TDR Targets

Basic information

Technical information

TDR Targets ID: 730321
Name: phenylmethyl N-[4-(ethoxycarbonylamino)phenyl ]carbamate
MW: 314.336 | Formula: C17H18N2O4
H donors: 2 H acceptors: 2 LogP: 2.94 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)Nc1ccc(cc1)NC(=O)OCc1ccccc1
InChi: 1S/C17H18N2O4/c1-2-22-16(20)18-14-8-10-15(11-9-14)19-17(21)23-12-13-6-4-3-5-7-13/h3-11H,2,12H2,1H3,(H,18,20)(H,19,21)
InChiKey: MEIALJCNVKVJTC-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-[4-(ethoxycarbonylamino)phenyl]carbamic acid phenylmethyl ester
N-[4-(carbethoxyamino)phenyl]carbamic acid benzyl ester
ST5436080
ZINC00614146

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0027	0.0316	0.0467
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0781	0.0781
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0027	0.0316	0.0467
Brugia malayi	RNA binding protein	0.0214	0.5122	0.5122
Schistosoma mansoni	tar DNA-binding protein	0.0214	0.5122	1
Schistosoma mansoni	transcription factor LCR-F1	0.0161	0.3757	0.7291
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0781	0.1388
Loa Loa (eye worm)	Smad1	0.0027	0.0316	0.0316
Schistosoma mansoni	smad1 5 8 and	0.0027	0.0316	0.0467
Loa Loa (eye worm)	MH2 domain-containing protein	0.0402	1	1
Trypanosoma brucei	hypothetical protein, conserved	0.0227	0.5466	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0227	0.5466	1
Schistosoma mansoni	Smad4	0.0027	0.0316	0.0467
Entamoeba histolytica	hypothetical protein	0.0161	0.3757	0.5
Brugia malayi	MH1 domain containing protein	0.0027	0.0316	0.0316
Schistosoma mansoni	tar DNA-binding protein	0.0214	0.5122	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0781	0.1388
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0283	0.5
Loa Loa (eye worm)	transcription factor SMAD2	0.0402	1	1
Brugia malayi	Smad1	0.0027	0.0316	0.0316
Brugia malayi	hypothetical protein	0.0161	0.3757	0.3757
Brugia malayi	hypothetical protein	0.0161	0.3769	0.3769
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0026	0.0283	0.0375
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0161	0.3757	0.7291
Schistosoma mansoni	hypothetical protein	0.0161	0.3757	0.7291
Brugia malayi	MH1 domain containing protein	0.0027	0.0316	0.0316
Brugia malayi	Isocitrate dehydrogenase	0.0018	0.0081	0.0081
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0018	0.0081	0.5
Brugia malayi	TAR-binding protein	0.0214	0.5122	0.5122
Schistosoma mansoni	smad1 5 8 and	0.0027	0.0316	0.0467
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0781	0.1388
Entamoeba histolytica	hypothetical protein	0.0161	0.3757	0.5
Entamoeba histolytica	hypothetical protein	0.0161	0.3757	0.5
Loa Loa (eye worm)	TAR-binding protein	0.0214	0.5122	0.5122
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0027	0.0316	0.0467
Schistosoma mansoni	tar DNA-binding protein	0.0214	0.5122	1
Schistosoma mansoni	smad1 5 8 and	0.0027	0.0316	0.0467
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0026	0.0283	0.0375
Leishmania major	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0026	0.0283	0.0375
Loa Loa (eye worm)	MH2 domain-containing protein	0.0027	0.0316	0.0316
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0781	0.1388
Mycobacterium ulcerans	citrate lyase beta subunit, CitE_2	0.0026	0.0283	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0214	0.5122	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0781	0.1388
Echinococcus multilocularis	smad	0.0027	0.0316	0.0467
Echinococcus granulosus	tar DNA binding protein	0.0214	0.5122	1
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0026	0.0283	0.5
Mycobacterium tuberculosis	Conserved protein	0.0026	0.0283	1
Echinococcus granulosus	mothers against decapentaplegic 5	0.0027	0.0316	0.0467
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0214	0.5122	0.5122
Loa Loa (eye worm)	RNA binding protein	0.0214	0.5122	0.5122
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.0026	0.0283	0.5
Echinococcus granulosus	citrate lyase subunit beta protein	0.0026	0.0283	0.04
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0018	0.0081	0.5
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0027	0.0316	0.0467
Trypanosoma cruzi	hypothetical protein, conserved	0.0227	0.5466	1
Echinococcus multilocularis	tar DNA binding protein	0.0214	0.5122	1
Loa Loa (eye worm)	hypothetical protein	0.0161	0.3769	0.3769
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0018	0.0081	0.0081
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0026	0.0283	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0781	0.1388
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0283	0.5
Toxoplasma gondii	isocitrate dehydrogenase	0.0018	0.0081	0.5
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0781	0.0781
Toxoplasma gondii	isocitrate dehydrogenase	0.0018	0.0081	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0781	0.1388
Schistosoma mansoni	smad	0.0027	0.0316	0.0467
Echinococcus granulosus	Smad4	0.0027	0.0316	0.0467
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0161	0.3757	0.7291
Schistosoma mansoni	tar DNA-binding protein	0.0214	0.5122	1
Onchocerca volvulus		0.0161	0.3769	0.5
Echinococcus multilocularis	citrate lyase subunit beta protein	0.0026	0.0283	0.04
Brugia malayi	isocitrate dehydrogenase	0.0018	0.0081	0.0081
Leishmania major	hypothetical protein, conserved	0.0227	0.5466	1
Echinococcus granulosus	smad	0.0027	0.0316	0.0467
Loa Loa (eye worm)	MH1 domain-containing protein	0.0027	0.0316	0.0316
Mycobacterium tuberculosis	Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase)	0.0026	0.0283	1
Brugia malayi	MH2 domain containing protein	0.0027	0.0316	0.0316
Echinococcus multilocularis	Smad4	0.0027	0.0316	0.0467
Entamoeba histolytica	hypothetical protein	0.0161	0.3757	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.0214	0.5122	0.5122
Brugia malayi	MH2 domain containing protein	0.0027	0.0316	0.0316

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 730321