Detailed information for compound 730953

Basic information

Technical information
  • TDR Targets ID: 730953
  • Name: 4-[(3,4-dichlorophenyl)amino]-4-oxo-3-(phenyl methyl)butanoic acid
  • MW: 352.212 | Formula: C17H15Cl2NO3
  • H donors: 2 H acceptors: 3 LogP: 3.78 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CC(C(=O)Nc1ccc(c(c1)Cl)Cl)Cc1ccccc1
  • InChi: 1S/C17H15Cl2NO3/c18-14-7-6-13(10-15(14)19)20-17(23)12(9-16(21)22)8-11-4-2-1-3-5-11/h1-7,10,12H,8-9H2,(H,20,23)(H,21,22)
  • InChiKey: MLGXDUNJKHXECW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(benzyl)-4-[(3,4-dichlorophenyl)amino]-4-keto-butyric acid
  • CBKinase1_001607
  • CBKinase1_014007

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0057 0.0057
Loa Loa (eye worm) acetyltransferase 0.0144 0.0348 0.0348
Mycobacterium ulcerans carbohydrate kinase CbhK 0.0368 0.1047 0.6172
Brugia malayi hypothetical protein 0.0034 0.0001 0.0001
Echinococcus multilocularis adenosine kinase 0.323 1 1
Schistosoma mansoni microtubule-associated protein tau 0.0692 0.206 0.206
Loa Loa (eye worm) hypothetical protein 0.0368 0.1047 0.1047
Leishmania major cathepsin L-like protease 0.005 0.0051 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0032 0.019
Trypanosoma brucei ingi protein (ORF1) 0.0145 0.0348 0.0347
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.0368 0.1047 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0015 0.0146
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0032 0.0298
Brugia malayi Pao retrotransposon peptidase family protein 0.0034 0.0001 0.0001
Echinococcus granulosus cathepsin l1 0.005 0.0051 0.0051
Trypanosoma brucei hypothetical protein, conserved 0.0145 0.0348 0.0347
Plasmodium falciparum glutathione reductase 0.0046 0.0039 0.5563
Brugia malayi Cathepsin L-like precursor 0.005 0.0051 0.0051
Schistosoma mansoni glutaminase 0.0569 0.1677 0.1677
Entamoeba histolytica hypothetical protein 0.0035 0.0006 0.0059
Trypanosoma brucei adenosine kinase, putative 0.323 1 1
Treponema pallidum ribonuclease H (rnhA) 0.0111 0.0243 0.5
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0034 0.0001 0.0004
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0132 0.0132
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0222 0.2113
Leishmania major trypanothione reductase 0.0046 0.0039 0.0007
Echinococcus multilocularis microtubule associated protein 2 0.0692 0.206 0.2059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.0489 0.0488
Brugia malayi Pao retrotransposon peptidase family protein 0.0034 0.0001 0.0001
Trichomonas vaginalis reverse transcriptases, putative 0.0034 0.0001 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.0489 0.0488
Trichomonas vaginalis reverse transcriptases, putative 0.0034 0.0001 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.0489 0.0488
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0035 0.0209
Plasmodium falciparum thioredoxin reductase 0.0046 0.0039 0.5563
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0015 0.014
Onchocerca volvulus Ribonuclease H1 homolog 0.0111 0.0243 0.0275
Entamoeba histolytica hypothetical protein 0.0035 0.0006 0.0059
Onchocerca volvulus 0.0368 0.1047 0.1183
Trypanosoma cruzi cysteine peptidase, putative 0.019 0.0489 0.0488
Leishmania major cathepsin L-like protease 0.019 0.0489 0.0459
Trichomonas vaginalis esterase, putative 0.0043 0.0032 0.019
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0326 0.0326
Schistosoma mansoni hypothetical protein 0.0035 0.0006 0.0006
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0047 0.0047
Echinococcus multilocularis ribonuclease H1 0.0111 0.0243 0.0242
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0051 0.0307
Giardia lamblia Ribonuclease H 0.0111 0.0243 0.2316
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0032
Echinococcus granulosus RNA directed DNA polymerase 0.0034 0.0001 0.0001
Leishmania major ribokinase, putative 0.0368 0.1047 0.1019
Plasmodium vivax vivapain-2 0.005 0.0051 0.4082
Echinococcus granulosus adenosine kinase 0.323 1 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0039 0.0038
Brugia malayi reverse transcriptase 0.0034 0.0001 0.0001
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0057 0.0057
Onchocerca volvulus Cathepsin L homolog 0.005 0.0051 0.0058
Brugia malayi Pao retrotransposon peptidase family protein 0.0034 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.0489 0.0488
Trypanosoma brucei ingi protein (ORF1) 0.0145 0.0348 0.0347
Onchocerca volvulus 0.0043 0.0032 0.0036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0051 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0051 0.0307
Mycobacterium tuberculosis Conserved protein 0.0043 0.0032 0.0298
Schistosoma mansoni adenosine kinase 0.323 1 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0034 0.0001 0.0001
Trypanosoma brucei unspecified product 0.0145 0.0348 0.0347
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0051 0.0307
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0051 0.0492
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0034 0.0001 0.0001
Toxoplasma gondii kinase, pfkB family protein 0.0368 0.1047 0.1019
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0051 0.0492
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0258 0.2461
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0034 0.0001 0.0001
Leishmania major adenosine kinase-like protein 0.0368 0.1047 0.1019
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.0368 0.1047 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.0039 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0051 0.0307
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0034 0.0001 0.0001
Schistosoma mansoni cathepsin F (C01 family) 0.005 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0032
Trypanosoma cruzi cysteine peptidase, putative 0.019 0.0489 0.0488
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.008 0.0048
Brugia malayi Pao retrotransposon peptidase family protein 0.0034 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0051 0.0307
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0035 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0051 0.0307
Trypanosoma cruzi major cysteine proteinase, putative 0.0149 0.0362 0.0361
Brugia malayi Pre-SET motif family protein 0.041 0.118 0.118
Loa Loa (eye worm) hypothetical protein 0.005 0.0051 0.0051
Brugia malayi RNase H family protein 0.0111 0.0243 0.0243
Echinococcus granulosus cathepsin l cysteine peptidase 0.005 0.0051 0.0051
Trypanosoma cruzi cysteine peptidase, putative 0.019 0.0489 0.0488
Brugia malayi glutaminase DH11.1 0.0569 0.1677 0.1677
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0051 0.0307
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0032 0.0031
Toxoplasma gondii thioredoxin reductase 0.0046 0.0039 0.0007
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.008 0.0079
Loa Loa (eye worm) hypothetical protein 0.0368 0.1047 0.1047
Echinococcus granulosus cathepsin L cysteine proteinase 0.005 0.0051 0.0051
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0032 0.019
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0057 0.0026
Onchocerca volvulus 0.0034 0.0001 0.0001
Toxoplasma gondii ribonuclease HI protein 0.0111 0.0243 0.0212
Leishmania major cathepsin L-like protease 0.019 0.0489 0.0459
Brugia malayi Zinc knuckle family protein 0.0034 0.0001 0.0001
Trypanosoma brucei trypanothione reductase 0.0046 0.0039 0.0038
Giardia lamblia Ribokinase 0.0368 0.1047 1
Schistosoma mansoni cathepsin F (C01 family) 0.005 0.0051 0.0051
Leishmania major tagatose-6-phosphate kinase-like protein 0.0368 0.1047 0.1019
Loa Loa (eye worm) hypothetical protein 0.0055 0.0068 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0051 0.0307
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0032 0.0298
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0368 0.1047 0.1047
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0111 0.0243 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.0489 0.0488
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0765 0.7303
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0039 0.0039
Plasmodium falciparum cysteine proteinase falcipain 2b 0.005 0.0051 0.8591
Brugia malayi Cathepsin L-like precursor 0.005 0.0051 0.0051
Brugia malayi beta-lactamase 0.0043 0.0032 0.0032
Trypanosoma cruzi ribokinase, putative 0.0368 0.1047 0.1047
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0051 0.0051
Leishmania major adenosine kinase, putative 0.323 1 1
Brugia malayi Cathepsin L-like precursor 0.005 0.0051 0.0051
Loa Loa (eye worm) ctsf protein 0.005 0.0051 0.0051
Loa Loa (eye worm) glutaminase 0.0569 0.1677 0.1677
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0034 0.0001 0.0001
Echinococcus multilocularis cysteine protease 0.005 0.0051 0.0051
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0032 0.0298
Onchocerca volvulus 0.005 0.0051 0.0058
Brugia malayi beta-lactamase family protein 0.0043 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0032
Onchocerca volvulus 0.005 0.0051 0.0058
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0032 0.0031
Echinococcus granulosus microtubule associated protein 2 0.0692 0.206 0.206
Leishmania major cysteine peptidase A (CPA) 0.005 0.0051 0.002
Brugia malayi Bromodomain containing protein 0.0094 0.019 0.019
Brugia malayi hypothetical protein 0.0034 0.0001 0.0001
Trichomonas vaginalis ribokinase, putative 0.0368 0.1047 0.6244
Brugia malayi hypothetical protein 0.0034 0.0001 0.0001
Echinococcus granulosus ribokinase 0.0368 0.1047 0.1047
Onchocerca volvulus 0.0059 0.008 0.009
Onchocerca volvulus 0.0034 0.0001 0.0001
Leishmania major cathepsin L-like protease 0.005 0.0051 0.002
Brugia malayi PHD-finger family protein 0.0034 0.0001 0.0001
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0032 0.0298
Brugia malayi beta-lactamase family protein 0.0043 0.0032 0.0032
Brugia malayi Ribokinase 0.0368 0.1047 0.1047
Onchocerca volvulus 0.005 0.0051 0.0058
Echinococcus multilocularis cathepsin L cysteine protease 0.005 0.0051 0.0051
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0006 0.0006
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.0368 0.1047 1
Schistosoma mansoni hypothetical protein 0.0034 0.0001 0.0001
Onchocerca volvulus 0.2862 0.8849 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.005 0.0051 0.0051
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0035 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0079 0.0144 0.0144
Trypanosoma cruzi cruzipain precursor, putative 0.019 0.0489 0.0488
Toxoplasma gondii cathepsin CPL 0.005 0.0051 0.002
Echinococcus multilocularis tumor protein p63 0.033 0.0929 0.0928
Leishmania major cathepsin L-like protease 0.005 0.0051 0.002
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0222 0.2113
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.0348 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0051 0.0307
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0051 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.0489 0.0488
Mycobacterium ulcerans fructokinase, PfkB 0.0368 0.1047 0.6172
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0039 0.0038
Schistosoma mansoni protein kinase 0.0034 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0051 0.0307
Leishmania major putative PfkB family sugar kinase 0.0368 0.1047 0.1019
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0222 0.2113
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.0222 0.1871
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0051 0.0307
Plasmodium vivax glutathione reductase, putative 0.0046 0.0039 0.143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0051 0.0307
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0057 0.5315
Brugia malayi Pao retrotransposon peptidase family protein 0.0034 0.0001 0.0001
Brugia malayi hypothetical protein 0.0035 0.0006 0.0006
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0032 0.0298
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0032 0.0032
Plasmodium vivax SET domain protein, putative 0.0059 0.008 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0035 0.0003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.041 0.118 0.118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.0489 0.0488
Onchocerca volvulus 0.0043 0.0032 0.0036
Loa Loa (eye worm) hypothetical protein 0.0046 0.0041 0.0041
Trypanosoma cruzi adenosine kinase, putative 0.323 1 1
Echinococcus multilocularis ribokinase 0.0368 0.1047 0.1047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0051 0.0307
Brugia malayi Bromodomain containing protein 0.005 0.0051 0.0051
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0032 0.0032
Onchocerca volvulus 0.0048 0.0047 0.0053
Leishmania major cathepsin L-like protease 0.005 0.0051 0.002
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0057 0.0057
Echinococcus granulosus histone lysine methyltransferase setb 0.0079 0.0144 0.0144
Schistosoma mansoni bromodomain containing protein 0.008 0.0146 0.0146
Onchocerca volvulus Ribokinase homolog 0.0368 0.1047 0.1183
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.008 0.008
Leishmania major hypothetical protein, conserved 0.0052 0.0057 0.0026
Toxoplasma gondii kinase, pfkB family protein 0.323 1 1
Onchocerca volvulus 0.005 0.0051 0.0058
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0032
Loa Loa (eye worm) beta-lactamase 0.0043 0.0032 0.0032
Echinococcus multilocularis cysteine protease 0.005 0.0051 0.0051
Schistosoma mansoni adenosine kinase 0.323 1 1
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0368 0.1047 0.1047
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0032 0.0298
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0222 0.2113
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0051 0.0307
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0032 0.0032
Trypanosoma brucei ribonuclease H1 0.0111 0.0243 0.0242
Loa Loa (eye worm) glutaminase 2 0.0569 0.1677 0.1677
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0032 0.0032
Trichomonas vaginalis ribokinase, putative 0.0368 0.1047 0.6244
Brugia malayi RNase H family protein 0.0111 0.0243 0.0243
Trypanosoma brucei ribokinase, putative 0.0368 0.1047 0.1047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0051 0.0307
Trypanosoma cruzi adenosine kinase, putative 0.323 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0032 0.019
Loa Loa (eye worm) hypothetical protein 0.0052 0.0057 0.0057
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0034 0.0001 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0079 0.0144 0.0144
Onchocerca volvulus Cathepsin L homolog 0.005 0.0051 0.0058
Mycobacterium leprae Probable adenosine kinase adk 0.0368 0.1047 1
Trichomonas vaginalis conserved hypothetical protein 0.0368 0.1047 0.6244
Trypanosoma cruzi ribonuclease H1, putative 0.0111 0.0243 0.0242
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.005 0.0051 0.0051
Onchocerca volvulus 0.005 0.0051 0.0058
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0073 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0051 0.0307
Onchocerca volvulus Putative pyridoxal kinase 0.0368 0.1047 0.1183
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0051 0.0307
Brugia malayi Pao retrotransposon peptidase family protein 0.0034 0.0001 0.0001
Leishmania major tagatose-6-phosphate kinase-like protein 0.0368 0.1047 0.1019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.008 0.008
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0032 0.0298
Plasmodium falciparum cysteine proteinase falcipain 3 0.005 0.0051 0.8591
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0032 0.0031
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0132 0.0132
Mycobacterium tuberculosis Ribokinase RbsK 0.0368 0.1047 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0032 0.0032
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0039 0.143
Echinococcus multilocularis cathepsin L cysteine protease 0.005 0.0051 0.0051
Onchocerca volvulus 0.0043 0.0032 0.0036
Mycobacterium tuberculosis Conserved protein 0.0043 0.0032 0.0298
Onchocerca volvulus 0.005 0.0051 0.0058
Loa Loa (eye worm) fibroinase 0.005 0.0051 0.0051
Loa Loa (eye worm) cysteine protease 0.005 0.0051 0.0051
Echinococcus multilocularis cathepsin l cysteine peptidase 0.005 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0051 0.0307
Brugia malayi Pao retrotransposon peptidase family protein 0.0034 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0035 0.0006 0.0059
Trichomonas vaginalis glutaminase, putative 0.0569 0.1677 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0032 0.0032
Brugia malayi Cathepsin L-like precursor 0.005 0.0051 0.0051
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0222 0.2113
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0032 0.019
Leishmania major cathepsin L-like protease 0.005 0.0051 0.002
Onchocerca volvulus Cathepsin F homolog 0.005 0.0051 0.0058
Brugia malayi Pao retrotransposon peptidase family protein 0.0034 0.0001 0.0001
Schistosoma mansoni phosphoglucomutase 0.0111 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0032
Leishmania major ribonuclease H1, putative 0.0111 0.0243 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0051 0.0307
Schistosoma mansoni hypothetical protein 0.0034 0.0001 0.0001
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0034 0.0001 0.0001
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0039 0.0364
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0035 0.067
Schistosoma mansoni phosphoglucomutase 0.0111 0.0243 0.0243
Brugia malayi hypothetical protein 0.0052 0.0057 0.0057
Brugia malayi Pao retrotransposon peptidase family protein 0.0034 0.0001 0.0001
Onchocerca volvulus 0.005 0.0051 0.0058
Entamoeba histolytica hypothetical protein 0.0035 0.0006 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.0489 0.0488
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0173 0.0437 0.0437
Echinococcus granulosus ribonuclease H1 0.0111 0.0243 0.0243
Trypanosoma cruzi adenosine kinase, putative 0.0368 0.1047 0.1047
Trichomonas vaginalis ribokinase, putative 0.0368 0.1047 0.6244
Entamoeba histolytica fructokinase, putative 0.0368 0.1047 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0006 0.0006
Brugia malayi Pao retrotransposon peptidase family protein 0.0034 0.0001 0.0001
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0051 0.0051
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.0348 0.0348
Mycobacterium ulcerans glutaminase 0.0569 0.1677 1
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0034 0.0001 0.0001
Brugia malayi Cathepsin L-like precursor 0.005 0.0051 0.0051
Brugia malayi Zinc knuckle family protein 0.0034 0.0001 0.0001
Brugia malayi Pao retrotransposon peptidase family protein 0.0034 0.0001 0.0001
Leishmania major cathepsin L-like protease 0.019 0.0489 0.0459
Onchocerca volvulus 0.0467 0.1357 0.1534
Brugia malayi hypothetical protein 0.0034 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0051 0.0307
Loa Loa (eye worm) hypothetical protein 0.0079 0.0144 0.0144
Schistosoma mansoni phosphoglucomutase 0.0111 0.0243 0.0243
Trypanosoma brucei RNA helicase, putative 0.1479 0.4525 0.4524
Entamoeba histolytica kinase, PfkB family 0.0368 0.1047 1
Echinococcus granulosus tumor protein p63 0.033 0.0929 0.0929
Trichomonas vaginalis set domain proteins, putative 0.0467 0.1357 0.8094
Brugia malayi glutathione reductase 0.0046 0.0039 0.0039
Brugia malayi Pao retrotransposon peptidase family protein 0.0034 0.0001 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0057 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0258 0.2461
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0006 0.0006
Brugia malayi Thioredoxin reductase 0.0046 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.1479 0.4525 0.4525
Brugia malayi Pao retrotransposon peptidase family protein 0.0034 0.0001 0.0001
Brugia malayi Pre-SET motif family protein 0.0059 0.008 0.008
Mycobacterium tuberculosis Adenosine kinase 0.0368 0.1047 1
Brugia malayi Cathepsin L-like precursor 0.005 0.0051 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.0489 0.0488
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0032 0.019
Mycobacterium tuberculosis Probable reductase 0.0104 0.0222 0.2113
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0145 0.0348 0.0347
Mycobacterium tuberculosis Conserved protein 0.0043 0.0032 0.0298
Trypanosoma brucei adenosine kinase, putative 0.323 1 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.0348 0.0347
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.0489 0.0488
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0258 0.2229
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0258 0.2461
Echinococcus granulosus KRAB A domain containing protein 0.0034 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0032 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.005 0.0051 0.0307
Entamoeba histolytica ribokinase, putative 0.0368 0.1047 1
Loa Loa (eye worm) hypothetical protein 0.323 1 1
Trypanosoma cruzi ribonuclease H1, putative 0.0111 0.0243 0.0242
Leishmania major adenosine kinase-like protein 0.0368 0.1047 0.1019
Brugia malayi hypothetical protein 0.0368 0.1047 0.1047
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0035 0.0209
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0039 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.0489 0.0488
Trichomonas vaginalis ribonuclease H1, putative 0.0111 0.0243 0.1449
Plasmodium falciparum cysteine proteinase falcipain 2a 0.005 0.0051 0.8591
Entamoeba histolytica cysteine protease, putative 0.005 0.0051 0.0492
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0051 0.0307
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0079 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0053 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0085 0.0163 0.0163
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0032 0.0031
Brugia malayi reverse transcriptase 0.0034 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.005 0.0051 0.0307
Trypanosoma brucei ribokinase, putative 0.0368 0.1047 0.1047
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0057 1
Trypanosoma cruzi adenosine kinase, putative 0.0368 0.1047 0.1047
Brugia malayi RNase H family protein 0.0111 0.0243 0.0243
Brugia malayi reverse transcriptase 0.0034 0.0001 0.0001
Plasmodium vivax vivapain-2 0.005 0.0051 0.4082
Schistosoma mansoni ribokinase 0.0368 0.1047 0.1047

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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