Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1286 | 0.478 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0025 | 0.0086 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 0.0178 | 0.0662 |
Schistosoma mansoni | ferritin | 0.0025 | 0.0086 | 0.0086 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0391 | 0.5416 | 0.5416 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0031 | 0.0178 | 0.0662 |
Mycobacterium leprae | conserved hypothetical protein | 0.0107 | 0.1286 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0031 | 0.0178 | 0.0178 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0147 | 0.0546 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0031 | 0.0178 | 0.0662 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0147 | 0.0147 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0031 | 0.0178 | 0.0662 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0107 | 0.1286 | 0.1286 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 0.0178 | 0.0662 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0031 | 0.0178 | 0.0662 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0107 | 0.1286 | 0.1323 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0147 | 0.0147 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0107 | 0.1286 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0107 | 0.1286 | 0.1286 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.1499 | 0.5572 |
Onchocerca volvulus | 0.0048 | 0.0423 | 0.0936 | |
Schistosoma mansoni | ferritin | 0.0025 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.1499 | 0.5572 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0178 | 0.0662 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 0.0178 | 0.0178 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0178 | 0.0662 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0706 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0107 | 0.1286 | 0.1323 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 0.0178 | 0.0662 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0147 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1286 | 0.478 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0147 | 0.0147 |
Echinococcus granulosus | ferritin | 0.0025 | 0.0086 | 0.0086 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0031 | 0.0178 | 0.0178 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0031 | 0.0178 | 0.0662 |
Brugia malayi | nuclear hormone receptor | 0.0031 | 0.0178 | 0.0662 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0031 | 0.0178 | 0.0662 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0031 | 0.0178 | 0.0662 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0031 | 0.0178 | 0.0662 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0031 | 0.0178 | 0.0662 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0178 | 0.0662 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 0.0178 | 0.0178 |
Brugia malayi | beta-lactamase family protein | 0.0107 | 0.1286 | 0.478 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0031 | 0.0178 | 0.0662 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0706 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0031 | 0.0178 | 0.0662 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0031 | 0.0178 | 0.0662 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0031 | 0.0178 | 0.0178 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0107 | 0.1286 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0107 | 0.1286 | 0.1323 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0031 | 0.0178 | 0.0178 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0031 | 0.0178 | 0.0178 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0031 | 0.0178 | 0.0178 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0107 | 0.1286 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0031 | 0.0178 | 0.0178 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0107 | 0.1286 | 0.1323 |
Leishmania major | hypothetical protein, conserved | 0.0107 | 0.1286 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0031 | 0.0178 | 0.0178 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0107 | 0.1286 | 0.1323 |
Onchocerca volvulus | 0.0107 | 0.1286 | 0.3857 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0107 | 0.1286 | 0.4148 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0031 | 0.0178 | 0.0178 |
Plasmodium vivax | hypothetical protein, conserved | 0.0107 | 0.1286 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0178 | 0.0662 |
Brugia malayi | Pre-SET motif family protein | 0.0204 | 0.269 | 1 |
Onchocerca volvulus | 0.0031 | 0.0178 | 0.0106 | |
Echinococcus granulosus | FTZ F1 alpha | 0.0031 | 0.0178 | 0.0178 |
Schistosoma mansoni | apoferritin-2 | 0.0025 | 0.0086 | 0.0086 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0031 | 0.0178 | 0.0178 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0031 | 0.0178 | 0.0178 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 0.0178 | 0.0662 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0107 | 0.1286 | 0.1323 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0107 | 0.1286 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0147 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1286 | 0.478 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0147 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1286 | 0.478 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0178 | 0.0662 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0025 | 0.0086 | 0.0665 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0147 | 0.0546 |
Mycobacterium ulcerans | hypothetical protein | 0.0107 | 0.1286 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0031 | 0.0178 | 0.0662 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0031 | 0.0178 | 0.0662 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 0.0178 | 0.0662 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0107 | 0.1286 | 0.1286 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0031 | 0.0178 | 0.0662 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0031 | 0.0178 | 0.0178 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0031 | 0.0178 | 0.0178 |
Schistosoma mansoni | thyroid hormone receptor | 0.0422 | 0.5873 | 0.5873 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0391 | 0.5416 | 0.5416 |
Schistosoma mansoni | thyroid hormone receptor | 0.0422 | 0.5873 | 0.5873 |
Schistosoma mansoni | hypothetical protein | 0.0391 | 0.5416 | 0.5416 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0031 | 0.0178 | 0.0178 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0031 | 0.0178 | 0.0178 |
Schistosoma mansoni | ferritin | 0.0025 | 0.0086 | 0.0086 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0031 | 0.0178 | 0.0178 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 0.0178 | 0.0178 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0178 | 0.0662 |
Echinococcus granulosus | tumor protein p63 | 0.0329 | 0.452 | 0.452 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0025 | 0.0086 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0107 | 0.1286 | 0.1323 |
Mycobacterium ulcerans | beta-lactamase | 0.0107 | 0.1286 | 1 |
Echinococcus multilocularis | expressed protein | 0.0025 | 0.0086 | 0.0086 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0147 | 0.0147 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0031 | 0.0178 | 0.0662 |
Mycobacterium tuberculosis | Conserved protein | 0.0107 | 0.1286 | 0.1323 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0107 | 0.1286 | 0.4148 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0107 | 0.1286 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0031 | 0.0178 | 0.0178 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0031 | 0.0178 | 0.0178 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0025 | 0.0086 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0423 | 0.1573 |
Trichomonas vaginalis | esterase, putative | 0.0107 | 0.1286 | 0.4148 |
Schistosoma mansoni | apoferritin-2 | 0.0025 | 0.0086 | 0.0086 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 0.0178 | 0.0178 |
Loa Loa (eye worm) | beta-lactamase | 0.0107 | 0.1286 | 0.478 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0031 | 0.0178 | 0.0662 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 0.0178 | 0.0662 |
Trichomonas vaginalis | ferritin, putative | 0.0025 | 0.0086 | 0.0276 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0422 | 0.5873 | 0.5873 |
Brugia malayi | beta-lactamase | 0.0107 | 0.1286 | 0.478 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0031 | 0.0178 | 0.0178 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0107 | 0.1286 | 0.4148 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1286 | 0.478 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0107 | 0.1286 | 0.1323 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0025 | 0.0086 | 0.0665 |
Onchocerca volvulus | 0.0107 | 0.1286 | 0.3857 | |
Brugia malayi | nuclear receptor NHR-88 | 0.0031 | 0.0178 | 0.0662 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0423 | 0.0423 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.1499 | 0.5572 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0131 | 0.0131 |
Onchocerca volvulus | 0.0232 | 0.3101 | 1 | |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0031 | 0.0178 | 0.0178 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0031 | 0.0178 | 0.0662 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0204 | 0.269 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0329 | 0.452 | 0.452 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0031 | 0.0178 | 0.0106 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0107 | 0.1286 | 0.4148 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0025 | 0.0086 | 0.0088 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0686 | 0.9721 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0178 | 0.0662 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0107 | 0.1286 | 0.478 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1286 | 0.478 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0107 | 0.1286 | 0.4148 |
Brugia malayi | beta-lactamase family protein | 0.0107 | 0.1286 | 0.478 |
Schistosoma mansoni | nuclear hormone receptor | 0.0031 | 0.0178 | 0.0178 |
Mycobacterium ulcerans | lipase LipD | 0.0107 | 0.1286 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0031 | 0.0178 | 0.0178 |
Onchocerca volvulus | 0.0107 | 0.1286 | 0.3857 | |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0031 | 0.0178 | 0.0178 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0031 | 0.0178 | 0.0106 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0031 | 0.0178 | 0.0106 |
Schistosoma mansoni | ferritin light chain | 0.0025 | 0.0086 | 0.0086 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0107 | 0.1286 | 0.1323 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0107 | 0.1286 | 0.1286 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0107 | 0.1286 | 0.478 |
Brugia malayi | ecdysteroid receptor | 0.0031 | 0.0178 | 0.0662 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0031 | 0.0178 | 0.0662 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0178 | 0.0662 |
Echinococcus multilocularis | ferritin | 0.0025 | 0.0086 | 0.0086 |
Echinococcus granulosus | expressed protein | 0.0025 | 0.0086 | 0.0086 |
Schistosoma mansoni | ferritin light chain | 0.0025 | 0.0086 | 0.0086 |
Mycobacterium leprae | Probable lipase LipE | 0.0107 | 0.1286 | 1 |
Schistosoma mansoni | ferritin | 0.0025 | 0.0086 | 0.0086 |
Trichomonas vaginalis | set domain proteins, putative | 0.0232 | 0.3101 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0107 | 0.1286 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.