Detailed information for compound 731066

Basic information

Technical information
  • TDR Targets ID: 731066
  • Name: N-(4-iodophenyl)-2-(4-methyl-6-phenylpyrimidi n-2-yl)sulfanylacetamide
  • MW: 461.319 | Formula: C19H16IN3OS
  • H donors: 1 H acceptors: 3 LogP: 4.66 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)I)CSc1nc(C)cc(n1)c1ccccc1
  • InChi: 1S/C19H16IN3OS/c1-13-11-17(14-5-3-2-4-6-14)23-19(21-13)25-12-18(24)22-16-9-7-15(20)8-10-16/h2-11H,12H2,1H3,(H,22,24)
  • InChiKey: SAMMWEOXGHEGSU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-iodophenyl)-2-(4-methyl-6-phenyl-pyrimidin-2-yl)sulfanyl-acetamide
  • N-(4-iodophenyl)-2-[(4-methyl-6-phenyl-2-pyrimidinyl)thio]acetamide
  • N-(4-iodophenyl)-2-[(4-methyl-6-phenyl-pyrimidin-2-yl)thio]acetamide
  • N-(4-iodophenyl)-2-(4-methyl-6-phenyl-pyrimidin-2-yl)sulfanyl-ethanamide
  • CBKinase1_012128
  • CBKinase1_024528
  • ZINC02881298

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0305 0.0364
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0305 0.0364
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0218 0.0681
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0778 0.2595
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0068 0.0839 0.2803
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0748 0.0731
Brugia malayi hypoxia-induced factor 1 0.0148 0.216 0.7335
Schistosoma mansoni apoferritin-2 0.0028 0.0184 0.0166
Loa Loa (eye worm) hypothetical protein 0.0035 0.0305 0.0979
Plasmodium vivax glutathione reductase, putative 0.0196 0.2945 1
Loa Loa (eye worm) aminopeptidase N 0.0035 0.0293 0.0939
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0498 0.7894 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0305 0.0979
Leishmania major cathepsin L-like protease 0.0064 0.0778 0.2595
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0305 0.2706
Plasmodium vivax thioredoxin reductase, putative 0.0196 0.2945 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0305 0.0979
Loa Loa (eye worm) hypothetical protein 0.0023 0.0093 0.0253
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0152 0.0457
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0839 0.2803
Schistosoma mansoni inositol monophosphatase 0.0036 0.032 0.0302
Schistosoma mansoni ferritin light chain 0.0028 0.0184 0.0166
Echinococcus granulosus tar DNA binding protein 0.0062 0.0748 0.2492
Brugia malayi TAR-binding protein 0.0062 0.0748 0.254
Schistosoma mansoni ferritin 0.0028 0.0184 0.0166
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0305 0.1037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0778 0.2595
Echinococcus multilocularis muscleblind protein 1 0.0147 0.2141 0.7253
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.032 0.1031
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0152 0.0457
Onchocerca volvulus 0.0035 0.0305 0.55
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0305 0.0287
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.032 0.264
Plasmodium falciparum thioredoxin reductase 0.0196 0.2945 1
Trichomonas vaginalis esterase, putative 0.0035 0.0305 0.2706
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.032 0.1031
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0748 0.0731
Echinococcus granulosus expressed protein 0.0028 0.0184 0.0565
Echinococcus granulosus chromobox protein 1 0.0083 0.1078 0.3619
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0839 0.2803
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0778 0.2595
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0305 0.2706
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0482 0.4375
Treponema pallidum bacterioferrin (TpF1) 0.0028 0.0184 0.1447
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0258 0.0303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0778 0.2595
Schistosoma mansoni chromobox protein 0.0083 0.1078 0.1061
Plasmodium falciparum thioredoxin reductase 0.0068 0.0839 0.2803
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0305 0.0364
Trypanosoma cruzi trypanothione reductase, putative 0.0068 0.0839 0.2803
Schistosoma mansoni apoferritin-2 0.0028 0.0184 0.0166
Loa Loa (eye worm) hypothetical protein 0.0161 0.2365 0.8018
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0748 0.0731
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0778 0.2595
Echinococcus granulosus muscleblind protein 0.0147 0.2141 0.7253
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0778 0.2595
Echinococcus multilocularis muscleblind protein 0.0147 0.2141 0.7253
Onchocerca volvulus 0.0035 0.0305 0.55
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0068 0.0839 0.2803
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0305 0.0979
Trichomonas vaginalis mercuric reductase, putative 0.0068 0.0839 0.7747
Brugia malayi Peptidase family M1 containing protein 0.0035 0.0293 0.0996
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0068 0.0839 0.0822
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.032 0.1031
Echinococcus granulosus chromobox protein 1 0.0083 0.1078 0.3619
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0482 0.4375
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.032 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0748 0.0731
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0498 0.7894 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.032 0.0302
Schistosoma mansoni single-minded 0.0048 0.051 0.0492
Schistosoma mansoni ferritin light chain 0.0028 0.0184 0.0166
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.032 0.1031
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.032 0.2849
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0152 0.0457
Echinococcus granulosus thioredoxin glutathione reductase 0.0196 0.2945 1
Loa Loa (eye worm) inositol-1 0.0036 0.032 0.1031
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0152 0.0457
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0068 0.0839 0.7181
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0448 0.7074 0.8958
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0305 0.0979
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0748 0.2492
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0035 0.0293 0.0939
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0088 0.1161 0.3904
Mycobacterium ulcerans aminopeptidase N PepN 0.0035 0.0293 0.2405
Trichomonas vaginalis chromobox protein, putative 0.005 0.054 0.492
Brugia malayi glutathione reductase 0.0196 0.2945 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0293 0.0939
Onchocerca volvulus Heterochromatin protein 1 homolog 0.005 0.054 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0068 0.0839 0.7181
Mycobacterium ulcerans hypothetical protein 0.0035 0.0305 0.2508
Brugia malayi hypothetical protein 0.0161 0.2365 0.803
Mycobacterium tuberculosis Probable reductase 0.0448 0.7074 0.8958
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0675 0.2241
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.005 0.0543 0.1843
Loa Loa (eye worm) hypothetical protein 0.0035 0.0305 0.0979
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0068 0.0839 0.2803
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0778 0.2595
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0068 0.0839 0.2803
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0023 0.0093 0.0253
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.003 0.0218 0.0253
Toxoplasma gondii hypothetical protein 0.003 0.0218 0.0681
Brugia malayi PAS domain containing protein 0.0048 0.051 0.1732
Entamoeba histolytica aminopeptidase, putative 0.0035 0.0293 0.9107
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0018 0.0019 0.0064
Trichomonas vaginalis chromobox protein, putative 0.0083 0.1078 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0041 0.0394 0.0376
Brugia malayi Inositol-1 0.0036 0.032 0.1088
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0675 0.0657
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0068 0.0839 0.7181
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0675 0.2241
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0068 0.0839 0.7181
Toxoplasma gondii NADPH-glutathione reductase 0.0068 0.0839 0.2803
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0305 0.0979
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0305 0.2706
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0293 0.0939
Schistosoma mansoni thyroid hormone receptor 0.0133 0.191 0.1895
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0686 0.2281
Echinococcus granulosus ferritin 0.0028 0.0184 0.0565
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0068 0.0839 0.2803
Loa Loa (eye worm) hypothetical protein 0.0147 0.2141 0.7253
Onchocerca volvulus 0.0035 0.0293 0.5273
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0305 0.0364
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0498 0.7894 1
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0035 0.0293 0.0939
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0068 0.0839 0.2803
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0152 0.0457
Brugia malayi beta-lactamase family protein 0.0035 0.0305 0.1037
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0068 0.0839 0.2803
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0068 0.0839 0.2803
Loa Loa (eye worm) hypothetical protein 0.0035 0.0305 0.0979
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.1747 0.5907
Schistosoma mansoni chromobox protein 0.0083 0.1078 0.1061
Brugia malayi Peptidase family M1 containing protein 0.0035 0.0293 0.0996
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0778 0.2595
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.216 0.7318
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0218 0.0681
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0023 0.0093 0.0074
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.1161 0.3904
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0305 0.0364
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0088 0.1161 0.3904
Toxoplasma gondii ABC1 family protein 0.0035 0.0305 0.0979
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0088 0.1161 0.1451
Leishmania major cathepsin L-like protease 0.0064 0.0778 0.2595
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0305 0.0364
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.051 0.0492
Brugia malayi beta-lactamase family protein 0.0035 0.0305 0.1037
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0196 0.2945 0.3716
Loa Loa (eye worm) heterochromatin protein 1 0.0083 0.1078 0.3619
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0305 0.0979
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.032 0.1031
Trichomonas vaginalis glutathione reductase, putative 0.0068 0.0839 0.7747
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0448 0.7074 0.8958
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0068 0.0839 0.2803
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0305 0.2706
Echinococcus granulosus peptidase Clp S14 family 0.0057 0.0665 0.221
Trypanosoma cruzi Aminopeptidase M1, putative 0.0035 0.0293 0.0939
Loa Loa (eye worm) hypothetical protein 0.0088 0.1161 0.3904
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0675 0.2241
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.005 0.0543 0.1843
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0028 0.0184 0.021
Echinococcus granulosus aminopeptidase N 0.0035 0.0293 0.0939
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0088 0.1161 0.3904
Echinococcus multilocularis thioredoxin glutathione reductase 0.0196 0.2945 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0448 0.7074 0.8958
Loa Loa (eye worm) hypothetical protein 0.0046 0.0482 0.1583
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0035 0.0293 0.0939
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0068 0.0839 0.2803
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0305 0.0979
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0675 0.2241
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0293 0.0939
Loa Loa (eye worm) thioredoxin reductase 0.0196 0.2945 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0068 0.0839 0.2803
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.032 0.2849
Loa Loa (eye worm) RNA binding protein 0.0062 0.0748 0.2492
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0023 0.0093 0.0253
Loa Loa (eye worm) beta-lactamase 0.0035 0.0305 0.0979
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0035 0.0293 0.0939
Loa Loa (eye worm) hypothetical protein 0.0023 0.0093 0.0253
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0552 0.1822
Echinococcus multilocularis thyroid hormone receptor alpha 0.0133 0.191 0.6463
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.032 0.2849
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0778 0.2595
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0152 0.0457
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0035 0.0293 0.0939
Loa Loa (eye worm) hypothetical protein 0.0147 0.2141 0.7253
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.1161 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0305 0.0364
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0778 0.2595
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0778 0.2595
Echinococcus multilocularis ferritin 0.0028 0.0184 0.0565
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0839 0.2803
Leishmania major hypothetical protein, conserved 0.0026 0.0152 0.0457
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0068 0.0839 0.2803
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0068 0.0839 0.2803
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0293 0.0939
Schistosoma mansoni ferritin 0.0028 0.0184 0.0166
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0748 0.2492
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0305 0.0287
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0748 0.2492
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0305 0.2508
Echinococcus multilocularis chromobox protein 1 0.0083 0.1078 0.3619
Loa Loa (eye worm) hypothetical protein 0.0023 0.0093 0.0253
Trypanosoma brucei Aminopeptidase M1, putative 0.0035 0.0293 0.0939
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0305 0.0979
Leishmania major cathepsin L-like protease 0.0064 0.0778 0.2595
Brugia malayi jmjC domain containing protein 0.0058 0.0675 0.2291
Echinococcus granulosus single minded 2 0.0035 0.0305 0.0979
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.1161 1
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0675 0.0657
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0748 0.0731
Brugia malayi Thioredoxin reductase 0.0196 0.2945 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0448 0.7074 0.8958
Trichomonas vaginalis chromobox protein, putative 0.005 0.054 0.492
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0305 0.2508
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.3447 0.4353
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.1747 0.5907
Mycobacterium ulcerans lipase LipD 0.0035 0.0305 0.2508
Echinococcus multilocularis expressed protein 0.0028 0.0184 0.0565
Mycobacterium tuberculosis Conserved protein 0.0035 0.0305 0.0364
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0068 0.0839 0.2803
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0088 0.1161 0.3904
Echinococcus multilocularis peptidase Clp (S14 family) 0.0057 0.0665 0.221
Mycobacterium ulcerans bacterioferritin BfrA 0.0028 0.0184 0.1447
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0035 0.0293 0.2594
Trichomonas vaginalis chromobox protein, putative 0.0083 0.1078 1
Schistosoma mansoni hypothetical protein 0.0123 0.1747 0.1732
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.026 0.228
Toxoplasma gondii thioredoxin reductase 0.0196 0.2945 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0482 0.8893
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.026 0.228
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0675 0.2241
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0028 0.0184 0.021
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0068 0.0839 0.2803
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0293 0.0939
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0305 0.0364
Brugia malayi Probable ClpP-like protease 0.0088 0.1161 0.3943
Trypanosoma cruzi aminopeptidase, putative 0.0035 0.0293 0.0939
Loa Loa (eye worm) glutathione reductase 0.0196 0.2945 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0068 0.0839 0.7181
Trypanosoma brucei Aminopeptidase M1, putative 0.0035 0.0293 0.0939
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0018 0.0019 0.0064
Mycobacterium ulcerans beta-lactamase 0.0035 0.0305 0.2508
Onchocerca volvulus 0.0036 0.0318 0.5742
Brugia malayi Muscleblind-like protein 0.0147 0.2141 0.727
Brugia malayi hypothetical protein 0.0035 0.0293 0.0996
Brugia malayi chromobox protein homolog 3 0.0046 0.0482 0.1637
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0293 0.0939
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0035 0.0293 0.0275
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0778 0.2595
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0035 0.0293 0.2594
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0258 0.0303
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0068 0.0839 0.2803
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0778 0.2595
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0305 0.0364
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0839 0.2803
Brugia malayi RNA binding protein 0.0062 0.0748 0.254
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0018 0.0019 0.0064
Plasmodium falciparum glutathione reductase 0.0068 0.0839 0.2803
Onchocerca volvulus 0.0035 0.0305 0.55
Schistosoma mansoni peptidase Clp (S14 family) 0.0088 0.1161 0.1145
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.1161 0.3904
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.032 0.1031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0778 0.2595
Schistosoma mansoni ferritin 0.0028 0.0184 0.0166
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0068 0.0839 0.2849
Loa Loa (eye worm) hypothetical protein 0.0035 0.0305 0.0979
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0293 0.0939
Mycobacterium tuberculosis Probable dehydrogenase 0.0448 0.7074 0.8958
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0088 0.1161 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0839 0.2803
Giardia lamblia NADH oxidase lateral transfer candidate 0.0068 0.0839 1
Echinococcus multilocularis chromobox protein 1 0.0083 0.1078 0.3619
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0293 0.0939
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0088 0.1161 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0305 0.2706
Mycobacterium leprae Probable lipase LipE 0.0035 0.0305 0.0364
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.032 0.1031
Loa Loa (eye worm) hypothetical protein 0.0026 0.0152 0.0457
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0028 0.0184 0.021
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0675 0.0657
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.0218 0.1744
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.032 0.264
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0068 0.0839 0.1042
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0448 0.7074 0.8958
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0057 0.0665 0.0821
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0057 0.0665 0.0821
Loa Loa (eye worm) hypothetical protein 0.0035 0.0305 0.0979
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0152 0.0457
Brugia malayi beta-lactamase 0.0035 0.0305 0.1037
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0305 0.1037
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0057 0.0665 0.0821
Leishmania major hypothetical protein, conserved 0.0035 0.0305 0.0979
Mycobacterium tuberculosis Conserved protein 0.0035 0.0305 0.0364
Brugia malayi hypothetical protein 0.0026 0.0152 0.0518
Echinococcus multilocularis aminopeptidase N 0.0035 0.0293 0.0939
Plasmodium falciparum glutathione reductase 0.0196 0.2945 1
Schistosoma mansoni thyroid hormone receptor 0.0133 0.191 0.1895
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0839 0.2803
Brugia malayi glutamate synthase 0.0018 0.0019 0.0064
Mycobacterium ulcerans bacterioferritin BfrB 0.0028 0.0184 0.1447
Trichomonas vaginalis ferritin, putative 0.0028 0.0184 0.1561
Trypanosoma brucei trypanothione reductase 0.0196 0.2945 1
Schistosoma mansoni ferritin 0.0028 0.0184 0.0166
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0778 0.2595
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0068 0.0839 0.7181
Leishmania major trypanothione reductase 0.0196 0.2945 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0305 0.2508
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0748 0.254
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.1161 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0498 0.7894 1
Onchocerca volvulus 0.0035 0.0305 0.55
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0068 0.0839 0.2803
Loa Loa (eye worm) hypothetical protein 0.0035 0.0305 0.0979
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0293 0.0939
Trypanosoma cruzi trypanothione reductase, putative 0.0196 0.2945 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0028 0.0184 0.1447
Treponema pallidum NADH oxidase 0.0068 0.0839 0.7181
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.1161 1
Brugia malayi Heterochromatin protein 1 0.0083 0.1078 0.3659
Loa Loa (eye worm) hypothetical protein 0.0036 0.0318 0.1022
Onchocerca volvulus 0.0035 0.0293 0.5273
Brugia malayi jmjC domain containing protein 0.0058 0.0675 0.2291

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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