Detailed information for compound 728648

Basic information

Technical information
  • TDR Targets ID: 728648
  • Name: N-(3-cyano-5,6-dihydro-4H-cyclopenta[d]thioph en-2-yl)-2-(4-oxoquinazolin-3-yl)acetamide
  • MW: 350.394 | Formula: C18H14N4O2S
  • H donors: 1 H acceptors: 3 LogP: 2.76 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(NC(=O)Cn2cnc3c(c2=O)cccc3)sc2c1CCC2
  • InChi: 1S/C18H14N4O2S/c19-8-13-11-5-3-7-15(11)25-17(13)21-16(23)9-22-10-20-14-6-2-1-4-12(14)18(22)24/h1-2,4,6,10H,3,5,7,9H2,(H,21,23)
  • InChiKey: NEMXUWHUSVPTHD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-cyano-5,6-dihydro-4H-cyclopenta[d]thiophen-2-yl)-2-(4-oxo-3-quinazolinyl)acetamide
  • N-(3-cyano-5,6-dihydro-4H-cyclopenta[d]thiophen-2-yl)-2-(4-ketoquinazolin-3-yl)acetamide
  • N-(3-cyano-5,6-dihydro-4H-cyclopenta[d]thiophen-2-yl)-2-(4-oxoquinazolin-3-yl)ethanamide
  • CBKinase1_009366
  • STK241395
  • CBKinase1_021766
  • ZINC02867170

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tar DNA binding protein 0.0062 0.1357 0.1357
Brugia malayi hypothetical protein 0.0011 0.0071 0.0106
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0732 0.6854
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0201 0.4812 0.4812
Echinococcus granulosus acetylcholinesterase 0.0201 0.4812 0.4812
Brugia malayi nuclear receptor RXR 0.001 0.0042 0.0052
Brugia malayi nuclear receptor NHR-88 0.0021 0.0319 0.055
Echinococcus granulosus polycystin 2 0.0011 0.0068 0.0068
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.1008 0.1784
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0721 0.1261
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0071 0.0071
Brugia malayi RNA binding protein 0.0062 0.1357 0.241
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0319 0.0319
Schistosoma mansoni nuclear hormone receptor 0.001 0.0042 0.0042
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0633 0.8779
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.1008 0.1008
Brugia malayi Latrophilin receptor protein 2 0.0049 0.1008 0.1784
Brugia malayi Carboxylesterase family protein 0.0034 0.0642 0.1128
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.572 1
Onchocerca volvulus 0.0037 0.0721 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0047
Mycobacterium tuberculosis Conserved protein 0.0037 0.0721 0.1261
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.3631 0.6487
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0319 0.055
Loa Loa (eye worm) hypothetical protein 0.0034 0.0642 0.1123
Brugia malayi hypothetical protein 0.0011 0.0071 0.0106
Schistosoma mansoni hypothetical protein 0.0408 1 1
Brugia malayi beta-lactamase family protein 0.0037 0.0721 0.1271
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.1008 0.178
Echinococcus multilocularis GPCR, family 2 0.0049 0.1008 0.1008
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0617 0.1083
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0617 0.5669
Mycobacterium ulcerans beta-lactamase 0.0037 0.0721 0.5583
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0617 0.1079
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0721 0.6748
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0617 0.1079
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0617 0.4483
Schistosoma mansoni gliotactin 0.0034 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0047
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0721 0.5583
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.3271 0.3271
Echinococcus granulosus acetylcholinesterase 0.0201 0.4812 0.4812
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0042 0.0042
Schistosoma mansoni neuroligin 3 (S09 family) 0.0034 0.0642 0.0642
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0721 0.1261
Loa Loa (eye worm) hypothetical protein 0.0034 0.0642 0.1123
Loa Loa (eye worm) hypothetical protein 0.0037 0.0721 0.1266
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0732 1
Chlamydia trachomatis pyruvate kinase 0.0033 0.0617 0.5
Trichomonas vaginalis spcc417.12 protein, putative 0.0034 0.0642 0.877
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1292 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.0071 0.01
Echinococcus granulosus carboxylesterase 5A 0.0201 0.4812 0.4812
Brugia malayi nuclear hormone receptor 0.0021 0.0319 0.055
Brugia malayi Carboxylesterase family protein 0.0201 0.4812 0.8604
Schistosoma mansoni nuclear hormone receptor 0.001 0.0042 0.0042
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0033 0.0617 0.1079
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0617 0.1083
Echinococcus multilocularis pyruvate kinase 0.0017 0.0216 0.0216
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0042 0.0047
Brugia malayi hypothetical protein 0.0032 0.0596 0.1045
Brugia malayi ecdysone receptor 0.001 0.0042 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0047
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1357 0.1357
Loa Loa (eye worm) hypothetical protein 0.0037 0.0721 0.1266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0319 0.0545
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0319 0.055
Brugia malayi beta-lactamase family protein 0.0037 0.0721 0.1271
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0042 0.0042
Brugia malayi nuclear hormone receptor 0.001 0.0042 0.0052
Onchocerca volvulus 0.0037 0.0721 1
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0721 0.1261
Echinococcus multilocularis cpg binding protein 0.003 0.0551 0.0551
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0047
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0721 0.1266
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0319 0.0545
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0319 0.055
Onchocerca volvulus 0.0034 0.0642 0.8827
Brugia malayi Carboxylesterase family protein 0.0034 0.0642 0.1128
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0042 0.0042
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0319 0.055
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0368 0.0632
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.1008 0.1008
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0732 0.0732
Schistosoma mansoni zinc finger protein 0.001 0.0042 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.3271 0.3271
Mycobacterium tuberculosis Conserved protein 0.0037 0.0721 0.1261
Loa Loa (eye worm) hypothetical protein 0.0034 0.0642 0.1123
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0034 0.0642 0.1122
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.559 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0034 0.0642 0.4966
Brugia malayi hypothetical protein 0.011 0.2553 0.4554
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0319 0.0319
Echinococcus multilocularis pyruvate kinase 0.0017 0.0216 0.0216
Plasmodium falciparum pyruvate kinase 0.0033 0.0617 0.4887
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0319 0.0319
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0617 0.1078
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.1036 1
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0319 0.4087
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0732 0.542
Schistosoma mansoni pyruvate kinase 0.0017 0.0216 0.0216
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0721 0.9861
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0042 0.0047
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0721 0.9861
Schistosoma mansoni hypothetical protein 0.0049 0.1008 0.1008
Giardia lamblia Pyruvate kinase 0.0033 0.0617 1
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0617 0.4887
Echinococcus multilocularis BC026374 protein (S09 family) 0.0034 0.0642 0.0642
Loa Loa (eye worm) carboxylesterase 0.0034 0.0642 0.1123
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.051 0.0888
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.2553 0.2553
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0617 0.5669
Schistosoma mansoni pyruvate kinase 0.0033 0.0617 0.0617
Echinococcus multilocularis polycystic kidney disease protein 2 0.0011 0.0068 0.0068
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0042 0.0042
Echinococcus granulosus GPCR family 2 0.0049 0.1008 0.1008
Loa Loa (eye worm) RNA binding protein 0.0062 0.1357 0.2406
Entamoeba histolytica hypothetical protein 0.011 0.2553 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0721 0.6748
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0721 0.1261
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.1292 0.1292
Echinococcus granulosus neuroligin 0.0034 0.0642 0.0642
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.3271 0.3271
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0351 0.0351
Schistosoma mansoni coup transcription factor 0.0021 0.0319 0.0319
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.3271 0.3271
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0732 0.5662
Leishmania major hypothetical protein, conserved 0.005 0.1036 0.7908
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.3631 0.6487
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0732 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0732 0.0732
Onchocerca volvulus 0.0034 0.0642 0.8827
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0319 0.055
Toxoplasma gondii ABC1 family protein 0.0037 0.0721 0.5337
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0042 0.0042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0042 0.0042
Brugia malayi hypothetical protein 0.0034 0.0642 0.1128
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0732 0.542
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0216 0.1209
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0042 0.0052
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0319 0.0319
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.1292 0.2259
Schistosoma mansoni hypothetical protein 0.0011 0.0068 0.0068
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0732 0.1665
Schistosoma mansoni mucolipin 0.0131 0.3077 0.3077
Loa Loa (eye worm) acetylcholinesterase 1 0.0201 0.4812 0.8603
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0034 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0037 0.0721 0.1266
Brugia malayi Carboxylesterase family protein 0.0034 0.0642 0.1128
Brugia malayi steroid hormone receptor 0.0021 0.0319 0.055
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0732 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1292 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0047
Schistosoma mansoni hypothetical protein 0.0105 0.2417 0.2417
Loa Loa (eye worm) carboxylesterase 0.0034 0.0642 0.1123
Echinococcus granulosus pyruvate kinase 0.0033 0.0617 0.0617
Echinococcus multilocularis neuroligin 0.0034 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0037 0.0721 0.1266
Brugia malayi follicle stimulating hormone receptor 0.0232 0.559 1
Schistosoma mansoni nuclear receptor 0.001 0.0042 0.0042
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1151 0.8851
Loa Loa (eye worm) hypothetical protein 0.0037 0.0721 0.1266
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0319 0.055
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0732 0.0732
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0319 0.0545
Schistosoma mansoni mucolipin 0.012 0.2802 0.2802
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0047
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0319 0.055
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0042 0.0042
Mycobacterium ulcerans hypothetical protein 0.0037 0.0721 0.5583
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0042 0.0042
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0034 0.0642 0.0642
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0047
Schistosoma mansoni hypothetical protein 0.0011 0.0068 0.0068
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0319 0.0319
Onchocerca volvulus 0.0029 0.051 0.6896
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0319 0.0319
Brugia malayi Nuclear hormone receptor E75 0.001 0.0042 0.0052
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0042 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0047
Onchocerca volvulus 0.0037 0.0721 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0721 0.0721
Loa Loa (eye worm) hypothetical protein 0.0105 0.2417 0.4307
Entamoeba histolytica hypothetical protein 0.011 0.2553 1
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0721 0.1261
Loa Loa (eye worm) hypothetical protein 0.005 0.1036 0.1831
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0319 0.0545
Brugia malayi TAR-binding protein 0.0062 0.1357 0.241
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0319 0.055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.3271 0.3271
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0721 0.0721
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.1008 0.1008
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0047
Schistosoma mansoni BC026374 protein (S09 family) 0.0034 0.0642 0.0642
Leishmania major pyruvate kinase 0.0033 0.0617 0.4483
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0319 0.0319
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0319 0.0319
Entamoeba histolytica hypothetical protein 0.011 0.2553 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0153 0.3631 0.6485
Echinococcus multilocularis Polycystic kidney disease protein 0.0011 0.0068 0.0068
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0721 0.5583
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0319 0.0319
Brugia malayi CXXC zinc finger family protein 0.0029 0.051 0.0892
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0721 0.6748
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0034 0.0642 0.0642
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0319 0.0319
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0034 0.0642 0.1122
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0319 0.0319
Echinococcus multilocularis dnaJ subfamily B 0.0408 1 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0721 0.1261
Echinococcus multilocularis pyruvate kinase 0.0033 0.0617 0.0617
Loa Loa (eye worm) hypothetical protein 0.0021 0.0319 0.0545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0319 0.0545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0319 0.0545
Loa Loa (eye worm) hypothetical protein 0.0011 0.0071 0.01
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1357 0.1357
Echinococcus multilocularis pyruvate kinase 0.0017 0.0216 0.0216
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0721 0.0721
Loa Loa (eye worm) hypothetical protein 0.0021 0.0319 0.0545
Leishmania major pyruvate kinase 0.0033 0.0617 0.4483
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.1008 0.1008
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0721 0.6161
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0319 0.055
Echinococcus multilocularis pyruvate kinase 0.0026 0.0443 0.0443
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1357 0.1357
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0015 0.0015
Brugia malayi Carboxylesterase family protein 0.0034 0.0642 0.1128
Echinococcus granulosus pyruvate kinase 0.0033 0.0617 0.0617
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0721 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0642 0.1123
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0319 0.0319
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0732 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.3631 0.6485
Loa Loa (eye worm) hypothetical protein 0.0021 0.0319 0.0545
Loa Loa (eye worm) hypothetical protein 0.0034 0.0642 0.1123
Schistosoma mansoni pyruvate kinase 0.0033 0.0617 0.0617
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1357 0.1357
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0617 0.8463
Echinococcus granulosus Polycystic kidney disease protein 0.0011 0.0068 0.0068
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0319 0.0319
Brugia malayi hypothetical protein 0.001 0.0042 0.0052
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0071 0.0106
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.3271 0.5841
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0034 0.0642 0.0642
Brugia malayi beta-lactamase 0.0037 0.0721 0.1271
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0319 0.4087
Schistosoma mansoni hypothetical protein 0.011 0.2553 0.2553
Mycobacterium leprae Probable lipase LipE 0.0037 0.0721 1
Onchocerca volvulus 0.0034 0.0642 0.8827
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.1292 0.1292
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.2417 0.431
Echinococcus granulosus mucolipin 3 0.0131 0.3077 0.3077
Brugia malayi Nuclear hormone receptor E75 0.001 0.0042 0.0052
Loa Loa (eye worm) hypothetical protein 0.0049 0.1008 0.178
Brugia malayi nuclear receptor NHR-67 0.001 0.0042 0.0052
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.1292 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0319 0.0545
Schistosoma mansoni hypothetical protein 0.0022 0.0351 0.0351
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0319 0.055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0319 0.0319
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0319 0.0319
Schistosoma mansoni acetylcholinesterase 0.0034 0.0642 0.0642
Brugia malayi hypothetical protein 0.005 0.1036 0.1835
Loa Loa (eye worm) carboxylesterase 0.0201 0.4812 0.8603
Loa Loa (eye worm) hypothetical protein 0.0034 0.0642 0.1123
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0042 0.0047
Brugia malayi nuclear receptor RXR 0.0011 0.0071 0.0106
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0732 0.6854
Treponema pallidum bacterioferrin (TpF1) 0.0008 0 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.1036 1
Onchocerca volvulus 0.0021 0.0319 0.4087
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.1036 1
Schistosoma mansoni polycystin 1-related 0.0011 0.0068 0.0068
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0319 0.0319
Echinococcus multilocularis mucolipin 3 0.0131 0.3077 0.3077
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1357 0.1357
Trichomonas vaginalis esterase, putative 0.0037 0.0721 0.9861
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0047
Onchocerca volvulus 0.0034 0.0642 0.8827
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.1036 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0319 0.0545
Loa Loa (eye worm) hypothetical protein 0.0021 0.0319 0.0545
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0617 0.8552
Schistosoma mansoni nuclear receptor 0.001 0.0042 0.0042
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0042 0.0052
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0042 0.0042
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0034 0.0642 0.0642
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0319 0.0545
Echinococcus multilocularis pyruvate kinase 0.0033 0.0617 0.0617
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0043 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0319 0.055
Schistosoma mansoni cpg binding protein 0.003 0.0551 0.0551
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0071 0.0071
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0319 0.0319
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0721 0.1261
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0617 0.8463
Brugia malayi hypothetical protein 0.001 0.0042 0.0052
Schistosoma mansoni inositol monophosphatase 0.0037 0.0732 0.0732
Loa Loa (eye worm) hypothetical protein 0.0011 0.0071 0.01
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0071 0.01
Brugia malayi Carboxylesterase family protein 0.0201 0.4812 0.8604
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1357 0.1357
Schistosoma mansoni hypothetical protein 0.0049 0.1008 0.1008
Loa Loa (eye worm) inositol-1 0.0037 0.0732 0.1284
Schistosoma mansoni transcription factor LCR-F1 0.011 0.2553 0.2553
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0319 0.0545
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0617 0.4774
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0721 0.0721
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0319 0.0319
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.2553 0.2553
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0071 0.0106
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0617 0.8432
Brugia malayi Inositol-1 0.0037 0.0732 0.1289
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0319 0.055
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0319 0.055
Loa Loa (eye worm) hypothetical protein 0.0201 0.4812 0.8603
Loa Loa (eye worm) beta-lactamase 0.0037 0.0721 0.1266
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0071 0.0071
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.0021 0.0319 0.0545
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0319 0.055
Schistosoma mansoni cpg binding protein 0.0029 0.051 0.051
Schistosoma mansoni hypothetical protein 0.0049 0.1008 0.1008
Loa Loa (eye worm) hypothetical protein 0.0201 0.4812 0.8603
Schistosoma mansoni cpg binding protein 0.003 0.0551 0.0551
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.3271 0.5839
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0319 0.4087
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0617 0.1079
Brugia malayi conserved hypotetical protein 0.001 0.0042 0.0052
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.1292 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0721 0.9861
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0319 0.0319
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.1036 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0216 0.0216
Brugia malayi tailless protein 0.001 0.0042 0.0052
Mycobacterium tuberculosis Carboxylesterase LipT 0.0034 0.0642 0.1122
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1357 0.241
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0633 0.1107
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0319 0.055
Loa Loa (eye worm) hypothetical protein 0.0011 0.0071 0.01
Loa Loa (eye worm) hypothetical protein 0.0023 0.0368 0.0632
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0319 0.0319
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0617 0.5669
Echinococcus multilocularis carboxylesterase 5A 0.0201 0.4812 0.4812
Brugia malayi Coelomocyte uptake defective protein 5 0.0131 0.3077 0.5493
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0015 0.0015
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1357 0.2406
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0617 0.5669
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0721 0.9861
Echinococcus granulosus BC026374 protein S09 family 0.0034 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0047
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0319 0.0319
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0042 0.0042
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0319 0.0319
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0042 0.0052
Loa Loa (eye worm) hypothetical protein 0.0021 0.0319 0.0545
Entamoeba histolytica hypothetical protein 0.011 0.2553 1
Echinococcus granulosus cpg binding protein 0.003 0.0551 0.0551
Echinococcus granulosus para nitrobenzyl esterase 0.0034 0.0642 0.0642
Echinococcus multilocularis acetylcholinesterase 0.0201 0.4812 0.4812
Echinococcus granulosus pyruvate kinase 0.0017 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0047
Loa Loa (eye worm) hypothetical protein 0.0037 0.0721 0.1266
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.1036 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1292 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0642 0.1123
Loa Loa (eye worm) mucolipin 1 0.0131 0.3077 0.5491
Loa Loa (eye worm) hypothetical protein 0.0011 0.0071 0.01
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.3271 0.3271
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0319 0.0319
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1292 0.1292
Echinococcus granulosus polycystic kidney disease protein 2 0.0011 0.0068 0.0068
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0034 0.0642 0.877
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0319 0.0319
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0617 0.8432
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0319 0.0319
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0721 0.9861
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0047
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0319 0.0319
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1357 0.2406
Mycobacterium ulcerans lipase LipD 0.0037 0.0721 0.5583
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0042 0.0042
Echinococcus multilocularis acetylcholinesterase 0.0201 0.4812 0.4812
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0319 0.055
Schistosoma mansoni hypothetical protein 0.0049 0.1008 0.1008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.3271 0.3271
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0319 0.0319
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1292 0.1292
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0721 0.1271
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.1036 0.7908
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0617 0.8463
Brugia malayi nuclear receptor NHR-88 0.001 0.0042 0.0052
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0042 0.0042
Leishmania major hypothetical protein, conserved 0.0037 0.0721 0.5337
Echinococcus multilocularis para nitrobenzyl esterase 0.0034 0.0642 0.0642
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0732 0.6854
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1314 0.1314
Loa Loa (eye worm) DR-78 0.001 0.0042 0.0047
Brugia malayi ecdysteroid receptor 0.0021 0.0319 0.055
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0721 0.1261
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0042 0.0042
Onchocerca volvulus 0.0034 0.0642 0.8827
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0319 0.0319

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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