Detailed information for compound 728241

Basic information

Technical information
  • TDR Targets ID: 728241
  • Name: 5-[4-(5-chlorothiophen-2-yl)sulfonylpiperazin -1-yl]-3-methyl-5-oxopentanoic acid
  • MW: 394.894 | Formula: C14H19ClN2O5S2
  • H donors: 1 H acceptors: 5 LogP: 1.54 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CC(=O)O)CC(=O)N1CCN(CC1)S(=O)(=O)c1ccc(s1)Cl
  • InChi: 1S/C14H19ClN2O5S2/c1-10(9-13(19)20)8-12(18)16-4-6-17(7-5-16)24(21,22)14-3-2-11(15)23-14/h2-3,10H,4-9H2,1H3,(H,19,20)
  • InChiKey: FVOPYXPNXAVVKI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-[4-[(5-chloro-2-thienyl)sulfonyl]piperazin-1-yl]-3-methyl-5-oxo-pentanoic acid
  • 5-[4-[(5-chloro-2-thienyl)sulfonyl]-1-piperazinyl]-3-methyl-5-oxopentanoic acid
  • 5-[4-[(5-chloro-2-thienyl)sulfonyl]piperazin-1-yl]-5-keto-3-methyl-valeric acid
  • 5-[4-(5-chlorothiophen-2-yl)sulfonylpiperazin-1-yl]-3-methyl-5-oxo-pentanoic acid
  • IVK/0017758

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.1186
Leishmania major cathepsin L-like protease 0.0063 0.0852 1
Toxoplasma gondii ABC1 family protein 0.0037 0.0412 0.0351
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0105 0.0543
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0062 0.0076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0079 0.021
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.1186
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0105 0.11
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0452 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0105 0.0483
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0412 0.0335
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0062 0.0031
Toxoplasma gondii thioredoxin reductase 0.0051 0.064 0.0581
Leishmania major cathepsin L-like protease 0.0063 0.0852 1
Loa Loa (eye worm) cysteine protease 0.0017 0.0062 0.0076
Plasmodium falciparum glutathione reductase 0.0051 0.064 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0452 0.0392
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.218 0.8628
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0076
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0412 0.0335
Mycobacterium tuberculosis Conserved protein 0.0037 0.0412 0.0335
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0062 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0852 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0105 0.0027
Echinococcus granulosus tumor protein p63 0.0328 0.5335 1
Echinococcus multilocularis cysteine protease 0.0017 0.0062 0.0031
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0079 0.0017
Brugia malayi Cathepsin L-like precursor 0.0017 0.0062 0.0286
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0105 0.0543
Mycobacterium tuberculosis Conserved protein 0.0037 0.0412 0.0335
Brugia malayi Cathepsin L-like precursor 0.0017 0.0062 0.0286
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0079 0.021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.218 0.4034
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.1958 0.1639
Loa Loa (eye worm) hypothetical protein 0.0048 0.0594 0.257
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0079 0.0133
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0079 0.021
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0412 0.0335
Onchocerca volvulus 0.0048 0.0594 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0412 0.1478
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0852 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.1186
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0079 0.0287
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0412 0.0335
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0852 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0618 0.2679
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0412 0.0335
Schistosoma mansoni inositol monophosphatase 0.004 0.0452 0.1641
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0452 0.528
Loa Loa (eye worm) hypothetical protein 0.0037 0.0412 0.1713
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0412 0.1713
Trypanosoma brucei unspecified product 0.0019 0.0105 0.1186
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.1958 0.1894
Echinococcus granulosus dna polymerase eta 0.0019 0.0105 0.0112
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0105 0.0543
Loa Loa (eye worm) inositol-1 0.004 0.0452 0.1902
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.064 0.7316
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0079 0.0876
Brugia malayi Cathepsin L-like precursor 0.0017 0.0062 0.0286
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1744 0.7956
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0079 0.0425
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0412 0.4424
Plasmodium falciparum glutathione reductase 0.0018 0.0079 0.0287
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0105 0.0112
Loa Loa (eye worm) ctsf protein 0.0017 0.0062 0.0076
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0412 0.0691
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0105 0.0112
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0412 0.8963
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.1186
Echinococcus multilocularis cysteine protease 0.0017 0.0062 0.0031
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0412 0.8963
Loa Loa (eye worm) hypothetical protein 0.0037 0.0412 0.1713
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0079 0.021
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.064 0.2783
Toxoplasma gondii pantoate-beta-alanine ligase 0.0604 1 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0452 0.4936
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0105 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.1186
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.174 0.1674
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0079 0.021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0852 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.0105 0.0112
Onchocerca volvulus 0.0037 0.0412 0.6564
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.218 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0079 0.0062
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0079 0.0362
Brugia malayi MH2 domain containing protein 0.0116 0.1744 0.8
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.174 0.1674
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0105 0.11
Brugia malayi Cathepsin L-like precursor 0.0017 0.0062 0.0286
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0105 0.0543
Loa Loa (eye worm) glutathione reductase 0.0051 0.064 0.2783
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0079 0.021
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0079 0.0425
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0079 0.021
Treponema pallidum NADH oxidase 0.0018 0.0079 0.5
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0079 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.0412 0.1713
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0079 0.021
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0046 0.0212
Giardia lamblia DINP protein human, muc B family 0.0019 0.0105 1
Leishmania major trypanothione reductase 0.0051 0.064 0.7316
Mycobacterium ulcerans hypothetical protein 0.0037 0.0412 0.0335
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.174 0.1674
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0852 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0452 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.218 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.218 0.4034
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0062 0.0031
Mycobacterium ulcerans lipase LipD 0.0037 0.0412 0.0335
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0079 0.0876
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0452 0.0376
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.064 0.1123
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.1186
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0062 0.0066
Brugia malayi beta-lactamase 0.0037 0.0412 0.1888
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0382 0.0305
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.064 0.0565
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.0604 1 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0412 0.0335
Trichomonas vaginalis esterase, putative 0.0037 0.0412 0.8963
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0079 0.0062
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0412 0.1478
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0062 0.0031
Mycobacterium tuberculosis Conserved protein 0.0037 0.0412 0.0335
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0604 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0105 0.0239
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.218 0.8628
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0105 0.0027
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.064 0.1123
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0412 0.0335
Loa Loa (eye worm) hypothetical protein 0.0034 0.0353 0.1439
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0079 0.0876
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0062 0.0076
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1744 0.7956
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.1186
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0412 0.6047
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.064 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0412 0.8963
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0105 0.1186
Plasmodium vivax glutathione reductase, putative 0.0051 0.064 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0412 0.1713
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0062 0.0031
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0452 0.0767
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0759 0.8824
Onchocerca volvulus 0.0037 0.0412 0.6564
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0852 1
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0452 0.0767
Loa Loa (eye worm) hypothetical protein 0.0049 0.0618 0.2679
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0105 0.0112
Mycobacterium ulcerans beta-lactamase 0.0037 0.0412 0.0335
Mycobacterium tuberculosis Probable reductase 0.0116 0.174 0.1674
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0412 0.0031
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0412 0.8963
Brugia malayi glutathione reductase 0.0051 0.064 0.2936
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0062 0.0286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0852 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.1186
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0618 0.2834
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0079 0.0017
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0105 0.1186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.218 0.8628
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0079 0.021
Leishmania major cathepsin L-like protease 0.0063 0.0852 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.0105 0.0543
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0412 0.8963
Loa Loa (eye worm) hypothetical protein 0.0037 0.0412 0.1713
Trypanosoma brucei trypanothione reductase 0.0051 0.064 0.7499
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0618 0.2834
Loa Loa (eye worm) fibroinase 0.0017 0.0062 0.0076
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0105 0.0027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0079 0.021
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0452 1
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0852 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0412 0.1713
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.174 0.1412
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0852 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0105 0.0239
Brugia malayi Inositol-1 0.004 0.0452 0.2074
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0105 0.1186
Schistosoma mansoni inositol monophosphatase 0.004 0.0452 0.1641
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0452 1
Echinococcus multilocularis tumor protein p63 0.0328 0.5335 1
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0062 0.0066
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0079 0.0287
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0105 0.11
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0105 0.0277
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.218 0.4034
Echinococcus granulosus dna polymerase kappa 0.0019 0.0105 0.0112
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0079 0.0876
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.174 0.1674
Brugia malayi beta-lactamase family protein 0.0037 0.0412 0.1888
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0623 0.7098
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.174 0.1674
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0412 0.0335
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0105 0.0543
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0594 0.2217
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0079 0.021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0852 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0062 0.0286
Brugia malayi beta-lactamase family protein 0.0037 0.0412 0.1888
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0852 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.218 0.4034
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0412 0.1888
Brugia malayi Thioredoxin reductase 0.0051 0.064 0.2936
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0079 0.0287
Loa Loa (eye worm) hypothetical protein 0.0019 0.0105 0.0277
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0105 0.0483
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0852 1
Onchocerca volvulus 0.0037 0.0412 0.6564
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.1958 0.1894
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0062 0.0031
Mycobacterium leprae Probable lipase LipE 0.0037 0.0412 0.0031
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.1958 0.1894
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0452 1
Plasmodium falciparum thioredoxin reductase 0.0051 0.064 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0105 0.0543
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0353 0.162
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0452 0.4936
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0105 0.0239
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0852 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0105 0.0543
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0852 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0412 0.0335
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0046 0.0212
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.1186
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0079 0.021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0079 0.021
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0412 0.4803
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0079 0.0287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0852 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0412 0.0691
Schistosoma mansoni hypothetical protein 0.0034 0.0353 0.1242
Loa Loa (eye worm) beta-lactamase 0.0037 0.0412 0.1713
Leishmania major hypothetical protein, conserved 0.0037 0.0412 0.4424
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0412 0.4424
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0452 0.4936
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0105 0.1186
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.3807 0.3758
Brugia malayi Cathepsin L-like precursor 0.0017 0.0062 0.0286
Echinococcus granulosus cathepsin l1 0.0017 0.0062 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.1186
Plasmodium falciparum thioredoxin reductase 0.0018 0.0079 0.0287

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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