Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.2444 | 0.4171 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0012 | 0.0427 | 0.0729 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0072 | 1 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0046 | 0.5858 | 0.5436 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.1314 | 0.5 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0046 | 0.5858 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.3956 | 0.6753 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.1565 | 0.0706 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.2287 | 0.2762 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0925 | 0.1579 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.2871 | 0.4901 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0046 | 0.5858 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.2287 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.2437 | 0.4161 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.1565 | 0.2672 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.2287 | 0.0856 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.2287 | 0.2762 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.1565 | 0.3956 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.1565 | 0.1298 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.2287 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1314 | 0.2243 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0925 | 0.1579 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.1565 | 0.2583 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.1565 | 0.0706 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.4339 | 0.7408 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0046 | 0.5858 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.3956 | 0.6753 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.2871 | 0.4901 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.3956 | 0.6753 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.2287 | 0.1501 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0022 | 0.1946 | 0.207 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.2287 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0925 | 0.1579 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0046 | 0.5858 | 1 |
Onchocerca volvulus | 0.0024 | 0.2287 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.2287 | 0.3905 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0046 | 0.5858 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0046 | 0.5858 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0925 | 0.1579 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1314 | 0.2243 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.1565 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.1565 | 0.1298 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0925 | 0.1579 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.1565 | 0.0706 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.1565 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.2287 | 0.3905 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.1314 | 0.139 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.4339 | 0.7408 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0046 | 0.5858 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1314 | 0.2243 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.2287 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0072 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.1565 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1314 | 0.2243 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.2444 | 0.4171 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.2287 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.2871 | 0.4901 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.3956 | 0.6753 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.2437 | 0.4161 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.2444 | 0.4171 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1314 | 0.2243 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.3956 | 0.6753 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.2287 | 0.3905 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.1565 | 0.2672 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.1565 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0031 | 0.3414 | 0.5829 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.3254 | 0.5555 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.2287 | 1 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0037 | 0.4346 | 0.6934 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0019 | 0.1519 | 0.1204 |
Giardia lamblia | GTOR | 0.0046 | 0.5858 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.1565 | 0.2672 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.4339 | 0.7408 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.1565 | 0.3614 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 1 | 1 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0046 | 0.5858 | 0.5436 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.2287 | 0.0856 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.004 | 0.4773 | 0.8147 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0046 | 0.5858 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.2287 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.2287 | 0.1501 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0046 | 0.5858 | 0.5436 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.1565 | 0.0706 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.2287 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.3956 | 0.6753 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.4339 | 0.7408 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0046 | 0.5858 | 0.5089 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.2287 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.2827 | 0.4826 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.2287 | 0.2762 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0046 | 0.5858 | 0.5436 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.1565 | 0.0706 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.2287 | 0.1501 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.1565 | 0.1298 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.2287 | 1 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0037 | 0.4346 | 0.6934 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.3956 | 0.6753 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0016 | 0.0925 | 0.1579 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.2444 | 0.4171 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0046 | 0.5858 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.2287 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.2287 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.2827 | 0.4826 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0046 | 0.5858 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.4339 | 0.7408 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0046 | 0.5858 | 0.5089 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0037 | 0.4346 | 0.6934 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.2287 | 0.0856 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.1565 | 0.1298 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.2437 | 0.4161 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0034 | 0.3956 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.