Detailed information for compound 729374

Basic information

Technical information
  • TDR Targets ID: 729374
  • Name: N-[[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]m ethyl]-N-methylmorpholine-4-carboxamide
  • MW: 336.773 | Formula: C15H17ClN4O3
  • H donors: 0 H acceptors: 3 LogP: 1.4 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)N1CCOCC1)Cc1onc(n1)c1ccc(cc1)Cl
  • InChi: 1S/C15H17ClN4O3/c1-19(15(21)20-6-8-22-9-7-20)10-13-17-14(18-23-13)11-2-4-12(16)5-3-11/h2-5H,6-10H2,1H3
  • InChiKey: AKMGYRIABOALRT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl]-N-methyl-morpholine-4-carboxamide
  • N-[[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl]-N-methyl-4-morpholinecarboxamide
  • STOCK6S-08051
  • ZINC04943765
  • ASN 13321714

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0393 0.0446
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0032 0.0036
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0043 0.012
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0586 0.0665
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0775 0.0775
Loa Loa (eye worm) hypothetical protein 0.0174 0.1899 0.343
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.1603 0.445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0123 0.1083
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0013
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.0003 0.001
Brugia malayi hypothetical protein 0.0478 0.5535 1
Onchocerca volvulus 0.0312 0.3554 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0393 0.1091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0562 0.1559
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0005 0.0013
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0101 0.0115
Loa Loa (eye worm) ctsf protein 0.0017 0.0005 0.0009
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.1112 0.1365
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0274 0.076
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0005 0.0005
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0081 0.0775 0.088
Schistosoma mansoni lamin 0.0084 0.0811 0.092
Toxoplasma gondii ABC1 family protein 0.0109 0.1112 0.4358
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.3603 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0562 0.1559
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0005 0.0005
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0393 0.1091
Mycobacterium ulcerans hypothetical protein 0.0167 0.1806 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0393 0.1091
Plasmodium falciparum ataxin-2 like protein, putative 0.0229 0.2551 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.1112 0.2008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0157 0.1387
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0032 0.0236
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0562 0.1559
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0032 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0029 0.0033
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0253 0.284 0.513
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0101 0.0101
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.0393 0.3414
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0013
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1219 0.2203
Echinococcus multilocularis survival motor neuron protein 1 0.0478 0.5535 0.5535
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.1112 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0457 0.1269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0273 0.2434
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0032 0.0255
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.1112 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0775 0.14
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0013
Loa Loa (eye worm) fibroinase 0.0017 0.0005 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0013
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0005 0.0019
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0032 0.0088
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.1112 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0291 0.0331
Echinococcus multilocularis tumor protein p63 0.0744 0.8737 0.8737
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0393 0.0446
Onchocerca volvulus 0.0109 0.1112 0.3118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0157 0.1387
Entamoeba histolytica hypothetical protein 0.0111 0.1142 1
Trypanosoma brucei PAB1-binding protein , putative 0.0229 0.2551 0.7079
Echinococcus granulosus cathepsin l1 0.0017 0.0005 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0154 0.1356
Brugia malayi beta-lactamase 0.0109 0.1112 0.2008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0187 0.1661
Schistosoma mansoni tar DNA-binding protein 0.0253 0.284 0.3222
Schistosoma mansoni hypothetical protein 0.0097 0.0975 0.1107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0032 0.0088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0013
Leishmania major DNA polymerase kappa, putative 0.0019 0.0032 0.0088
Schistosoma mansoni hypothetical protein 0.0174 0.1899 0.2155
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0005 0.0013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0043 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0243 0.2161
Echinococcus granulosus zinc finger protein 0.0021 0.0062 0.0071
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0586 0.0586
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0005 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0562 0.1559
Brugia malayi hypothetical protein 0.0111 0.1142 0.2064
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0029 0.0029
Leishmania major cathepsin L-like protease 0.0063 0.0562 0.1559
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.1112 0.1365
Brugia malayi Bromodomain containing protein 0.0082 0.0785 0.1419
Echinococcus multilocularis cysteine protease 0.0017 0.0005 0.0005
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.1112 0.1262
Schistosoma mansoni cellular tumor antigen P53 0.0109 0.1114 0.1264
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0029 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0013
Schistosoma mansoni hypothetical protein 0.0081 0.0775 0.088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0243 0.2161
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0052 0.0434 0.0533
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0003 0.0004
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0005 0.0006
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0274 0.076
Leishmania major hypothetical protein, conserved 0.0229 0.2551 0.7079
Onchocerca volvulus 0.0084 0.0811 0.2271
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0393 0.3517
Schistosoma mansoni tar DNA-binding protein 0.0253 0.284 0.3222
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.1112 0.1365
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0043 0.0359
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0005 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0088
Echinococcus multilocularis ferritin 0.0052 0.0434 0.0434
Echinococcus multilocularis geminin 0.0348 0.3986 0.3986
Trypanosoma brucei unspecified product 0.0019 0.0032 0.0088
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0052 0.0434 0.0533
Brugia malayi latrophilin 2 splice variant baaae 0.0174 0.1899 0.343
Echinococcus multilocularis musashi 0.0084 0.0811 0.0811
Mycobacterium ulcerans bacterioferritin BfrB 0.0052 0.0434 0.2269
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0695 0.8144 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0341 0.0945
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.1112 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0005 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0013
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0341 0.0945
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0775 0.14
Loa Loa (eye worm) hypothetical protein 0.0255 0.2867 0.518
Schistosoma mansoni hypothetical protein 0.0348 0.3986 0.4523
Echinococcus multilocularis tar DNA binding protein 0.0253 0.284 0.284
Onchocerca volvulus 0.0109 0.1114 0.3125
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0052 0.0434 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.073 0.1318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0154 0.1356
Loa Loa (eye worm) hypothetical protein 0.0081 0.0775 0.14
Schistosoma mansoni bromodomain containing protein 0.0069 0.0633 0.0718
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0032 0.0088
Mycobacterium tuberculosis Conserved protein 0.0109 0.1112 0.1365
Mycobacterium leprae conserved hypothetical protein 0.0109 0.1112 1
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.1112 0.3085
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0043 0.0359
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0003 0.0003
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0003 0.001
Mycobacterium tuberculosis Conserved protein 0.0109 0.1112 0.1365
Entamoeba histolytica hypothetical protein 0.0111 0.1142 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0123 0.1078
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.1112 0.1112
Schistosoma mansoni survival motor neuron protein 0.0097 0.0975 0.1107
Schistosoma mansoni hypothetical protein 0.0022 0.0076 0.0086
Schistosoma mansoni hypothetical protein 0.0103 0.1037 0.1177
Schistosoma mansoni lamin 0.0084 0.0811 0.092
Schistosoma mansoni tar DNA-binding protein 0.0253 0.284 0.3222
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0043 0.0053
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0032 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0273 0.2434
Mycobacterium leprae Probable lipase LipE 0.0109 0.1112 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0393 0.1091
Schistosoma mansoni tar DNA-binding protein 0.0253 0.284 0.3222
Onchocerca volvulus 0.0097 0.0975 0.2734
Brugia malayi RNA binding protein 0.0253 0.284 0.513
Schistosoma mansoni DNA polymerase eta 0.0019 0.0032 0.0036
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0084 0.0233
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0029 0.0033
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.1112 0.1365
Brugia malayi beta-lactamase family protein 0.0109 0.1112 0.2008
Trypanosoma cruzi ISWI complex protein 0.0017 0.0006 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0562 0.1559
Echinococcus granulosus intermediate filament protein 0.0084 0.0811 0.092
Echinococcus multilocularis microtubule associated protein 2 0.0751 0.8812 0.8812
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0562 0.1559
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0005 0.0006
Leishmania major cathepsin L-like protease 0.0063 0.0562 0.1559
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.1142 0.1296
Echinococcus multilocularis expressed protein 0.0052 0.0434 0.0434
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0562 0.1559
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0005 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0562 0.1559
Schistosoma mansoni ap endonuclease 0.002 0.0043 0.0049
Leishmania major cathepsin L-like protease 0.0063 0.0562 0.1559
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.1112 0.3085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0562 0.1559
Brugia malayi TAR-binding protein 0.0253 0.284 0.513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0123 0.1083
Loa Loa (eye worm) hypothetical protein 0.0046 0.0363 0.0656
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.02 0.1775
Schistosoma mansoni tar DNA-binding protein 0.0253 0.284 0.3222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0013
Treponema pallidum bacterioferrin (TpF1) 0.0052 0.0434 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0562 0.1559
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0084 0.0811 0.1465
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.1112 0.1365
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0009
Entamoeba histolytica hypothetical protein 0.0111 0.1142 1
Schistosoma mansoni zinc finger protein 0.0017 0.0006 0.0007
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0043 0.012
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0243 0.0952
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.1112 0.6085
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0032 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0562 0.1559
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0393 0.071
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0276 0.0313
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0029 0.0033
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.005 0.014
Echinococcus granulosus tar DNA binding protein 0.0253 0.284 0.3222
Echinococcus granulosus lamin 0.0084 0.0811 0.092
Mycobacterium ulcerans hypothetical protein 0.0109 0.1112 0.6085
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.1112 0.1262
Brugia malayi hypothetical protein 0.0312 0.3554 0.6421
Schistosoma mansoni apoferritin-2 0.0052 0.0434 0.0493
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0043 0.0169
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0013
Trypanosoma brucei ISWI complex protein 0.0017 0.0006 0.0018
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0014
Schistosoma mansoni ferritin light chain 0.0052 0.0434 0.0493
Echinococcus granulosus microtubule associated protein 2 0.0751 0.8812 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.1112 0.2008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0243 0.2161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0273 0.2434
Echinococcus multilocularis dna polymerase eta 0.0019 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0039 0.0273 0.0493
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0053
Loa Loa (eye worm) hypothetical protein 0.0312 0.3554 0.6421
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0043 0.0318
Echinococcus granulosus lamin dm0 0.0084 0.0811 0.092
Trichomonas vaginalis ferritin, putative 0.0052 0.0434 0.3888
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0032 0.0039
Loa Loa (eye worm) hypothetical protein 0.0109 0.1112 0.2008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0273 0.2434
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0043 0.0043
Echinococcus multilocularis lamin 0.0084 0.0811 0.0811
Brugia malayi MH2 domain containing protein 0.0118 0.1219 0.2203
Schistosoma mansoni microtubule-associated protein tau 0.0751 0.8812 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0393 0.071
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.1112 0.1365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0393 0.3517
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0005 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0013
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.0003 0.001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0003 0.0006
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0009
Leishmania major mitochondrial DNA polymerase beta 0.0316 0.3603 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0274 0.076
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.1112 0.1262
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0029 0.0033
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0032 0.0039
Toxoplasma gondii hypothetical protein 0.0051 0.0419 0.1643
Brugia malayi intermediate filament protein 0.0084 0.0811 0.1465
Schistosoma mansoni ferritin light chain 0.0052 0.0434 0.0493
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.1142 0.1142
Schistosoma mansoni hypothetical protein 0.0017 0.0006 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0013
Plasmodium falciparum ataxin-2 like protein, putative 0.0229 0.2551 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0088
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0341 0.0945
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0123 0.1083
Schistosoma mansoni hypothetical protein 0.0081 0.0775 0.088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0243 0.2161
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0005 0.0014
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0032 0.0088
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0393 0.0393
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0009
Echinococcus granulosus dna polymerase eta 0.0019 0.0032 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0255 0.2867 0.518
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0307 0.2743
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0032 0.0057
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0032 0.0088
Onchocerca volvulus 0.0109 0.1112 0.3118
Loa Loa (eye worm) RNA binding protein 0.0253 0.284 0.513
Toxoplasma gondii exonuclease III APE 0.002 0.0043 0.0169
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0013
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0043 0.0049
Loa Loa (eye worm) hypothetical protein 0.0109 0.1112 0.2008
Loa Loa (eye worm) hypothetical protein 0.0109 0.1112 0.2008
Schistosoma mansoni ap endonuclease 0.002 0.0043 0.0049
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0255 0.2867 0.518
Echinococcus multilocularis lamin dm0 0.0084 0.0811 0.0811
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0014
Echinococcus granulosus geminin 0.0348 0.3986 0.4523
Schistosoma mansoni ferritin 0.0052 0.0434 0.0493
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0101 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0123 0.1078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0013
Trypanosoma cruzi PAB1-binding protein , putative 0.0229 0.2551 0.7079
Echinococcus granulosus survival motor neuron protein 1 0.0478 0.5535 0.6281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0013
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0014
Schistosoma mansoni hypothetical protein 0.0111 0.1142 0.1296
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0345 0.0623
Trypanosoma cruzi PAB1-binding protein , putative 0.0229 0.2551 0.7079
Mycobacterium tuberculosis Conserved protein 0.0109 0.1112 0.1365
Brugia malayi beta-lactamase family protein 0.0109 0.1112 0.2008
Leishmania major hypothetical protein, conserved 0.0017 0.0006 0.0018
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0345 0.0623
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0276 0.0276
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0043 0.0337
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0032 0.0088
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0496 0.1377
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0043 0.012
Mycobacterium ulcerans bacterioferritin BfrA 0.0052 0.0434 0.2269
Onchocerca volvulus 0.0084 0.0811 0.2271
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0088
Schistosoma mansoni hypothetical protein 0.0081 0.0775 0.088
Echinococcus multilocularis GPCR, family 2 0.0081 0.0775 0.0775
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0032 0.0036
Loa Loa (eye worm) hypothetical protein 0.0478 0.5535 1
Loa Loa (eye worm) beta-lactamase 0.0109 0.1112 0.2008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0088
Schistosoma mansoni ferritin 0.0052 0.0434 0.0493
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.0003 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0243 0.2161
Plasmodium vivax hypothetical protein, conserved 0.0109 0.1112 0.4358
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0005 0.0005
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.1112 0.1365
Echinococcus multilocularis zinc finger protein 0.0021 0.0062 0.0062
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0003 0.0006
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.1112 0.6085
Plasmodium vivax vivapain-2 0.0017 0.0005 0.0019
Giardia lamblia GTOR 0.0049 0.0393 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0103 0.1037 0.1177
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.0393 0.3414
Loa Loa (eye worm) hypothetical protein 0.0109 0.1114 0.2013
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0088
Loa Loa (eye worm) intermediate filament protein 0.0084 0.0811 0.1465
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0003 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0562 0.1559
Brugia malayi hypothetical protein 0.0148 0.1578 0.2851
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.1806 0.2218
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.1112 0.2008
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0043 0.0078
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0975 0.1762
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0003 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0088
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0029 0.0033
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0775 0.088
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.1603 0.445
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.04 0.111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0243 0.2161
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0005 0.0006
Loa Loa (eye worm) cysteine protease 0.0017 0.0005 0.0009
Onchocerca volvulus 0.0109 0.1112 0.3118
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.0003 0.001
Brugia malayi Calcitonin receptor-like protein seb-1 0.0255 0.2867 0.518
Schistosoma mansoni ferritin 0.0052 0.0434 0.0493
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0013
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0032 0.0032
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0291 0.0291
Leishmania major hypothetical protein, conserved 0.0109 0.1112 0.3085
Echinococcus granulosus ferritin 0.0052 0.0434 0.0493
Echinococcus granulosus expressed protein 0.0052 0.0434 0.0493
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0005 0.0009
Brugia malayi RNA recognition motif domain containing protein 0.0253 0.284 0.513
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0032 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0243 0.2161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0157 0.1387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0123 0.1078
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0562 0.1559
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1219 0.2203
Brugia malayi PHD-finger family protein 0.0027 0.0132 0.0238
Schistosoma mansoni intermediate filament proteins 0.0084 0.0811 0.092
Loa Loa (eye worm) hypothetical protein 0.0082 0.0793 0.1432
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0393 0.1091
Schistosoma mansoni hypothetical protein 0.0348 0.3986 0.4523
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0775 0.088
Schistosoma mansoni apoferritin-2 0.0052 0.0434 0.0493
Loa Loa (eye worm) hypothetical protein 0.0229 0.2551 0.4608
Echinococcus granulosus tumor protein p63 0.0744 0.8737 0.9916
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0316 0.3603 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0393 0.3517
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0009
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0032 0.0088
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0013
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.1603 0.445
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0013
Mycobacterium ulcerans beta-lactamase 0.0109 0.1112 0.6085
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.1142 0.1296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0273 0.2434
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0043 0.0169
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0775 0.14
Toxoplasma gondii LsmAD domain-containing protein 0.0229 0.2551 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0005 0.0009
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0562 0.1559
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0076 0.0137
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.3603 1
Schistosoma mansoni zinc finger protein 0.0021 0.0062 0.0071
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0032 0.0088
Echinococcus granulosus dna polymerase kappa 0.0019 0.0032 0.0036
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0043 0.0078
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.1112 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0032 0.0057
Trichomonas vaginalis esterase, putative 0.0109 0.1112 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0032 0.0088
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0043 0.0065
Loa Loa (eye worm) hypothetical protein 0.004 0.0291 0.0526
Mycobacterium ulcerans lipase LipD 0.0109 0.1112 0.6085
Loa Loa (eye worm) hypothetical protein 0.0039 0.0273 0.0493
Brugia malayi Intermediate filament tail domain containing protein 0.0084 0.0811 0.1465
Plasmodium vivax vivapain-2 0.0017 0.0005 0.0019
Loa Loa (eye worm) hypothetical protein 0.0084 0.0811 0.1465
Entamoeba histolytica hypothetical protein 0.0111 0.1142 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0393 0.1091
Toxoplasma gondii cathepsin CPL 0.0017 0.0005 0.0019
Brugia malayi Bromodomain containing protein 0.0042 0.0307 0.0554
Echinococcus multilocularis cysteine protease 0.0017 0.0005 0.0005
Leishmania major DNA polymerase eta, putative 0.0019 0.0032 0.0088
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0775 0.0775
Loa Loa (eye worm) hypothetical protein 0.0109 0.1112 0.2008
Schistosoma mansoni ferritin 0.0052 0.0434 0.0493
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0123 0.1083
Plasmodium vivax ataxin-2 like protein, putative 0.0229 0.2551 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0562 0.1559
Echinococcus granulosus GPCR family 2 0.0081 0.0775 0.088
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0029 0.0033
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0341 0.0945
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0037 0.0067
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0103 0.1037 0.1037
Loa Loa (eye worm) TAR-binding protein 0.0253 0.284 0.513
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0088
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0042 0.0307 0.0556
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.1112 0.3085
Loa Loa (eye worm) hypothetical protein 0.0044 0.0338 0.0611
Brugia malayi hypothetical protein 0.0229 0.2551 0.4608
Trypanosoma cruzi ISWI complex protein 0.0017 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0109 0.1112 0.2008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0013

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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