Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0275 | 1 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0876 | 0.218 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0224 | 0.7881 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0122 | 0.3609 | 0.3609 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.4017 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0281 | 0.0701 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0056 | 0.0876 | 1 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0132 | 0.4017 | 0.4017 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0281 | 0.0281 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0281 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.3609 | 0.8986 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0281 | 0.0281 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0876 | 0.218 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0281 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.4017 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0281 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0275 | 1 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0.3609 | 0.3609 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0281 | 0.0281 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0281 | 0.0701 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0281 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0876 | 0.0876 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.