Detailed information for compound 729139

Basic information

Technical information
  • TDR Targets ID: 729139
  • Name: 3-[2-(5-chlorothiophen-2-yl)-2-oxoethyl]-1-[( 3,4-dimethoxyphenyl)methyl]-3-hydroxyindol-2- one
  • MW: 457.927 | Formula: C23H20ClNO5S
  • H donors: 1 H acceptors: 3 LogP: 4.5 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)CN1c2ccccc2C(C1=O)(O)CC(=O)c1ccc(s1)Cl
  • InChi: 1S/C23H20ClNO5S/c1-29-18-8-7-14(11-19(18)30-2)13-25-16-6-4-3-5-15(16)23(28,22(25)27)12-17(26)20-9-10-21(24)31-20/h3-11,28H,12-13H2,1-2H3
  • InChiKey: DREUZNJLPZVVAM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[2-(5-chloro-2-thienyl)-2-oxo-ethyl]-1-[(3,4-dimethoxyphenyl)methyl]-3-hydroxy-indolin-2-one
  • 3-[2-(5-chloro-2-thienyl)-2-oxoethyl]-1-[(3,4-dimethoxyphenyl)methyl]-3-hydroxy-2-indolinone
  • 3-[2-(5-chloro-2-thienyl)-2-keto-ethyl]-1-(3,4-dimethoxybenzyl)-3-hydroxy-oxindole
  • 3-[2-(5-chlorothiophen-2-yl)-2-oxo-ethyl]-1-[(3,4-dimethoxyphenyl)methyl]-3-hydroxy-indol-2-one
  • STK214967
  • CBKinase1_006873
  • CBKinase1_019273

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0079 0.0359 0.2257
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0267 0.0924
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.01 0.2306
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0037 0.0286
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0025 0.0003
Loa Loa (eye worm) hypothetical protein 0.0102 0.05 0.0608
Mycobacterium ulcerans lipase LipD 0.0079 0.0359 0.276
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.0762 0.0742
Echinococcus granulosus para nitrobenzyl esterase 0.0237 0.13 0.1556
Onchocerca volvulus 0.0051 0.0197 0.1162
Trypanosoma brucei glucosidase, putative 0.0038 0.0117 0.2819
Loa Loa (eye worm) hypothetical protein 0.0237 0.13 0.1579
Brugia malayi Carboxylesterase family protein 0.1402 0.8236 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0206 0.5464
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0359 0.1244
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0206 0.0989
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0025 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0503 0.2885 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0025 0.0688
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.1884 1
Loa Loa (eye worm) hypothetical protein 0.1402 0.8236 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0267 0.0298
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0199 0.0242
Loa Loa (eye worm) hypothetical protein 0.0237 0.13 0.1579
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0117 0.2819
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.1884 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0359 0.0338
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0022 0.0027
Loa Loa (eye worm) carboxylesterase 0.1402 0.8236 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0211 0.0256
Loa Loa (eye worm) hypothetical protein 0.0079 0.0359 0.0436
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0206 0.0224
Loa Loa (eye worm) hypothetical protein 0.0237 0.13 0.1579
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0267 0.0298
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.05 0.257
Trypanosoma brucei protein kinase, putative 0.0053 0.0206 0.5464
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0206 0.0185
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0267 0.0245
Mycobacterium ulcerans hypothetical protein 0.0025 0.0037 0.0286
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0206 0.0989
Loa Loa (eye worm) hypothetical protein 0.0079 0.0359 0.0436
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0359 1
Trichomonas vaginalis set domain proteins, putative 0.0271 0.1506 0.7971
Loa Loa (eye worm) hypothetical protein 0.0025 0.0037 0.0045
Mycobacterium tuberculosis Carboxylesterase LipT 0.0237 0.13 0.4508
Brugia malayi Glycosyl hydrolases family 31 protein 0.0172 0.0912 0.1083
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0094 0.0088
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0172 0.0912 0.1107
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0094 0.0088
Trichomonas vaginalis esterase, putative 0.0079 0.0359 0.181
Brugia malayi Pre-SET motif family protein 0.0034 0.0094 0.0088
Echinococcus multilocularis geminin 0.0183 0.0978 0.0958
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0117 0.0142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.046 0.0534
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0117 0.051
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0238 0.131 0.159
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.1356 0.1624
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0359 0.181
Trichomonas vaginalis spcc417.12 protein, putative 0.0237 0.13 0.6867
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0037 0.0286
Onchocerca volvulus 0.0237 0.13 0.8613
Loa Loa (eye worm) hypothetical protein 0.0079 0.0359 0.0436
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0267 0.0298
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0037 0.0286
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0105 0.0101
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.046 0.0534
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.1356 0.1337
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0206 0.0989
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0359 0.3891
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.1884 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.01 0.2306
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0206 0.5464
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0206 0.5464
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0117 0.087
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.01 0.2306
Schistosoma mansoni lipoxygenase 0.0023 0.0025 0.0003
Entamoeba histolytica hypothetical protein 0.0037 0.0113 0.0491
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0025 0.0003
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0335 0.1884 1
Schistosoma mansoni hypothetical protein 0.0037 0.0113 0.0111
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0022 0.0168
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0359 0.276
Echinococcus granulosus acetylcholinesterase 0.1402 0.8236 1
Echinococcus multilocularis protein dispatched 1 0.005 0.0189 0.0168
Echinococcus granulosus expressed protein 0.0036 0.0105 0.0101
Loa Loa (eye worm) hypothetical protein 0.0025 0.0037 0.0045
Entamoeba histolytica hypothetical protein 0.0037 0.0113 0.0491
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0359 0.041
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0037 0.0286
Loa Loa (eye worm) hypothetical protein 0.0079 0.0359 0.0436
Schistosoma mansoni hypothetical protein 0.0023 0.0025 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.046 0.0534
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0206 0.0185
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0037 0.0019
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0117 0.0116
Loa Loa (eye worm) hypothetical protein 0.0044 0.0152 0.0185
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.1884 1
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0206 0.0989
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0037 0.0082
Loa Loa (eye worm) hypothetical protein 0.0079 0.0359 0.0436
Brugia malayi hypothetical protein 0.0246 0.1356 0.1624
Mycobacterium ulcerans beta-lactamase 0.0079 0.0359 0.276
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.046 0.0534
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.0762 0.0901
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0094 0.0088
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0267 0.205
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0152 0.0699
Mycobacterium leprae Probable lipase LipE 0.0079 0.0359 0.3891
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0206 0.5464
Onchocerca volvulus 0.0099 0.0481 0.3081
Echinococcus multilocularis tumor protein p63 0.0352 0.1984 0.1967
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0117 0.051
Mycobacterium tuberculosis Conserved protein 0.0079 0.0359 0.1244
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0063 0.0267 0.0245
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0037 0.0082
Echinococcus granulosus neuroligin 0.0237 0.13 0.1556
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0359 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0152 0.0131
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0335 0.1884 1
Loa Loa (eye worm) acetylcholinesterase 1 0.1402 0.8236 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0237 0.13 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0094 0.0072
Brugia malayi Carboxylesterase family protein 0.0237 0.13 0.1556
Echinococcus multilocularis acetylcholinesterase 0.1402 0.8236 0.8232
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0206 0.025
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0152 0.0159
Onchocerca volvulus 0.0237 0.13 0.8613
Onchocerca volvulus 0.0079 0.0359 0.2257
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0113 0.0111
Echinococcus granulosus lysosomal alpha glucosidase 0.0172 0.0912 0.1083
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0152 0.0185
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.01 0.0417
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0237 0.13 0.1556
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0359 0.181
Brugia malayi Carboxylesterase family protein 0.0237 0.13 0.1556
Schistosoma mansoni hypothetical protein 0.0042 0.0143 0.0147
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.1884 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0094 0.0088
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0267 0.205
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.01 0.2306
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0025 0.0003
Echinococcus granulosus BC026374 protein S09 family 0.0237 0.13 0.1556
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0037 0.0129
Brugia malayi beta-lactamase family protein 0.0079 0.0359 0.041
Onchocerca volvulus 0.0271 0.1506 1
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0022 0.0168
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0117 0.051
Schistosoma mansoni alpha-glucosidase 0.0148 0.0769 0.091
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.003
Schistosoma mansoni patched 1 0.0044 0.0152 0.0159
Loa Loa (eye worm) hypothetical protein 0.1402 0.8236 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0237 0.13 0.6867
Onchocerca volvulus 0.0237 0.13 0.8613
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.05 0.048
Trichomonas vaginalis rotamase, putative 0.0035 0.01 0.0417
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.01 0.0217
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.0912 0.0892
Loa Loa (eye worm) hypothetical protein 0.0051 0.0197 0.0239
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0105 0.0127
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0027
Echinococcus multilocularis expressed conserved protein 0.0096 0.0463 0.0443
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.0912 0.0892
Mycobacterium ulcerans hypothetical protein 0.0079 0.0359 0.276
Brugia malayi Pre-SET motif family protein 0.0238 0.131 0.1568
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0117 0.2819
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0037 0.0019
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.05 0.0583
Brugia malayi hypothetical protein 0.0037 0.0113 0.0111
Brugia malayi hypothetical protein 0.0237 0.13 0.1556
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0359 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0267 0.7259
Echinococcus multilocularis RUN 0.0023 0.0025 0.0003
Onchocerca volvulus 0.0237 0.13 0.8613
Schistosoma mansoni rotamase 0.0036 0.0105 0.0101
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0267 0.6515
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0037 0.0129
Schistosoma mansoni hypothetical protein 0.0183 0.0978 0.1164
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0359 0.1244
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0206 0.5464
Loa Loa (eye worm) hypothetical protein 0.0246 0.1356 0.1646
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0206 0.0224
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0206 0.0224
Loa Loa (eye worm) hypothetical protein 0.0035 0.0101 0.0123
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0101 0.0097
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0267 0.205
Echinococcus multilocularis expressed protein 0.0036 0.0105 0.0083
Schistosoma mansoni hypothetical protein 0.0042 0.0143 0.0147
Loa Loa (eye worm) hypothetical protein 0.0237 0.13 0.1579
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0164 0.0864 1
Entamoeba histolytica hypothetical protein 0.0037 0.0113 0.0491
Schistosoma mansoni loxhd1 0.0023 0.0025 0.0003
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0359 0.041
Echinococcus granulosus expressed conserved protein 0.0096 0.0463 0.0538
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0117 0.051
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0022 0.0076
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0199 0.0216
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.1884 1
Loa Loa (eye worm) carboxylesterase 0.0237 0.13 0.1579
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0359 0.1244
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0113 0.0111
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0037 0.0082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.046 0.044
Echinococcus multilocularis para nitrobenzyl esterase 0.0237 0.13 0.1281
Echinococcus granulosus tumor protein p63 0.0352 0.1984 0.2389
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0063 0.0267 0.0298
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0094 0.0088
Onchocerca volvulus 0.0025 0.0037 0.0084
Loa Loa (eye worm) hypothetical protein 0.0237 0.13 0.1579
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0359 0.1244
Loa Loa (eye worm) beta-lactamase 0.0079 0.0359 0.0436
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0237 0.13 0.4508
Schistosoma mansoni hypothetical protein 0.0035 0.0101 0.0097
Schistosoma mansoni hypothetical protein 0.0042 0.0143 0.0147
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0025 0.0003
Onchocerca volvulus 0.005 0.0189 0.111
Echinococcus multilocularis acetylcholinesterase 0.1402 0.8236 0.8232
Treponema pallidum fructose-bisphosphate aldolase 0.0335 0.1884 0.5
Schistosoma mansoni lipoxygenase 0.0063 0.0267 0.0298
Loa Loa (eye worm) hypothetical protein 0.0052 0.0199 0.0242
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0237 0.13 0.1556
Echinococcus granulosus carboxylesterase 5A 0.1402 0.8236 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0237 0.13 0.4508
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0152 0.0159
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0359 0.181
Entamoeba histolytica hypothetical protein 0.0037 0.0113 0.0491
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0359 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0359 0.0436
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0359 0.1244
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0199 0.0216
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0117 0.051
Schistosoma mansoni rab6-interacting 0.0023 0.0025 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0037 0.0454
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0037 0.0454
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.046 0.0559
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0117 0.051
Brugia malayi hypothetical protein 0.0023 0.0025 0.0003
Echinococcus multilocularis BC026374 protein (S09 family) 0.0237 0.13 0.1281
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0164 0.0864 0.6644
Schistosoma mansoni BC026374 protein (S09 family) 0.0237 0.13 0.1556
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0117 0.051
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0025 0.0003
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0359 0.181
Brugia malayi beta-lactamase family protein 0.0079 0.0359 0.041
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0359 0.276
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0237 0.13 0.1556
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0117 0.051
Brugia malayi Doublecortin family protein 0.0023 0.0025 0.0003
Onchocerca volvulus 0.0034 0.0094 0.0467
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0359 0.1244
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0206 0.5464
Schistosoma mansoni neuroligin 3 (S09 family) 0.0237 0.13 0.1556
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0117 0.0095
Echinococcus granulosus RUN 0.0023 0.0025 0.0003
Schistosoma mansoni hypothetical protein 0.0183 0.0978 0.1164
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0025 0.003
Giardia lamblia Fructose-bisphosphate aldolase 0.0335 0.1884 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0117 0.051
Brugia malayi MAP kinase sur-1 0.0053 0.0206 0.0224
Schistosoma mansoni survival motor neuron protein 0.005 0.0189 0.0204
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0359 0.1244
Brugia malayi Carboxylesterase family protein 0.0237 0.13 0.1556
Loa Loa (eye worm) hypothetical protein 0.0237 0.13 0.1579
Schistosoma mansoni hypothetical protein 0.005 0.0189 0.0204
Schistosoma mansoni alpha-glucosidase 0.0148 0.0769 0.091
Echinococcus granulosus acetylcholinesterase 0.1402 0.8236 1
Schistosoma mansoni alpha glucosidase 0.0038 0.0117 0.0116
Echinococcus multilocularis neuroligin 0.0237 0.13 0.1281
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0037 0.0019
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0037 0.0454
Loa Loa (eye worm) hypothetical protein 0.0237 0.13 0.1579
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0025 0.0003
Schistosoma mansoni acetylcholinesterase 0.0237 0.13 0.1556
Brugia malayi Carboxylesterase family protein 0.1402 0.8236 1
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0197 0.0213
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0359 0.041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.046 0.044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.1884 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0359 0.0436
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0037 0.0286
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.003
Echinococcus multilocularis protein patched 0.0044 0.0152 0.0131
Plasmodium vivax SET domain protein, putative 0.0034 0.0094 0.2614
Trichomonas vaginalis rotamase, putative 0.0036 0.0105 0.0445
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0359 0.041
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0117 0.2819
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.1884 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0117 0.051
Mycobacterium tuberculosis Conserved protein 0.0079 0.0359 0.1244
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0037 0.0286
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0206 0.4232
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0037 0.0286
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0206 0.5464
Brugia malayi hypothetical protein 0.0023 0.0025 0.0003
Schistosoma mansoni rab6-interacting 0.0023 0.0025 0.0003
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0189 0.0204
Onchocerca volvulus 0.0079 0.0359 0.2257
Leishmania major hypothetical protein, conserved 0.0079 0.0359 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0022 0.0076
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.051 0.0594
Echinococcus multilocularis carboxylesterase 5A 0.1402 0.8236 0.8232
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1402 0.8236 1
Schistosoma mansoni gliotactin 0.0237 0.13 0.1556
Loa Loa (eye worm) hypothetical protein 0.0034 0.0094 0.0114
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0094 0.0072
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0117 0.051
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0113 0.0092
Brugia malayi Carboxylesterase family protein 0.0237 0.13 0.1556
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0117 0.0116
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0237 0.13 0.1556
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.05 0.0583
Loa Loa (eye worm) carboxylesterase 0.0237 0.13 0.1579
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0237 0.13 0.1281
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0206 0.0989
Onchocerca volvulus 0.0237 0.13 0.8613
Loa Loa (eye worm) hypothetical protein 0.0025 0.0037 0.0045
Echinococcus granulosus geminin 0.0183 0.0978 0.1164
Brugia malayi beta-lactamase 0.0079 0.0359 0.041
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0164 0.0864 0.2995
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0086 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0105 0.0445
Toxoplasma gondii ABC1 family protein 0.0079 0.0359 1
Schistosoma mansoni polycystin 1-related 0.0023 0.0025 0.0003
Schistosoma mansoni hypothetical protein 0.0042 0.0143 0.0147
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.046 0.0534
Mycobacterium tuberculosis Conserved protein 0.0079 0.0359 0.1244
Brugia malayi CHE-14 protein 0.0044 0.0152 0.0159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.046 0.0534
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0359 0.181

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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