinococcus multilocularis hexokinase 0.0659 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0523 0.0523
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0567 0.0684
Echinococcus granulosus hexokinase type 2 0.0659 1 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0735 0.0735
Schistosoma mansoni hypothetical protein 0.0036 0.0307 0.0307
Schistosoma mansoni glutaminase 0.0544 0.8221 0.8221
Trypanosoma cruzi polo-like protein kinase, putative 0.0188 0.2676 0.2672
Loa Loa (eye worm) hexokinase 0.0204 0.292 0.292
Loa Loa (eye worm) 6-phosphogluconolactonase 0.0017 0.0005 0.0005
Trypanosoma brucei hexokinase 0.0659 1 1
Schistosoma mansoni hypothetical protein 0.0034 0.0278 0.0278
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0144 0.1982 0.1978
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0567 0.0684
Brugia malayi Cell death protein 3 precursor 0.0053 0.0567 0.0567
Schistosoma mansoni caspase-7 (C14 family) 0.0053 0.0567 0.0567
Brugia malayi Hexokinase family protein 0.0204 0.292 0.292
Loa Loa (eye worm) hexokinase 0.0413 0.618 0.618
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0283 0.4152 0.3801
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0735 0.0735
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0053 0.0567 0.0567
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0735 0.0735
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0307 0.0307
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.045 0.6749 1
Echinococcus granulosus 6 phosphogluconolactonase 0.0017 0.0005 0.0005
Loa Loa (eye worm) glutaminase 2 0.0544 0.8221 0.8221
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0567 0.0684
Echinococcus multilocularis citrate lyase subunit beta protein 0.0049 0.0507 0.0507
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0735 0.073
Trypanosoma brucei metacaspase MCA3 0.0053 0.0567 0.0562
Echinococcus multilocularis hexokinase type 2 0.0659 1 1
Trypanosoma brucei metacaspase 0.0053 0.0567 0.0562
Plasmodium vivax hexokinase, putative 0.0659 1 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0567 0.0567
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.045 0.6749 0.6553
Loa Loa (eye worm) hexokinase 0.0659 1 1
Trypanosoma brucei metacaspase MCA2 0.0053 0.0567 0.0562
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0567 0.0684
Mycobacterium leprae Probable 6-phosphogluconolactonase DevB (6PGL) 0.0017 0.0005 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0735 0.0888
Brugia malayi glucose-6-phosphate dehydrogenase 0.0433 0.6492 0.6492
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0735 0.1442
Trypanosoma cruzi metacaspase, putative 0.0053 0.0567 0.0562
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0567 0.0684
Echinococcus granulosus hexokinase 0.0659 1 1
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0433 0.6492 0.649
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0433 0.6492 0.6492
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0053 0.0567 0.0567
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.2676 0.325
Echinococcus multilocularis caspase 0.0197 0.2813 0.2813
Trypanosoma brucei hexokinase, putative 0.0659 1 1
Onchocerca volvulus 0.0659 1 1
Echinococcus granulosus citrate lyase subunit beta protein 0.0049 0.0507 0.0507
Echinococcus multilocularis hexokinase 0.0659 1 1
Toxoplasma gondii hexokinase 0.0659 1 1
Trypanosoma brucei hexokinase 0.0659 1 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0197 0.2813 0.2813
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1197 0.1451
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0049 0.0507 0.0611
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0567 0.0684
Mycobacterium ulcerans hypothetical protein 0.0049 0.0507 0.0611
Brugia malayi glutaminase DH11.1 0.0544 0.8221 0.8221
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.2676 0.325
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0735 0.0178
Onchocerca volvulus Serine\/threonine kinase homolog 0.0188 0.2676 0.2235
Mycobacterium ulcerans hypothetical protein 0.0049 0.0507 0.0611
Entamoeba histolytica serine/threonine protein kinase, putative 0.0188 0.2676 0.2672
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.2676 0.325
Onchocerca volvulus 0.0413 0.618 0.595
Onchocerca volvulus Hexokinase homolog 0.0413 0.618 0.595
Echinococcus multilocularis caspase 2 0.0053 0.0567 0.0567
Trypanosoma brucei Metacaspase-4 0.0053 0.0567 0.0562
Trypanosoma cruzi metacaspase, putative 0.0053 0.0567 0.0562
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0567 0.0684
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0567 0.0684
Leishmania major hexokinase, putative 0.0659 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0735 0.0735
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0049 0.0507 0.0502
Mycobacterium ulcerans glutaminase 0.0544 0.8221 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0567 0.0567
Echinococcus granulosus hexokinase 0.0659 1 1
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.045 0.6749 0.8209
Loa Loa (eye worm) hexokinase type II 0.0659 1 1
Trypanosoma cruzi hexokinase, putative 0.0659 1 1
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.045 0.6749 0.6553
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.2676 0.325
Trypanosoma cruzi hypothetical protein, conserved 0.0424 0.6341 0.634
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.2676 0.2676
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1197 0.1451
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0567 0.0684
Loa Loa (eye worm) hexokinase 0.0659 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.0307 0.0302
Loa Loa (eye worm) hypothetical protein 0.0209 0.3007 0.3007
Entamoeba histolytica hypothetical protein 0.0036 0.0307 0.0302
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0307 0.0307
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0209 0.3007 0.3007
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.045 0.6749 0.8209
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.0017 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0034 0.0278 0.0278
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0307 0.0307
Brugia malayi Hexokinase family protein 0.0659 1 1
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0049 0.0507 0.0611
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0278 0.0278

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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