Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | mercuric reductase, putative | 0.0018 | 0 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0052 | 0.186 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.1767 | 0.1767 |
Mycobacterium tuberculosis | Probable reductase | 0.0119 | 0.5507 | 0.8837 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0202 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0018 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0133 | 0.6231 | 1 |
Brugia malayi | glutathione reductase | 0.0052 | 0.186 | 0.186 |
Plasmodium falciparum | thioredoxin reductase | 0.0052 | 0.186 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0052 | 0.186 | 0.186 |
Schistosoma mansoni | tar DNA-binding protein | 0.0202 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1767 | 0.1767 |
Loa Loa (eye worm) | glutathione reductase | 0.0052 | 0.186 | 0.0113 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0133 | 0.6231 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0018 | 0 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0052 | 0.186 | 0.186 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0119 | 0.5507 | 0.8837 |
Treponema pallidum | NADH oxidase | 0.0018 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0202 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1767 | 0.1767 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0052 | 0.186 | 0.2985 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0202 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0052 | 0.186 | 0.0113 |
Trypanosoma brucei | trypanothione reductase | 0.0052 | 0.186 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0052 | 0.186 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0133 | 0.6231 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0119 | 0.5507 | 0.8837 |
Schistosoma mansoni | tar DNA-binding protein | 0.0202 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0202 | 1 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0119 | 0.5507 | 0.8837 |
Brugia malayi | TAR-binding protein | 0.0202 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0202 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0052 | 0.186 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0202 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0052 | 0.186 | 0.186 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0018 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0052 | 0.186 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0052 | 0.186 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0133 | 0.6231 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0202 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1767 | 0.1767 |
Toxoplasma gondii | thioredoxin reductase | 0.0052 | 0.186 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0202 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1767 | 0.1767 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0119 | 0.5507 | 0.8837 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1767 | 0.1767 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0119 | 0.5507 | 0.8837 |
Echinococcus granulosus | tar DNA binding protein | 0.0202 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1767 | 0.1767 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1767 | 0.1767 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0018 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.