Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | conserved hypothetical protein | 0.0079 | 0.0835 | 1 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0153 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0835 | 0.2761 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0835 | 0.2761 |
Brugia malayi | beta-lactamase family protein | 0.0079 | 0.0835 | 0.242 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1921 | 0.6449 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0079 | 0.0835 | 0.1256 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0079 | 0.0835 | 0.0835 |
Echinococcus multilocularis | GPCR, family 2 | 0.005 | 0.0441 | 0.0441 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0153 | 0.1607 |
Echinococcus multilocularis | tar DNA binding protein | 0.0137 | 0.1622 | 0.1622 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.1236 | 0.4122 |
Loa Loa (eye worm) | RNA binding protein | 0.0137 | 0.1622 | 0.5433 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0165 | 0.1978 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0277 | 0.3315 |
Loa Loa (eye worm) | beta-lactamase | 0.0079 | 0.0835 | 0.2761 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0085 | 0.1022 |
Entamoeba histolytica | hypothetical protein | 0.0268 | 0.3413 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0241 | 0.2889 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0022 | 0.0265 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.021 | 0.2511 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.0702 | 0.0702 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.0326 | 0.2333 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0079 | 0.0835 | 0.1256 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0036 | 0.0242 | 0.2701 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0045 | 0.0366 | 0.1168 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0835 | 0.2761 |
Onchocerca volvulus | 0.0079 | 0.0835 | 1 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.021 | 0.2511 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0117 | 0.14 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0022 | 0.0022 |
Schistosoma mansoni | hypothetical protein | 0.0108 | 0.1236 | 0.1236 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0079 | 0.0835 | 0.2761 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0411 | 0.0411 |
Echinococcus granulosus | tumor protein p63 | 0.0367 | 0.4772 | 0.4772 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0241 | 0.2889 |
Mycobacterium ulcerans | beta-lactamase | 0.0079 | 0.0835 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0079 | 0.0835 | 0.1256 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.1426 | 0.4158 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0045 | 0.0366 | 0.432 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0411 | 0.1172 |
Schistosoma mansoni | hypothetical protein | 0.0268 | 0.3413 | 0.3413 |
Entamoeba histolytica | hypothetical protein | 0.0268 | 0.3413 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0235 | 0.2966 | 0.2966 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0326 | 0.3909 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0079 | 0.0835 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0045 | 0.0366 | 0.4383 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0079 | 0.0835 | 0.0835 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.1622 | 0.1622 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0079 | 0.0835 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0137 | 0.1622 | 0.1622 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0079 | 0.0835 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0286 | 0.1726 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0505 | 0.6651 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0268 | 0.3413 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0441 | 0.1422 |
Onchocerca volvulus | 0.0079 | 0.0835 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0286 | 0.3427 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0045 | 0.0366 | 0.0366 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0159 | 0.1921 | 0.5612 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0022 | 0.0155 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0045 | 0.0366 | 0.4231 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0159 | 0.1921 | 0.6449 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0108 | 0.1236 | 0.3598 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0377 | 0.0377 |
Brugia malayi | TAR-binding protein | 0.0137 | 0.1622 | 0.4732 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0022 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0241 | 0.2889 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0045 | 0.0366 | 0.4383 |
Loa Loa (eye worm) | TAR-binding protein | 0.0137 | 0.1622 | 0.5433 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0022 | 0.0033 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0079 | 0.0835 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.021 | 0.2511 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0022 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0286 | 0.3427 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.005 | 0.0441 | 0.0441 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0022 | 0.0029 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0079 | 0.0835 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0121 | 0.1443 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0085 | 0.1016 |
Echinococcus granulosus | GPCR family 2 | 0.005 | 0.0441 | 0.0441 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0159 | 0.1921 | 0.5612 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0377 | 0.0377 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0045 | 0.0366 | 0.1041 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0153 | 0.1607 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0079 | 0.0835 | 0.242 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.005 | 0.0441 | 0.0441 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.0702 | 0.0702 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0085 | 0.1022 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0085 | 0.1016 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0268 | 0.3413 | 0.3413 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0268 | 0.3413 | 0.3413 |
Brugia malayi | hypothetical protein | 0.0268 | 0.3413 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0367 | 0.4772 | 0.4772 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0153 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0079 | 0.0835 | 0.1256 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0241 | 0.2889 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.0702 | 0.2309 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0326 | 0.3909 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0152 | 0.182 |
Onchocerca volvulus | 0.0079 | 0.0835 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0268 | 0.3413 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0079 | 0.0835 | 0.1256 |
Brugia malayi | beta-lactamase family protein | 0.0079 | 0.0835 | 0.242 |
Onchocerca volvulus | 0.0054 | 0.049 | 0.48 | |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0021 | 0.0044 | 0.0425 |
Brugia malayi | RNA binding protein | 0.0137 | 0.1622 | 0.4732 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.0702 | 0.0702 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0411 | 0.0411 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.1622 | 0.1622 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0079 | 0.0835 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0079 | 0.0835 | 0.1256 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0079 | 0.0835 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0377 | 0.0377 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0045 | 0.0366 | 0.4231 |
Plasmodium vivax | hypothetical protein, conserved | 0.0079 | 0.0835 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0085 | 0.1016 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0036 | 0.0242 | 0.2814 |
Onchocerca volvulus | 0.0048 | 0.0411 | 0.3605 | |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0045 | 0.0366 | 0.0366 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0022 | 0.0022 |
Brugia malayi | hypothetical protein | 0.0235 | 0.2966 | 0.8686 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0117 | 0.14 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0377 | 0.0377 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0085 | 0.1022 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.1622 | 0.1622 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.1622 | 0.1622 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0045 | 0.0366 | 0.4231 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0835 | 0.2761 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0033 | 0.021 | 0.2307 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0137 | 0.1622 | 0.5433 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0377 | 0.0377 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0045 | 0.0366 | 0.1014 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0036 | 0.0242 | 0.2701 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0441 | 0.0441 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0153 | 0.0444 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0079 | 0.0835 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0835 | 0.2761 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.005 | 0.0441 | 0.0441 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0045 | 0.0366 | 0.1014 |
Mycobacterium ulcerans | lipase LipD | 0.0079 | 0.0835 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0079 | 0.0835 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0131 | 0.1573 |
Schistosoma mansoni | microtubule-associated protein tau | 0.075 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.0702 | 0.0702 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0153 | 0.1607 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0153 | 0.1607 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0172 | 0.0508 |
Brugia malayi | beta-lactamase | 0.0079 | 0.0835 | 0.242 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0377 | 0.1073 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0137 | 0.1622 | 0.4732 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0153 | 0.1737 |
Toxoplasma gondii | ABC1 family protein | 0.0079 | 0.0835 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0079 | 0.0835 | 0.1256 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.049 | 0.1589 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0079 | 0.0835 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0054 | 0.049 | 0.049 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0153 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.2966 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0241 | 0.2889 |
Mycobacterium leprae | Probable lipase LipE | 0.0079 | 0.0835 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0235 | 0.2966 | 0.2966 |
Leishmania major | hypothetical protein, conserved | 0.0079 | 0.0835 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0377 | 0.1205 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.1426 | 0.4769 |
Trichomonas vaginalis | esterase, putative | 0.0079 | 0.0835 | 1 |
Giardia lamblia | GTOR | 0.0045 | 0.0366 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.075 | 1 | 1 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0045 | 0.0366 | 0.0366 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0835 | 0.2761 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0121 | 0.1443 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0079 | 0.0835 | 0.0835 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0045 | 0.0366 | 0.4383 |
Brugia malayi | chromobox protein homolog 3 | 0.0039 | 0.0286 | 0.0806 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0441 | 0.0441 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0079 | 0.0835 | 0.1256 |
Brugia malayi | Latrophilin receptor protein 2 | 0.005 | 0.0441 | 0.1261 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.0702 | 0.8404 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.0702 | 0.0702 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.005 | 0.0441 | 0.1261 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0441 | 0.0441 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0153 | 0.1607 |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.0702 | 0.2028 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0121 | 0.1443 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.021 | 0.2511 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0286 | 0.0897 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0085 | 0.1022 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.1426 | 0.4769 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0022 | 0.0022 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0131 | 0.1573 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0022 | 0.0265 |
Mycobacterium tuberculosis | Conserved protein | 0.0079 | 0.0835 | 0.1256 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.021 | 0.2511 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0441 | 0.0441 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.021 | 0.2511 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0268 | 0.3413 | 0.3413 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0045 | 0.0366 | 0.4231 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0377 | 0.0377 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.005 | 0.0441 | 0.1422 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.0702 | 0.8404 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.1622 | 0.1622 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.005 | 0.0441 | 0.0441 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.021 | 0.2511 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0377 | 0.0377 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0045 | 0.0366 | 0.432 |
Mycobacterium ulcerans | hypothetical protein | 0.0079 | 0.0835 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0079 | 0.0835 | 0.0835 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.0702 | 0.0702 |
Mycobacterium tuberculosis | Conserved protein | 0.0079 | 0.0835 | 0.1256 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0022 | 0.0265 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.