Detailed information for compound 728559

Basic information

Technical information
  • TDR Targets ID: 728559
  • Name: CBKinase1_020448
  • MW: 467.751 | Formula: C17H17Cl3N2O5S
  • H donors: 1 H acceptors: 3 LogP: 3.8 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)c(cc1NC(=O)CN(S(=O)(=O)c1cc(Cl)ccc1Cl)C)Cl
  • InChi: 1S/C17H17Cl3N2O5S/c1-22(28(24,25)16-6-10(18)4-5-11(16)19)9-17(23)21-13-7-12(20)14(26-2)8-15(13)27-3/h4-8H,9H2,1-3H3,(H,21,23)
  • InChiKey: YQLUZZZINMIEIM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC01124759
  • STK226014
  • CBKinase1_008048

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Macrophage migration inhibitory factor 0.0387 1 1
Schistosoma mansoni tar DNA-binding protein 0.0269 0.6904 1
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0444 0.0202
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0171 0.4312 0.6241
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0675 0.0666
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0171 0.4312 0.4307
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0247 0.0347
Schistosoma mansoni cpg binding protein 0.003 0.0614 0.0889
Echinococcus granulosus Protein son of sevenless 0.0007 0.0009 0.0001
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0026 0.0499 0.049
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0026 0.0499 0.0711
Echinococcus multilocularis tar DNA binding protein 0.0269 0.6904 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1616 1
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0034 0.0705 0.0696
Schistosoma mansoni hypothetical protein 0.0032 0.0675 0.0977
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0499 0.1137
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0444 0.0643
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.1664 0.1657
Brugia malayi CXXC zinc finger family protein 0.0028 0.0571 0.0563
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0499 0.0258
Brugia malayi N-terminal motif family protein 0.0203 0.5155 0.515
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0444 0.0435
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0009 0.0013
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0571 0.0563
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1173 0.1699
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0171 0.4312 0.4307
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0026 0.0499 0.0722
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0499 0.0418
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0171 0.4312 0.6241
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0499 0.0418
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0675 0.0967
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0092 0.2252 0.2245
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0026 0.0499 0.0722
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0009 0.0013
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0499 0.049
Plasmodium falciparum macrophage migration inhibitory factor 0.0387 1 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0104 0.2559 0.2552
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0171 0.4312 0.4307
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0499 0.0258
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0444 0.0435
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.1616 0.2331
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0171 0.4312 0.4307
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0171 0.4312 0.4307
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0092 0.2252 0.2245
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0026 0.0499 0.0722
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0387 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0499 0.0418
Schistosoma mansoni hypothetical protein 0.007 0.1664 0.2411
Brugia malayi hypothetical protein 0.001 0.0084 0.0075
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0026 0.0499 0.1137
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0247 0.0238
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0171 0.4312 0.4307
Schistosoma mansoni dishevelled 0.001 0.0084 0.0122
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0008 0.0012
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.4312 0.4307
Entamoeba histolytica hypothetical protein 0.0037 0.0791 0.0782
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0026 0.0499 0.0722
Onchocerca volvulus 0.0034 0.0705 0.1352
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.2517 0.251
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0026 0.0499 0.049
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0171 0.4312 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0054 0.0066
Giardia lamblia Hypothetical protein 0.0026 0.0499 0.0057
Schistosoma mansoni cpg binding protein 0.003 0.0614 0.0889
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0247 0.0347
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0026 0.0499 0.0722
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.1616 1
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0084 0.0111
Leishmania major hypothetical protein, conserved 0.0026 0.0499 0.0258
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.4312 0.4307
Onchocerca volvulus 0.0034 0.0705 0.1352
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0171 0.4312 0.4307
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0026 0.0499 0.049
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0026 0.0499 0.0711
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0499 0.0418
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0675 0.0967
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0067 0.1575 0.9705
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0092 0.2252 0.2245
Echinococcus multilocularis son of sevenless 1 0.0007 0.0009 0.0001
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0026 0.0499 0.0711
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0104 0.2559 0.5925
Echinococcus multilocularis cpg binding protein 0.003 0.0614 0.0878
Brugia malayi RNA binding protein 0.0269 0.6904 0.6901
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0187 0.4748 0.4743
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0499 0.0618
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0675 0.0666
Echinococcus granulosus tar DNA binding protein 0.0269 0.6904 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0026 0.0499 0.0711
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0034 0.0705 0.0696
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0499 0.0618
Leishmania major macrophage migration inhibitory factor-like protein 0.0387 1 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0104 0.2559 0.2552
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0499 0.0418
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.4312 0.4307
Loa Loa (eye worm) TAR-binding protein 0.0269 0.6904 0.6901
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0084 0.0075
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0084 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0499 0.049
Brugia malayi isocitrate dehydrogenase 0.0016 0.0247 0.0238
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.1616 0.2331
Toxoplasma gondii GAF domain-containing protein 0.0067 0.1575 0.1503
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1616 1
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0084 0.0111
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0444 0.0435
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0675 0.0666
Echinococcus granulosus cpg binding protein 0.003 0.0614 0.0878
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0092 0.2252 0.2245
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0007 0.0009 0.0001
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0444 0.0202
Entamoeba histolytica hypothetical protein 0.0037 0.0791 0.0782
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.4312 0.4307
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0171 0.4312 0.6246
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0026 0.0499 0.1137
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0026 0.0499 0.049
Plasmodium falciparum GAF domain-related protein, putative 0.0067 0.1575 0.1362
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.4312 0.4307
Schistosoma mansoni dep domain containing protein 0.001 0.0084 0.0122
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1173 0.1689
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0791 0.1135
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0444 0.0643
Entamoeba histolytica hypothetical protein 0.0037 0.0791 0.0782
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0092 0.2252 0.3254
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0092 0.2252 0.3262
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0444 0.0202
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.4312 0.4307
Giardia lamblia hypothetical protein 0.0026 0.0499 0.0057
Schistosoma mansoni cpg binding protein 0.0028 0.0571 0.0827
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0247 0.0238
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0026 0.0499 0.049
Loa Loa (eye worm) hypothetical protein 0.0026 0.0499 0.049
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0026 0.0499 0.0258
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0499 0.049
Brugia malayi hypothetical protein 0.015 0.3764 0.3758
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0387 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0791 0.1135
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0026 0.0499 0.0057
Echinococcus granulosus ras GTP exchange factor 0.0007 0.0009 0.0001
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.1616 0.1403
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0026 0.0499 0.0711
Loa Loa (eye worm) PDE1B protein 0.0026 0.0499 0.049
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0187 0.4748 0.4743
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0026 0.0499 0.0711
Brugia malayi DIX domain containing protein 0.001 0.0084 0.0075
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0444 0.0484
Leishmania major hypothetical protein, conserved 0.0026 0.0499 0.0258
Loa Loa (eye worm) hypothetical protein 0.0026 0.0499 0.049
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.4312 0.4307
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1173 0.1699
Schistosoma mansoni dishevelled 0.001 0.0084 0.0122
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0499 0.0258
Loa Loa (eye worm) hypothetical protein 0.0067 0.1575 0.1568
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0026 0.0499 0.0711
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0171 0.4312 0.4307
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0084 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0145 0.3635 0.363
Loa Loa (eye worm) hypothetical protein 0.0034 0.0705 0.0696
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0084 0.0111
Schistosoma mansoni tar DNA-binding protein 0.0269 0.6904 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0026 0.0499 0.0711
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.1575 0.1568
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1173 0.1689
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0171 0.4312 0.4307
Schistosoma mansoni hypothetical protein 0.0037 0.0791 0.1145
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0009 0.0013
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0247 0.0347
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0499 0.0418
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0026 0.0499 0.1137
Loa Loa (eye worm) hypothetical protein 0.0034 0.0705 0.0696
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0026 0.0499 0.0722
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0084 0.0111
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0026 0.0499 0.049
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0067 0.1575 0.9705
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0075
Loa Loa (eye worm) hypothetical protein 0.0034 0.0705 0.0696
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0247 0.0347
Brugia malayi RNA recognition motif domain containing protein 0.0269 0.6904 0.6901
Schistosoma mansoni regulator of G protein signaling 0.001 0.0084 0.0122
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0499 0.0258
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0026 0.0499 0.0711
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0387 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0499 0.0418
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1173 0.1689
Echinococcus multilocularis Protein son of sevenless 0.0007 0.0009 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0499 0.1137
Loa Loa (eye worm) hypothetical protein 0.007 0.1664 0.1657
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0499 0.0418
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0026 0.0499 0.049
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0171 0.4312 1
Trichomonas vaginalis conserved hypothetical protein 0.0387 1 1
Loa Loa (eye worm) hypothetical protein 0.015 0.3764 0.3758
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.4312 0.4307
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0499 0.0418
Brugia malayi secreted modular calcium-binding protein 1 0.0034 0.0705 0.0696
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0499 0.049
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0084 0.0111
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.2517 0.251
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0499 0.1137
Loa Loa (eye worm) RNA binding protein 0.0269 0.6904 0.6901
Leishmania major cAMP-specific phosphodiesterase, putative 0.0026 0.0499 0.0258
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0203 0.5155 1
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0007 0.0009 0.0001
Plasmodium vivax phosphodiesterase gamma, putative 0.0026 0.0499 0.0258
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0084 0.0111
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0499 0.0618
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0009 0.0013
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0675 0.0967
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0026 0.0499 0.0722
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0444 0.0643
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0034 0.0705 0.0696
Schistosoma mansoni tar DNA-binding protein 0.0269 0.6904 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0499 0.0418
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0247 0.0554
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.1173 0.1165
Schistosoma mansoni tar DNA-binding protein 0.0269 0.6904 1
Toxoplasma gondii hypothetical protein 0.0067 0.1575 0.1503
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0085 0.0124
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0084 0.0111
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.4312 0.4307
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0051 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0145 0.3635 0.363
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0026 0.0499 0.0722
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0026 0.0499 0.0258
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.2517 0.251
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.1616 0.1544
Onchocerca volvulus 0.015 0.3764 0.7297
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0171 0.4312 0.4307
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0026 0.0499 0.0618
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.4312 0.4307
Leishmania major macrophage migration inhibitory factor-like protein 0.0387 1 1
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0444 0.0632
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0444 0.0363
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0499 0.0418
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0084 0.0075
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0387 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1616 0.234
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0007 0.0009 0.0001
Schistosoma mansoni hypothetical protein 0.0032 0.0675 0.0977
Loa Loa (eye worm) hypothetical protein 0.0032 0.0675 0.0666
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0247 0.0347
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0026 0.0499 0.049
Onchocerca volvulus 0.0034 0.0705 0.1352
Loa Loa (eye worm) hypothetical protein 0.0026 0.0499 0.049
Brugia malayi hypothetical protein 0.001 0.0084 0.0075
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0247 0.0164
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0034 0.0705 0.0696
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1616 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0499 0.0418
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0054 0.0066
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1173 0.1689
Mycobacterium leprae conserved hypothetical protein 0.0067 0.1575 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0499 0.0418
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0247 0.0358
Loa Loa (eye worm) hypothetical protein 0.0092 0.2252 0.2245
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1241 0.1167
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0026 0.0499 0.0722
Brugia malayi hypothetical protein 0.0037 0.0791 0.0782
Loa Loa (eye worm) hypothetical protein 0.0102 0.2517 0.251
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0247 0.0164
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0171 0.4312 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0026 0.0499 0.0711
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0171 0.4312 0.4307
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0054 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0499 0.1137
Plasmodium vivax hypothetical protein, conserved 0.0067 0.1575 0.1362
Loa Loa (eye worm) hypothetical protein 0.0203 0.5155 0.515
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0026 0.0499 0.0258
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0026 0.0499 0.0711
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0092 0.2252 0.2245
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0171 0.4312 0.4307
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0499 0.0418
Schistosoma mansoni hypothetical protein 0.0032 0.0675 0.0977
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0084 0.0111
Onchocerca volvulus 0.0028 0.0571 0.1092
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0444 0.0435
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0444 0.1011
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0007 0.0009 0.0001
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0026 0.0499 0.0711
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.4312 0.4307
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0499 0.049
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0499 0.049
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0084 0.0146
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0499 0.0418
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.4312 0.4307
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0499 0.0418
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0269 0.6904 0.6901
Echinococcus multilocularis GPCR, family 2 0.0032 0.0675 0.0967
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0387 1 1
Schistosoma mansoni tar DNA-binding protein 0.0269 0.6904 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0499 0.0418
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0791 0.1145
Onchocerca volvulus 0.0034 0.0705 0.1352
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0444 0.0435
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0171 0.4312 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0247 0.0347
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0499 0.049
Trichomonas vaginalis chaperonin, putative 0.0024 0.0444 0.0435
Brugia malayi TAR-binding protein 0.0269 0.6904 0.6901
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0171 0.4312 0.4307
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0499 0.1137
Onchocerca volvulus 0.001 0.0084 0.0146
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0675 0.0967
Trichomonas vaginalis conserved hypothetical protein 0.0145 0.3635 0.363
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.4312 0.4307
Toxoplasma gondii hypothetical protein 0.0067 0.1575 0.1503
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0499 0.1137
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1616 0.234
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0247 0.0554
Echinococcus granulosus son of sevenless 1 0.0007 0.0009 0.0001
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0092 0.2252 0.3254
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0084 0.0075
Toxoplasma gondii hypothetical protein 0.0145 0.3635 0.3581
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0084 0.0111
Echinococcus multilocularis ras GTP exchange factor 0.0007 0.0009 0.0001
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0026 0.0499 0.049
Schistosoma mansoni hypothetical protein 0.0032 0.0675 0.0977
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.1173 0.1165
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0075
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0026 0.0499 0.0258
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0499 0.0418
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0171 0.4312 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0705 0.0696
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0026 0.0499 0.1137
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0034 0.0705 0.0696
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0075
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0026 0.0499 0.0618
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0026 0.0499 0.049
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0171 0.4312 0.4307
Echinococcus granulosus GPCR family 2 0.0032 0.0675 0.0967
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0444 0.0632
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0084 0.0122
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0009 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1411 0.2044
Plasmodium falciparum phosphodiesterase delta, putative 0.0026 0.0499 0.0258
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.4312 0.4307
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1173 0.1699
Plasmodium falciparum phosphodiesterase gamma, putative 0.0026 0.0499 0.0258
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.4312 0.4307
Entamoeba histolytica hypothetical protein 0.0037 0.0791 0.0782
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0084 0.0075

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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