Detailed information for compound 727997

Basic information

Technical information
  • TDR Targets ID: 727997
  • Name: 1-[4-[[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-y l]methyl]piperazin-1-yl]ethanone
  • MW: 320.774 | Formula: C15H17ClN4O2
  • H donors: 0 H acceptors: 3 LogP: 1.57 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)N1CCN(CC1)Cc1onc(n1)c1ccc(cc1)Cl
  • InChi: 1S/C15H17ClN4O2/c1-11(21)20-8-6-19(7-9-20)10-14-17-15(18-22-14)12-2-4-13(16)5-3-12/h2-5H,6-10H2,1H3
  • InChiKey: CCLFQIYBJLZHFK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-[[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl]-1-piperazinyl]ethanone
  • T5815818

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0851 0.0812
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0063 0.0021
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0159 0.3363 1
Schistosoma mansoni tar DNA-binding protein 0.0126 0.2617 0.2617
Toxoplasma gondii target of rapamycin (TOR), putative 0.0011 0.0063 0.0012
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0851 0.0851
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0057 0.1077 0.1854
Leishmania major phosphatidylinositol 3-kinase, putative 0.0011 0.0063 0.0012
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0011 0.0063 0.0012
Trypanosoma cruzi oligopeptidase b 0.0027 0.0411 0.0648
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0159 0.3363 1
Echinococcus multilocularis serine protein kinase ATM 0.0015 0.0156 0.0156
Plasmodium falciparum carbamoyl phosphate synthetase 0.0036 0.0617 0.0868
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0036 0.0617 0.0617
Trypanosoma cruzi target of rapamycin kinase 3 0.0011 0.0063 0.0019
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0015 0.0142 0.01
Trypanosoma brucei unspecified product 0.0105 0.2147 0.2308
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0011 0.0063 0.0063
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0015 0.0142 0.0161
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0851 0.0851
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0027 0.0411 0.0395
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.1407 0.1407
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.1222 0.1289
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0057 0.1077 0.3096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0057 0.1077 0.3096
Loa Loa (eye worm) TAR-binding protein 0.0126 0.2617 0.2584
Mycobacterium tuberculosis Probable peptidase 0.0027 0.0411 0.1083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Entamoeba histolytica hypothetical protein 0.0071 0.1407 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.3089 0.306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Trypanosoma cruzi acetyl-CoA carboxylase 0.0259 0.5581 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0015 0.0142 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.2441 0.2407
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0036 0.0617 0.0622
Brugia malayi CXXC zinc finger family protein 0.0033 0.0558 0.0518
Trypanosoma brucei acetyl-CoA carboxylase 0.0418 0.9128 1
Echinococcus granulosus dnaJ subfamily B 0.0243 0.5231 0.5231
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.3089 0.3057
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0015 0.0156 0.0186
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.0403 0.8801 0.8796
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0097
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0015 0.0142 0.0137
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0015 0.0142 0.01
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0015 0.0142 0.0142
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component 0.0015 0.0142 0.0269
Mycobacterium ulcerans pyruvate carboxylase 0.0159 0.3363 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0015 0.0142 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Trypanosoma brucei oligopeptidase b 0.0027 0.0411 0.0395
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0067 0.1313 0.1313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0015 0.0156 0.0156
Echinococcus multilocularis tar DNA binding protein 0.0126 0.2617 0.2617
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0015 0.0142 0.0161
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0159 0.3363 0.3363
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0011 0.0063 0.0063
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0057 0.1077 0.3096
Schistosoma mansoni tar DNA-binding protein 0.0126 0.2617 0.2617
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.2617 0.2584
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0015 0.0142 0.0098
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0851 0.0851
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0011 0.0053 0.0053
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0067 0.1313 0.1313
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0851 0.0851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Trypanosoma cruzi prolyl endopeptidase 0.0067 0.1313 0.228
Echinococcus granulosus GPCR family 2 0.0046 0.0851 0.0851
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0015 0.0142 0.0142
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0057 0.1077 0.2905
Toxoplasma gondii carbamoylphosphate synthetase 0.0036 0.0617 0.0622
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0013 0.0108 0.01
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0057 0.1077 0.3096
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0015 0.0142 0.0098
Schistosoma mansoni cpg binding protein 0.0033 0.0558 0.0558
Wolbachia endosymbiont of Brugia malayi branched-chain alpha-keto acid dehydrogenase subunit E2 0.0015 0.0142 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0057 0.1077 0.1129
Schistosoma mansoni acetyl-CoA carboxylase 0.0418 0.9128 0.9128
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0027 0.0411 0.0395
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0027 0.0411 0.0837
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0015 0.0142 0.0161
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0011 0.0063 0.0012
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0011 0.0063 0.0012
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.0418 0.9128 0.9128
Brugia malayi TAR-binding protein 0.0126 0.2617 0.2586
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0057 0.1077 0.3096
Entamoeba histolytica hypothetical protein 0.0071 0.1407 1
Entamoeba histolytica hypothetical protein 0.0071 0.1407 1
Brugia malayi exodeoxyribonuclease III family protein 0.0011 0.0053 0.001
Chlamydia trachomatis biotin carboxylase 0.0144 0.3036 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0159 0.3363 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.1407 0.1407
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0159 0.3363 0.5987
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0851 0.081
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0057 0.1077 0.1129
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0015 0.0142 0.0161
Brugia malayi Carboxyl transferase domain containing protein 0.0403 0.8801 0.8796
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0036 0.0617 0.1705
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0011 0.0063 0.0012
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0011 0.0063 0.0019
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0027 0.0411 0.1083
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0011 0.0053 0.0053
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0015 0.0142 0.0098
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0011 0.0063 0.0063
Schistosoma mansoni pyruvate carboxylase 0.0159 0.3363 0.3363
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0011 0.0063 0.0012
Schistosoma mansoni hypothetical protein 0.0243 0.5231 0.5231
Brugia malayi prolyl oligopeptidase family protein 0.0067 0.1313 0.1276
Echinococcus granulosus tar DNA binding protein 0.0126 0.2617 0.2617
Entamoeba histolytica hypothetical protein 0.0071 0.1407 1
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0015 0.0142 0.0137
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0015 0.0142 0.0142
Schistosoma mansoni cpg binding protein 0.0035 0.06 0.06
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0457 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.0063 0.0018
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.2441 0.2407
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0156 0.0114
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0057 0.1077 0.2905
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0011 0.0063 0.0012
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0457 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Echinococcus granulosus serine protein kinase ATM 0.0015 0.0156 0.0156
Schistosoma mansoni hypothetical protein 0.0046 0.0851 0.0851
Echinococcus multilocularis dnaJ subfamily B 0.0243 0.5231 0.5231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0057 0.1077 0.1854
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0015 0.0142 0.0161
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0045 0.0045
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0036 0.0617 0.0617
Schistosoma mansoni cpg binding protein 0.0035 0.06 0.06
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Schistosoma mansoni ap endonuclease 0.0011 0.0053 0.0053
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0015 0.0142 0.0098
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0011 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0046 0.0851 0.081
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0057 0.1077 0.3096
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0036 0.0617 0.1021
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0159 0.3363 0.3363
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0159 0.3363 0.3363
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0015 0.0142 0.0142
Leishmania major carbamoyl-phosphate synthase, putative 0.0036 0.0617 0.0622
Schistosoma mansoni hypothetical protein 0.01 0.2053 0.2053
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.1391 0.1391
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0057 0.1077 0.1129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0015 0.0142 0.0142
Schistosoma mansoni hypothetical protein 0.0046 0.0851 0.0851
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0159 0.3363 1
Mycobacterium ulcerans hypothetical protein 0.0015 0.0142 0.0269
Schistosoma mansoni ap endonuclease 0.0011 0.0053 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0015 0.0142 0.0269
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0159 0.3363 0.3363
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0015 0.0142 0.0269
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0011 0.0063 0.0012
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0057 0.1077 0.3096
Brugia malayi hypothetical protein 0.0071 0.1407 0.137
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0097
Entamoeba histolytica hypothetical protein 0.0015 0.0156 0.0761
Echinococcus granulosus c-Jun N-terminal kinases 0.0457 1 1
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0015 0.0142 0.0098
Schistosoma mansoni aspartate carbamoyltransferase 0.0036 0.0617 0.0617
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0015 0.0156 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0156 1
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0015 0.0142 0.0098
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0045 0.0045
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0015 0.0142 0.0269
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0036 0.0617 0.1021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.2053 0.2019
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.0063 0.0018
Echinococcus multilocularis prolyl endopeptidase 0.0067 0.1313 0.1313
Echinococcus granulosus prolyl endopeptidase 0.0067 0.1313 0.1313
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0159 0.3363 0.3647
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0036 0.0617 0.1705
Echinococcus multilocularis GPCR, family 2 0.0046 0.0851 0.0851
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0159 0.3363 1
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0159 0.3363 1
Schistosoma mansoni hypothetical protein 0.0046 0.0851 0.0851
Loa Loa (eye worm) hypothetical protein 0.0013 0.0108 0.0063
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0057 0.1077 0.1854
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0011 0.0063 0.0012
Toxoplasma gondii prolyl endopeptidase 0.0067 0.1313 0.1389
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0011 0.0063 0.0019
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0015 0.0142 0.0098
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0027 0.0411 0.0648
Giardia lamblia GTOR 0.0011 0.0063 0.0077
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0057 0.1077 0.1077
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0057 0.1077 0.3096
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0057 0.1077 0.1129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0302 0.6554 1
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0015 0.0142 0.0142
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0071 0.1404 0.9977
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0011 0.0063 0.0063
Leishmania major acetyl-CoA carboxylase, putative 0.0418 0.9128 1
Echinococcus multilocularis cpg binding protein 0.0035 0.06 0.06
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0015 0.0142 0.0142
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.2617 0.2586
Echinococcus granulosus Biotin lipoyl attachment 0.0015 0.0142 0.0142
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0027 0.0411 0.0648
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0159 0.3363 0.3647
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0011 0.0063 0.0063
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0015 0.0142 0.0098
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0015 0.0142 0.0161
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0071 0.1404 1
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0159 0.3363 0.5987
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.0418 0.9128 1
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0027 0.0411 0.1083
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0067 0.1313 0.1389
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0057 0.1077 0.2905
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0015 0.0142 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Echinococcus granulosus cpg binding protein 0.0035 0.06 0.06
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.3089 0.306
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0057 0.1077 0.3233
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0159 0.3363 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0011 0.0063 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0015 0.0142 0.0142
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0011 0.0063 0.0077
Loa Loa (eye worm) hypothetical protein 0.01 0.2053 0.2017
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0015 0.0142 0.0269
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0015 0.0142 0.0098
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0558 0.0515
Trypanosoma brucei prolyl endopeptidase 0.0067 0.1313 0.1389
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0011 0.0063 0.0077
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0851 0.0812
Toxoplasma gondii pyruvate carboxylase 0.0159 0.3363 0.3647
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Brugia malayi RNA binding protein 0.0126 0.2617 0.2586
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0015 0.0142 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0457 1 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0011 0.0063 0.0012
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.006 0.1156 0.3334
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0011 0.0064 0.002
Onchocerca volvulus Prolyl endopeptidase homolog 0.0067 0.1313 1
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0057 0.1077 0.1077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Loa Loa (eye worm) hypothetical protein 0.0147 0.3089 0.3057
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.1407 0.1407
Brugia malayi MH2 domain containing protein 0.0118 0.2441 0.2409
Toxoplasma gondii FATC domain-containing protein 0.0015 0.0156 0.0113
Echinococcus multilocularis Biotin lipoyl attachment 0.0015 0.0142 0.0142
Schistosoma mansoni hypothetical protein 0.0071 0.1407 0.1407
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.0418 0.9128 0.9128
Loa Loa (eye worm) hypothetical protein 0.0067 0.1313 0.1274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Trypanosoma brucei prolyl oligopeptidase, putative 0.0027 0.0411 0.0395
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0015 0.0142 0.0098
Schistosoma mansoni tar DNA-binding protein 0.0126 0.2617 0.2617
Leishmania major phosphatidylinositol kinase related protein, putative 0.0011 0.0064 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0126 0.2617 0.2617
Schistosoma mansoni hypothetical protein 0.0046 0.0851 0.0851
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0015 0.0142 0.01
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0015 0.0142 0.0137
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0159 0.3363 0.3647
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0011 0.0053 0.0008
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0015 0.0142 0.0269
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0015 0.0142 0.0098
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0057 0.1077 0.1077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Trypanosoma cruzi oligopeptidase b 0.0027 0.0411 0.0648
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0063 0.0021
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0302 0.6554 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0097
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0057 0.1077 0.3096
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0036 0.0617 0.0868
Treponema pallidum pyruvate carboxylase subunit B 0.0015 0.0142 1
Schistosoma mansoni tar DNA-binding protein 0.0126 0.2617 0.2617
Leishmania major oligopeptidase b 0.0027 0.0411 0.0395
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0015 0.0142 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.1015
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0011 0.0063 0.0019
Loa Loa (eye worm) RNA binding protein 0.0126 0.2617 0.2584
Leishmania major carboxylase, putative 0.0159 0.3363 0.3647
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.0418 0.9128 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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