Detailed information for compound 728279

Basic information

Technical information
  • TDR Targets ID: 728279
  • Name: 1-acetyl-N-(4-bromophenyl)piperidine-4-carbox amide
  • MW: 325.201 | Formula: C14H17BrN2O2
  • H donors: 1 H acceptors: 2 LogP: 1.74 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCN(CC1)C(=O)C)Nc1ccc(cc1)Br
  • InChi: 1S/C14H17BrN2O2/c1-10(18)17-8-6-11(7-9-17)14(19)16-13-4-2-12(15)3-5-13/h2-5,11H,6-9H2,1H3,(H,16,19)
  • InChiKey: BUNVQBBBJKNDLS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-acetyl-N-(4-bromophenyl)-4-piperidinecarboxamide
  • 1-acetyl-N-(4-bromophenyl)isonipecotamide
  • N-(4-bromophenyl)-1-ethanoyl-piperidine-4-carboxamide
  • IVK/0017738
  • ZINC06727131

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0018 0.0049 0.0157
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0158 0.1054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.014
Schistosoma mansoni cation-transporting ATPase 0.0018 0.0041 0.0029
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0123 0.0678
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0672 0.5263
Echinococcus multilocularis lamin dm0 0.0026 0.0149 0.0134
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0053 0.0042
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0185 0.1185
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0018 0.0041 0.0091
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0018 0.0041 0.0026
Loa Loa (eye worm) hypothetical protein 0.0144 0.158 0.5338
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0018 0.0041 0.0091
Onchocerca volvulus 0.0027 0.0158 0.0942
Brugia malayi Cathepsin L-like precursor 0.0018 0.0049 0.0167
Leishmania major P-type H -ATPase, putative 0.0018 0.0041 0.0091
Loa Loa (eye worm) beta-lactamase 0.0117 0.125 0.4223
Schistosoma mansoni hypothetical protein 0.0017 0.003 0.0016
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0117 0.125 0.4223
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0053 0.0042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0061 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0049 0.0066
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.1149 0.9163
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0075 0.0275
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.009 0.0918 0.791
Loa Loa (eye worm) hypothetical protein 0.0183 0.2056 0.6944
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0049 0.0037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0049 0.0066
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.0777 0.6087
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0203 0.1461
Schistosoma mansoni tar DNA-binding protein 0.0258 0.2961 0.3291
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0158 0.0966
Onchocerca volvulus 0.0117 0.125 0.9753
Echinococcus granulosus microtubule associated protein 2 0.0752 0.8965 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.1149 0.1248
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0185 0.1185
Plasmodium vivax vivapain-2 0.0018 0.0049 0.0066
Trypanosoma cruzi P-type H+-ATPase, putative 0.0018 0.0041 0.0091
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0016 0.0053
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0049 0.0072
Schistosoma mansoni atpase class VI type 11c 0.0018 0.0041 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.014
Loa Loa (eye worm) cysteine protease 0.0018 0.0049 0.0167
Brugia malayi RNA binding protein 0.0258 0.2961 1
Schistosoma mansoni cation-transporting atpase worm 0.0018 0.0041 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0158 0.0534
Mycobacterium ulcerans esterase/lipase LipP 0.0117 0.125 1
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0018 0.0041 0.014
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0053 0.0042
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0185 0.1185
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0777 0.6123
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0422 0.1427
Trypanosoma cruzi P-type H+-ATPase, putative 0.0018 0.0041 0.0091
Trypanosoma brucei hypothetical protein, conserved 0.0117 0.125 1
Mycobacterium ulcerans hypothetical protein 0.0117 0.125 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0167
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0018 0.0041 0.014
Schistosoma mansoni lamin 0.0026 0.0149 0.0149
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.009 0.0918 0.7248
Trypanosoma cruzi cation-transporting ATPase, putative 0.0018 0.0041 0.0091
Loa Loa (eye worm) phosphofructokinase 0.0109 0.1149 0.3882
Schistosoma mansoni hypothetical protein 0.0022 0.0101 0.0095
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.014
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0018 0.0041 0.0091
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.1149 0.917
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0185 0.1294
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.009 0.0918 0.7248
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0185 0.1185
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.1149 1
Loa Loa (eye worm) fibroinase 0.0018 0.0049 0.0167
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0078 0.0777 0.6643
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.0599 0.4662
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0049 0.0167
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0117 0.125 0.4223
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.125 1
Echinococcus granulosus cation transporting ATPase 13A3 0.0018 0.0041 0.0029
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0252
Trichomonas vaginalis D-aminoacylase, putative 0.0117 0.125 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0907 0.0996
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0049 0.0167
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0123 0.0764
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0123 0.0764
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0049 0.0066
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0117 0.125 0.138
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0258 0.2961 1
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0018 0.0041 0.0029
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0018 0.0041 0.014
Loa Loa (eye worm) hypothetical protein 0.0117 0.125 0.4223
Echinococcus multilocularis beta LACTamase domain containing family member 0.0117 0.125 0.1237
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0534
Trichomonas vaginalis D-aminoacylase, putative 0.0117 0.125 1
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.1149 0.1135
Trypanosoma brucei cation-transporting ATPase, putative 0.0018 0.0041 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0158 0.0966
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0158 0.0966
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0049 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0049 0.0066
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0018 0.0041 0.0026
Loa Loa (eye worm) hypothetical protein 0.0054 0.0483 0.163
Schistosoma mansoni zinc finger protein 0.0021 0.0087 0.0079
Brugia malayi Bromodomain containing protein 0.0042 0.0335 0.1131
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0078 0.0777 0.6087
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0049 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0672 0.5263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0672 0.5263
Echinococcus multilocularis cysteine protease 0.0018 0.0049 0.0034
Loa Loa (eye worm) TAR-binding protein 0.0258 0.2961 1
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.1149 0.9163
Echinococcus granulosus copper transporting ATPase 1 0.0018 0.0041 0.0029
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0053
Echinococcus multilocularis phosphoserine phosphatase 0.0018 0.0041 0.0026
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0185 0.1185
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0126 0.0123
Loa Loa (eye worm) hypothetical protein 0.0117 0.125 0.4223
Echinococcus granulosus inositol monophosphatase 1 0.0078 0.0777 0.0851
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0907 0.0893
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0018 0.0041 0.0029
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0185 0.1185
Brugia malayi beta-lactamase family protein 0.0117 0.125 0.4223
Echinococcus granulosus tar DNA binding protein 0.0258 0.2961 0.3291
Leishmania major cathepsin L-like protease 0.007 0.0672 0.5263
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0203 0.1847
Echinococcus multilocularis tumor protein p63 0.0368 0.4302 0.4293
Schistosoma mansoni tar DNA-binding protein 0.0258 0.2961 0.3291
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0049 0.0066
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0185 0.1185
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0018 0.0041 0.0091
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0018 0.0041 0.0029
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0062 0.0208
Brugia malayi Cathepsin L-like precursor 0.0018 0.0049 0.0167
Leishmania major hypothetical protein, conserved 0.0117 0.125 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0049 0.0066
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.1149 0.9163
Loa Loa (eye worm) hypothetical protein 0.0117 0.125 0.4223
Mycobacterium ulcerans hypothetical protein 0.0027 0.0158 0.0966
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0053 0.0042
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.007 0.0678 0.0717
Trichomonas vaginalis esterase, putative 0.0117 0.125 1
Leishmania major cathepsin L-like protease 0.0018 0.0049 0.0157
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0672 0.5263
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0101 0.0341
Loa Loa (eye worm) RNA binding protein 0.0258 0.2961 1
Echinococcus granulosus zinc finger protein 0.0021 0.0087 0.0079
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0181
Brugia malayi hypothetical protein 0.0018 0.0041 0.014
Leishmania major cathepsin L-like protease 0.007 0.0672 0.5263
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0117 0.125 0.1362
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0185 0.1185
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0018 0.0041 0.0091
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.1149 0.1266
Trypanosoma cruzi phospholipid-transporting ATPase-like protein, putative 0.0018 0.0041 0.0091
Onchocerca volvulus 0.0026 0.0149 0.0871
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0049 0.0066
Echinococcus multilocularis muscleblind protein 0.0144 0.158 0.1567
Toxoplasma gondii hypothetical protein 0.0031 0.0203 0.1338
Brugia malayi E1-E2 ATPase family protein 0.0018 0.0041 0.014
Echinococcus multilocularis cation transporting atpase worm 0.0018 0.0041 0.0026
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.1149 0.917
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0158 0.0966
Loa Loa (eye worm) hypothetical protein 0.0042 0.0336 0.1134
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0303 0.0288
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0049 0.0157
Loa Loa (eye worm) hypothetical protein 0.012 0.1281 0.4327
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0149 0.0505
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0018 0.0041 0.0026
Schistosoma mansoni intermediate filament proteins 0.0026 0.0149 0.0149
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0126 0.0123
Schistosoma mansoni zinc finger protein 0.0017 0.003 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0672 0.5263
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0049 0.0064
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0123 0.0936
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0117 0.125 0.138
Onchocerca volvulus 0.0054 0.0483 0.3559
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0672 0.5263
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0049 0.0034
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0158 0.1054
Echinococcus multilocularis phosphoserine phosphatase 0.0018 0.0041 0.0026
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0907 0.3063
Mycobacterium ulcerans lipase LipD 0.0117 0.125 1
Brugia malayi E1-E2 ATPase family protein 0.0018 0.0041 0.014
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0018 0.0041 0.014
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0158 0.0132
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.009 0.0918 0.0903
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0158 0.1048
Brugia malayi beta-lactamase 0.0117 0.125 0.4223
Brugia malayi Probable ClpP-like protease 0.009 0.0918 0.31
Trypanosoma brucei P-type H+-ATPase, putative 0.0018 0.0041 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0049 0.0066
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0049 0.0034
Brugia malayi Cathepsin L-like precursor 0.0018 0.0049 0.0167
Brugia malayi hypothetical protein 0.0016 0.0019 0.0063
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.014
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0053 0.0038
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.1149 0.1266
Echinococcus multilocularis phosphoserine phosphatase 0.0018 0.0041 0.0026
Loa Loa (eye worm) hypothetical protein 0.0117 0.125 0.4223
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0018 0.0041 0.0026
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0252
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0158 0.0132
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.1149 0.3882
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0049 0.0037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0049 0.0066
Leishmania major cathepsin L-like protease 0.0018 0.0049 0.0157
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0158 0.1054
Loa Loa (eye worm) inositol-1 0.0078 0.0777 0.2626
Trichomonas vaginalis inositol monophosphatase, putative 0.0078 0.0777 0.6087
Trichomonas vaginalis D-aminoacylase, putative 0.0117 0.125 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0185 0.1635
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0534
Leishmania major cathepsin L-like protease 0.0018 0.0049 0.0157
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0018 0.0041 0.0091
Onchocerca volvulus 0.0018 0.0049 0.0064
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0777 0.6123
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.009 0.0918 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0234 0.0791
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0018 0.0041 0.0091
Mycobacterium tuberculosis Probable lipase LipD 0.0117 0.125 0.1362
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0185 0.1185
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0018 0.0041 0.0029
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0185 0.1185
Echinococcus granulosus beta LACTamase domain containing family member 0.0117 0.125 0.138
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.009 0.0918 1
Echinococcus multilocularis musashi 0.0026 0.0149 0.0134
Loa Loa (eye worm) calcium ATPase 0.0018 0.0041 0.014
Leishmania major cathepsin L-like protease 0.007 0.0672 0.5263
Echinococcus multilocularis phosphoserine phosphatase 0.0018 0.0041 0.0026
Brugia malayi Cathepsin L-like precursor 0.0018 0.0049 0.0167
Echinococcus granulosus muscleblind protein 0.0144 0.158 0.1748
Leishmania major hypothetical protein, conserved 0.0024 0.0123 0.0764
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0185 0.1635
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0049 0.0066
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0049 0.0091
Mycobacterium leprae Probable lipase LipE 0.0117 0.125 1
Schistosoma mansoni tar DNA-binding protein 0.0258 0.2961 0.3291
Mycobacterium leprae conserved hypothetical protein 0.0117 0.125 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0422 0.1427
Echinococcus granulosus lamin 0.0026 0.0149 0.0149
Onchocerca volvulus 0.0018 0.0049 0.0064
Brugia malayi phosphofructokinase 0.0109 0.1149 0.3882
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0672 0.5263
Leishmania major proton motive ATPase, putative 0.0018 0.0041 0.0091
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0185 0.1185
Loa Loa (eye worm) ctsf protein 0.0018 0.0049 0.0167
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0075 0.0037
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.007 0.0678 0.5264
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0078 0.0777 0.6087
Mycobacterium ulcerans beta-lactamase 0.0117 0.125 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0117 0.125 1
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0123 0.0678
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0049 0.0091
Schistosoma mansoni tar DNA-binding protein 0.0258 0.2961 0.3291
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0049 0.0066
Schistosoma mansoni eyes absent homolog 0.0183 0.2056 0.228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0672 0.5263
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0185 1
Leishmania major P-type H -ATPase, putative 0.0018 0.0041 0.0091
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0123 0.0936
Echinococcus granulosus phospholipid transporting ATPase VA 0.0018 0.0041 0.0029
Brugia malayi 6-phosphofructokinase 0.0109 0.1149 0.3882
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0049 0.0066
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0049 0.0167
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0534
Brugia malayi Inositol-1 0.0078 0.0777 0.2626
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0018 0.0041 0.014
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.0777 0.6087
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.1149 1
Echinococcus multilocularis tar DNA binding protein 0.0258 0.2961 0.295
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0483 0.0521
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0049 0.0037
Schistosoma mansoni lamin 0.0026 0.0149 0.0149
Echinococcus multilocularis zinc finger protein 0.0021 0.0087 0.0071
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0018 0.0041 0.0091
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0672 0.5263
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0618 0.0603
Schistosoma mansoni copper ABC transporter ATPase 0.0018 0.0041 0.0029
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0016 0.0053
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0117 0.125 0.1362
Echinococcus multilocularis cation transporting ATPase 13A1 0.0018 0.0041 0.0026
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0059 0.0542 0.0564
Loa Loa (eye worm) hypothetical protein 0.0117 0.125 0.4223
Trypanosoma brucei P-type H+-ATPase, putative 0.0018 0.0041 0.0091
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0777 0.6123
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.1149 0.1266
Brugia malayi 6-phosphofructokinase 0.0109 0.1149 0.3882
Onchocerca volvulus 0.0018 0.0049 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0049 0.0066
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0672 0.5263
Onchocerca volvulus 0.0026 0.0149 0.0871
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0203 0.1338
Loa Loa (eye worm) E1-E2 ATPase 0.0018 0.0041 0.014
Brugia malayi Na,K-ATPase alpha subunit 0.0018 0.0041 0.014
Echinococcus multilocularis inositol monophosphatase 1 0.0078 0.0777 0.0763
Echinococcus granulosus intermediate filament protein 0.0026 0.0149 0.0149
Mycobacterium tuberculosis Probable hydrolase 0.0117 0.125 0.1362
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0158 0.0966
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0049 0.0066
Mycobacterium tuberculosis Probable esterase LipL 0.0117 0.125 0.1362
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.1149 0.917
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0053 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0049 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0049 0.0066
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.1149 0.9163
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0018 0.0041 0.0091
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0049 0.0034
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0158 0.0966
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0748 0.8918 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0185 0.1635
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.1149 0.3882
Loa Loa (eye worm) hypothetical protein 0.0026 0.0144 0.0485
Onchocerca volvulus 0.0117 0.125 0.9753
Brugia malayi beta-lactamase family protein 0.0117 0.125 0.4223
Brugia malayi Cathepsin L-like precursor 0.0018 0.0049 0.0167
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0149 0.0505
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.1149 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0149 0.0505
Schistosoma mansoni cation-transporting atpase worm 0.0018 0.0041 0.0029
Onchocerca volvulus Huntingtin homolog 0.012 0.1281 1
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0049 0.0157
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0907 0.3063
Schistosoma mansoni ATPase 0.0018 0.0041 0.0029
Echinococcus multilocularis copper transporting ATPase 1 0.0018 0.0041 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.125 1
Onchocerca volvulus 0.0018 0.0049 0.0064
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0018 0.0041 0.0029
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0252
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0049 0.0091
Toxoplasma gondii ABC1 family protein 0.0117 0.125 1
Mycobacterium tuberculosis Probable lipase LipE 0.0117 0.125 0.1362
Mycobacterium tuberculosis Conserved protein 0.0117 0.125 0.1362
Brugia malayi hypothetical protein 0.0024 0.0123 0.0417
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0907 0.0893
Loa Loa (eye worm) hypothetical protein 0.0024 0.0123 0.0417
Loa Loa (eye worm) hypothetical protein 0.009 0.0918 0.31
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0907 0.0996
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0061 0.0022
Brugia malayi Muscleblind-like protein 0.0144 0.158 0.5338
Onchocerca volvulus 0.0018 0.0049 0.0064
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0158 0.0966
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0049 0.0066
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0185 0.1185
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.009 0.0918 0.7248
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0907 0.0996
Onchocerca volvulus Huntingtin homolog 0.012 0.1281 1
Mycobacterium tuberculosis Conserved protein 0.0117 0.125 0.1362
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0049 0.0034
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0123 0.0764
Trichomonas vaginalis penicillin-binding protein, putative 0.0117 0.125 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.014
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.1149 0.9163
Echinococcus granulosus cathepsin l1 0.0018 0.0049 0.0037
Leishmania major calcium-translocating P-type ATPase 0.0018 0.0041 0.0091
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0049 0.0072
Schistosoma mansoni microtubule-associated protein tau 0.0752 0.8965 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0618 0.0673
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0907 0.0996
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0018 0.0041 0.014
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0672 0.5263
Plasmodium vivax vivapain-2 0.0018 0.0049 0.0066
Echinococcus multilocularis peptidase Clp (S14 family) 0.0059 0.0542 0.0527
Plasmodium vivax hypothetical protein, conserved 0.0117 0.125 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0392 0.1325
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0059 0.0542 0.4142
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0018 0.0041 0.0091
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0059 0.0542 0.0564
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0672 0.5263
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0075 0.0275
Trypanosoma cruzi copper-transporting ATPase, putative 0.0018 0.0041 0.0091
Echinococcus multilocularis phosphoserine phosphatase 0.0018 0.0041 0.0026
Loa Loa (eye worm) hypothetical protein 0.0044 0.0367 0.124
Schistosoma mansoni tar DNA-binding protein 0.0258 0.2961 0.3291
Echinococcus multilocularis cysteine protease 0.0018 0.0049 0.0034
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0031 0.0203 0.1338
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0117 0.125 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0303 0.0321
Schistosoma mansoni inositol monophosphatase 0.0078 0.0777 0.0851
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0117 0.125 0.1362
Echinococcus granulosus tumor protein p63 0.0368 0.4302 0.4789
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0158 0.0966
Trypanosoma cruzi proton motive ATPase 1, putative 0.0018 0.0041 0.0091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0049 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0672 0.5263
Brugia malayi hypothetical protein 0.0183 0.2056 0.6944
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0158 0.0534
Brugia malayi RNA recognition motif domain containing protein 0.0258 0.2961 1
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0049 0.0037
Loa Loa (eye worm) hypothetical protein 0.0144 0.158 0.5338
Schistosoma mansoni hypothetical protein 0.0033 0.0234 0.0244
Onchocerca volvulus 0.0117 0.125 0.9753
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0672 0.5263
Echinococcus multilocularis lamin 0.0026 0.0149 0.0134
Schistosoma mansoni ATPase 0.0018 0.0041 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0672 0.5263
Loa Loa (eye worm) hypothetical protein 0.0077 0.0764 0.2581
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0049 0.0064
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.1149 0.9163
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.009 0.0918 0.7248
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.1149 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0049 0.0066
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0075 0.0379
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0049 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0049 0.0066
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0185 0.1294
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0158 0.0534
Onchocerca volvulus 0.0018 0.0049 0.0064
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0075 0.0379
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0049 0.0066
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0907 0.0996
Loa Loa (eye worm) hypothetical protein 0.012 0.1281 0.4327
Schistosoma mansoni peptidase Clp (S14 family) 0.009 0.0918 0.1008
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.009 0.0918 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0234 0.0791
Loa Loa (eye worm) hypothetical protein 0.0183 0.2056 0.6944
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0061 0.0022
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0018 0.0041 0.0091
Schistosoma mansoni phosphoserine phosphatase 0.0018 0.0041 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0049 0.0066
Leishmania major cathepsin L-like protease 0.0018 0.0049 0.0157
Brugia malayi Cathepsin L-like precursor 0.0018 0.0049 0.0167
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.009 0.0918 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0185 0.1635
Echinococcus granulosus lamin dm0 0.0026 0.0149 0.0149
Echinococcus multilocularis microtubule associated protein 2 0.0752 0.8965 0.8964
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0158 0.1048
Echinococcus multilocularis cation transporting ATPase 13A3 0.0018 0.0041 0.0026
Brugia malayi PHD-finger family protein 0.0027 0.0157 0.0532
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0018 0.0041 0.0026
Brugia malayi TAR-binding protein 0.0258 0.2961 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0252
Brugia malayi Bromodomain containing protein 0.0082 0.0821 0.2772
Entamoeba histolytica cysteine protease, putative 0.0018 0.0049 0.0072
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0422 0.1427
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.009 0.0918 0.7248
Echinococcus multilocularis phosphoserine phosphatase 0.0018 0.0041 0.0026
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0158 0.0966
Echinococcus granulosus cation transporting atpase worm 0.0018 0.0041 0.0029
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0053 0.0038
Schistosoma mansoni inositol monophosphatase 0.0078 0.0777 0.0851
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.009 0.0918 0.1008
Echinococcus granulosus peptidase Clp S14 family 0.0059 0.0542 0.0588
Brugia malayi hypothetical protein 0.012 0.1281 0.4327
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0016 0.0053
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0126 0.011
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0158 0.1048
Onchocerca volvulus 0.0018 0.0049 0.0064
Loa Loa (eye worm) hypothetical protein 0.0049 0.0422 0.1427
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0018 0.0041 0.0091
Brugia malayi intermediate filament protein 0.0026 0.0149 0.0505
Echinococcus multilocularis muscleblind protein 1 0.0144 0.158 0.1567
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0492 0.3781
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0049 0.0066
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0777 0.6123
Loa Loa (eye worm) hypothetical protein 0.0117 0.125 0.4223
Leishmania major copper-transporting ATPase-like protein, putative 0.0018 0.0041 0.0091
Mycobacterium tuberculosis Conserved protein 0.0117 0.125 0.1362
Toxoplasma gondii cathepsin CPL 0.0018 0.0049 0.0066
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0061 0.0022
Echinococcus granulosus cation transporting ATPase 13A1 0.0018 0.0041 0.0029
Loa Loa (eye worm) hypothetical protein 0.0026 0.0149 0.0505
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.009 0.0918 0.7248
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0053 0.0042
Schistosoma mansoni bromodomain containing protein 0.0069 0.0666 0.0726
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0018 0.0041 0.0029
Schistosoma mansoni type V p-type atpase isoform 0.0018 0.0041 0.0029

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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