Detailed information for compound 732004

Basic information

Technical information
  • TDR Targets ID: 732004
  • Name: (2-chlorophenyl)-[4-(phenylmethyl)piperidin-1 -yl]methanone
  • MW: 313.821 | Formula: C19H20ClNO
  • H donors: 0 H acceptors: 1 LogP: 4.71 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccccc1C(=O)N1CCC(CC1)Cc1ccccc1
  • InChi: 1S/C19H20ClNO/c20-18-9-5-4-8-17(18)19(22)21-12-10-16(11-13-21)14-15-6-2-1-3-7-15/h1-9,16H,10-14H2
  • InChiKey: RBCUCXILXJXLTB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2-chlorophenyl)-[4-(phenylmethyl)-1-piperidyl]methanone
  • (2-chlorophenyl)-[4-(phenylmethyl)-1-piperidinyl]methanone
  • [4-(benzyl)-1-piperidyl]-(2-chlorophenyl)methanone
  • Oprea1_184492
  • Oprea1_095873
  • ZINC00009079
  • STK034825

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 14 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus hypothetical protein Get druggable targets OG5_144688 All targets in OG5_144688
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_144688 All targets in OG5_144688
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 14 360 aa 336 aa 33.3 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Thioredoxin reductase 0.0051 0.0239 0.0528
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.0795 0.0793
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0077 0.0171
Leishmania major importin beta-1 subunit, putative 0.0047 0.0211 0.1432
Schistosoma mansoni thyroid hormone receptor 0.0164 0.1035 0.2061
Mycobacterium ulcerans carboxylesterase, LipT 0.0102 0.0599 0.4092
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0219 0.0421
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.032 0.2181
Echinococcus multilocularis musashi 0.0028 0.0077 0.0134
Brugia malayi TAR-binding protein 0.0128 0.0786 0.174
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0023 0.0144
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.014 0.095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0103 0.0228
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0152 0.0262
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.032 0.0318
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0315 0.0697
Echinococcus granulosus mitogen activated protein kinase 14 0.0152 0.0953 0.1639
Echinococcus granulosus hypothetical protein 0.0839 0.5818 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0102 0.0599 0.1158
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.032 0.0637
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.015 0.1018
Loa Loa (eye worm) hypothetical protein 0.0604 0.4153 0.9195
Loa Loa (eye worm) hypothetical protein 0.0493 0.3368 0.7457
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.0795 0.0793
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0052 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0103 0.0228
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 0.0953 0.6523
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0002 0.0004
Schistosoma mansoni thyroid hormone receptor 0.0164 0.1035 0.2061
Brugia malayi hypothetical protein 0.0102 0.0599 0.1326
Brugia malayi Carboxylesterase family protein 0.0604 0.4153 0.9195
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0103 0.0228
Leishmania major cytochrome p450-like protein 0.0025 0.0052 0.0348
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0103 0.0178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0103 0.0228
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.0219 0.0421
Schistosoma mansoni hypothetical protein 0.0064 0.0329 0.0655
Echinococcus granulosus histone lysine methyltransferase setb 0.0094 0.0542 0.0931
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0239 0.0528
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0152 0.1027
Schistosoma mansoni importin beta-1 0.0058 0.0289 0.0575
Loa Loa (eye worm) hypothetical protein 0.0032 0.0103 0.0228
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0152 0.0953 0.2111
Echinococcus granulosus neuroligin 0.0102 0.0599 0.1029
Echinococcus granulosus ubiquitin specific protease 41 0.0048 0.0219 0.0376
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0103 0.0228
Brugia malayi nuclear receptor NHR-88 0.0032 0.0103 0.0228
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.0786 0.174
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0103 0.0177
Trypanosoma brucei hypothetical protein, conserved 0.0224 0.1461 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0048 0.0219 0.0378
Plasmodium vivax hypothetical protein, conserved 0.0224 0.1461 1
Trypanosoma brucei glucosidase, putative 0.0037 0.014 0.095
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0094 0.0542 0.3701
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0241 0.8346
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0048 0.0219 0.0376
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.004 0.0069
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0023 0.005
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0103 0.0178
Brugia malayi Importin beta-1 subunit 0.0058 0.0289 0.0639
Echinococcus granulosus acetylcholinesterase 0.0604 0.4153 0.7137
Loa Loa (eye worm) hypothetical protein 0.0102 0.0599 0.1326
Echinococcus granulosus lamin dm0 0.0028 0.0077 0.0133
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0102 0.0599 0.1029
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 0.0953 0.165
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0052 0.0116
Echinococcus multilocularis survival motor neuron protein 1 0.0493 0.3368 0.5827
Schistosoma mansoni BC026374 protein (S09 family) 0.0102 0.0599 0.1192
Loa Loa (eye worm) carboxylesterase 0.0102 0.0599 0.1326
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0103 0.0178
Echinococcus granulosus para nitrobenzyl esterase 0.0102 0.0599 0.1029
Onchocerca volvulus 0.0102 0.0599 0.1027
Entamoeba histolytica hypothetical protein 0.0112 0.0672 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0239 0.0413
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.12 0.239
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0103 0.0228
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0171
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0103 0.0178
Loa Loa (eye worm) inositol-1 0.0039 0.0152 0.0336
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0023 0.0144
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.0795 0.0793
Trichomonas vaginalis set domain proteins, putative 0.0745 0.5157 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0102 0.0599 0.1192
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0023 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.0224 0.1461 0.283
Schistosoma mansoni acetylcholinesterase 0.0102 0.0599 0.1192
Leishmania major GTP-binding protein, putative 0.0021 0.0023 0.0144
Echinococcus granulosus BC026374 protein S09 family 0.0102 0.0599 0.1029
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.014 0.0269
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.1035 0.1791
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0094 0.0542 0.0937
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0103 0.0205
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0329 0.0728
Echinococcus multilocularis tumor protein p63 0.0353 0.2379 0.4116
Brugia malayi hypothetical protein 0.0493 0.3368 0.7457
Loa Loa (eye worm) hypothetical protein 0.0138 0.0854 0.1892
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0242 0.0483
Brugia malayi Inositol-1 0.0039 0.0152 0.0336
Leishmania major hypothetical protein, conserved 0.0224 0.1461 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.015 0.1018
Loa Loa (eye worm) hypothetical protein 0.0052 0.0241 0.0534
Toxoplasma gondii ABC1 family protein 0.0224 0.1461 1
Mycobacterium tuberculosis Conserved protein 0.0224 0.1461 0.1459
Trypanosoma cruzi hypothetical protein, conserved 0.0224 0.1461 1
Schistosoma mansoni hypothetical protein 0.0132 0.0809 0.161
Plasmodium falciparum glutathione reductase 0.0051 0.0239 0.8252
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0132 0.0809 0.1399
Brugia malayi P38 map kinase family protein 2 0.0152 0.0953 0.2111
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0152 0.0291
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0048 0.0219 0.0484
Echinococcus granulosus acetylcholinesterase 0.0604 0.4153 0.7137
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.015 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.12 0.239
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0187 0.12 0.2658
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0152 0.0953 0.6523
Plasmodium vivax glutathione reductase, putative 0.0051 0.0239 0.1623
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0103 0.0228
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0103 0.0228
Echinococcus granulosus lamin 0.0028 0.0077 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0103 0.0228
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.0672 0.1156
Loa Loa (eye worm) hypothetical protein 0.0126 0.0772 0.1708
Plasmodium falciparum importin beta, putative 0.0058 0.0289 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0023 0.0039
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0103 0.0178
Loa Loa (eye worm) hypothetical protein 0.0604 0.4153 0.9195
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.009 0.0517 0.0889
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0002 0.0003
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.0703 0.0701
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0103 0.0205
Echinococcus multilocularis carboxylesterase 5A 0.0604 0.4153 0.7185
Brugia malayi intermediate filament protein 0.0028 0.0077 0.0171
Schistosoma mansoni hypothetical protein 0.0691 0.4771 0.95
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.0672 0.1163
Mycobacterium tuberculosis Probable esterase LipL 0.0224 0.1461 0.1459
Loa Loa (eye worm) hypothetical protein 0.0102 0.0599 0.1326
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0102 0.0599 0.1036
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0103 0.0228
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0211 0.1432
Schistosoma mansoni hypothetical protein 0.0622 0.428 0.8523
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0211 0.0405
Brugia malayi beta-lactamase 0.0224 0.1461 0.3235
Schistosoma mansoni gliotactin 0.0102 0.0599 0.1192
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0224 0.1461 0.1459
Echinococcus granulosus microtubule associated protein 2 0.0726 0.5022 0.8632
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0094 0.0542 0.1079
Brugia malayi RNA binding protein 0.0128 0.0786 0.174
Echinococcus multilocularis neuroligin 0.0102 0.0599 0.1036
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.014 0.095
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.032 0.2181
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0224 0.1461 0.2909
Echinococcus multilocularis tar DNA binding protein 0.0128 0.0786 0.136
Echinococcus granulosus tumor protein p63 0.0353 0.2379 0.4089
Plasmodium vivax SET domain protein, putative 0.0094 0.0542 0.3701
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0103 0.0228
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0002 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.12 0.2063
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.0219 0.1486
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.015 0.9916
Echinococcus multilocularis beta LACTamase domain containing family member 0.0224 0.1461 0.2527
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1067 0.1846
Onchocerca volvulus Huntingtin homolog 0.0126 0.0772 0.1367
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0103 0.0177
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0023 0.0967
Loa Loa (eye worm) hypothetical protein 0.0032 0.0103 0.0228
Brugia malayi Carboxylesterase family protein 0.0102 0.0599 0.1326
Brugia malayi Cytochrome P450 family protein 0.0062 0.0315 0.0697
Onchocerca volvulus 0.0102 0.0599 0.1027
Mycobacterium tuberculosis Conserved protein 0.0224 0.1461 0.1459
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0103 0.005
Loa Loa (eye worm) RNA binding protein 0.0128 0.0786 0.174
Loa Loa (eye worm) hypothetical protein 0.0058 0.0289 0.0639
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0052 0.0116
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0103 0.0178
Leishmania major trypanothione reductase 0.0051 0.0239 0.1623
Brugia malayi hypothetical protein 0.0112 0.0672 0.1489
Schistosoma mansoni lamin 0.0028 0.0077 0.0154
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0052 0.0348
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0102 0.0599 0.1192
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0152 0.026
Loa Loa (eye worm) beta-lactamase 0.0224 0.1461 0.3235
Onchocerca volvulus 0.0032 0.0103 0.005
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.0854 0.1892
Loa Loa (eye worm) carboxylesterase 0.0604 0.4153 0.9195
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.014 0.1812
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.015 0.0258
Echinococcus multilocularis lamin 0.0028 0.0077 0.0134
Mycobacterium ulcerans hypothetical protein 0.0224 0.1461 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.015 0.5177
Loa Loa (eye worm) hypothetical protein 0.0032 0.0103 0.0228
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0239 0.0237
Loa Loa (eye worm) hypothetical protein 0.0032 0.0103 0.0228
Echinococcus granulosus importin subunit beta 1 0.0058 0.0289 0.0496
Echinococcus multilocularis importin subunit beta 1 0.0058 0.0289 0.0499
Mycobacterium tuberculosis Probable lipase LipD 0.0224 0.1461 0.1459
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.014 0.0243
Mycobacterium ulcerans lipase LipD 0.0224 0.1461 1
Loa Loa (eye worm) hypothetical protein 0.0224 0.1461 0.3235
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.12 0.2077
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0241 0.1642
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0103 0.0205
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0103 0.0205
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0329 0.0728
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.014 0.0269
Brugia malayi Calcitonin receptor-like protein seb-1 0.0202 0.1307 0.2895
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0048 0.0219 0.1486
Loa Loa (eye worm) hypothetical protein 0.0094 0.0542 0.1199
Onchocerca volvulus 0.0745 0.5157 1
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.015 0.0333
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.032 0.2181
Onchocerca volvulus 0.0224 0.1461 0.2724
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0023 0.0144
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.0703 0.0701
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0103 0.0177
Schistosoma mansoni survival motor neuron protein 0.0101 0.0588 0.1171
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0103 0.0177
Loa Loa (eye worm) hypothetical protein 0.0224 0.1461 0.3235
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0103 0.005
Mycobacterium tuberculosis Conserved protein 0.0224 0.1461 0.1459
Schistosoma mansoni hypothetical protein 0.0691 0.4771 0.95
Loa Loa (eye worm) hypothetical protein 0.0102 0.0599 0.1326
Entamoeba histolytica hypothetical protein 0.0112 0.0672 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.015 0.1964
Brugia malayi hypothetical protein 0.0052 0.0241 0.0534
Echinococcus multilocularis acetylcholinesterase 0.0604 0.4153 0.7185
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.015 0.6852
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.014 0.0269
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0224 0.1461 0.2909
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0542 0.1079
Loa Loa (eye worm) hypothetical protein 0.0102 0.0599 0.1326
Schistosoma mansoni intermediate filament proteins 0.0028 0.0077 0.0154
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.015 0.0288
Plasmodium vivax importin-beta 2, putative 0.0058 0.0289 0.1967
Mycobacterium leprae conserved hypothetical protein 0.0224 0.1461 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 0.0953 0.165
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0329 0.0728
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.014 0.0269
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.014 0.0269
Trichomonas vaginalis ran, putative 0.0021 0.0023 0.0041
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.0786 0.174
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0786 0.1565
Echinococcus granulosus snurportin 1 0.0622 0.428 0.7357
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.12 0.2077
Loa Loa (eye worm) hypothetical protein 0.0102 0.0599 0.1326
Echinococcus multilocularis lamin dm0 0.0028 0.0077 0.0134
Brugia malayi ecdysteroid receptor 0.0032 0.0103 0.0228
Entamoeba histolytica hypothetical protein 0.0112 0.0672 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0101 0.0588 0.1303
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0103 0.0228
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0202 0.1307 0.2895
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0241 0.8346
Loa Loa (eye worm) hypothetical protein 0.0032 0.0103 0.0228
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0023 0.0144
Loa Loa (eye worm) hypothetical protein 0.0224 0.1461 0.3235
Brugia malayi Cytochrome P450 family protein 0.0025 0.0052 0.0116
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0241 0.1642
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0103 0.0178
Loa Loa (eye worm) acetylcholinesterase 1 0.0604 0.4153 0.9195
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0023 0.005
Echinococcus multilocularis microtubule associated protein 2 0.0726 0.5022 0.8689
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0103 0.0228
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0102 0.0599 0.0597
Schistosoma mansoni inositol monophosphatase 0.0039 0.0152 0.0302
Entamoeba histolytica hypothetical protein 0.0112 0.0672 1
Loa Loa (eye worm) glutathione reductase 0.0051 0.0239 0.0528
Mycobacterium ulcerans beta-lactamase 0.0224 0.1461 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.0772 0.1708
Echinococcus granulosus mitogen activated protein kinase 11 0.0152 0.0953 0.1639
Trichomonas vaginalis penicillin-binding protein, putative 0.0224 0.1461 0.283
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0329 0.0569
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0103 0.0228
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 0.0953 0.165
Schistosoma mansoni inositol monophosphatase 0.0039 0.0152 0.0302
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0103 0.0228
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0048 0.0219 0.0435
Schistosoma mansoni alpha-glucosidase 0.0145 0.0901 0.1794
Brugia malayi MH2 domain containing protein 0.0257 0.1694 0.3752
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0329 0.0569
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.015 0.026
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0002 0.0003
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.014 0.0311
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.0703 0.0701
Loa Loa (eye worm) transcription factor SMAD2 0.0257 0.1694 0.3752
Onchocerca volvulus 0.0102 0.0599 0.1027
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0329 0.0565
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.015 0.0333
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0211 0.0405
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0241 0.1642
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.004 0.0069
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0002 0.0003
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.014 0.0311
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0103 0.0178
Loa Loa (eye worm) hypothetical protein 0.0064 0.0329 0.0728
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0152 0.1027
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 0.0953 0.6523
Brugia malayi hypothetical protein 0.0126 0.0772 0.1708
Loa Loa (eye worm) hypothetical protein 0.0102 0.0599 0.1326
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0077 0.0171
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0786 0.1565
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.032 0.2181
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0103 0.0228
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0123 0.0121
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.0795 0.5025
Loa Loa (eye worm) hypothetical protein 0.0224 0.1461 0.3235
Schistosoma mansoni hypothetical protein 0.0101 0.0588 0.1171
Entamoeba histolytica hypothetical protein 0.0047 0.0211 0.2894
Mycobacterium tuberculosis Probable hydrolase 0.0224 0.1461 0.1459
Loa Loa (eye worm) hypothetical protein 0.0202 0.1307 0.2895
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.015 0.0149
Brugia malayi glutathione reductase 0.0051 0.0239 0.0528
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.12 0.2063
Echinococcus multilocularis GPCR, family 2 0.0064 0.0329 0.0569
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.015 0.1018
Toxoplasma gondii exonuclease III APE 0.0039 0.015 0.1018
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0052 0.0116
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0048 0.0219 0.0378
Trichomonas vaginalis penicillin-binding protein, putative 0.0224 0.1461 0.283
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0103 0.0205
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0622 0.428 0.9478
Toxoplasma gondii thioredoxin reductase 0.0051 0.0239 0.1623
Brugia malayi Carboxylesterase family protein 0.0102 0.0599 0.1326
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0239 0.1623
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.1067 0.2362
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0103 0.0177
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.014 0.0241
Loa Loa (eye worm) hypothetical protein 0.0224 0.1461 0.3235
Echinococcus granulosus beta LACTamase domain containing family member 0.0224 0.1461 0.2511
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.0703 0.4335
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.0219 0.1486
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.032 0.055
Loa Loa (eye worm) carboxylesterase 0.0102 0.0599 0.1326
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0604 0.4153 0.8269
Schistosoma mansoni microtubule-associated protein tau 0.0726 0.5022 1
Mycobacterium ulcerans esterase/lipase LipP 0.0224 0.1461 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0655 0.4516 1
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.0672 0.1339
Trichomonas vaginalis spcc417.12 protein, putative 0.0102 0.0599 0.1158
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0103 0.0228
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0103 0.0228
Onchocerca volvulus 0.0094 0.0542 0.0914
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.0219 0.1486
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.015 0.1018
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0224 0.1461 0.3235
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0241 0.1642
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0132 0.0809 0.139
Loa Loa (eye worm) TAR-binding protein 0.0128 0.0786 0.174
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0023 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0103 0.0228
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0289 0.1967
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0152 0.0291
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0241 0.1642
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0289 0.1967
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0077 0.0171
Schistosoma mansoni hypothetical protein 0.0112 0.0672 0.1339
Brugia malayi Carboxylesterase family protein 0.0102 0.0599 0.1326
Loa Loa (eye worm) hypothetical protein 0.0102 0.0599 0.1326
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.014 0.095
Echinococcus granulosus survival motor neuron protein 1 0.0493 0.3368 0.5788
Echinococcus multilocularis acetylcholinesterase 0.0604 0.4153 0.7185
Schistosoma mansoni neuroligin 3 (S09 family) 0.0102 0.0599 0.1192
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0103 0.0228
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0152 0.1984
Schistosoma mansoni hypothetical protein 0.0064 0.0329 0.0655
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.1067 0.2362
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0152 0.1027
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0048 0.0219 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0152 0.1027
Onchocerca volvulus Huntingtin homolog 0.0126 0.0772 0.1367
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0094 0.0542 0.0937
Trichomonas vaginalis D-aminoacylase, putative 0.0224 0.1461 0.283
Loa Loa (eye worm) hypothetical protein 0.0032 0.0103 0.0228
Onchocerca volvulus 0.0224 0.1461 0.2724
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.015 0.1018
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.032 0.2181
Mycobacterium tuberculosis Probable lipase LipE 0.0224 0.1461 0.1459
Trypanosoma brucei trypanothione reductase 0.0051 0.0239 0.1623
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0103 0.0205
Schistosoma mansoni hypothetical protein 0.0138 0.0854 0.1701
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0103 0.0177
Schistosoma mansoni hypothetical protein 0.0023 0.004 0.0079
Brugia malayi beta-lactamase family protein 0.0224 0.1461 0.3235
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0103 0.0205
Onchocerca volvulus 0.0102 0.0599 0.1027
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0224 0.1461 0.3235
Onchocerca volvulus 0.0097 0.0565 0.096
Brugia malayi hypothetical protein 0.0033 0.0112 0.0248
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1067 0.1846
Schistosoma mansoni alpha-glucosidase 0.0145 0.0901 0.1794
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0152 0.1027
Brugia malayi Pre-SET motif family protein 0.0094 0.0542 0.1199
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.1067 0.1834
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0786 0.1565
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.032 0.0637
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0103 0.0177
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0152 0.0953 0.6523
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0224 0.1461 0.1459
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.014 0.095
Plasmodium falciparum thioredoxin reductase 0.0051 0.0239 0.8252
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0103 0.0177
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.0703 0.0701
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.0703 0.0701
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0152 0.1027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.12 0.239
Echinococcus granulosus geminin 0.0691 0.4771 0.82
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.015 0.0288
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0211 0.0405
Echinococcus granulosus intermediate filament protein 0.0028 0.0077 0.0133
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0052 0.0348
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0102 0.0599 0.1192
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0239 0.041
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0048 0.0219 0.3015
Onchocerca volvulus 0.0102 0.0599 0.1027
Brugia malayi steroid hormone receptor 0.0032 0.0103 0.0228
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0103 0.0205
Echinococcus granulosus tar DNA binding protein 0.0128 0.0786 0.1351
Brugia malayi Carboxylesterase family protein 0.0102 0.0599 0.1326
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0239 0.1623
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0542 0.1079
Trichomonas vaginalis D-aminoacylase, putative 0.0224 0.1461 0.283
Mycobacterium leprae Probable lipase LipE 0.0224 0.1461 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.014 0.0269
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.014 0.0269
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0187 0.12 0.2658
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0224 0.1461 0.1459
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0329 0.0565
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0103 0.0228
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.032 0.0553
Onchocerca volvulus 0.0052 0.0242 0.0325
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0103 0.0228
Leishmania major hypothetical protein, conserved 0.0052 0.0241 0.1642
Echinococcus multilocularis geminin 0.0691 0.4771 0.8254
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0224 0.1461 1
Brugia malayi RNA, U transporter 1 0.0166 0.1049 0.2324
Brugia malayi Carboxylesterase family protein 0.0604 0.4153 0.9195
Schistosoma mansoni lamin 0.0028 0.0077 0.0154
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0023 0.073
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 0.0953 0.165
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.0219 0.0421
Echinococcus multilocularis para nitrobenzyl esterase 0.0102 0.0599 0.1036
Brugia malayi Pre-SET motif family protein 0.0655 0.4516 1
Schistosoma mansoni coup transcription factor 0.0032 0.0103 0.0205
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0786 0.1565
Trypanosoma cruzi hypothetical protein, conserved 0.0224 0.1461 1
Schistosoma mansoni ap endonuclease 0.0039 0.015 0.0299
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0052 0.0348
Loa Loa (eye worm) MH2 domain-containing protein 0.0257 0.1694 0.3752
Echinococcus multilocularis ubiquitin specific protease 41 0.0048 0.0219 0.0378
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0103 0.0177
Loa Loa (eye worm) hypothetical protein 0.0048 0.0219 0.0484
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.015 0.1018
Brugia malayi nuclear hormone receptor 0.0032 0.0103 0.0228
Echinococcus granulosus carboxylesterase 5A 0.0604 0.4153 0.7137
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0103 0.005
Schistosoma mansoni ap endonuclease 0.0039 0.015 0.0299
Echinococcus granulosus GPCR family 2 0.0064 0.0329 0.0565
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0103 0.0228
Mycobacterium tuberculosis Probable reductase 0.0117 0.0703 0.0701
Loa Loa (eye worm) hypothetical protein 0.0032 0.0103 0.0228
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.0289 0.1967
Loa Loa (eye worm) hypothetical protein 0.0052 0.0242 0.0537
Schistosoma mansoni hypothetical protein 0.0064 0.0329 0.0655
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0152 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0048 0.0219 0.0376
Onchocerca volvulus 0.0101 0.0588 0.1006
Mycobacterium tuberculosis Carboxylesterase LipT 0.0102 0.0599 0.0597
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0786 0.1565
Echinococcus multilocularis BC026374 protein (S09 family) 0.0102 0.0599 0.1036
Schistosoma mansoni ran 0.0021 0.0023 0.0045
Brugia malayi beta-lactamase family protein 0.0224 0.1461 0.3235
Loa Loa (eye worm) hypothetical protein 0.0032 0.0103 0.0228
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.014 0.0269
Trichomonas vaginalis esterase, putative 0.0224 0.1461 0.283
Echinococcus multilocularis snurportin 1 0.0622 0.428 0.7406
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.014 0.1812
Schistosoma mansoni hypothetical protein 0.0064 0.0329 0.0655
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0152 0.0291
Onchocerca volvulus 0.0224 0.1461 0.2724
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0048 0.0219 0.0435
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.014 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0103 0.0228
Loa Loa (eye worm) hypothetical protein 0.0028 0.0074 0.0163
Schistosoma mansoni alpha glucosidase 0.0037 0.014 0.0279
Brugia malayi Cytochrome P450 family protein 0.0025 0.0052 0.0116
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0103 0.0205
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0103 0.0205
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0542 0.1079
Loa Loa (eye worm) hypothetical protein 0.0224 0.1461 0.3235
Echinococcus multilocularis conserved hypothetical protein 0.0833 0.578 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.1307 0.2895
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0102 0.0599 0.0597
Schistosoma mansoni ran 0.0021 0.0023 0.0045

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CXCR1 (IL-8A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
IC50 (binding) = 0.2 uM DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) = 0.833 uM DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) = 1.508 uM DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
IC50 (binding) = 2 uM DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CXCR1 (IL-8A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) ChEMBL. No reference
Ki (binding) = 0.96 uM DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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