TDR Targets

Basic information

Technical information

TDR Targets ID: 730272
Name: 4-(2,2,3,3-tetrafluoropropoxymethyl)benzoic a cid
MW: 266.189 | Formula: C11H10F4O3
H donors: 1 H acceptors: 2 LogP: 2.62 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: FC(C(COCc1ccc(cc1)C(=O)O)(F)F)F
InChi: 1S/C11H10F4O3/c12-10(13)11(14,15)6-18-5-7-1-3-8(4-2-7)9(16)17/h1-4,10H,5-6H2,(H,16,17)
InChiKey: WBQDFRPLOUVDKJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

STK086098

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0929	0.1999
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0037	0.248	0.2824
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.002	0.0929	0.0841
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.1923	0.1895
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0085	0.6779	0.8837
Brugia malayi	Inositol-1	0.0037	0.2489	0.228
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0049	0.3561	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0094	0.7635	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0099	0.8092	0.8039
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.002	0.0929	0.2977
Schistosoma mansoni	ap endonuclease	0.0037	0.248	0.2511
Schistosoma mansoni	hypothetical protein	0.0016	0.0551	0.0558
Brugia malayi	Thioredoxin reductase	0.0037	0.247	0.2259
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0929	0.261
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.002	0.0929	0.0841
Onchocerca volvulus	Huntingtin homolog	0.0121	1	1
Echinococcus multilocularis	musashi	0.0031	0.1923	0.2112
Schistosoma mansoni	inositol monophosphatase	0.0037	0.2489	0.252
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.248	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0037	0.248	1
Schistosoma mansoni	intermediate filament proteins	0.0031	0.1923	0.1947
Loa Loa (eye worm)	hypothetical protein	0.0121	1	1
Toxoplasma gondii	NADPH-glutathione reductase	0.0013	0.0272	0.0763
Schistosoma mansoni	DNA helicase recq1	0.002	0.0929	0.0941
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0085	0.6779	0.8837
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.002	0.0929	0.0841
Loa Loa (eye worm)	hypothetical protein	0.0035	0.2228	0.22
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.2489	0.6991
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0013	0.0272	0.067
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0551	0.0517
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.248	1
Onchocerca volvulus	Huntingtin homolog	0.0121	1	1
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0034	0.2135	0.253
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0037	0.248	0.6715
Echinococcus multilocularis	bloom syndrome protein	0.002	0.0929	0.0841
Plasmodium falciparum	glutathione reductase	0.0037	0.247	0.9952
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0085	0.6779	0.8443
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0013	0.0272	0.1095
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0551	0.0517
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0049	0.3561	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0035	0.00000000075444
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0099	0.8092	0.8192
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.1923	0.1895
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.3672	0.365
Echinococcus granulosus	mitogen activated protein kinase 3	0.0049	0.3561	0.4206
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0615	0.0582
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0013	0.0272	0.1095
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.2489	0.6742
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0099	0.8092	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0094	0.7635	1
Schistosoma mansoni	blooms syndrome DNA helicase	0.001	0.0035	0.0036
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.248	0.6715
Toxoplasma gondii	exonuclease III APE	0.0037	0.248	0.6966
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0037	0.2489	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.1872	0.1843
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.3561	1
Trichomonas vaginalis	DNA helicase recq1, putative	0.002	0.0929	0.1999
Entamoeba histolytica	recQ family DNA helicase	0.001	0.0035	0.0142
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0551	0.0287
Loa Loa (eye worm)	glutathione reductase	0.0037	0.247	0.2443
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0049	0.3561	1
Brugia malayi	intermediate filament protein	0.0031	0.1923	0.1698
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0037	0.248	0.2999
Toxoplasma gondii	thioredoxin reductase	0.0037	0.247	0.6936
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.1923	0.1698
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0551	0.0357
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.002	0.0929	0.0897
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.248	0.6715
Plasmodium vivax	glutathione reductase, putative	0.0037	0.247	0.9957
Schistosoma mansoni	hypothetical protein	0.0016	0.0551	0.0558
Mycobacterium tuberculosis	Probable reductase	0.0085	0.6779	0.8837
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0013	0.0272	0.5
Trypanosoma cruzi	trypanothione reductase, putative	0.0013	0.0272	0.067
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0551	0.0287
Trypanosoma cruzi	trypanothione reductase, putative	0.0037	0.247	0.6905
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.3561	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0272	0.067
Schistosoma mansoni	hypothetical protein	0.0016	0.0551	0.0558
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.002	0.0929	0.0841
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0037	0.248	0.6935
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0414	0.038
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.3561	1
Schistosoma mansoni	ap endonuclease	0.0037	0.248	0.2511
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0099	0.8092	0.8192
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0037	0.248	0.9959
Loa Loa (eye worm)	thioredoxin reductase	0.0037	0.247	0.2443
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0049	0.3561	1
Echinococcus multilocularis	lamin	0.0031	0.1923	0.2112
Echinococcus granulosus	lamin	0.0031	0.1923	0.2112
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0099	0.8092	0.8192
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0013	0.0272	0.067
Echinococcus granulosus	lamin dm0	0.0031	0.1923	0.2112
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0272	0.067
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0015	0.0466	0.0248
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0049	0.3561	0.3538
Schistosoma mansoni	lamin	0.0031	0.1923	0.1947
Trypanosoma brucei	protein kinase, putative	0.0049	0.3561	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0272	0.067
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0037	0.247	0.2985
Loa Loa (eye worm)	hypothetical protein	0.0031	0.1923	0.1895
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0049	0.3561	0.4206
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0037	0.248	0.6715
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0929	0.0676
Echinococcus multilocularis	lamin dm0	0.0031	0.1923	0.2112
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.0929	0.2977
Trypanosoma brucei	trypanothione reductase	0.0037	0.247	0.6683
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0551	0.0357
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0099	0.8092	1
Giardia lamblia	Sgs1 DNA helicase, putative	0.002	0.0929	0.1999
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.3672	0.3496
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0037	0.248	0.6715
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.2228	0.2011
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.0929	0.1999
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0414	0.038
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.2489	0.6742
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.3672	0.3496
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.3561	0.3605
Echinococcus granulosus	thioredoxin glutathione reductase	0.0038	0.2515	0.2868
Brugia malayi	MAP kinase sur-1	0.0049	0.3561	0.3381
Brugia malayi	glutathione reductase	0.0037	0.247	0.2259
Loa Loa (eye worm)	RecQ helicase	0.002	0.0929	0.0897
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0099	0.8092	0.8086
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0466	0.0432
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.3561	1
Schistosoma mansoni	DNA helicase recq5	0.002	0.0929	0.0941
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0094	0.7635	1
Schistosoma mansoni	lamin	0.0031	0.1923	0.1947
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.2489	0.6961
Mycobacterium tuberculosis	Probable dehydrogenase	0.0085	0.6779	0.8837
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0272	0.067
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0037	0.248	0.2454
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.2489	0.6742
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0.2489	1
Entamoeba histolytica	recQ family helicase, putative	0.002	0.0929	0.3733
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0013	0.0272	0.0763
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0049	0.3561	1
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0049	0.3561	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0037	0.248	0.9959
Schistosoma mansoni	hypothetical protein	0.0016	0.0551	0.0558
Giardia lamblia	Kinase, CMGC MAPK	0.0049	0.3561	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0099	0.8092	1
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0615	0.0353
Loa Loa (eye worm)	hypothetical protein	0.002	0.0929	0.0897
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.2489	0.6961
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0015	0.0466	0.0248
Schistosoma mansoni	inositol monophosphatase	0.0037	0.2489	0.252
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.2489	1
Brugia malayi	Bloom's syndrome protein homolog	0.002	0.0929	0.0676
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.2489	0.2836
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0035	0.0099
Echinococcus granulosus	mitogen activated protein kinase	0.0049	0.3561	0.4206
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0085	0.6779	0.8837
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0929	0.1999
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.2489	0.2836
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0049	0.3561	1
Treponema pallidum	NADH oxidase	0.0013	0.0272	0.0967
Plasmodium vivax	thioredoxin reductase, putative	0.0037	0.247	0.9957
Loa Loa (eye worm)	inositol-1	0.0037	0.2489	0.2463
Echinococcus granulosus	GPCR family 2	0.0016	0.0551	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0121	1	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0551	0.0357
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0551	0.0357
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.001	0.0035	0.0143
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0272	0.067
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0099	0.8092	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0094	0.7635	1
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.0929	0.1999
Echinococcus granulosus	intermediate filament protein	0.0031	0.1923	0.2112
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0038	0.2515	0.2868
Echinococcus granulosus	bloom syndrome protein	0.002	0.0929	0.0841
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0085	0.6779	0.8837
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0013	0.0272	0.0275
Plasmodium falciparum	thioredoxin reductase	0.0037	0.247	0.9952
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0037	0.248	0.2824
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0272	0.067
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.2489	0.6742
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0037	0.248	0.6935
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0929	0.0676
Brugia malayi	exodeoxyribonuclease III family protein	0.0037	0.248	0.227
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0929	0.2536
Echinococcus multilocularis	mitogen activated protein kinase	0.0049	0.3561	0.4206
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0049	0.3561	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.3672	0.365
Schistosoma mansoni	hypothetical protein	0.0035	0.2228	0.2255
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0929	0.261
Leishmania major	trypanothione reductase	0.0037	0.247	0.6683
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0037	0.248	0.9964
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0551	0.0357
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.2489	0.6742

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 730272