Detailed information for compound 729466

Basic information

Technical information
  • TDR Targets ID: 729466
  • Name: N-[4-(4-acetylpiperazin-1-yl)-3-chlorophenyl] -4-ethoxybenzamide
  • MW: 401.887 | Formula: C21H24ClN3O3
  • H donors: 1 H acceptors: 2 LogP: 3.12 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)C(=O)Nc1ccc(c(c1)Cl)N1CCN(CC1)C(=O)C
  • InChi: 1S/C21H24ClN3O3/c1-3-28-18-7-4-16(5-8-18)21(27)23-17-6-9-20(19(22)14-17)25-12-10-24(11-13-25)15(2)26/h4-9,14H,3,10-13H2,1-2H3,(H,23,27)
  • InChiKey: SHWJLGBFUAZPTK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-(4-acetylpiperazin-1-yl)-3-chloro-phenyl]-4-ethoxy-benzamide
  • N-[4-(4-acetyl-1-piperazinyl)-3-chlorophenyl]-4-ethoxybenzamide
  • N-[3-chloro-4-(4-ethanoylpiperazin-1-yl)phenyl]-4-ethoxy-benzamide
  • BAS 11781118
  • N-[4-(4-Acetyl-piperazin-1-yl)-3-chloro-phenyl]-4-ethoxy-benzamide
  • ZINC04412810
  • STK294732

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi mothers against decapentaplegic homolog 3 0.0024 0.0044 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0133 0.0671
Schistosoma mansoni lamin 0.008 0.0449 0.0449
Brugia malayi Cathepsin L-like precursor 0.0054 0.0263 0.0471
Echinococcus granulosus tumor protein p63 0.1062 0.76 0.7598
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0263 0.1359
Loa Loa (eye worm) hypothetical protein 0.008 0.0449 0.0805
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0053 0.0259 0.0259
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0168 0.1095 0.1089
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0044 0.0079
Brugia malayi hypothetical protein 0.0242 0.1633 0.2928
Brugia malayi MH2 domain containing protein 0.0053 0.0259 0.0465
Echinococcus multilocularis lamin 0.008 0.0449 0.0443
Brugia malayi MH2 domain containing protein 0.0053 0.0259 0.0465
Echinococcus granulosus geminin 0.0331 0.228 0.2275
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0408 0.0731
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0006 0.0024
Entamoeba histolytica cysteine protease, putative 0.0028 0.0072 0.0231
Loa Loa (eye worm) nuclear factor I 0.003 0.0085 0.0153
Leishmania major cathepsin L-like protease 0.0205 0.1366 0.524
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0125 0.0458
Echinococcus granulosus GPCR family 2 0.0047 0.021 0.0204
Loa Loa (eye worm) MH1 domain-containing protein 0.0053 0.0259 0.0465
Schistosoma mansoni ferritin 0.0061 0.0314 0.0314
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.021 0.0204
Echinococcus multilocularis mothers against decapentaplegic 6 0.0024 0.0044 0.0038
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0302 0.0295
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0168 0.1095 0.1089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0125 0.0125
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.0263 0.0896
Schistosoma mansoni gabp alpha 0.0081 0.0456 0.0456
Leishmania major hypothetical protein, conserved 0.0074 0.0408 0.1547
Echinococcus granulosus mothers against decapentaplegic 6 0.0024 0.0044 0.0038
Schistosoma mansoni lamin 0.008 0.0449 0.0449
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0408 0.1567
Echinococcus multilocularis cathepsin L 0.0028 0.0072 0.0066
Schistosoma mansoni bromodomain containing protein 0.0063 0.0327 0.0327
Loa Loa (eye worm) Smad1 0.0053 0.0259 0.0465
Loa Loa (eye worm) cysteine protease 0.0054 0.0263 0.0471
Entamoeba histolytica cysteine proteinase 1, putative 0.0028 0.0072 0.0231
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0244 0.1647 0.2953
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0408 0.1547
Plasmodium falciparum cysteine proteinase falcipain 3 0.0054 0.0263 0.0988
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.0263 0.101
Loa Loa (eye worm) hypothetical protein 0.0297 0.2031 0.364
Onchocerca volvulus 0.008 0.0449 0.2038
Loa Loa (eye worm) hypothetical protein 0.0038 0.0147 0.0264
Onchocerca volvulus Cathepsin L homolog 0.0054 0.0263 0.1101
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0072 0.0279
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.021 0.0377
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0061 0.0314 0.0932
Mycobacterium leprae Probable lipase LipE 0.0074 0.0408 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1366 0.524
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1366 0.524
Echinococcus granulosus mothers against decapentaplegic 5 0.0053 0.0259 0.0253
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0019 0.0035
Loa Loa (eye worm) transcription factor SMAD2 0.0784 0.5579 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0375 0.2601 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0061 0.0314 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.0263 0.1359
Schistosoma mansoni zinc finger protein 0.0019 0.0012 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0248 0.0248
Echinococcus granulosus intermediate filament protein 0.008 0.0449 0.0443
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0054 0.0263 0.0988
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.0079
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0408 0.1217
Schistosoma mansoni smad 0.0024 0.0044 0.0044
Mycobacterium tuberculosis Conserved protein 0.0074 0.0408 0.1217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0263 0.1359
Entamoeba histolytica hypothetical protein 0.0412 0.2868 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0438 0.0786
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0072 0.0255
Leishmania major cathepsin L-like protease 0.0205 0.1366 0.524
Onchocerca volvulus Cathepsin L homolog 0.0054 0.0263 0.1101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0263 0.1359
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1366 0.524
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0408 0.1567
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0072 0.035
Echinococcus multilocularis smad 0.0053 0.0259 0.0253
Schistosoma mansoni apoferritin-2 0.0061 0.0314 0.0314
Entamoeba histolytica cysteine protease, putative 0.0028 0.0072 0.0231
Entamoeba histolytica cysteine proteinase 2 0.0028 0.0072 0.0231
Plasmodium vivax ataxin-2 like protein, putative 0.0375 0.2601 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0248 0.0242
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0263 0.1359
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1366 0.524
Schistosoma mansoni hypothetical protein 0.002 0.0019 0.0019
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.3304 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0605 0.1084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0263 0.1359
Plasmodium vivax vivapain-2 0.0054 0.0263 0.101
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0072 0.013
Loa Loa (eye worm) intermediate filament protein 0.008 0.0449 0.0805
Trichomonas vaginalis ferritin, putative 0.0061 0.0314 0.1629
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0006 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.0408 0.0731
Onchocerca volvulus Cathepsin F homolog 0.0054 0.0263 0.1101
Brugia malayi hypothetical protein 0.0297 0.2031 0.364
Schistosoma mansoni Smad4 0.0053 0.0259 0.0259
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.0263 0.0896
Brugia malayi Cathepsin L-like precursor 0.0036 0.0133 0.0238
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0263 0.1359
Plasmodium falciparum ataxin-2 like protein, putative 0.0375 0.2601 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0033 0.0033
Schistosoma mansoni smad1 5 8 and 0.0053 0.0259 0.0259
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0263 0.1359
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0408 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0944 0.1693
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0006 0.0024
Schistosoma mansoni hypothetical protein 0.0168 0.1095 0.1095
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.004 0.0165 0.0295
Schistosoma mansoni smad1 5 8 and 0.0053 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0074 0.0408 0.0731
Onchocerca volvulus 0.0036 0.0133 0.0448
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0061 0.0314 0.0932
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0263 0.1359
Brugia malayi Cathepsin L-like precursor 0.0054 0.0263 0.0471
Entamoeba histolytica cysteine protease, putative 0.0028 0.0072 0.0231
Schistosoma mansoni hypothetical protein 0.0047 0.021 0.021
Schistosoma mansoni hypothetical protein 0.0331 0.228 0.228
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0408 0.1217
Loa Loa (eye worm) hypothetical protein 0.0074 0.0408 0.0731
Mycobacterium tuberculosis Conserved protein 0.0074 0.0408 0.1217
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.0263 0.0257
Brugia malayi hypothetical protein 0.0375 0.2601 0.4663
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0038 0.015 0.0143
Schistosoma mansoni ap endonuclease 0.0019 0.0006 0.0006
Brugia malayi PHD-finger family protein 0.0025 0.005 0.009
Loa Loa (eye worm) hypothetical protein 0.0054 0.0263 0.0471
Echinococcus multilocularis microtubule associated protein 2 0.1391 1 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0053 0.0259 0.0253
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0408 0.0731
Loa Loa (eye worm) hypothetical protein 0.003 0.0085 0.0153
Leishmania major cathepsin L-like protease 0.0054 0.0263 0.0988
Leishmania major cathepsin L-like protease 0.0054 0.0263 0.0988
Brugia malayi Pre-SET motif family protein 0.0035 0.0125 0.0224
Trypanosoma brucei PAB1-binding protein , putative 0.0375 0.2601 1
Echinococcus multilocularis GPCR, family 2 0.0047 0.021 0.0204
Brugia malayi beta-lactamase 0.0074 0.0408 0.0731
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0263 0.1359
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0133 0.0671
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0408 0.0408
Brugia malayi Cathepsin L-like precursor 0.0054 0.0263 0.0471
Loa Loa (eye worm) hypothetical protein 0.0042 0.0178 0.032
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0408 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0238
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0263 0.1359
Schistosoma mansoni hypothetical protein 0.0412 0.2868 0.2868
Brugia malayi cathepsin L-like precursor 0.0036 0.0133 0.0238
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0054 0.0263 0.0471
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1366 0.524
Toxoplasma gondii ABC1 family protein 0.0074 0.0408 0.1547
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.0263 0.0257
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0944 0.1693
Brugia malayi MH2 domain containing protein 0.0784 0.5579 1
Toxoplasma gondii cathepsin CPL 0.0054 0.0263 0.0988
Echinococcus multilocularis zinc finger protein 0.0019 0.0012 0.0005
Echinococcus granulosus cathepsin L cysteine proteinase 0.0054 0.0263 0.0257
Schistosoma mansoni ferritin 0.0061 0.0314 0.0314
Toxoplasma gondii LsmAD domain-containing protein 0.0375 0.2601 1
Schistosoma mansoni transcription factor LCR-F1 0.0412 0.2868 0.2868
Plasmodium falciparum ataxin-2 like protein, putative 0.0375 0.2601 1
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0605 0.1084
Echinococcus multilocularis cysteine protease 0.0054 0.0263 0.0257
Schistosoma mansoni apoferritin-2 0.0061 0.0314 0.0314
Echinococcus granulosus TGF beta signal transducer SmadC 0.0053 0.0259 0.0253
Echinococcus multilocularis ferritin 0.0061 0.0314 0.0307
Loa Loa (eye worm) hypothetical protein 0.007 0.0381 0.0683
Onchocerca volvulus 0.0035 0.0125 0.0408
Loa Loa (eye worm) hypothetical protein 0.0074 0.0408 0.0731
Echinococcus granulosus lamin 0.008 0.0449 0.0443
Onchocerca volvulus 0.008 0.0449 0.2038
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.021 0.0204
Brugia malayi Ets-domain containing protein 0.0081 0.0456 0.0818
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0188 0.1236 0.4752
Echinococcus multilocularis GA binding protein alpha chain 0.0081 0.0456 0.045
Echinococcus granulosus Smad4 0.0053 0.0259 0.0253
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0408 0.1217
Loa Loa (eye worm) hypothetical protein 0.0047 0.021 0.0377
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0408 0.1567
Mycobacterium tuberculosis Conserved protein 0.0074 0.0408 0.1217
Loa Loa (eye worm) hypothetical protein 0.0037 0.0139 0.0249
Schistosoma mansoni hypothetical protein 0.0331 0.228 0.228
Entamoeba histolytica cysteine protease, putative 0.0028 0.0072 0.0231
Plasmodium vivax vivapain-2 0.0054 0.0263 0.101
Loa Loa (eye worm) hypothetical protein 0.0074 0.0408 0.0731
Loa Loa (eye worm) ctsf protein 0.0054 0.0263 0.0471
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0408 0.0408
Onchocerca volvulus 0.0297 0.2031 1
Onchocerca volvulus 0.0278 0.1893 0.9305
Echinococcus granulosus cysteine protease 0.0028 0.0072 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0248 0.0248
Brugia malayi Ets-domain containing protein 0.0081 0.0456 0.0818
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0028 0.0072 0.0279
Echinococcus multilocularis musashi 0.008 0.0449 0.0443
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0006 0.0024
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0302 0.0295
Echinococcus multilocularis tumor protein p63 0.1062 0.76 0.7598
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0408 0.1217
Brugia malayi MH1 domain containing protein 0.003 0.0085 0.0153
Entamoeba histolytica cysteine protease, putative 0.0028 0.0072 0.0231
Schistosoma mansoni ferritin 0.0061 0.0314 0.0314
Schistosoma mansoni cellular tumor antigen P53 0.0155 0.1002 0.1002
Onchocerca volvulus 0.0054 0.0263 0.1101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0263 0.1359
Echinococcus granulosus zinc finger protein 0.0019 0.0012 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0263 0.1359
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0263 0.1359
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.021 0.0204
Schistosoma mansoni ferritin 0.0061 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0052 0.0248 0.0445
Brugia malayi Smad1 0.0053 0.0259 0.0465
Trypanosoma cruzi cysteine peptidase, putative 0.0205 0.1366 0.5251
Entamoeba histolytica hypothetical protein 0.0412 0.2868 1
Entamoeba histolytica cysteine protease, putative 0.0028 0.0072 0.0231
Entamoeba histolytica cysteine protease, putative 0.0028 0.0072 0.0231
Trypanosoma cruzi cysteine peptidase, putative 0.0205 0.1366 0.5251
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.0263 0.0471
Onchocerca volvulus 0.0155 0.1002 0.4819
Schistosoma mansoni hypothetical protein 0.0101 0.0605 0.0605
Brugia malayi intermediate filament protein 0.008 0.0449 0.0805
Schistosoma mansoni Smad4 0.0024 0.0044 0.0044
Brugia malayi Cathepsin L-like precursor 0.0054 0.0263 0.0471
Leishmania major cathepsin L-like protease 0.0054 0.0263 0.0988
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.018 0.0323
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0263 0.1359
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.013 0.0124
Schistosoma mansoni hypothetical protein 0.0047 0.021 0.021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0263 0.1359
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0408 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0028 0.0072 0.0255
Schistosoma mansoni ferritin light chain 0.0061 0.0314 0.0314
Treponema pallidum bacterioferrin (TpF1) 0.0061 0.0314 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0784 0.5579 1
Plasmodium vivax unspecified product 0.0028 0.0072 0.0279
Echinococcus granulosus lamin dm0 0.008 0.0449 0.0443
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.013 0.0124
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.0263 0.0257
Loa Loa (eye worm) MH2 domain-containing protein 0.0053 0.0259 0.0465
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0408 0.2128
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0072 0.0072
Schistosoma mansoni intermediate filament proteins 0.008 0.0449 0.0449
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.021 0.0377
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0408 0.2128
Brugia malayi MH2 domain containing protein 0.0024 0.0044 0.0079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0263 0.1359
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0408 0.1217
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0408 0.2128
Onchocerca volvulus 0.0054 0.0263 0.1101
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0125 0.0125
Brugia malayi beta-lactamase family protein 0.0074 0.0408 0.0731
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.0263 0.1359
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1366 0.524
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1366 0.524
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0081 0.0456 0.0818
Schistosoma mansoni hypothetical protein 0.0047 0.021 0.021
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0408 0.0402
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.0263 0.0263
Schistosoma mansoni microtubule-associated protein tau 0.1391 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1366 0.524
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0263 0.1359
Echinococcus multilocularis lamin dm0 0.008 0.0449 0.0443
Schistosoma mansoni ap endonuclease 0.0019 0.0006 0.0006
Plasmodium vivax vivapain-1 0.0028 0.0072 0.0279
Entamoeba histolytica cysteine protease, putative 0.0028 0.0072 0.0231
Plasmodium vivax vivapain-3 0.0028 0.0072 0.0279
Entamoeba histolytica hypothetical protein 0.0412 0.2868 1
Leishmania major cathepsin L-like protease 0.0054 0.0263 0.0988
Echinococcus granulosus GA binding protein alpha chain 0.0081 0.0456 0.045
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0072 0.0231
Brugia malayi Cathepsin L-like precursor 0.0036 0.0133 0.0238
Mycobacterium ulcerans hypothetical protein 0.0074 0.0408 1
Onchocerca volvulus 0.0054 0.0263 0.1101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0263 0.1359
Schistosoma mansoni Smad4 0.0024 0.0044 0.0044
Trypanosoma cruzi major cysteine proteinase, putative 0.0161 0.1046 0.4021
Trypanosoma cruzi cruzipain precursor, putative 0.0205 0.1366 0.5251
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0072 0.0279
Brugia malayi Cathepsin L-like precursor 0.0054 0.0263 0.0471
Echinococcus granulosus ferritin 0.0061 0.0314 0.0307
Schistosoma mansoni smad 0.0053 0.0259 0.0259
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0248 0.0242
Brugia malayi Cathepsin L-like cysteine proteinase 0.0036 0.0133 0.0238
Onchocerca volvulus 0.0054 0.0263 0.1101
Echinococcus granulosus mothers against decapentaplegic 2 0.0024 0.0044 0.0038
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0072 0.0231
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0006 0.0011
Trypanosoma cruzi PAB1-binding protein , putative 0.0375 0.2601 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0054 0.0263 0.0988
Entamoeba histolytica cysteine protease, putative 0.0028 0.0072 0.0231
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0116 0.0109
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0944 0.1693
Brugia malayi Pre-SET motif family protein 0.0244 0.1647 0.2953
Loa Loa (eye worm) hypothetical protein 0.0037 0.0139 0.0249
Brugia malayi Bromodomain containing protein 0.0038 0.0147 0.0263
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0408 0.0402
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.018 0.0323
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0408 0.1217
Loa Loa (eye worm) hypothetical protein 0.0375 0.2601 0.4663
Onchocerca volvulus 0.0074 0.0408 0.183
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.0263 0.0257
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0412 0.2868 0.2864
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0072 0.0231
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0072 0.013
Loa Loa (eye worm) hypothetical protein 0.0038 0.015 0.0268
Brugia malayi Intermediate filament tail domain containing protein 0.008 0.0449 0.0805
Loa Loa (eye worm) hypothetical protein 0.0148 0.0944 0.1693
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0133 0.0133
Trypanosoma cruzi cysteine protease, putative 0.0028 0.0072 0.0279
Brugia malayi Latrophilin receptor protein 2 0.0047 0.021 0.0377
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.0263 0.0263
Loa Loa (eye worm) beta-lactamase 0.0074 0.0408 0.0731
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0408 0.1217
Leishmania major cathepsin L-like protease 0.0054 0.0263 0.0988
Echinococcus multilocularis mothers against decapentaplegic 2 0.0024 0.0044 0.0038
Mycobacterium ulcerans lipase LipD 0.0074 0.0408 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1366 0.524
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0263 0.1359
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0044 0.0079
Echinococcus granulosus cathepsin l1 0.0054 0.0263 0.0257
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0072 0.0072
Plasmodium vivax SET domain protein, putative 0.0035 0.0125 0.0481
Mycobacterium ulcerans beta-lactamase 0.0074 0.0408 1
Trichomonas vaginalis esterase, putative 0.0074 0.0408 0.2128
Onchocerca volvulus 0.0054 0.0263 0.1101
Echinococcus granulosus smad 0.0053 0.0259 0.0253
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0238
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0263 0.1359
Schistosoma mansoni ets-related 0.0244 0.165 0.165
Mycobacterium ulcerans bacterioferritin BfrA 0.0061 0.0314 0.7657
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0125 0.0119
Brugia malayi Cathepsin L-like precursor 0.0054 0.0263 0.0471
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0133 0.0443
Onchocerca volvulus 0.0074 0.0408 0.183
Trichomonas vaginalis set domain proteins, putative 0.0278 0.1893 1
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0072 0.0231
Entamoeba histolytica cysteine protease, putative 0.0028 0.0072 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0263 0.1359
Brugia malayi beta-lactamase family protein 0.0074 0.0408 0.0731
Echinococcus granulosus cathepsin l cysteine peptidase 0.0054 0.0263 0.0257
Trypanosoma cruzi cysteine peptidase, putative 0.0205 0.1366 0.5251
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0408 0.2128
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0033 0.0027
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0072 0.0279
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0238
Loa Loa (eye worm) hypothetical protein 0.0069 0.0371 0.0666
Echinococcus granulosus cathepsin L 0.0028 0.0072 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1366 0.524
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0263 0.1359
Echinococcus granulosus cathepsin L cysteine protease 0.0028 0.0072 0.0066
Echinococcus multilocularis mothers against decapentaplegic 5 0.0053 0.0259 0.0253
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.008 0.0449 0.0805
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.0263 0.0471
Leishmania major hypothetical protein, conserved 0.0375 0.2601 1
Entamoeba histolytica cysteine protease, putative 0.0028 0.0072 0.0231
Brugia malayi MH1 domain containing protein 0.003 0.0085 0.0153
Loa Loa (eye worm) hypothetical protein 0.0074 0.0408 0.0731
Entamoeba histolytica cysteine protease, putative 0.0054 0.0263 0.0896
Onchocerca volvulus 0.0054 0.0263 0.1101
Onchocerca volvulus 0.0054 0.0263 0.1101
Entamoeba histolytica cysteine protease, putative 0.0028 0.0072 0.0231
Echinococcus multilocularis geminin 0.0331 0.228 0.2275
Brugia malayi MH1 domain containing protein 0.0053 0.0259 0.0465
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0072 0.035
Brugia malayi MH1 domain containing protein 0.0053 0.0259 0.0465
Echinococcus multilocularis Smad4 0.0053 0.0259 0.0253
Schistosoma mansoni ferritin light chain 0.0061 0.0314 0.0314
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1366 0.524
Schistosoma mansoni smad1 5 8 and 0.0053 0.0259 0.0259
Brugia malayi Bromodomain containing protein 0.0074 0.0412 0.0739
Onchocerca volvulus 0.0074 0.0408 0.183
Loa Loa (eye worm) fibroinase 0.0054 0.0263 0.0471
Echinococcus multilocularis expressed protein 0.0061 0.0314 0.0307
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0412 0.2868 0.2864
Loa Loa (eye worm) fli-1 protein 0.0244 0.165 0.2958
Echinococcus multilocularis cysteine protease 0.0054 0.0263 0.0257
Brugia malayi hypothetical protein 0.0412 0.2868 0.5141
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0806 0.5741 0.5738
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0263 0.1359
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0033 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0072 0.0255
Echinococcus granulosus cathepsin l1 0.0036 0.0133 0.0127
Entamoeba histolytica cysteine protease, putative 0.0028 0.0072 0.0231
Leishmania major cathepsin L-like protease 0.0205 0.1366 0.524
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0408 0.2128
Loa Loa (eye worm) hypothetical protein 0.0155 0.1002 0.1795
Leishmania major cysteine peptidase A (CPA) 0.0054 0.0263 0.0988
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0038 0.015 0.0143
Echinococcus granulosus expressed protein 0.0061 0.0314 0.0307
Brugia malayi Fli-1 protein 0.0244 0.165 0.2958
Mycobacterium ulcerans bacterioferritin BfrB 0.0061 0.0314 0.7657
Schistosoma mansoni hypothetical protein 0.0047 0.021 0.021
Entamoeba histolytica hypothetical protein 0.0412 0.2868 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.021 0.0204

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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