Detailed information for compound 729540

Basic information

Technical information
  • TDR Targets ID: 729540
  • Name: 2-methoxy-N-methyl-5-[(4-methylpyridin-2-yl)s ulfamoyl]benzamide
  • MW: 335.378 | Formula: C15H17N3O4S
  • H donors: 2 H acceptors: 4 LogP: 1.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)c1cc(ccc1OC)S(=O)(=O)Nc1nccc(c1)C
  • InChi: 1S/C15H17N3O4S/c1-10-6-7-17-14(8-10)18-23(20,21)11-4-5-13(22-3)12(9-11)15(19)16-2/h4-9H,1-3H3,(H,16,19)(H,17,18)
  • InChiKey: JOMGLYPPYPQEQM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-methoxy-N-methyl-5-[(4-methyl-2-pyridyl)sulfamoyl]benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0053 0.0187 0.0262
Onchocerca volvulus 0.0053 0.0187 0.0725
Echinococcus granulosus geminin 0.0336 0.2924 0.2924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0187 0.0754
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0089 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0187 0.0754
Schistosoma mansoni apoferritin-2 0.006 0.0251 0.038
Schistosoma mansoni hypothetical protein 0.0062 0.0273 0.0412
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0187 0.0754
Trypanosoma cruzi cysteine peptidase, putative 0.0203 0.1639 0.4407
Echinococcus multilocularis lamin 0.0081 0.0452 0.0452
Brugia malayi Cathepsin L-like precursor 0.0053 0.0187 0.0262
Echinococcus multilocularis mothers against decapentaplegic 5 0.0053 0.0181 0.0181
Entamoeba histolytica hypothetical protein 0.0342 0.2983 1
Echinococcus granulosus smad 0.0053 0.0181 0.0181
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0363 0.1527
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0363 0.1527
Trypanosoma cruzi cysteine peptidase, putative 0.0203 0.1639 0.4407
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0177 0.138 0.138
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.0273 0.0381
Brugia malayi MH2 domain containing protein 0.0053 0.0181 0.0253
Schistosoma mansoni ets-related 0.0248 0.2073 0.3135
Plasmodium vivax ataxin-2 like protein, putative 0.0394 0.3481 1
Brugia malayi Cathepsin L-like precursor 0.0036 0.0017 0.0023
Schistosoma mansoni apoferritin-2 0.006 0.0251 0.038
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0187 0.0754
Leishmania major cathepsin L-like protease 0.0203 0.1639 0.4407
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0363 0.0363
Mycobacterium ulcerans beta-lactamase 0.0071 0.0363 1
Loa Loa (eye worm) fibroinase 0.0053 0.0187 0.0262
Loa Loa (eye worm) hypothetical protein 0.0394 0.3481 0.4863
Brugia malayi MH2 domain containing protein 0.0773 0.7158 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0237 0.1965 0.2745
Toxoplasma gondii LsmAD domain-containing protein 0.0394 0.3481 1
Echinococcus multilocularis Smad4 0.0053 0.0181 0.0181
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.0273 0.0273
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0187 0.0754
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0363 0.029
Brugia malayi beta-lactamase 0.0071 0.0363 0.0507
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0187 0.0754
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1639 0.4093
Entamoeba histolytica cysteine protease, putative 0.0053 0.0187 0.0576
Echinococcus granulosus TGF beta signal transducer SmadC 0.0053 0.0181 0.0181
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0363 0.029
Loa Loa (eye worm) hypothetical protein 0.007 0.0347 0.0485
Echinococcus multilocularis smad 0.0053 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0156 0.1183 0.1652
Brugia malayi Intermediate filament tail domain containing protein 0.0081 0.0452 0.0632
Loa Loa (eye worm) hypothetical protein 0.0071 0.0363 0.0507
Echinococcus granulosus Smad4 0.0053 0.0181 0.0181
Brugia malayi beta-lactamase family protein 0.0071 0.0363 0.0507
Onchocerca volvulus 0.027 0.2282 0.8821
Schistosoma mansoni cathepsin F (C01 family) 0.0053 0.0187 0.0283
Loa Loa (eye worm) hypothetical protein 0.0071 0.0363 0.0507
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1639 0.4093
Schistosoma mansoni smad 0.0053 0.0181 0.0274
Mycobacterium leprae Probable lipase LipE 0.0071 0.0363 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0048 0.0067
Loa Loa (eye worm) hypothetical protein 0.0062 0.0273 0.0381
Onchocerca volvulus 0.0053 0.0187 0.0725
Brugia malayi Fli-1 protein 0.0248 0.2073 0.2895
Schistosoma mansoni smad1 5 8 and 0.0053 0.0181 0.0274
Plasmodium falciparum ataxin-2 like protein, putative 0.0394 0.3481 1
Plasmodium vivax vivapain-2 0.0053 0.0187 0.0538
Brugia malayi Ets-domain containing protein 0.0082 0.0462 0.0645
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0053 0.0187 0.0187
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0363 0.029
Brugia malayi Cathepsin L-like precursor 0.0053 0.0187 0.0262
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1639 0.4093
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0186 0.1468 0.3888
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0187 0.0754
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0818 0.7595 0.7595
Leishmania major cathepsin L-like protease 0.0203 0.1639 0.4407
Echinococcus granulosus intermediate filament protein 0.0081 0.0452 0.0452
Onchocerca volvulus 0.0053 0.0187 0.0725
Trypanosoma cruzi major cysteine proteinase, putative 0.016 0.1218 0.3128
Brugia malayi hypothetical protein 0.0254 0.2131 0.2977
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0363 0.0507
Schistosoma mansoni hypothetical protein 0.0342 0.2983 0.4511
Loa Loa (eye worm) hypothetical protein 0.0071 0.0363 0.0507
Leishmania major hypothetical protein, conserved 0.0394 0.3481 1
Echinococcus multilocularis cysteine protease 0.0053 0.0187 0.0187
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0363 0.029
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0047
Schistosoma mansoni hypothetical protein 0.0062 0.0273 0.0412
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0187 0.0754
Schistosoma mansoni Smad4 0.0053 0.0181 0.0274
Brugia malayi Cathepsin L-like precursor 0.0053 0.0187 0.0262
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0342 0.2983 0.2983
Echinococcus granulosus cathepsin l1 0.0053 0.0187 0.0187
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0053 0.0181 0.0181
Mycobacterium tuberculosis Conserved protein 0.0071 0.0363 0.029
Echinococcus multilocularis cysteine protease 0.0053 0.0187 0.0187
Echinococcus granulosus cathepsin l1 0.0036 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0062 0.0273 0.0412
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.0273 0.0273
Echinococcus granulosus lamin dm0 0.0081 0.0452 0.0452
Echinococcus multilocularis microtubule associated protein 2 0.0717 0.6612 0.6612
Loa Loa (eye worm) ctsf protein 0.0053 0.0187 0.0262
Brugia malayi Cathepsin L-like precursor 0.0036 0.0017 0.0023
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0048 0.0048
Trypanosoma brucei PAB1-binding protein , putative 0.0394 0.3481 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1639 0.4093
Trypanosoma cruzi cysteine peptidase, putative 0.0203 0.1639 0.4407
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0177 0.138 0.138
Echinococcus granulosus cathepsin l cysteine peptidase 0.0053 0.0187 0.0187
Schistosoma mansoni intermediate filament proteins 0.0081 0.0452 0.0684
Brugia malayi latrophilin 2 splice variant baaae 0.0134 0.0971 0.1357
Schistosoma mansoni cathepsin F (C01 family) 0.0053 0.0187 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0053 0.0187 0.0754
Leishmania major cathepsin L-like protease 0.0203 0.1639 0.4407
Schistosoma mansoni ferritin 0.006 0.0251 0.038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1639 0.4093
Schistosoma mansoni gabp alpha 0.0082 0.0462 0.0699
Trichomonas vaginalis esterase, putative 0.0071 0.0363 0.1527
Loa Loa (eye worm) Smad1 0.0053 0.0181 0.0253
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0363 0.029
Loa Loa (eye worm) intermediate filament protein 0.0081 0.0452 0.0632
Brugia malayi cathepsin L-like precursor 0.0036 0.0017 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0187 0.0754
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0363 0.1527
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0363 0.0507
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0187 0.0754
Brugia malayi beta-lactamase family protein 0.0071 0.0363 0.0507
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0363 0.029
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.0273 0.0381
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.0273 0.0273
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0187 0.0754
Schistosoma mansoni lamin 0.0081 0.0452 0.0684
Echinococcus multilocularis musashi 0.0081 0.0452 0.0452
Mycobacterium tuberculosis Conserved protein 0.0071 0.0363 0.029
Brugia malayi MH1 domain containing protein 0.0053 0.0181 0.0253
Trypanosoma cruzi PAB1-binding protein , putative 0.0394 0.3481 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1639 0.4093
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0053 0.0187 0.0187
Onchocerca volvulus 0.0156 0.1183 0.4572
Echinococcus granulosus cathepsin L cysteine proteinase 0.0053 0.0187 0.0187
Schistosoma mansoni microtubule-associated protein tau 0.0717 0.6612 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0363 0.0549
Echinococcus multilocularis cathepsin L cysteine protease 0.0053 0.0187 0.0187
Echinococcus granulosus GPCR family 2 0.0062 0.0273 0.0273
Schistosoma mansoni smad1 5 8 and 0.0053 0.0181 0.0274
Schistosoma mansoni transcription factor LCR-F1 0.0342 0.2983 0.4511
Entamoeba histolytica hypothetical protein 0.0342 0.2983 1
Brugia malayi hypothetical protein 0.0394 0.3481 0.4863
Brugia malayi Latrophilin receptor protein 2 0.0062 0.0273 0.0381
Onchocerca volvulus Cathepsin L homolog 0.0053 0.0187 0.0725
Schistosoma mansoni hypothetical protein 0.0134 0.0971 0.1469
Echinococcus multilocularis lamin dm0 0.0081 0.0452 0.0452
Treponema pallidum bacterioferrin (TpF1) 0.006 0.0251 0.5
Mycobacterium ulcerans hypothetical protein 0.0071 0.0363 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0773 0.7158 1
Schistosoma mansoni hypothetical protein 0.0177 0.138 0.2087
Echinococcus granulosus ferritin 0.006 0.0251 0.0251
Schistosoma mansoni ferritin 0.006 0.0251 0.038
Brugia malayi MH2 domain containing protein 0.0053 0.0181 0.0253
Onchocerca volvulus 0.0053 0.0187 0.0725
Schistosoma mansoni ferritin light chain 0.006 0.0251 0.038
Onchocerca volvulus Cathepsin F homolog 0.0053 0.0187 0.0725
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0196 0.1573 0.2197
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0047
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0082 0.0462 0.0645
Brugia malayi Ets-domain containing protein 0.0082 0.0462 0.0645
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0023
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0363 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0363 0.0507
Loa Loa (eye worm) hypothetical protein 0.0071 0.0363 0.0507
Schistosoma mansoni hypothetical protein 0.0336 0.2924 0.4422
Leishmania major hypothetical protein, conserved 0.0071 0.0363 0.0532
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0187 0.0754
Plasmodium vivax vivapain-2 0.0053 0.0187 0.0538
Trichomonas vaginalis set domain proteins, putative 0.027 0.2282 1
Onchocerca volvulus 0.0301 0.2587 1
Mycobacterium ulcerans lipase LipD 0.0071 0.0363 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0023
Echinococcus granulosus GA binding protein alpha chain 0.0082 0.0462 0.0462
Toxoplasma gondii ABC1 family protein 0.0071 0.0363 0.1042
Schistosoma mansoni cellular tumor antigen P53 0.0156 0.1183 0.1789
Brugia malayi Calcitonin receptor-like protein seb-1 0.0196 0.1573 0.2197
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0053 0.0187 0.0262
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0363 1
Echinococcus multilocularis expressed protein 0.006 0.0251 0.0251
Mycobacterium tuberculosis Conserved protein 0.0071 0.0363 0.029
Loa Loa (eye worm) hypothetical protein 0.0301 0.2587 0.3614
Schistosoma mansoni ferritin light chain 0.006 0.0251 0.038
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0187 0.0576
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0089 0.0125
Entamoeba histolytica hypothetical protein 0.0342 0.2983 1
Onchocerca volvulus 0.0053 0.0187 0.0725
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0187 0.0754
Brugia malayi MH1 domain containing protein 0.0053 0.0181 0.0253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0187 0.0754
Onchocerca volvulus 0.0053 0.0187 0.0725
Loa Loa (eye worm) beta-lactamase 0.0071 0.0363 0.0507
Echinococcus multilocularis tumor protein p63 0.1067 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0053 0.0181 0.0253
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0187 0.0262
Plasmodium falciparum ataxin-2 like protein, putative 0.0394 0.3481 1
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0363 0.029
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0363 0.0532
Brugia malayi Cathepsin L-like precursor 0.0053 0.0187 0.0262
Loa Loa (eye worm) MH1 domain-containing protein 0.0053 0.0181 0.0253
Onchocerca volvulus 0.0071 0.0363 0.1402
Toxoplasma gondii cathepsin CPL 0.0053 0.0187 0.0538
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0187 0.0754
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0363 0.1527
Echinococcus multilocularis geminin 0.0336 0.2924 0.2924
Loa Loa (eye worm) hypothetical protein 0.0071 0.0363 0.0507
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0363 0.0363
Onchocerca volvulus Cathepsin L homolog 0.0053 0.0187 0.0725
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0342 0.2983 0.2983
Brugia malayi Cathepsin L-like precursor 0.0053 0.0187 0.0262
Trichomonas vaginalis ferritin, putative 0.006 0.0251 0.1036
Echinococcus granulosus lamin 0.0081 0.0452 0.0452
Onchocerca volvulus 0.0036 0.0017 0.0065
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0187 0.0754
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0363 0.1042
Onchocerca volvulus 0.0071 0.0363 0.1402
Loa Loa (eye worm) hypothetical protein 0.0079 0.0438 0.0612
Trypanosoma cruzi PAB1-binding protein , putative 0.0394 0.3481 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0053 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0053 0.0187 0.0262
Schistosoma mansoni ferritin 0.006 0.0251 0.038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1639 0.4093
Schistosoma mansoni hypothetical protein 0.0062 0.0273 0.0412
Trypanosoma cruzi cruzipain precursor, putative 0.0203 0.1639 0.4407
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0048 0.0048
Brugia malayi hypothetical protein 0.0342 0.2983 0.4167
Echinococcus granulosus microtubule associated protein 2 0.0717 0.6612 0.6612
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0187 0.0576
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1639 0.4093
Loa Loa (eye worm) hypothetical protein 0.0134 0.0971 0.1357
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0456 0.409 1
Onchocerca volvulus 0.0053 0.0187 0.0725
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0053 0.0181 0.0274
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0081 0.0452 0.0632
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.0273 0.0273
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1639 0.4093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0187 0.0754
Schistosoma mansoni smad1 5 8 and 0.0053 0.0181 0.0274
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0053 0.0187 0.0754
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1639 0.4093
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0363 0.1527
Schistosoma mansoni ferritin 0.006 0.0251 0.038
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0017 0.0025
Entamoeba histolytica hypothetical protein 0.0342 0.2983 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0187 0.0754
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0363 1
Schistosoma mansoni hypothetical protein 0.0336 0.2924 0.4422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1639 0.4093
Echinococcus granulosus mothers against decapentaplegic 5 0.0053 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0081 0.0452 0.0632
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0187 0.0754
Loa Loa (eye worm) transcription factor SMAD2 0.0773 0.7158 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0187 0.0754
Onchocerca volvulus 0.0081 0.0452 0.1748
Brugia malayi Pre-SET motif family protein 0.0237 0.1965 0.2745
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0196 0.1573 0.2197
Brugia malayi intermediate filament protein 0.0081 0.0452 0.0632
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0187 0.0754
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0363 0.0532
Onchocerca volvulus 0.0081 0.0452 0.1748
Echinococcus multilocularis GPCR, family 2 0.0062 0.0273 0.0273
Brugia malayi Smad1 0.0053 0.0181 0.0253
Loa Loa (eye worm) cysteine protease 0.0053 0.0187 0.0262
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0363 0.0549
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0053 0.0187 0.0262
Loa Loa (eye worm) fli-1 protein 0.0248 0.2073 0.2895
Brugia malayi hypothetical protein 0.0301 0.2587 0.3614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0187 0.0754
Schistosoma mansoni lamin 0.0081 0.0452 0.0684
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0187 0.0754
Echinococcus multilocularis ferritin 0.006 0.0251 0.0251
Brugia malayi Cathepsin L-like cysteine proteinase 0.0036 0.0017 0.0023
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.006 0.0251 0.5
Loa Loa (eye worm) hypothetical protein 0.0196 0.1573 0.2197
Echinococcus granulosus expressed protein 0.006 0.0251 0.0251
Echinococcus multilocularis GA binding protein alpha chain 0.0082 0.0462 0.0462
Onchocerca volvulus 0.0071 0.0363 0.1402

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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