Detailed information for compound 731006

Basic information

Technical information
  • TDR Targets ID: 731006
  • Name: N-(2,4-dioxo-1H-pyrimidin-5-yl)-2-(2-methoxyp henoxy)acetamide
  • MW: 291.259 | Formula: C13H13N3O5
  • H donors: 3 H acceptors: 5 LogP: 1 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1OCC(=O)Nc1cnc(nc1O)O
  • InChi: 1S/C13H13N3O5/c1-20-9-4-2-3-5-10(9)21-7-11(17)15-8-6-14-13(19)16-12(8)18/h2-6H,7H2,1H3,(H,15,17)(H2,14,16,18,19)
  • InChiKey: HMAOBOKXMQMCFE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,4-diketo-1H-pyrimidin-5-yl)-2-(2-methoxyphenoxy)acetamide
  • N-(2,4-dioxo-1H-pyrimidin-5-yl)-2-(2-methoxyphenoxy)ethanamide
  • BAS 02982212
  • N-(2,4-Dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-2-(2-methoxy-phenoxy)-acetamide
  • CBKinase1_014014
  • CBKinase1_001614
  • ZINC00070176
  • EU-0010658
  • STK223185

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0422 0.5744
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0133 0.1815
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0036 0.0252 0.3258
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0619 0.8431
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0022 0.0297
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0752 1
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0279 0.0406
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0279 0.3796
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0619 0.8431
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0175 0.0265
Brugia malayi beta-lactamase family protein 0.0075 0.0734 0.1109
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0279 0.3796
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0135 0.1675
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0076 0.0114
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0114
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0279 0.0421
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0076 0.0076
Trypanosoma brucei unspecified product 0.0026 0.0133 0.1815
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0428 0.0732
Plasmodium vivax vivapain-2 0.0017 0.0022 0.0297
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0446 0.6073
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0076 0.0076
Leishmania major DNA polymerase kappa, putative 0.0038 0.0279 0.3796
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0153 0.2086
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.001 0.0139
Mycobacterium ulcerans glutaminase 0.055 0.6618 1
Trypanosoma brucei trypanothione reductase 0.0047 0.0388 0.5292
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0279 0.047
Brugia malayi Bromodomain containing protein 0.0078 0.0771 0.1165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0619 0.8431
Brugia malayi Cathepsin L-like precursor 0.0017 0.0022 0.0034
Brugia malayi beta-lactamase 0.0075 0.0734 0.1109
Schistosoma mansoni apoferritin-2 0.0036 0.0252 0.0274
Echinococcus multilocularis GPCR, family 2 0.0032 0.0207 0.0207
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0207 0.0312
Loa Loa (eye worm) hypothetical protein 0.0028 0.0153 0.0231
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0752 0.1123
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0076 0.0082
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0076 0.0114
Loa Loa (eye worm) hypothetical protein 0.0075 0.0734 0.1109
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0279 0.047
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.1276 0.222
Leishmania major cathepsin L-like protease 0.0017 0.0022 0.0305
Loa Loa (eye worm) hypothetical protein 0.0038 0.0279 0.0421
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0752 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0076 0.0114
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0422 0.0637
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0036 0.0252 0.0424
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0388 0.0663
Brugia malayi Cathepsin L-like precursor 0.0017 0.0022 0.0034
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0114
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.1129 0.1962
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0296 0.0448
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0288 0.3827
Echinococcus granulosus zinc finger protein 0.0023 0.0093 0.0101
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0734 0.1095
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0428 0.0465
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0076 0.0082
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0076 0.0114
Schistosoma mansoni ferritin 0.0036 0.0252 0.0274
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0022 0.0297
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0022 0.0022
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0752 0.0752
Loa Loa (eye worm) fibroinase 0.0017 0.0022 0.0034
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.001 0.0139
Plasmodium vivax vivapain-2 0.0017 0.0022 0.0297
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.001 0.0143
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0279 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0265 0.04
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0279 0.0279
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0752 0.1123
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0076 0.0082
Mycobacterium ulcerans lipase LipD 0.0075 0.0734 0.1095
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0734 0.1109
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0752 0.0818
Echinococcus granulosus GPCR family 2 0.0032 0.0207 0.0225
Schistosoma mansoni ferritin light chain 0.0036 0.0252 0.0274
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0133 0.1815
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0022 0.0034
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.001 0.0139
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0422 0.5744
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0422 0.0458
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0114
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0734 0.1109
Loa Loa (eye worm) glutaminase 0.055 0.6618 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0076 0.0114
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.001 0.0011
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.0422 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0332 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.014 0.0212
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0022 0.0022
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.1276 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0022 0.0034
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0279 0.3796
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0114
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0076 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0279 0.3796
Onchocerca volvulus 0.0049 0.0415 0.5654
Echinococcus multilocularis expressed protein 0.0036 0.0252 0.0252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.022 0.0333
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0114
Schistosoma mansoni thyroid hormone receptor 0.0289 0.3383 0.3678
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0022 0.0022
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0428 0.0732
Loa Loa (eye worm) beta-lactamase 0.0075 0.0734 0.1109
Entamoeba histolytica cysteine protease, putative 0.0017 0.0022 0.053
Leishmania major cathepsin L-like protease 0.0017 0.0022 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0172 0.026
Leishmania major hypothetical protein, conserved 0.0028 0.0153 0.2086
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0086 0.0093
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1063 0.1606
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0019 0.002
Onchocerca volvulus 0.0021 0.0076 0.1031
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0022 0.0024
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0752 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0279 0.3796
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0288 0.683
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.0422 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0279 0.0303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0022 0.0034
Onchocerca volvulus 0.0017 0.0022 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.014 0.0212
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0279 0.3796
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0296 0.0448
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.1611 0.1611
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0015 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0015 0.0023
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0015 0.0207
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0076 0.0082
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0584 0.0584
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0022 0.0034
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0207 0.0312
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0279 0.3796
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0015 0.0023
Brugia malayi Cathepsin L-like precursor 0.0017 0.0022 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0019 0.002
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0549 0.7475
Loa Loa (eye worm) hypothetical protein 0.007 0.0675 0.102
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.1611 0.1752
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0076 0.0076
Treponema pallidum bacterioferrin (TpF1) 0.0036 0.0252 0.3258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0296 0.0448
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0019 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.014 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0022 0.0034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.001 0.0143
Brugia malayi glutathione reductase 0.0047 0.0388 0.0587
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0153 0.2035
Toxoplasma gondii cathepsin CPL 0.0017 0.0022 0.0297
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0022 0.0034
Schistosoma mansoni ferritin 0.0036 0.0252 0.0274
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0153 0.2086
Mycobacterium tuberculosis Conserved protein 0.0075 0.0734 0.1269
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.001 0.0139
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.001 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0207 0.0313
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0076 0.0114
Onchocerca volvulus 0.0075 0.0734 1
Brugia malayi steroid hormone receptor 0.0021 0.0076 0.0114
Loa Loa (eye worm) hypothetical protein 0.0069 0.0667 0.1007
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0279 0.0421
Mycobacterium tuberculosis Probable reductase 0.0107 0.1129 0.1962
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0619 0.8431
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.1129 0.1962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0619 0.8431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0619 0.8431
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0076 0.0114
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0153 0.2086
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1249 0.1887
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0207 0.0207
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.036 0.0544
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0388 0.0587
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0297 0.4046
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0584 0.0634
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0734 0.1269
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.036 0.4789
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0076 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0015 0.0023
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0019 0.002
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1249 0.1887
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0296 0.0448
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0076 0.0076
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0279 0.0279
Echinococcus multilocularis cysteine protease 0.0017 0.0022 0.0022
Echinococcus granulosus dna polymerase eta 0.0038 0.0279 0.0303
Echinococcus multilocularis dna polymerase eta 0.0038 0.0279 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0422 0.0637
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0076 0.0114
Trypanosoma brucei unspecified product 0.0026 0.0133 0.1815
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0135 0.1791
Brugia malayi Cathepsin L-like precursor 0.0017 0.0022 0.0034
Schistosoma mansoni hypothetical protein 0.0032 0.0207 0.0225
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0022 0.0024
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0099 0.1353
Schistosoma mansoni bromodomain containing protein 0.0066 0.0627 0.0682
Leishmania major hypothetical protein, conserved 0.0075 0.0734 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0422 0.0637
Schistosoma mansoni ferritin light chain 0.0036 0.0252 0.0274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0022 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0422 0.0637
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.036 0.0544
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0022 0.0034
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0015 0.0016
Leishmania major trypanothione reductase 0.0047 0.0388 0.5292
Echinococcus granulosus ferritin 0.0036 0.0252 0.0274
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0388 0.0422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0022 0.0034
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0076 0.0076
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.1129 0.8711
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0076 0.0082
Giardia lamblia GTOR 0.0049 0.0422 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0265 0.04
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1063 0.1606
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0022 0.0034
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0015 0.0207
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.025 0.0271
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0114
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0022 0.0034
Loa Loa (eye worm) hypothetical protein 0.0075 0.0734 0.1109
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0019 0.0019
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.001 0.0139
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.001 0.0143
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0076 0.0076
Brugia malayi glutaminase DH11.1 0.055 0.6618 1
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0022 0.0305
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0752 1
Schistosoma mansoni hypothetical protein 0.0032 0.0207 0.0225
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0076 0.0082
Brugia malayi MH2 domain containing protein 0.0116 0.1249 0.1887
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.001 0.0143
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0207 0.0207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0076 0.0114
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.001 0.0143
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.001 0.0143
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0388 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0076 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0076 0.0114
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0752 0.0818
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0022 0.0034
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0062 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0265 0.04
Loa Loa (eye worm) glutaminase 2 0.055 0.6618 1
Loa Loa (eye worm) ctsf protein 0.0017 0.0022 0.0034
Mycobacterium tuberculosis Conserved protein 0.0075 0.0734 0.1269
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.001 0.0143
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0076 0.1031
Loa Loa (eye worm) acetyltransferase 0.0146 0.1611 0.2435
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.0015 0.0207
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0034
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0752 0.541
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0022 0.0034
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.001 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0076 0.0114
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.036 0.0392
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0076 0.0082
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0279 0.0303
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0422 0.0458
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.001 0.0143
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.001 0.0143
Brugia malayi nuclear receptor NHR-88 0.0021 0.0076 0.0114
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0388 0.5162
Loa Loa (eye worm) hypothetical protein 0.0101 0.1063 0.1606
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.036 0.4789
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0279 0.3796
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0022 0.0034
Brugia malayi Cathepsin L-like precursor 0.0017 0.0022 0.0034
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0135 0.1791
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0076 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0076 0.0114
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0619 0.8431
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.1129 0.1962
Schistosoma mansoni coup transcription factor 0.0021 0.0076 0.0082
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0022 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0076 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.014 0.0211
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.001 0.0143
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.001 0.0016
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0734 0.1109
Loa Loa (eye worm) hypothetical protein 0.0075 0.0734 0.1109
Brugia malayi nuclear hormone receptor 0.0021 0.0076 0.0114
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.007 0.0105
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0022 0.0024
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0153 0.2035
Leishmania major cathepsin L-like protease 0.0065 0.0619 0.8431
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0422 0.5744
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0279 0.6608
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.001 0.0016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0734 0.0798
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0279 0.3796
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0022 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0265 0.04
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0076 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0022 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0076 0.0114
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0279 0.3796
Schistosoma mansoni hypothetical protein 0.0267 0.3118 0.3389
Echinococcus multilocularis tumor protein p63 0.0334 0.3942 0.3942
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0422 0.0422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0022 0.0034
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0267 0.3118 0.3389
Plasmodium vivax glutathione reductase, putative 0.0047 0.0388 0.5162
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1063 0.1606
Brugia malayi hypothetical protein 0.0018 0.0032 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0734 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0422 0.5744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0265 0.04
Mycobacterium ulcerans hypothetical protein 0.0075 0.0734 0.1095
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0015 0.0015
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0022 0.053
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0279 0.0303
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0086 0.0093
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0734 0.9755
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0036 0.0252 0.1029
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0022 0.0297
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.014 0.0211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0076 0.0114
Mycobacterium ulcerans bacterioferritin BfrB 0.0036 0.0252 0.0366
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.025 0.025
Plasmodium falciparum glutathione reductase 0.0016 0.001 0.0139
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0114
Loa Loa (eye worm) hypothetical protein 0.0038 0.0279 0.0422
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0279 0.3796
Trichomonas vaginalis esterase, putative 0.0075 0.0734 0.1109
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0619 0.8431
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0734 0.1269
Onchocerca volvulus 0.0017 0.0022 0.0305
Schistosoma mansoni hypothetical protein 0.0032 0.0207 0.0225
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0619 0.8431
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0207 0.0312
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0734 0.5248
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.001 0.0139
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0015 0.0207
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.001 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0619 0.8431
Plasmodium falciparum thioredoxin reductase 0.0047 0.0388 0.5162
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0752 1
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0076 0.0082
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0734 0.0734
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0076 0.0082
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0477 0.5712 1
Onchocerca volvulus 0.0017 0.0022 0.0305
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0022 0.053
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0279 0.3796
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0288 0.683
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0207 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0172 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0022 0.0034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0076 0.0114
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.001 0.0143
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0064 0.0873
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.014 0.0212
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.001 0.0143
Onchocerca volvulus 0.0017 0.0022 0.0305
Onchocerca volvulus 0.0017 0.0022 0.0305
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0279 0.0406
Giardia lamblia DINP protein human, muc B family 0.0038 0.0279 0.6608
Plasmodium falciparum thioredoxin reductase 0.0016 0.001 0.0139
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.1611 0.2435
Leishmania major cathepsin L-like protease 0.0065 0.0619 0.8431
Brugia malayi hypothetical protein 0.0028 0.0153 0.0231
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0015 0.0207
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0734 1
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0022 0.0305
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0022 0.0022
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0076 0.0082
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.001 0.0143
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0076 0.0076
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0015 0.0016
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.001 0.0249
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0734 0.1109
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0279 0.3796
Leishmania major cathepsin L-like protease 0.0017 0.0022 0.0305
Echinococcus multilocularis microtubule associated protein 2 0.0759 0.9199 0.9199
Brugia malayi Probable ClpP-like protease 0.0076 0.0752 0.1137
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0076 0.0082
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0734 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0076 0.0114
Mycobacterium leprae Probable lipase LipE 0.0075 0.0734 0.5248
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0076 0.0082
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0267 0.3118 0.3118
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0153 0.2035
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.1129 0.1962
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0022 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0022 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0619 0.8431
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0667 0.1007
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0076 0.0114
Schistosoma mansoni DNA polymerase eta 0.0038 0.0279 0.0303
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0153 0.2035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0265 0.04
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0422 0.0637
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0175 0.0265
Toxoplasma gondii hypothetical protein 0.0026 0.0135 0.1791
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0297 0.4046
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0133 0.1815
Toxoplasma gondii target of rapamycin (TOR), putative 0.0037 0.0265 0.3521
Onchocerca volvulus 0.0017 0.0022 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0265 0.04
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0076 0.1031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0619 0.8431
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0279 0.3796
Schistosoma mansoni microtubule-associated protein tau 0.0759 0.9199 1
Leishmania major cathepsin L-like protease 0.0017 0.0022 0.0305
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0022 0.0034
Schistosoma mansoni apoferritin-2 0.0036 0.0252 0.0274
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.1276 0.222
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0076 0.0082
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.036 0.4789
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0279 0.3796
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0036 0.0252 0.0424
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.1129 0.1962
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0046 0.0375 0.0567
Leishmania major cathepsin L-like protease 0.0065 0.0619 0.8431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0015 0.0023
Schistosoma mansoni hypothetical protein 0.0069 0.0667 0.0725
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0076 0.1031
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0734 0.1109
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0076 0.0114
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0428 0.2566
Leishmania major DNA polymerase eta, putative 0.0038 0.0279 0.3796
Onchocerca volvulus 0.0017 0.0022 0.0305
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0734 0.1269
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0734 0.1269
Echinococcus multilocularis ferritin 0.0036 0.0252 0.0252
Mycobacterium tuberculosis Conserved protein 0.0075 0.0734 0.1269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0619 0.8431
Brugia malayi ecdysteroid receptor 0.0021 0.0076 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0175 0.0265
Loa Loa (eye worm) hypothetical protein 0.0044 0.0352 0.0531
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.001 0.0143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0022 0.0034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0076 0.0114
Echinococcus granulosus microtubule associated protein 2 0.0759 0.9199 1
Plasmodium falciparum glutathione reductase 0.0047 0.0388 0.5162
Loa Loa (eye worm) cysteine protease 0.0017 0.0022 0.0034
Brugia malayi Thioredoxin reductase 0.0047 0.0388 0.0587
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0022 0.0034
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0734 0.1109
Schistosoma mansoni hypothetical protein 0.002 0.0062 0.0068
Echinococcus granulosus cathepsin l1 0.0017 0.0022 0.0024
Echinococcus granulosus tumor protein p63 0.0334 0.3942 0.4285
Loa Loa (eye worm) glutathione reductase 0.0047 0.0388 0.0587
Onchocerca volvulus 0.0075 0.0734 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.0015 0.0207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0022 0.0034
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0422 0.5744
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.1533 0.1666
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0752 1
Onchocerca volvulus 0.0075 0.0734 1
Trichomonas vaginalis glutaminase, putative 0.055 0.6618 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0297 0.4046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0296 0.0448
Schistosoma mansoni thyroid hormone receptor 0.0289 0.3383 0.3678
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0075 0.0734 0.1109
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0388 0.5292
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0022 0.0034
Brugia malayi beta-lactamase family protein 0.0075 0.0734 0.1109
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0076 0.0082
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0022 0.0034
Echinococcus multilocularis zinc finger protein 0.0023 0.0093 0.0093
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0734 0.0798
Schistosoma mansoni hypothetical protein 0.0032 0.0207 0.0225
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.001 0.0011
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0022 0.0305
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0279 0.3796
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0022 0.0034
Brugia malayi PHD-finger family protein 0.0028 0.0158 0.0239
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0734 0.1095
Echinococcus granulosus dna polymerase kappa 0.0038 0.0279 0.0303
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0734 0.1269
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0415 0.0451
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0752 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0076 0.0082
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0734 0.0798
Loa Loa (eye worm) hypothetical protein 0.0075 0.0734 0.1109
Mycobacterium ulcerans bacterioferritin BfrA 0.0036 0.0252 0.0366
Trichomonas vaginalis ferritin, putative 0.0036 0.0252 0.0381
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0734 0.1269
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0279 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.014 0.0211
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0734 0.1109
Trypanosoma brucei unspecified product 0.0038 0.0279 0.3796
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0022 0.0305
Echinococcus multilocularis cysteine protease 0.0017 0.0022 0.0022
Schistosoma mansoni zinc finger protein 0.0023 0.0093 0.0101
Leishmania major cathepsin L-like protease 0.0017 0.0022 0.0305
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0619 0.8431
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0076 0.0082
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0086 0.0086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0022 0.0034
Schistosoma mansoni ferritin 0.0036 0.0252 0.0274
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.001 0.0143
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.1276 0.222
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0114
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0279 0.3796
Brugia malayi Cathepsin L-like precursor 0.0017 0.0022 0.0034
Echinococcus granulosus expressed protein 0.0036 0.0252 0.0274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0619 0.8431
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0752 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0279 0.3796
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0422 0.5744
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0076 0.0114
Toxoplasma gondii ABC1 family protein 0.0075 0.0734 0.9755
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0734 0.1269
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.001 0.0143
Brugia malayi Bromodomain containing protein 0.0041 0.0322 0.0486
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0279 0.0421
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0076 0.0082
Schistosoma mansoni glutaminase 0.055 0.6618 0.7194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0015 0.0023
Schistosoma mansoni ferritin 0.0036 0.0252 0.0274
Toxoplasma gondii thioredoxin reductase 0.0047 0.0388 0.5162
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0207 0.0225
Loa Loa (eye worm) hypothetical protein 0.0076 0.0752 0.1137
Loa Loa (eye worm) hypothetical protein 0.0049 0.0415 0.0627
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0279 0.3796
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0428 0.0428
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0019 0.002
Echinococcus multilocularis thyroid hormone receptor alpha 0.0289 0.3383 0.3383
Loa Loa (eye worm) hypothetical protein 0.0075 0.0734 0.1109
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0076 0.0114
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0022 0.0305
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0028
Mycobacterium ulcerans beta-lactamase 0.0075 0.0734 0.1095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0015 0.0023
Loa Loa (eye worm) hypothetical protein 0.0032 0.0207 0.0312
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0279 0.3796

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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