TDR Targets

Basic information

Technical information

TDR Targets ID: 728067
Name: N-(4-methoxyphenyl)-2-(4-pyridin-2-ylpiperazi n-1-yl)acetamide
MW: 326.393 | Formula: C18H22N4O2
H donors: 1 H acceptors: 2 LogP: 1.99 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)NC(=O)CN1CCN(CC1)c1ccccn1
InChi: 1S/C18H22N4O2/c1-24-16-7-5-15(6-8-16)20-18(23)14-21-10-12-22(13-11-21)17-4-2-3-9-19-17/h2-9H,10-14H2,1H3,(H,20,23)
InChiKey: LJKNPCFKUQYLTF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-methoxyphenyl)-2-[4-(2-pyridyl)piperazin-1-yl]acetamide
N-(4-methoxyphenyl)-2-[4-(2-pyridyl)-1-piperazinyl]acetamide
N-(4-methoxyphenyl)-2-(4-pyridin-2-ylpiperazin-1-yl)ethanamide
IVK/0016239

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0018
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0012	0.5
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0243	0.0804
Trypanosoma cruzi	major cysteine proteinase, putative	0.0054	0.0496	0.7098
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0012	0.0166
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0243	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0486	0.1919
Schistosoma mansoni	bromodomain containing protein	0.0068	0.0691	0.0691
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0012	1
Echinococcus multilocularis	tar DNA binding protein	0.0202	0.2532	0.2532
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0243	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0243	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0064	0.0638	0.0638
Brugia malayi	RNA recognition motif domain containing protein	0.0202	0.2532	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0018	0.0005	0.0005
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0039	0.0285	0.0285
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0699	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0699	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0012	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0243	0.0961
Schistosoma mansoni	hypothetical protein	0.0022	0.0058	0.0058
Onchocerca volvulus		0.0036	0.0243	0.5007
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0699	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0243	0.0243
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0243	0.0243
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0243	0.0961
Brugia malayi	Bromodomain containing protein	0.0081	0.0865	0.3417
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0086	0.0086
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0012	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0202	0.2532	0.2532
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0699	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0243	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0243	0.0804
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0005	0.0005
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0243	0.3481
Schistosoma mansoni	tar DNA-binding protein	0.0202	0.2532	0.2532
Leishmania major	cathepsin L-like protease	0.0069	0.0699	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0243	1
Onchocerca volvulus		0.0053	0.0486	1
Brugia malayi	Bromodomain containing protein	0.0041	0.032	0.1264
Brugia malayi	TAR-binding protein	0.0202	0.2532	1
Echinococcus granulosus	tumor protein p63	0.0364	0.477	0.477
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0243	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0243	0.0961
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0699	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0243	0.0961
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0012	0.0046
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0699	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0699	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0243	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0321	0.1269
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0012	0.0166
Echinococcus granulosus	tar DNA binding protein	0.0202	0.2532	0.2532
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0243	0.0804
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0243	1
Brugia malayi	beta-lactamase	0.0036	0.0243	0.0961
Toxoplasma gondii	exonuclease III APE	0.0019	0.0012	0.0477
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0086	0.0086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0699	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0064	0.0638	0.0638
Schistosoma mansoni	ap endonuclease	0.0019	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0356	0.1407
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0243	0.0961
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0005	0.0005
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0243	0.0243
Onchocerca volvulus		0.0036	0.0243	0.5007
Onchocerca volvulus		0.0036	0.0243	0.5007
Brugia malayi	PHD-finger family protein	0.0027	0.0121	0.0479
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0699	1
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0243	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0243	0.0961
Echinococcus granulosus	histone lysine methyltransferase setb	0.0018	0.0005	0.0005
Loa Loa (eye worm)	RNA binding protein	0.0202	0.2532	1
Schistosoma mansoni	tar DNA-binding protein	0.0202	0.2532	0.2532
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0699	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0243	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0802	0.3166
Schistosoma mansoni	zinc finger protein	0.0021	0.0042	0.0042
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0243	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0012	0.5
Schistosoma mansoni	microtubule-associated protein tau	0.0744	1	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0012	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0243	0.3481
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0243	0.0804
Trichomonas vaginalis	esterase, putative	0.0036	0.0243	1
Echinococcus multilocularis	tumor protein p63	0.0364	0.477	0.477
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0012	0.0477
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0018	0.0005	0.0005
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0012	0.0046
Trypanosoma cruzi	cruzipain precursor, putative	0.0069	0.0699	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0243	0.0961
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0058	0.0228
Toxoplasma gondii	ABC1 family protein	0.0036	0.0243	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0243	0.0961
Echinococcus multilocularis	microtubule associated protein 2	0.0744	1	1
Leishmania major	hypothetical protein, conserved	0.0036	0.0243	0.3481
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0086	0.0086
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0699	1
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0018	0.0005	0.0005
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0243	1
Leishmania major	cathepsin L-like protease	0.0069	0.0699	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0699	1
Loa Loa (eye worm)	TAR-binding protein	0.0202	0.2532	1
Echinococcus multilocularis	zinc finger protein	0.0021	0.0042	0.0042
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0063	0.0617	0.8824
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0385	0.152
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0243	1
Loa Loa (eye worm)	bromodomain containing protein	0.0019	0.0014	0.0054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0699	1
Mycobacterium ulcerans	lipase LipD	0.0036	0.0243	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0012	0.0012
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0243	0.0804
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0243	1
Schistosoma mansoni	tar DNA-binding protein	0.0202	0.2532	0.2532
Brugia malayi	RNA binding protein	0.0202	0.2532	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0202	0.2532	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0243	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0243	0.0961
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0005	0.0005
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0012	0.0012
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0243	0.0804
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0243	0.0804
Echinococcus granulosus	zinc finger protein	0.0021	0.0042	0.0042
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0243	1
Leishmania major	cathepsin L-like protease	0.0069	0.0699	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0243	0.0804
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0005	0.0005
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0699	1
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0243	0.3371
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0012	0.0012
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0228	0.2894	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0012	0.0166
Schistosoma mansoni	cellular tumor antigen P53	0.0053	0.0486	0.0486
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0012	0.0477
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0039	0.0285	0.0285
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0243	0.0243
Schistosoma mansoni	tar DNA-binding protein	0.0202	0.2532	0.2532

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 728067