Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0171 | 0.5266 | 0.5193 |
Brugia malayi | MH2 domain containing protein | 0.014 | 0.3904 | 0.381 |
Schistosoma mansoni | hypothetical protein | 0.0117 | 0.2899 | 0.412 |
Onchocerca volvulus | 0.0057 | 0.0277 | 0.5 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0113 | 0.2723 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0211 | 0.7037 | 0.6991 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0277 | 0.0393 |
Leishmania major | hypothetical protein, conserved | 0.0113 | 0.2723 | 0.5 |
Brugia malayi | hypothetical protein | 0.0113 | 0.2723 | 0.2611 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0171 | 0.5266 | 0.5193 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0211 | 0.7037 | 0.6991 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0113 | 0.2723 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0054 | 0.0152 | 0.0152 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.0152 | 0.0152 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0211 | 0.7037 | 0.6991 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0113 | 0.2723 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0211 | 0.7037 | 0.6991 |
Schistosoma mansoni | survival motor neuron protein | 0.0057 | 0.0277 | 0.0393 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0152 | 0.0216 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 0.3904 | 0.381 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0057 | 0.0277 | 0.0126 |
Schistosoma mansoni | tar DNA-binding protein | 0.0211 | 0.7037 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0279 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0113 | 0.2723 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.5266 | 0.5193 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0279 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0073 | 0.0973 | 0.0834 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.2899 | 0.2789 |
Echinococcus granulosus | tar DNA binding protein | 0.0211 | 0.7037 | 0.7037 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2723 | 0.2611 |
Echinococcus granulosus | GPCR family 2 | 0.0054 | 0.0152 | 0.0152 |
Schistosoma mansoni | tar DNA-binding protein | 0.0211 | 0.7037 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0171 | 0.5266 | 0.5193 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0152 | 0.0216 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0117 | 0.2899 | 0.2789 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 0.3904 | 0.381 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0113 | 0.2723 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.0152 | 0.0152 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0152 | 0.0216 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0248 | 0.8632 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0211 | 0.7037 | 0.7037 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0152 | 0.0216 |
Schistosoma mansoni | tar DNA-binding protein | 0.0211 | 0.7037 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0211 | 0.7037 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.0152 | 0.0152 |
Brugia malayi | TAR-binding protein | 0.0211 | 0.7037 | 0.6991 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0113 | 0.2723 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0211 | 0.7037 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.0152 | 0.0152 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0113 | 0.2723 | 0.5 |
Brugia malayi | RNA binding protein | 0.0211 | 0.7037 | 0.6991 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.