Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.1509 | 1 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.1509 | 1 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.1509 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1509 | 1 | 0.5 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.1509 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.0088 | 0 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0934 | 0.5952 | 0.5952 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.1509 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0934 | 0.5952 | 0.5952 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1509 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0088 | 0 | 0.5 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.1509 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1509 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0474 | 0.2714 | 0.2714 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.1509 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1509 | 1 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.1509 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0934 | 0.5952 | 0.5952 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.1509 | 1 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.1509 | 1 | 1 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.1509 | 1 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1509 | 1 | 0.5 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.1509 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0934 | 0.5952 | 0.5952 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.1509 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 100 uM | Compound was tested for its cytotoxicity against HIV-1 infected MT-4 cell lines | ChEMBL. | No reference |
CC50 (functional) | = 100 uM | Compound was tested for its cytotoxicity against HIV-1 infected MT-4 cell lines | ChEMBL. | No reference |
CC50 (functional) | = 200 uM | Compound was tested for its cytotoxicity against against duck hepatitis B virus in duck fetal hepatocytes culture | ChEMBL. | No reference |
IC50 (functional) | = 2 uM | Compound was tested for its antiviral activity against hepatitis B virus(DHBV) in duck fetal hepatocytes culture | ChEMBL. | No reference |
IC50 (functional) | = 10 uM | Compound was tested to inhibit HIV-1 replication in MT-4 cell lines ; value may range from 1 - 10 | ChEMBL. | No reference |
IC50 (functional) | = 10 uM | Compound was tested to inhibit HIV-1 replication in MT-4 cell lines ; value may range from 1 - 10 | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.