Detailed information for compound 729460

Basic information

Technical information
  • TDR Targets ID: 729460
  • Name: N-(3,4-dimethylphenyl)-1-ethylsulfonylpiperid ine-3-carboxamide
  • MW: 324.438 | Formula: C16H24N2O3S
  • H donors: 1 H acceptors: 3 LogP: 1.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCS(=O)(=O)N1CCCC(C1)C(=O)Nc1ccc(c(c1)C)C
  • InChi: 1S/C16H24N2O3S/c1-4-22(20,21)18-9-5-6-14(11-18)16(19)17-15-8-7-12(2)13(3)10-15/h7-8,10,14H,4-6,9,11H2,1-3H3,(H,17,19)
  • InChiKey: DXRWZAJNWRMANU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3,4-dimethylphenyl)-1-ethylsulfonyl-piperidine-3-carboxamide
  • N-(3,4-dimethylphenyl)-1-ethylsulfonyl-3-piperidinecarboxamide
  • N-(3,4-dimethylphenyl)-1-ethylsulfonyl-nipecotamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH2 domain containing protein 0.0016 0.0018 0.0037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0666 0.0856
Loa Loa (eye worm) hypothetical protein 0.0026 0.025 0.0498
Loa Loa (eye worm) Smad1 0.0016 0.0018 0.0037
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.5023 1
Brugia malayi chromobox protein homolog 3 0.0038 0.0518 0.1031
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0032 0.0041
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0032 0.0063
Echinococcus multilocularis Smad4 0.0016 0.0018 0.0024
Echinococcus multilocularis thioredoxin glutathione reductase 0.0092 0.1757 0.2259
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0666 0.1046
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.1272 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.037 0.0476
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0998 0.6917
Schistosoma mansoni hypothetical protein 0.0109 0.2136 0.3357
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0092 0.1757 0.143
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0382 0.5
Echinococcus granulosus smad 0.0016 0.0018 0.0024
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.005
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0382 0.2173
Mycobacterium tuberculosis Conserved protein 0.0071 0.1272 0.0926
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0188 0.0375
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.2136 0.2747
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.021 0.4453 0.4233
Echinococcus granulosus GPCR family 2 0.0017 0.0032 0.0041
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.1272 0.0926
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.5023 1
Brugia malayi intermediate filament protein 0.0026 0.025 0.0498
Schistosoma mansoni hypothetical protein 0.0132 0.2679 0.421
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.1272 0.1636
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.1196 0.2381
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0583 0.0626
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0382 0.2173
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0233 0.4988 1
Trichomonas vaginalis esterase, putative 0.0071 0.1272 0.1981
Schistosoma mansoni hypothetical protein 0.0164 0.3406 0.5353
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1272 0.1999
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0382 0.2173
Entamoeba histolytica hypothetical protein 0.0109 0.2136 1
Plasmodium vivax hypothetical protein, conserved 0.0071 0.1272 0.7241
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0382 0.2173
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1272 0.1981
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0216 0.1229
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.1272 0.0926
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0382 0.5
Brugia malayi glutathione reductase 0.0092 0.1757 0.3498
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.005
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0132 0.2679 0.3445
Brugia malayi beta-lactamase 0.0071 0.1272 0.2533
Loa Loa (eye worm) hypothetical protein 0.0071 0.1272 0.2533
Echinococcus multilocularis smad 0.0016 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.0038 0.0518 0.1031
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.1272 0.1636
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0851 0.1694
Schistosoma mansoni intermediate filament proteins 0.0026 0.025 0.0393
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1272 0.1981
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0382 0.076
Mycobacterium ulcerans hypothetical protein 0.0071 0.1272 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0382 0.2173
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.1272 1
Brugia malayi MH2 domain containing protein 0.0016 0.0018 0.0037
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0018 0.0029
Schistosoma mansoni lamin 0.0026 0.025 0.0393
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0666 0.1046
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0998 0.5679
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0018 0.0024
Leishmania major trypanothione reductase 0.0092 0.1757 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.021 0.4453 0.4233
Brugia malayi MH1 domain containing protein 0.0016 0.0018 0.0037
Echinococcus multilocularis tumor protein p63 0.0355 0.7777 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0018 0.0029
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0998 0.1283
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.043
Loa Loa (eye worm) hypothetical protein 0.008 0.1482 0.2951
Brugia malayi hypothetical protein 0.0025 0.0216 0.043
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0851 0.1694
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0382 0.2173
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0216 0.1229
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0382 0.0491
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.1272 0.0926
Entamoeba histolytica hypothetical protein 0.0109 0.2136 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.021 0.4453 0.4233
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0955 0.1229
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0382 0.2173
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.037 0.0582
Echinococcus multilocularis GPCR, family 2 0.0017 0.0032 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0666 0.0856
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0216 0.1229
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1272 0.1981
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0382 0.06
Echinococcus multilocularis lamin 0.0026 0.025 0.0321
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0132 0.2679 0.3445
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0583 0.0626
Loa Loa (eye worm) glutathione reductase 0.0092 0.1757 0.3498
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0382 0.2173
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.037 0.0476
Echinococcus multilocularis chromobox protein 1 0.0067 0.1196 0.1538
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.1272 0.0926
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0666 0.1326
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1272 0.1981
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0382 0.2173
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0032 0.0063
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0382 0.2173
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0188 0.0375
Plasmodium falciparum thioredoxin reductase 0.0032 0.0382 0.2173
Echinococcus granulosus geminin 0.0164 0.3406 0.438
Schistosoma mansoni chromobox protein 0.0067 0.1196 0.1879
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0382 0.2173
Loa Loa (eye worm) hypothetical protein 0.0052 0.0842 0.1676
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.1272 0.2533
Mycobacterium tuberculosis Probable reductase 0.021 0.4453 0.4233
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0382 0.2173
Brugia malayi beta-lactamase family protein 0.0071 0.1272 0.2533
Mycobacterium ulcerans lipase LipD 0.0071 0.1272 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.0071 0.1272 0.2533
Plasmodium vivax glutathione reductase, putative 0.0092 0.1757 1
Mycobacterium ulcerans beta-lactamase 0.0071 0.1272 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1272 0.2533
Brugia malayi hypothetical protein 0.0109 0.2136 0.4252
Brugia malayi Smad1 0.0016 0.0018 0.0037
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.005
Brugia malayi MH1 domain containing protein 0.0016 0.0018 0.0037
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0216 0.1229
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.005
Echinococcus granulosus lamin dm0 0.0026 0.025 0.0321
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0998 0.5679
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0998 0.064
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.4656 0.927
Plasmodium falciparum thioredoxin reductase 0.0092 0.1757 1
Onchocerca volvulus 0.0052 0.0842 0.1161
Mycobacterium tuberculosis Conserved protein 0.0071 0.1272 0.0926
Plasmodium falciparum glutathione reductase 0.0032 0.0382 0.2173
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.2136 0.2747
Brugia malayi beta-lactamase family protein 0.0071 0.1272 0.2533
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0216 0.1229
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0382 0.2173
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.025 0.0498
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.025 0.0498
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.1272 0.7241
Echinococcus multilocularis chromobox protein 1 0.0067 0.1196 0.1538
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0842 0.1323
Trichomonas vaginalis chromobox protein, putative 0.0067 0.1196 0.1831
Echinococcus multilocularis musashi 0.0026 0.025 0.0321
Loa Loa (eye worm) hypothetical protein 0.0026 0.0239 0.0476
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.1272 0.0926
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0382 0.023
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0032 0.0041
Plasmodium vivax thioredoxin reductase, putative 0.0092 0.1757 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0382 0.2173
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1272 0.7241
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0851 0.1694
Mycobacterium tuberculosis Probable dehydrogenase 0.021 0.4453 0.4233
Brugia malayi Heterochromatin protein 1 0.0067 0.1196 0.2381
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0382 0.023
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0666 0.1326
Schistosoma mansoni Smad4 0.0016 0.0018 0.0029
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0998 0.6917
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0382 0.2173
Echinococcus granulosus thioredoxin glutathione reductase 0.0092 0.1757 0.2259
Loa Loa (eye worm) thioredoxin reductase 0.0092 0.1757 0.3498
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0955 0.1229
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0955 0.1229
Treponema pallidum NADH oxidase 0.0032 0.0382 0.5
Loa Loa (eye worm) hypothetical protein 0.0071 0.1272 0.2533
Echinococcus multilocularis thyroid hormone receptor alpha 0.0143 0.2922 0.3758
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0018 0.0037
Schistosoma mansoni thyroid hormone receptor 0.0143 0.2922 0.4592
Echinococcus granulosus Smad4 0.0016 0.0018 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0518 0.0497
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0382 0.2173
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0216 0.1229
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0382 0.2173
Loa Loa (eye worm) hypothetical protein 0.0071 0.1272 0.2533
Loa Loa (eye worm) hypothetical protein 0.0036 0.0472 0.0939
Onchocerca volvulus 0.0249 0.5348 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0955 0.1229
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.2136 0.3357
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1272 0.1999
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0666 0.1046
Entamoeba histolytica hypothetical protein 0.0109 0.2136 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0382 0.2173
Onchocerca volvulus 0.0042 0.0623 0.0732
Mycobacterium tuberculosis Probable oxidoreductase 0.0233 0.4988 0.479
Brugia malayi jmjC domain containing protein 0.0057 0.0955 0.1902
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.037 0.2108
Loa Loa (eye worm) hypothetical protein 0.0071 0.1272 0.2533
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0382 0.5
Plasmodium falciparum glutathione reductase 0.0092 0.1757 1
Trichomonas vaginalis chromobox protein, putative 0.0067 0.1196 0.1831
Brugia malayi jmjC domain containing protein 0.0057 0.0955 0.1902
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0955 0.1501
Brugia malayi Thioredoxin reductase 0.0092 0.1757 0.3498
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.1272 0.0926
Trypanosoma brucei trypanothione reductase 0.0092 0.1757 1
Trypanosoma cruzi trypanothione reductase, putative 0.0092 0.1757 1
Schistosoma mansoni hypothetical protein 0.0164 0.3406 0.5353
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0666 0.0856
Loa Loa (eye worm) hypothetical protein 0.0031 0.037 0.0737
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0032 0.0063
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0018 0.0024
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0018 0.0037
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0382 0.2173
Leishmania major hypothetical protein, conserved 0.0071 0.1272 0.7241
Trichomonas vaginalis set domain proteins, putative 0.0249 0.5348 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0998 0.1283
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.1272 0.0926
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.037 0.0582
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0955 0.1501
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0955 0.1501
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1272 0.1981
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1272 0.7241
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.021 0.4453 0.8559
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0233 0.4988 0.479
Schistosoma mansoni smad1 5 8 and 0.0016 0.0018 0.0029
Echinococcus granulosus chromobox protein 1 0.0067 0.1196 0.1538
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.1272 0.2533
Echinococcus granulosus lamin 0.0026 0.025 0.0321
Plasmodium vivax SET domain protein, putative 0.0031 0.037 0.2108
Onchocerca volvulus 0.003 0.0331 0.0159
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0623 0.0979
Schistosoma mansoni thyroid hormone receptor 0.0143 0.2922 0.4592
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.037 0.0476
Brugia malayi Pre-SET motif family protein 0.0219 0.4656 0.927
Brugia malayi hypothetical protein 0.0016 0.0016 0.0032
Echinococcus multilocularis geminin 0.0164 0.3406 0.438
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0382 0.2173
Echinococcus granulosus tumor protein p63 0.0355 0.7777 1
Schistosoma mansoni chromobox protein 0.0067 0.1196 0.1879
Onchocerca volvulus 0.0071 0.1272 0.2005
Onchocerca volvulus 0.0071 0.1272 0.2005
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0344 0.0442
Loa Loa (eye worm) hypothetical protein 0.0052 0.0851 0.1694
Echinococcus granulosus intermediate filament protein 0.0026 0.025 0.0321
Echinococcus multilocularis lamin dm0 0.0026 0.025 0.0321
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0666 0.0856
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0032 0.0041
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0583 0.0654
Toxoplasma gondii ABC1 family protein 0.0071 0.1272 0.7241
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0472 0.0939
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0998 0.1568
Echinococcus granulosus chromobox protein 1 0.0067 0.1196 0.1538
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0955 0.1902
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0382 0.2173
Schistosoma mansoni hypothetical protein 0.0036 0.0472 0.0742
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0998 0.6917
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.021 0.4453 0.4233
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0382 0.0491
Loa Loa (eye worm) hypothetical protein 0.003 0.0331 0.0659
Loa Loa (eye worm) beta-lactamase 0.0071 0.1272 0.2533
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0018 0.0024
Schistosoma mansoni lamin 0.0026 0.025 0.0393
Loa Loa (eye worm) intermediate filament protein 0.0026 0.025 0.0498
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0233 0.4988 0.479
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.037 0.0582
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0998 0.1568
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0382 0.2173
Brugia malayi MH2 domain containing protein 0.0235 0.5023 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0382 0.5
Schistosoma mansoni smad1 5 8 and 0.0016 0.0018 0.0029
Toxoplasma gondii thioredoxin reductase 0.0092 0.1757 1
Leishmania major hypothetical protein, conserved 0.0025 0.0216 0.1229
Mycobacterium tuberculosis Conserved protein 0.0071 0.1272 0.0926
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0216 0.1229
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0063
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0382 0.2173
Schistosoma mansoni smad 0.0016 0.0018 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0518 0.0497
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0032 0.0041
Brugia malayi Pre-SET motif family protein 0.0031 0.037 0.0737
Entamoeba histolytica hypothetical protein 0.0109 0.2136 1
Onchocerca volvulus 0.0071 0.1272 0.2005
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0518 0.0525

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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