Detailed information for compound 729547

Basic information

Technical information
  • TDR Targets ID: 729547
  • Name: N-ethyl-2-methoxy-5-(methyl-phenylsulfamoyl)b enzamide
  • MW: 348.417 | Formula: C17H20N2O4S
  • H donors: 1 H acceptors: 3 LogP: 2.24 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNC(=O)c1cc(ccc1OC)S(=O)(=O)N(c1ccccc1)C
  • InChi: 1S/C17H20N2O4S/c1-4-18-17(20)15-12-14(10-11-16(15)23-3)24(21,22)19(2)13-8-6-5-7-9-13/h5-12H,4H2,1-3H3,(H,18,20)
  • InChiKey: TZHYCXQAKLAELP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-ethyl-2-methoxy-5-(methyl-phenyl-sulfamoyl)benzamide
  • ZINC06747555

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0059 0.0513 0.1432
Loa Loa (eye worm) hypothetical protein 0.0076 0.0902 0.2519
Mycobacterium ulcerans beta-lactamase 0.0076 0.0902 0.5
Trichomonas vaginalis esterase, putative 0.0076 0.0902 0.5
Entamoeba histolytica hypothetical protein 0.0037 0.003 0.5
Echinococcus granulosus tumor protein p63 0.04 0.8091 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0902 0.2519
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0902 0.5
Echinococcus multilocularis geminin 0.0194 0.352 0.435
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0902 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0902 0.5
Mycobacterium ulcerans lipase LipD 0.0076 0.0902 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0708 0.1977
Loa Loa (eye worm) hypothetical protein 0.0179 0.3183 0.8893
Schistosoma mansoni hypothetical protein 0.0037 0.003 0.0084
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0902 0.5
Onchocerca volvulus 0.0076 0.0902 0.1456
Brugia malayi RNA recognition motif domain containing protein 0.0197 0.358 1
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0902 0.5
Brugia malayi beta-lactamase 0.0076 0.0902 0.2519
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0067 0.0708 0.0875
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0902 0.2519
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0902 0.1114
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0902 0.1114
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0067 0.0708 0.0875
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.003 0.0037
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0708 0.1977
Entamoeba histolytica hypothetical protein 0.0037 0.003 0.5
Loa Loa (eye worm) hypothetical protein 0.0076 0.0902 0.2519
Schistosoma mansoni hypothetical protein 0.0077 0.0913 0.2551
Leishmania major hypothetical protein, conserved 0.0076 0.0902 0.5
Loa Loa (eye worm) beta-lactamase 0.0076 0.0902 0.2519
Brugia malayi RNA binding protein 0.0197 0.358 1
Schistosoma mansoni tar DNA-binding protein 0.0197 0.358 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0902 0.2519
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0902 0.2519
Brugia malayi hypothetical protein 0.0179 0.3183 0.8893
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.003 0.0037
Schistosoma mansoni hypothetical protein 0.0194 0.352 0.9832
Echinococcus granulosus tar DNA binding protein 0.0197 0.358 0.4424
Echinococcus multilocularis lysine specific demethylase 5A 0.0067 0.0708 0.0875
Mycobacterium leprae Probable lipase LipE 0.0076 0.0902 0.5
Onchocerca volvulus 0.0076 0.0902 0.1456
Brugia malayi beta-lactamase family protein 0.0076 0.0902 0.2519
Brugia malayi jmjC domain containing protein 0.0067 0.0708 0.1977
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0708 0.1977
Schistosoma mansoni tar DNA-binding protein 0.0197 0.358 1
Echinococcus multilocularis tar DNA binding protein 0.0197 0.358 0.4424
Brugia malayi jmjC domain containing protein 0.0067 0.0708 0.1977
Brugia malayi TAR-binding protein 0.0197 0.358 1
Echinococcus granulosus geminin 0.0194 0.352 0.435
Onchocerca volvulus 0.0076 0.0902 0.1456
Schistosoma mansoni tar DNA-binding protein 0.0197 0.358 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0902 0.2519
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0902 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.17 0.4749
Loa Loa (eye worm) hypothetical protein 0.0112 0.17 0.4749
Brugia malayi hypothetical protein 0.0037 0.003 0.0084
Entamoeba histolytica hypothetical protein 0.0037 0.003 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0902 0.5
Entamoeba histolytica hypothetical protein 0.0037 0.003 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0902 0.2519
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0902 0.2519
Loa Loa (eye worm) hypothetical protein 0.0076 0.0902 0.2519
Loa Loa (eye worm) hypothetical protein 0.0077 0.0913 0.2551
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0902 0.5
Mycobacterium ulcerans hypothetical protein 0.0076 0.0902 0.5
Schistosoma mansoni tar DNA-binding protein 0.0197 0.358 1
Schistosoma mansoni hypothetical protein 0.0194 0.352 0.9832
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0902 0.5
Schistosoma mansoni cellular tumor antigen P53 0.0059 0.0513 0.1432
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.17 0.4749
Toxoplasma gondii ABC1 family protein 0.0076 0.0902 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.17 0.4749
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.0913 0.2551
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0197 0.358 1
Onchocerca volvulus 0.0179 0.3183 1
Loa Loa (eye worm) RNA binding protein 0.0197 0.358 1
Schistosoma mansoni jumonji domain containing protein 0.0067 0.0708 0.1977
Loa Loa (eye worm) TAR-binding protein 0.0197 0.358 1
Echinococcus multilocularis tumor protein p63 0.04 0.8091 1
Brugia malayi beta-lactamase family protein 0.0076 0.0902 0.2519
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0902 0.5
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0902 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.003 0.0084
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0902 0.5
Schistosoma mansoni tar DNA-binding protein 0.0197 0.358 1
Echinococcus granulosus lysine specific demethylase 5A 0.0067 0.0708 0.0875

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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