Detailed information for compound 729405

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 404.483 | Formula: C19H24N4O4S
  • H donors: 1 H acceptors: 4 LogP: 1.76 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCS(=O)(=O)N1CCC(CC1)n1nccc1NC(=O)c1ccc(cc1)OC
  • InChi: 1S/C19H24N4O4S/c1-3-14-28(25,26)22-12-9-16(10-13-22)23-18(8-11-20-23)21-19(24)15-4-6-17(27-2)7-5-15/h3-8,11,16H,1,9-10,12-14H2,2H3,(H,21,24)
  • InChiKey: QNPNIDZZMTWWIM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ferritin 0.0061 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0026 0.0046 0.0069
Plasmodium falciparum cysteine proteinase falcipain 3 0.0054 0.0253 0.081
Toxoplasma gondii ABC1 family protein 0.0073 0.0396 0.1223
Onchocerca volvulus 0.0073 0.0396 0.1967
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0054 0.0253 0.081
Brugia malayi beta-lactamase family protein 0.0073 0.0396 0.0657
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0123 0.0123
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0396 0.1838
Mycobacterium tuberculosis Conserved protein 0.0073 0.0396 0.0308
Brugia malayi Smad1 0.0053 0.0248 0.0389
Brugia malayi beta-lactamase 0.0073 0.0396 0.0657
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.008 0.0445 0.0786
Plasmodium vivax SET domain protein, putative 0.0035 0.0113 0.0219
Trypanosoma cruzi cysteine peptidase, putative 0.0205 0.1363 0.5502
Echinococcus multilocularis geminin 0.0166 0.1073 0.1073
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.0253 0.0253
Brugia malayi MH1 domain containing protein 0.0053 0.0248 0.0389
Schistosoma mansoni intermediate filament proteins 0.0053 0.0247 0.0247
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0396 0.0396
Brugia malayi Ets-domain containing protein 0.008 0.0445 0.0745
Brugia malayi hypothetical protein 0.0149 0.0953 0.1662
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1363 0.5502
Schistosoma mansoni smad 0.0053 0.0248 0.0248
Brugia malayi hypothetical protein 0.0411 0.2872 0.5125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1363 0.5502
Loa Loa (eye worm) hypothetical protein 0.004 0.0153 0.0261
Echinococcus granulosus cathepsin l1 0.0036 0.0123 0.0123
Brugia malayi Cathepsin L-like precursor 0.0054 0.0253 0.0399
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0062 0.0053
Loa Loa (eye worm) hypothetical protein 0.0073 0.0396 0.0698
Loa Loa (eye worm) MH2 domain-containing protein 0.0779 0.5573 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0253 0.1051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0253 0.1051
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0032 0.0044
Schistosoma mansoni ferritin 0.0061 0.0304 0.0304
Onchocerca volvulus Cathepsin L homolog 0.0054 0.0253 0.1193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0123 0.0334
Brugia malayi MH1 domain containing protein 0.0029 0.0074 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0253 0.1051
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0113 0.0113
Schistosoma mansoni lamin 0.0053 0.0247 0.0247
Trypanosoma brucei PAB1-binding protein , putative 0.035 0.2426 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0021 0.0021
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.0253 0.0681
Echinococcus multilocularis GPCR, family 2 0.0031 0.0089 0.0089
Echinococcus multilocularis musashi 0.0053 0.0247 0.0247
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0253 0.1051
Brugia malayi Cathepsin L-like precursor 0.0036 0.0123 0.0163
Echinococcus granulosus lamin dm0 0.0053 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.0044
Entamoeba histolytica hypothetical protein 0.0411 0.2872 1
Brugia malayi Cathepsin L-like precursor 0.0054 0.0253 0.0399
Echinococcus multilocularis expressed protein 0.0061 0.0304 0.0304
Plasmodium vivax ataxin-2 like protein, putative 0.035 0.2426 1
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0396 0.1415
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0104 0.0104
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0396 0.0308
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0089 0.0089
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0089 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1363 0.5502
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0587 0.1001
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0046 0.0046
Trichomonas vaginalis esterase, putative 0.0073 0.0396 0.1838
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0054 0.0253 0.081
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.0253 0.081
Schistosoma mansoni hypothetical protein 0.0166 0.1073 0.1073
Schistosoma mansoni microtubule-associated protein tau 0.1382 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1363 0.5502
Loa Loa (eye worm) hypothetical protein 0.0155 0.0996 0.1776
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0253 0.1051
Schistosoma mansoni ferritin light chain 0.0061 0.0304 0.0304
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.0253 0.0253
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0089 0.0089
Schistosoma mansoni gabp alpha 0.008 0.0445 0.0445
Echinococcus multilocularis lamin dm0 0.0053 0.0247 0.0247
Entamoeba histolytica hypothetical protein 0.0411 0.2872 1
Loa Loa (eye worm) Smad1 0.0053 0.0248 0.0431
Echinococcus granulosus cathepsin L cysteine protease 0.0028 0.0062 0.0062
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0253 0.1051
Onchocerca volvulus 0.0054 0.0253 0.1193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1363 0.5502
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0067 0.0106
Brugia malayi Bromodomain containing protein 0.0038 0.0135 0.0186
Echinococcus granulosus mothers against decapentaplegic 2 0.0024 0.0032 0.0032
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0396 0.0308
Trypanosoma cruzi cysteine peptidase, putative 0.0205 0.1363 0.5502
Loa Loa (eye worm) hypothetical protein 0.0053 0.0247 0.043
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0396 0.1415
Schistosoma mansoni Smad4 0.0053 0.0248 0.0248
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1363 0.5502
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0396 0.1415
Brugia malayi MH1 domain containing protein 0.0029 0.0074 0.0075
Mycobacterium ulcerans hypothetical protein 0.0073 0.0396 1
Schistosoma mansoni lamin 0.0053 0.0247 0.0247
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0113 0.0113
Schistosoma mansoni Smad4 0.0024 0.0032 0.0032
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0067 0.0062
Loa Loa (eye worm) hypothetical protein 0.0099 0.0587 0.1041
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0396 0.0396
Echinococcus granulosus GPCR family 2 0.0031 0.0089 0.0089
Schistosoma mansoni smad 0.0024 0.0032 0.0032
Brugia malayi Cathepsin L-like precursor 0.0054 0.0253 0.0399
Brugia malayi beta-lactamase family protein 0.0073 0.0396 0.0657
Schistosoma mansoni ferritin light chain 0.0061 0.0304 0.0304
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0062 0.0062
Schistosoma mansoni smad1 5 8 and 0.0053 0.0248 0.0248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0253 0.1051
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0157 0.101 0.101
Treponema pallidum bacterioferrin (TpF1) 0.0061 0.0304 0.5
Echinococcus granulosus lamin 0.0053 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0068 0.036 0.0633
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0089 0.0146
Echinococcus granulosus cathepsin L cysteine proteinase 0.0054 0.0253 0.0253
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0411 0.2872 0.2872
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0801 0.5734 0.5734
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.0253 0.1051
Schistosoma mansoni hypothetical protein 0.0411 0.2872 0.2872
Plasmodium vivax vivapain-2 0.0054 0.0253 0.081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1363 0.5502
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.0253 0.0399
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0061 0.0304 0.5
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0396 0.0308
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0237 0.0237
Schistosoma mansoni hypothetical protein 0.0166 0.1073 0.1073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0123 0.0334
Entamoeba histolytica hypothetical protein 0.0411 0.2872 1
Onchocerca volvulus 0.0036 0.0123 0.0488
Onchocerca volvulus 0.0054 0.0253 0.1193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1363 0.5502
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0253 0.1051
Schistosoma mansoni hypothetical protein 0.0031 0.0089 0.0089
Echinococcus granulosus mothers against decapentaplegic 5 0.0053 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0149 0.0953 0.1699
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0396 0.0657
Echinococcus granulosus geminin 0.0166 0.1073 0.1073
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0396 0.0308
Echinococcus multilocularis Smad4 0.0053 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0056
Plasmodium vivax vivapain-2 0.0054 0.0253 0.081
Loa Loa (eye worm) hypothetical protein 0.035 0.2426 0.4346
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0396 1
Echinococcus granulosus intermediate filament protein 0.0053 0.0247 0.0247
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.0253 0.0681
Trypanosoma cruzi cysteine peptidase, putative 0.0205 0.1363 0.5502
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.029 0.029
Schistosoma mansoni hypothetical protein 0.0031 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0253 0.1051
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0412
Loa Loa (eye worm) hypothetical protein 0.0042 0.0167 0.0286
Schistosoma mansoni hypothetical protein 0.002 0.0008 0.0008
Loa Loa (eye worm) MH1 domain-containing protein 0.0053 0.0248 0.0431
Loa Loa (eye worm) fli-1 protein 0.0243 0.164 0.2933
Onchocerca volvulus 0.0054 0.0253 0.1193
Onchocerca volvulus 0.0054 0.0253 0.1193
Echinococcus multilocularis ferritin 0.0061 0.0304 0.0304
Echinococcus granulosus GA binding protein alpha chain 0.008 0.0445 0.0445
Echinococcus multilocularis cysteine protease 0.0054 0.0253 0.0253
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0157 0.101 0.101
Loa Loa (eye worm) hypothetical protein 0.0054 0.0253 0.0441
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0123 0.0217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0253 0.1051
Echinococcus multilocularis lamin 0.0053 0.0247 0.0247
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0396 0.1838
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0089 0.0089
Brugia malayi Pre-SET motif family protein 0.0242 0.1637 0.2896
Loa Loa (eye worm) MH2 domain-containing protein 0.0053 0.0248 0.0431
Schistosoma mansoni ferritin 0.0061 0.0304 0.0304
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1363 0.5502
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0247 0.043
Toxoplasma gondii cathepsin CPL 0.0054 0.0253 0.0604
Brugia malayi MH2 domain containing protein 0.0053 0.0248 0.0389
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.029 0.029
Echinococcus multilocularis mothers against decapentaplegic 2 0.0024 0.0032 0.0032
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0396 0.1838
Onchocerca volvulus 0.0073 0.0396 0.1967
Loa Loa (eye worm) hypothetical protein 0.0073 0.0396 0.0698
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0237 0.0237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1363 0.5502
Onchocerca volvulus 0.0155 0.0996 0.5209
Brugia malayi MH2 domain containing protein 0.0053 0.0248 0.0389
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0396 0.1838
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0253 0.1051
Echinococcus multilocularis tumor protein p63 0.1059 0.7633 0.7633
Schistosoma mansoni smad1 5 8 and 0.0053 0.0248 0.0248
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0396 0.1838
Loa Loa (eye worm) nuclear factor I 0.0029 0.0074 0.0119
Brugia malayi Pre-SET motif family protein 0.0035 0.0113 0.0146
Leishmania major cathepsin L-like protease 0.0205 0.1363 0.5106
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0062 0.0053
Brugia malayi PHD-finger family protein 0.0025 0.0039 0.0011
Loa Loa (eye worm) hypothetical protein 0.0073 0.0396 0.0698
Onchocerca volvulus 0.0276 0.1883 1
Brugia malayi MH1 domain containing protein 0.0053 0.0248 0.0389
Brugia malayi Cathepsin L-like precursor 0.0036 0.0123 0.0163
Plasmodium falciparum ataxin-2 like protein, putative 0.035 0.2426 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0253 0.1051
Loa Loa (eye worm) hypothetical protein 0.0052 0.024 0.0417
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1363 0.5502
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0396 0.0396
Brugia malayi Cathepsin L-like precursor 0.0054 0.0253 0.0399
Leishmania major cathepsin L-like protease 0.0205 0.1363 0.5106
Brugia malayi Cathepsin L-like precursor 0.0054 0.0253 0.0399
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0253 0.1051
Mycobacterium ulcerans lipase LipD 0.0073 0.0396 1
Schistosoma mansoni Smad4 0.0024 0.0032 0.0032
Onchocerca volvulus 0.0053 0.0247 0.116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0253 0.1051
Brugia malayi Ets-domain containing protein 0.008 0.0445 0.0745
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0468 0.3296 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0161 0.1041 0.414
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0253 0.1051
Leishmania major hypothetical protein, conserved 0.035 0.2426 1
Brugia malayi MH2 domain containing protein 0.0779 0.5573 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0136 0.0231
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0187 0.1232 0.495
Trypanosoma cruzi cruzipain precursor, putative 0.0205 0.1363 0.5502
Schistosoma mansoni ferritin 0.0061 0.0304 0.0304
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0253 0.1051
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0118 0.0118
Echinococcus granulosus mothers against decapentaplegic 6 0.0024 0.0032 0.0032
Echinococcus granulosus cathepsin l cysteine peptidase 0.0054 0.0253 0.0253
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0253 0.1051
Entamoeba histolytica hypothetical protein 0.0411 0.2872 1
Mycobacterium ulcerans beta-lactamase 0.0073 0.0396 1
Schistosoma mansoni ferritin 0.0061 0.0304 0.0304
Trichomonas vaginalis ferritin, putative 0.0061 0.0304 0.1331
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0247 0.0387
Loa Loa (eye worm) hypothetical protein 0.0073 0.0396 0.0698
Loa Loa (eye worm) hypothetical protein 0.0036 0.0123 0.0207
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0253 0.1051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0253 0.1051
Schistosoma mansoni hypothetical protein 0.0031 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0253 0.1051
Trypanosoma cruzi PAB1-binding protein , putative 0.035 0.2426 1
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0396 0.1415
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0396 0.0396
Brugia malayi Fli-1 protein 0.0243 0.164 0.2901
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0356 0.0585
Loa Loa (eye worm) hypothetical protein 0.0036 0.0123 0.0207
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0021 0.0021
Echinococcus granulosus TGF beta signal transducer SmadC 0.0053 0.0248 0.0248
Entamoeba histolytica cysteine protease, putative 0.0054 0.0253 0.0681
Echinococcus granulosus expressed protein 0.0061 0.0304 0.0304
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0089 0.0102
Onchocerca volvulus 0.0053 0.0247 0.116
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0062 0.0062
Mycobacterium tuberculosis Conserved protein 0.0073 0.0396 0.0308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0253 0.1051
Loa Loa (eye worm) hypothetical protein 0.0068 0.0356 0.0627
Onchocerca volvulus 0.0035 0.0113 0.0438
Toxoplasma gondii LsmAD domain-containing protein 0.035 0.2426 1
Echinococcus granulosus smad 0.0053 0.0248 0.0248
Echinococcus granulosus cysteine protease 0.0028 0.0062 0.0062
Echinococcus granulosus Smad4 0.0053 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0056
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0396 1
Echinococcus granulosus cathepsin l1 0.0054 0.0253 0.0253
Brugia malayi intermediate filament protein 0.0053 0.0247 0.0387
Echinococcus multilocularis microtubule associated protein 2 0.1382 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.0253 0.0441
Onchocerca volvulus 0.0054 0.0253 0.1193
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0053 0.0248 0.0248
Plasmodium falciparum ataxin-2 like protein, putative 0.035 0.2426 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0074 0.0119
Echinococcus multilocularis smad 0.0053 0.0248 0.0248
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0237 0.0237
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0242 0.1637 0.2928
Echinococcus multilocularis cysteine protease 0.0054 0.0253 0.0253
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0396 0.0308
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0054 0.0253 0.0441
Schistosoma mansoni hypothetical protein 0.0031 0.0089 0.0089
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0396 0.0308
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0053 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0146
Schistosoma mansoni cellular tumor antigen P53 0.0155 0.0996 0.0996
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0587 0.1041
Schistosoma mansoni bromodomain containing protein 0.0062 0.0316 0.0316
Echinococcus multilocularis mothers against decapentaplegic 6 0.0024 0.0032 0.0032
Brugia malayi Bromodomain containing protein 0.0074 0.0401 0.0665
Brugia malayi cathepsin L-like precursor 0.0036 0.0123 0.0163
Brugia malayi hypothetical protein 0.0226 0.1516 0.2678
Schistosoma mansoni ets-related 0.0243 0.164 0.164
Onchocerca volvulus 0.0073 0.0396 0.1967
Mycobacterium tuberculosis Conserved protein 0.0073 0.0396 0.0308
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0253 0.1051
Schistosoma mansoni smad1 5 8 and 0.0053 0.0248 0.0248
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0089 0.0102
Trichomonas vaginalis set domain proteins, putative 0.0276 0.1883 1
Loa Loa (eye worm) hypothetical protein 0.007 0.037 0.0651
Leishmania major hypothetical protein, conserved 0.0073 0.0396 0.0659
Mycobacterium leprae Probable lipase LipE 0.0073 0.0396 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0036 0.0123 0.0163
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0157 0.101 0.101
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0396 0.0698
Loa Loa (eye worm) hypothetical protein 0.0036 0.0123 0.0207
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0396 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0113 0.0113
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.0253 0.0253
Onchocerca volvulus Cathepsin F homolog 0.0054 0.0253 0.1193
Loa Loa (eye worm) ctsf protein 0.0054 0.0253 0.0441
Onchocerca volvulus Cathepsin L homolog 0.0054 0.0253 0.1193
Onchocerca volvulus 0.0149 0.0953 0.4976
Loa Loa (eye worm) fibroinase 0.0054 0.0253 0.0441
Loa Loa (eye worm) cysteine protease 0.0054 0.0253 0.0441
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0032 0.0044
Schistosoma mansoni hypothetical protein 0.0068 0.0356 0.0356
Echinococcus granulosus tumor protein p63 0.1059 0.7633 0.7633
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0073 0.0396 0.0698
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.0253 0.1051
Brugia malayi Cathepsin L-like precursor 0.0054 0.0253 0.0399
Echinococcus multilocularis GA binding protein alpha chain 0.008 0.0445 0.0445
Trypanosoma cruzi PAB1-binding protein , putative 0.035 0.2426 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0411 0.2872 0.2872
Brugia malayi hypothetical protein 0.035 0.2426 0.432
Onchocerca volvulus 0.0054 0.0253 0.1193
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0247 0.043
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0587 0.1001
Echinococcus multilocularis mothers against decapentaplegic 5 0.0053 0.0248 0.0248
Loa Loa (eye worm) transcription factor SMAD2 0.0779 0.5573 1
Schistosoma mansoni apoferritin-2 0.0061 0.0304 0.0304
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.0253 0.0253
Leishmania major cathepsin L-like protease 0.0205 0.1363 0.5106
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.0253 0.0253
Schistosoma mansoni transcription factor LCR-F1 0.0411 0.2872 0.2872
Echinococcus multilocularis cathepsin L 0.0028 0.0062 0.0062
Onchocerca volvulus 0.0054 0.0253 0.1193
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0062 0.0062
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0118 0.0118
Loa Loa (eye worm) beta-lactamase 0.0073 0.0396 0.0698
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0396 0.0308
Loa Loa (eye worm) hypothetical protein 0.0073 0.0396 0.0698
Echinococcus granulosus cathepsin L 0.0028 0.0062 0.0062
Schistosoma mansoni apoferritin-2 0.0061 0.0304 0.0304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0253 0.1051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0237 0.0237

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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