Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.034 | 0.034 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.034 | 0.1071 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.016 | 0.1771 | 0.6452 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0109 | 0.1137 | 0.3596 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0012 | 0.0164 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0045 | 0.033 | 0.4447 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0256 | 0.3519 |
Onchocerca volvulus | 0.0077 | 0.0728 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.04 | 0.1423 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.016 | 0.1771 | 0.5609 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.04 | 0.04 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0256 | 0.3519 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0012 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0113 | 0.1549 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0012 | 0.0029 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0077 | 0.0728 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0132 | 0.1428 | 0.5195 |
Brugia malayi | TAR-binding protein | 0.0132 | 0.1428 | 0.4522 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0012 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0045 | 0.033 | 0.4536 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0215 | 0.2947 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0186 | 0.2546 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0077 | 0.0728 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0012 | 0.002 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.007 | 0.0958 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.007 | 0.0964 |
Echinococcus multilocularis | tumor protein p63 | 0.0399 | 0.4777 | 0.4777 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.027 | 0.3155 | 0.3155 |
Brugia malayi | hypothetical protein | 0.027 | 0.3155 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.027 | 0.3155 | 0.3155 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0045 | 0.033 | 0.1013 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.034 | 0.034 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0133 | 0.1693 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.016 | 0.1771 | 0.5609 |
Echinococcus granulosus | GPCR family 2 | 0.0051 | 0.04 | 0.04 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.007 | 0.0958 |
Echinococcus multilocularis | chromobox protein 1 | 0.007 | 0.0641 | 0.0641 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.04 | 0.04 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0077 | 0.0728 | 0.2301 |
Entamoeba histolytica | hypothetical protein | 0.027 | 0.3155 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0132 | 0.1812 |
Onchocerca volvulus | 0.0077 | 0.0728 | 1 | |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.0294 | 0.2482 |
Onchocerca volvulus | 0.0058 | 0.0499 | 0.6033 | |
Brugia malayi | beta-lactamase family protein | 0.0077 | 0.0728 | 0.2301 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0077 | 0.0728 | 0.123 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0215 | 0.2947 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0077 | 0.0728 | 0.123 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0133 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.007 | 0.0641 | 0.2308 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1137 | 0.4125 |
Loa Loa (eye worm) | RNA binding protein | 0.0132 | 0.1428 | 0.5195 |
Loa Loa (eye worm) | beta-lactamase | 0.0077 | 0.0728 | 0.2626 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.007 | 0.0964 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0248 | 0.34 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.015 | 0.0507 |
Brugia malayi | beta-lactamase family protein | 0.0077 | 0.0728 | 0.2301 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0728 | 0.2626 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0133 | 0.0413 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0728 | 0.2626 |
Mycobacterium leprae | conserved hypothetical protein | 0.0077 | 0.0728 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0132 | 0.1428 | 0.1428 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0077 | 0.0728 | 0.0728 |
Echinococcus multilocularis | GPCR, family 2 | 0.0051 | 0.04 | 0.04 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.1771 | 0.6452 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0133 | 0.1693 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0077 | 0.0728 | 0.123 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0012 | 0.0012 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0103 | 0.1411 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0186 | 0.2546 |
Onchocerca volvulus | 0.0077 | 0.0728 | 1 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0215 | 0.2947 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0012 | 0.016 |
Entamoeba histolytica | hypothetical protein | 0.027 | 0.3155 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0728 | 0.2626 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0045 | 0.033 | 0.4447 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0294 | 0.4031 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0036 | 0.0215 | 0.2839 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0077 | 0.0728 | 0.123 |
Echinococcus granulosus | chromobox protein 1 | 0.007 | 0.0641 | 0.0641 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0186 | 0.2546 |
Mycobacterium ulcerans | beta-lactamase | 0.0077 | 0.0728 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0215 | 0.2947 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.1312 | 0.4154 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0077 | 0.0728 | 0.123 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0372 | 0.0371 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0077 | 0.0728 | 0.2626 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.1137 | 0.1136 |
Echinococcus granulosus | tumor protein p63 | 0.0399 | 0.4777 | 0.4777 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0077 | 0.0728 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.1428 | 0.1428 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0077 | 0.0728 | 0.0728 |
Entamoeba histolytica | hypothetical protein | 0.027 | 0.3155 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0256 | 0.1836 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.049 | 0.5916 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0077 | 0.0728 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0132 | 0.1428 | 0.1428 |
Entamoeba histolytica | hypothetical protein | 0.027 | 0.3155 | 1 |
Schistosoma mansoni | hypothetical protein | 0.027 | 0.3155 | 0.3155 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0372 | 0.117 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.034 | 0.1205 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0077 | 0.0728 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.034 | 0.034 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0294 | 0.4031 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0237 | 0.2738 | 0.2738 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0045 | 0.033 | 0.4447 |
Trichomonas vaginalis | esterase, putative | 0.0077 | 0.0728 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.1312 | 0.477 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0045 | 0.033 | 0.4538 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0077 | 0.0728 | 0.0728 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0728 | 0.2626 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0103 | 0.1411 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0815 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0215 | 0.2947 |
Mycobacterium leprae | Probable lipase LipE | 0.0077 | 0.0728 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0133 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.2738 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0077 | 0.0728 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0237 | 0.2738 | 0.2738 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0051 | 0.04 | 0.126 |
Schistosoma mansoni | chromobox protein | 0.007 | 0.0641 | 0.0641 |
Trichomonas vaginalis | chromobox protein, putative | 0.007 | 0.0641 | 0.8808 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0077 | 0.0728 | 0.123 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0051 | 0.04 | 0.126 |
Brugia malayi | Heterochromatin protein 1 | 0.007 | 0.0641 | 0.2025 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0133 | 0.1693 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.04 | 0.04 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.04 | 0.04 |
Brugia malayi | chromobox protein homolog 3 | 0.0039 | 0.0256 | 0.0804 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0045 | 0.033 | 0.1039 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0186 | 0.2546 |
Mycobacterium tuberculosis | Conserved protein | 0.0077 | 0.0728 | 0.123 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.034 | 0.034 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.027 | 0.3155 | 0.3155 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.04 | 0.04 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0186 | 0.2546 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.1312 | 0.477 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0186 | 0.2546 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.007 | 0.0964 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0256 | 0.0897 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.01 | 0.1365 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0012 | 0.016 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0103 | 0.1411 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0077 | 0.0728 | 0.0728 |
Mycobacterium ulcerans | hypothetical protein | 0.0077 | 0.0728 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0045 | 0.033 | 0.4536 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0012 | 0.016 |
Mycobacterium tuberculosis | Conserved protein | 0.0077 | 0.0728 | 0.123 |
Schistosoma mansoni | chromobox protein | 0.007 | 0.0641 | 0.0641 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0045 | 0.033 | 0.4447 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.04 | 0.04 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0186 | 0.2546 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.1428 | 0.1428 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0051 | 0.04 | 0.1423 |
Trichomonas vaginalis | chromobox protein, putative | 0.007 | 0.0641 | 0.8808 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0045 | 0.033 | 0.033 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0045 | 0.033 | 0.033 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0036 | 0.0215 | 0.2956 |
Onchocerca volvulus | 0.0048 | 0.0372 | 0.3834 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.007 | 0.0958 |
Plasmodium vivax | hypothetical protein, conserved | 0.0077 | 0.0728 | 1 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0045 | 0.033 | 0.1013 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0077 | 0.0728 | 1 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0045 | 0.033 | 0.4538 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.01 | 0.1365 |
Brugia malayi | hypothetical protein | 0.0237 | 0.2738 | 0.8678 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0012 | 0.0012 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0372 | 0.0371 |
Echinococcus multilocularis | chromobox protein 1 | 0.007 | 0.0641 | 0.0641 |
Brugia malayi | RNA binding protein | 0.0132 | 0.1428 | 0.4522 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0021 | 0.0033 | 0.0447 |
Mycobacterium tuberculosis | Conserved protein | 0.0077 | 0.0728 | 0.123 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0077 | 0.0728 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.1428 | 0.1428 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0045 | 0.033 | 0.4536 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0132 | 0.1428 | 0.5195 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0036 | 0.0215 | 0.2839 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.034 | 0.034 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.1428 | 0.1428 |
Giardia lamblia | GTOR | 0.0045 | 0.033 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.1428 | 0.1428 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.007 | 0.0964 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0045 | 0.033 | 0.033 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0033 | 0.0186 | 0.2425 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0728 | 0.2626 |
Echinococcus granulosus | chromobox protein 1 | 0.007 | 0.0641 | 0.0641 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0113 | 0.1549 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0815 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0077 | 0.0728 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0077 | 0.0728 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.034 | 0.034 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.04 | 0.04 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0144 | 0.198 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0133 | 0.1693 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0133 | 0.1693 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0012 | 0.0012 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.04 | 0.04 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0077 | 0.0728 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0728 | 0.2626 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0133 | 0.0445 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0077 | 0.0728 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0499 | 0.1786 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0077 | 0.0728 | 0.123 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0058 | 0.0499 | 0.0499 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0132 | 0.1428 | 0.4522 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0045 | 0.033 | 0.1168 |
Brugia malayi | beta-lactamase | 0.0077 | 0.0728 | 0.2301 |
Toxoplasma gondii | ABC1 family protein | 0.0077 | 0.0728 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0133 | 0.1828 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.