Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | beta LACTamase domain containing family member | 0.007 | 0.0377 | 0.0377 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.007 | 0.0385 | 0.0027 |
Mycobacterium tuberculosis | Conserved protein | 0.007 | 0.0377 | 0.0585 |
Leishmania major | alpha glucosidase II subunit, putative | 0.007 | 0.0385 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.007 | 0.0385 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.007 | 0.0377 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.007 | 0.0385 | 0.0027 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.007 | 0.0377 | 0.0759 |
Loa Loa (eye worm) | beta-lactamase | 0.007 | 0.0377 | 0.0759 |
Brugia malayi | Fli-1 protein | 0.0218 | 0.2762 | 0.556 |
Brugia malayi | hypothetical protein | 0.0247 | 0.3222 | 0.6487 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0377 | 0.0759 |
Mycobacterium ulcerans | beta-lactamase | 0.007 | 0.0377 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0248 | 0.3244 | 0.3244 |
Onchocerca volvulus | 0.0096 | 0.0797 | 0.2327 | |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.0958 | 0.1488 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.1148 | 0.1784 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.007 | 0.0385 | 0.0385 |
Brugia malayi | beta-lactamase family protein | 0.007 | 0.0377 | 0.0759 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0669 | 1 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.007 | 0.0377 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0268 | 0.3565 | 0.3565 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.007 | 0.0385 | 0.0385 |
Trypanosoma brucei | hypothetical protein, conserved | 0.007 | 0.0377 | 0.9801 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.007 | 0.0377 | 0.0377 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.3222 | 0.6487 |
Schistosoma mansoni | thyroid hormone receptor | 0.0268 | 0.3565 | 0.3524 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0096 | 0.0797 | 0.074 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0317 | 0.4355 | 0.4355 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.007 | 0.0377 | 0.0759 |
Onchocerca volvulus | 0.007 | 0.0377 | 0.0997 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.007 | 0.0385 | 0.0027 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.007 | 0.0385 | 1 |
Onchocerca volvulus | 0.007 | 0.0377 | 0.0997 | |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.007 | 0.0377 | 0.0585 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.007 | 0.0385 | 0.0027 |
Brugia malayi | beta-lactamase family protein | 0.007 | 0.0377 | 0.0759 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.007 | 0.0385 | 0.0027 |
Mycobacterium tuberculosis | Conserved protein | 0.007 | 0.0377 | 0.0585 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.007 | 0.0377 | 0.0317 |
Trypanosoma brucei | glucosidase, putative | 0.007 | 0.0385 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0217 | 0.2739 | 0.5515 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0377 | 0.0759 |
Brugia malayi | MH2 domain containing protein | 0.0355 | 0.4967 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.0062 | 0.0125 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0355 | 0.4967 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0355 | 0.4967 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0657 | 0.9807 | 0.9807 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0317 | 0.4355 | 0.8768 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.007 | 0.0377 | 0.0317 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0248 | 0.3244 | 0.3244 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.1148 | 0.1784 |
Toxoplasma gondii | ABC1 family protein | 0.007 | 0.0377 | 0.9801 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.007 | 0.0377 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.007 | 0.0385 | 0.5 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0072 | 0.0408 | 0.0408 |
Onchocerca volvulus | 0.0247 | 0.3221 | 1 | |
Brugia malayi | Pre-SET motif family protein | 0.0217 | 0.2739 | 0.5515 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0317 | 0.4355 | 0.4355 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.1148 | 0.1784 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.007 | 0.0377 | 0.0585 |
Brugia malayi | Ets-domain containing protein | 0.0072 | 0.0408 | 0.0822 |
Leishmania major | hypothetical protein, conserved | 0.007 | 0.0377 | 0.9801 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.0958 | 0.1488 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.007 | 0.0377 | 0.0585 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.007 | 0.0377 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.0958 | 0.1488 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0247 | 0.3222 | 0.3222 |
Schistosoma mansoni | alpha-glucosidase | 0.0273 | 0.3645 | 0.3605 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.007 | 0.0377 | 0.0585 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0072 | 0.0408 | 0.0408 |
Mycobacterium tuberculosis | Conserved protein | 0.007 | 0.0377 | 0.0585 |
Schistosoma mansoni | alpha glucosidase | 0.007 | 0.0385 | 0.0325 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.007 | 0.0377 | 0.0585 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0247 | 0.3222 | 0.3222 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.007 | 0.0377 | 0.9801 |
Loa Loa (eye worm) | fli-1 protein | 0.0218 | 0.2762 | 0.556 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0377 | 0.0759 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0377 | 0.0759 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.007 | 0.0385 | 0.0774 |
Schistosoma mansoni | hypothetical protein | 0.0248 | 0.3244 | 0.3202 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.1148 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0072 | 0.0408 | 0.0822 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.024 | 0.0484 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.007 | 0.0385 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.0958 | 0.1488 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0106 | 0.0958 | 0.7533 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0377 | 0.0759 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.007 | 0.0385 | 0.0027 |
Onchocerca volvulus | 0.0184 | 0.2204 | 0.6779 | |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0317 | 0.4355 | 0.8768 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.007 | 0.0385 | 0.0027 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.007 | 0.0377 | 0.0585 |
Schistosoma mansoni | ets-related | 0.0218 | 0.2762 | 0.2717 |
Echinococcus granulosus | tumor protein p63 | 0.0657 | 0.9807 | 0.9807 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0317 | 0.4355 | 0.4355 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.007 | 0.0377 | 0.9801 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0273 | 0.3645 | 0.3605 |
Trichomonas vaginalis | set domain proteins, putative | 0.0247 | 0.3221 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.007 | 0.0377 | 0.0585 |
Brugia malayi | beta-lactamase | 0.007 | 0.0377 | 0.0759 |
Schistosoma mansoni | thyroid hormone receptor | 0.0268 | 0.3565 | 0.3524 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0669 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.007 | 0.0385 | 0.0027 |
Schistosoma mansoni | gabp alpha | 0.0072 | 0.0408 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0377 | 0.0759 |
Onchocerca volvulus | 0.007 | 0.0377 | 0.0997 | |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0797 | 0.1605 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.0958 | 0.1488 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.007 | 0.0385 | 0.0774 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0072 | 0.0408 | 0.0822 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.007 | 0.0385 | 0.0027 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.0958 | 0.1488 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0447 | 0.6438 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.007 | 0.0377 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.007 | 0.0385 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.