Detailed information for compound 73269

Basic information

Technical information
  • TDR Targets ID: 73269
  • Name: methyl 3-(6-methoxy-1,3-benzodioxol-5-yl)-3-( 4-methoxyphenyl)propanoate
  • MW: 344.359 | Formula: C19H20O6
  • H donors: 0 H acceptors: 1 LogP: 3.22 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)CC(c1cc2OCOc2cc1OC)c1ccc(cc1)OC
  • InChi: 1S/C19H20O6/c1-21-13-6-4-12(5-7-13)14(9-19(20)23-3)15-8-17-18(25-11-24-17)10-16(15)22-2/h4-8,10,14H,9,11H2,1-3H3
  • InChiKey: RMONCTIMDMCNME-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(6-methoxy-1,3-benzodioxol-5-yl)-3-(4-methoxyphenyl)propanoic acid methyl ester
  • 3-(6-methoxy-1,3-benzodioxol-5-yl)-3-(4-methoxyphenyl)propionic acid methyl ester
  • NSC353659

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Cathepsin B precursor 0.0099 0.0942 0.9024
Echinococcus granulosus GPCR family 2 0.0034 0.0255 0.0852
Entamoeba histolytica cysteine proteinase, putative 0.0021 0.012 0.0939
Schistosoma mansoni hypothetical protein 0.0034 0.0255 0.0852
Loa Loa (eye worm) beta-lactamase 0.0037 0.0286 0.0956
Loa Loa (eye worm) hypothetical protein 0.0037 0.0286 0.0956
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0185 0.0687
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0089 0.022
Loa Loa (eye worm) G-protein coupled receptor 0.0031 0.0225 0.0751
Echinococcus granulosus peptide allatostatin:somatostatin 0.0031 0.0225 0.0751
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0293 0.2991 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0089 0.0279
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0255 0.0852
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.02 0.2006 0.6706
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0185 0.0687
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0089 0.0249
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0016 0.0065 0.1728
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.0024 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0185 0.0687
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0065 0.0217
Echinococcus granulosus chromatin regulatory protein sir2 0.0108 0.1041 0.3481
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0089 0.025
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0016 0.0065 0.0065
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0286 0.0956
Onchocerca volvulus 0.0027 0.0185 0.0782
Schistosoma mansoni hypothetical protein 0.0031 0.0225 0.0751
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0207 0.0692
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.026 0.2322
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0286 0.0952
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0108 0.1041 1
Leishmania major cathepsin L-like protease 0.0027 0.0185 0.1228
Brugia malayi Melatonin receptor type 1A 0.0031 0.0225 0.0751
Echinococcus multilocularis neuropeptide FF receptor 2 0.0031 0.0225 0.0225
Brugia malayi follicle stimulating hormone receptor 0.0031 0.0225 0.0751
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0225 0.0225
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0225 0.0751
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0012 0.0024 0.0081
Schistosoma mansoni histamine h1 receptor 0.0031 0.0225 0.0751
Onchocerca volvulus 0.0021 0.012 0.0507
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0089 0.0278
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0031 0.0225 0.0225
Toxoplasma gondii cathepsin CPL 0.0027 0.0185 0.1751
Brugia malayi Cathepsin L-like precursor 0.0027 0.0185 0.0618
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0016 0.0065 0.0217
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Echinococcus granulosus g protein coupled receptor 0.0031 0.0225 0.0751
Echinococcus granulosus neuropeptide FF receptor 2 0.0031 0.0225 0.0751
Entamoeba histolytica cysteine protease, putative 0.0027 0.0185 0.158
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0225 0.0751
Echinococcus multilocularis GPCR, family 2 0.0034 0.0255 0.0255
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0185 0.0185
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Onchocerca volvulus Cathepsin L homolog 0.0012 0.0024 0.0102
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.103 0.3444
Brugia malayi ORL1-like opioid receptor 0.0031 0.0225 0.0751
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0099 0.0942 0.3149
Echinococcus multilocularis neuropeptide receptor 0.0031 0.0225 0.0225
Leishmania major basic transcription factor 3a, putative 0.0035 0.026 0.2001
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0286 0.0882
Entamoeba histolytica cysteine protease, putative 0.0018 0.0089 0.0641
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Onchocerca volvulus 0.0037 0.0286 0.121
Schistosoma mansoni biogenic amine receptor 0.0031 0.0225 0.0751
Echinococcus multilocularis neuropeptide receptor A26 0.0031 0.0225 0.0225
Onchocerca volvulus 0.0027 0.0185 0.0782
Echinococcus multilocularis neuropeptide receptor 0.0031 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Echinococcus granulosus sex peptide receptor 0.0031 0.0225 0.0751
Brugia malayi G-protein coupled receptor 0.0031 0.0225 0.0751
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0024 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0185 0.0687
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0225 0.0751
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0185 0.0687
Schistosoma mansoni ap endonuclease 0.0018 0.0089 0.0299
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0185 0.0687
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0065 0.0174
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0225 0.0225
Brugia malayi RNA binding protein 0.02 0.2006 0.6706
Brugia malayi hypothetical protein 0.0031 0.0225 0.0751
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0286 1
Onchocerca volvulus 0.0027 0.0185 0.0782
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0065 0.0217
Schistosoma mansoni tar DNA-binding protein 0.02 0.2006 0.6706
Echinococcus multilocularis neuropeptides capa receptor 0.0031 0.0225 0.0225
Echinococcus granulosus somatostatin receptor 0.0031 0.0225 0.0751
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0024 0.0081
Onchocerca volvulus 0.0031 0.0225 0.0951
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0031 0.0225 0.0751
Onchocerca volvulus 0.0031 0.0225 0.0951
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0065 0.0217
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0225 0.0225
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0286 0.0952
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.0024 0.0081
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0286 1
Leishmania major cathepsin L-like protease 0.0027 0.0185 0.1228
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0089 0.022
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.1041 0.3481
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0225 0.0225
Echinococcus granulosus neuropeptide receptor A26 0.0031 0.0225 0.0751
Onchocerca volvulus 0.0031 0.0225 0.0951
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0286 0.5
Schistosoma mansoni transcription factor btf3 0.0035 0.026 0.087
Echinococcus multilocularis fmrfamide receptor 0.0031 0.0225 0.0225
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0225 0.0225
Schistosoma mansoni hypothetical protein 0.0031 0.0225 0.0751
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0286 0.0956
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Leishmania major cathepsin L-like protease 0.008 0.0738 0.69
Brugia malayi GnHR receptor homolog 0.0031 0.0225 0.0751
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.103 0.3444
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0065 0.0174
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0027 0.0185 0.6805
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0185 0.1851 0.6188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0738 0.69
Schistosoma mansoni tar DNA-binding protein 0.02 0.2006 0.6706
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0031 0.0225 0.0751
Toxoplasma gondii ABC1 family protein 0.0037 0.0286 0.2852
Brugia malayi beta-lactamase 0.0037 0.0286 0.0956
Onchocerca volvulus 0.0234 0.2364 1
Entamoeba histolytica cysteine protease, putative 0.0018 0.0089 0.0641
Schistosoma mansoni neuropeptide receptor 0.0031 0.0225 0.0751
Entamoeba histolytica cysteine protease, putative 0.0018 0.0089 0.0641
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0185 0.0618
Brugia malayi hypothetical protein 0.0031 0.0225 0.0751
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0089 0.0299
Trypanosoma brucei cysteine peptidase C (CPC) 0.0099 0.0942 0.8983
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0031 0.0225 0.0225
Onchocerca volvulus 0.0031 0.0225 0.0951
Echinococcus multilocularis serotonin receptor 0.0031 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Echinococcus multilocularis neuropeptide s receptor 0.0031 0.0225 0.0225
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0108 0.1041 1
Loa Loa (eye worm) neuropeptide F receptor 0.0031 0.0225 0.0751
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0738 0.69
Echinococcus granulosus cathepsin L 0.0018 0.0089 0.0299
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0286 0.0286
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0089 0.0299
Leishmania major cathepsin L-like protease 0.008 0.0738 0.69
Mycobacterium ulcerans lipase LipD 0.0037 0.0286 1
Giardia lamblia Cathepsin B precursor 0.0099 0.0942 0.9024
Schistosoma mansoni hypothetical protein 0.017 0.1688 0.5645
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.026 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0207 0.0692
Onchocerca volvulus 0.0031 0.0225 0.0951
Echinococcus granulosus cysteine protease 0.0018 0.0089 0.0299
Schistosoma mansoni cathepsin F (C01 family) 0.0021 0.012 0.04
Brugia malayi putative neuropeptide receptor 0.0031 0.0225 0.0751
Leishmania major cathepsin L-like protease 0.0027 0.0185 0.1228
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0185 0.0542
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0286 0.0956
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0286 0.0952
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0065 0.0217
Echinococcus granulosus cathepsin L 0.0012 0.0024 0.0081
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0016 0.0065 0.0138
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0065 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.026 0.1009
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Echinococcus granulosus cathepsin b 0.0293 0.2991 1
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0286 0.0952
Plasmodium falciparum cysteine proteinase falcipain 1 0.0018 0.0089 0.2759
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0037 0.0286 0.0956
Loa Loa (eye worm) hypothetical protein 0.0029 0.0207 0.0692
Onchocerca volvulus 0.0037 0.0286 0.121
Brugia malayi Serotonin receptor 0.0031 0.0225 0.0751
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0286 0.0952
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0185 0.0687
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0031 0.0225 0.0751
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0293 0.2991 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0089 0.1105
Entamoeba histolytica cysteine protease, putative 0.0018 0.0089 0.0641
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0037 0.0286 0.0956
Mycobacterium tuberculosis Conserved protein 0.0037 0.0286 0.0952
Brugia malayi G protein-coupled receptor 0.0031 0.0225 0.0751
Trypanosoma cruzi cysteine peptidase, putative 0.008 0.0738 0.2408
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0286 0.1119
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0225 0.0225
Echinococcus multilocularis G protein coupled receptor 139 0.0031 0.0225 0.0225
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0089 0.5
Echinococcus granulosus cathepsin b 0.0293 0.2991 1
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0089 0.0299
Echinococcus granulosus cathepsin l cysteine peptidase 0.0027 0.0185 0.0618
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0031 0.0225 0.0751
Brugia malayi hypothetical protein 0.0031 0.0225 0.0751
Toxoplasma gondii cathepsin B 0.0099 0.0942 1
Plasmodium vivax NAD-dependent deacetylase, putative 0.0016 0.0065 0.1559
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0225 0.0751
Trypanosoma cruzi cysteine peptidase, putative 0.008 0.0738 0.2408
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0225 0.0751
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0031 0.0225 0.0951
Schistosoma mansoni neuropeptide receptor 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Schistosoma mansoni biogenic amine (5HT) receptor 0.0031 0.0225 0.0751
Onchocerca volvulus 0.0027 0.0185 0.0782
Onchocerca volvulus 0.0031 0.0225 0.0951
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0738 0.69
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0031 0.0225 0.0751
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0225 0.0751
Mycobacterium ulcerans beta-lactamase 0.0037 0.0286 1
Echinococcus granulosus serotonin receptor 0.0031 0.0225 0.0751
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0286 0.1119
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0065 0.0217
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0108 0.1041 0.3481
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0089 0.0641
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0255 0.0852
Toxoplasma gondii exonuclease III APE 0.0018 0.0089 0.0711
Schistosoma mansoni growth hormone secretagogue receptor 0.0031 0.0225 0.0751
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0031 0.0225 0.0751
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0293 0.2991 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0031 0.0225 0.0751
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0255 0.0255
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0065 0.0174
Loa Loa (eye worm) fibroinase 0.0027 0.0185 0.0618
Echinococcus granulosus tachykinin peptides receptor 99D 0.0031 0.0225 0.0751
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0286 1
Brugia malayi cathepsin L-like precursor 0.0021 0.012 0.04
Echinococcus granulosus cathepsin l1 0.0021 0.012 0.04
Echinococcus granulosus 7TM GPCR rhodopsin 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0034 0.0255 0.0852
Entamoeba histolytica cysteine protease, putative 0.0018 0.0089 0.0641
Entamoeba histolytica cysteine proteinase 1, putative 0.0018 0.0089 0.0641
Loa Loa (eye worm) TAR-binding protein 0.02 0.2006 0.6706
Brugia malayi G protein-coupled receptor F59B2.13 0.0031 0.0225 0.0751
Echinococcus granulosus neuropeptide s receptor 0.0031 0.0225 0.0751
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0065 0.0174
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0081
Onchocerca volvulus 0.0031 0.0225 0.0951
Loa Loa (eye worm) cathepsin B 0.0099 0.0942 0.3149
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0108 0.1041 1
Loa Loa (eye worm) neuropeptide F receptor 0.0031 0.0225 0.0751
Plasmodium vivax unspecified product 0.0018 0.0089 0.2488
Schistosoma mansoni hypothetical protein 0.0034 0.0255 0.0852
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0225 0.0225
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0016 0.0065 0.0065
Schistosoma mansoni biogenic amine (5HT) receptor 0.0031 0.0225 0.0751
Brugia malayi putative neuropeptide receptor NPR1 0.0031 0.0225 0.0751
Entamoeba histolytica hypothetical protein 0.0035 0.026 0.2322
Onchocerca volvulus 0.0031 0.0225 0.0951
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0089 0.0089
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0031 0.0225 0.0751
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0185 0.158
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.026 0.0796
Brugia malayi larval opioid receptor 0.0031 0.0225 0.0751
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0207 0.0692
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0065 0.0174
Echinococcus multilocularis sex peptide receptor 0.0031 0.0225 0.0225
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0024 0.0081
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.026 0.2001
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0012 0.0024 0.0081
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0016 0.0065 0.0401
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0089 0.0105
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0108 0.1041 0.1041
Leishmania major cathepsin L-like protease 0.0027 0.0185 0.1228
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0089 0.0299
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0286 0.0956
Onchocerca volvulus 0.0012 0.0024 0.0102
Echinococcus granulosus allatostatin A receptor 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Brugia malayi Tachykinin-like peptides receptor 99D 0.0031 0.0225 0.0751
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0225 0.0751
Echinococcus granulosus biogenic amine 5HT receptor 0.0031 0.0225 0.0751
Onchocerca volvulus 0.0031 0.0225 0.0951
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0185 0.0687
Schistosoma mansoni neuropeptide receptor 0.0031 0.0225 0.0751
Giardia lamblia Hypothetical protein 0.0108 0.1041 1
Onchocerca volvulus 0.0031 0.0225 0.0951
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0185 0.0687
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0031 0.0225 0.0751
Echinococcus multilocularis neuropeptides capa receptor 0.0031 0.0225 0.0225
Schistosoma mansoni adenoreceptor 0.0031 0.0225 0.0751
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0185 0.0687
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0012 0.0024 0.0081
Schistosoma mansoni myosin xvIII 0.0031 0.0225 0.0751
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0185 0.0618
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0016 0.0065 0.0401
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.2387 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0031 0.0225 0.0751
Echinococcus granulosus neuropeptide Y receptor 0.0031 0.0225 0.0751
Echinococcus multilocularis serotonin receptor 0.0031 0.0225 0.0225
Echinococcus granulosus neuropeptide receptor 0.0031 0.0225 0.0751
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0031 0.0225 0.0751
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0031 0.0225 0.0751
Giardia lamblia Cathepsin B precursor 0.0099 0.0942 0.9024
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0089 0.2492
Brugia malayi beta-lactamase family protein 0.0037 0.0286 0.0956
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0074 0.0673 0.2188
Schistosoma mansoni cathepsin B (C01 family) 0.0012 0.0024 0.0081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0225 0.0751
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0031 0.0225 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.012 0.0408
Entamoeba histolytica cysteine protease, putative 0.0018 0.0089 0.0641
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0031 0.0225 0.0751
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0016 0.0065 0.0217
Onchocerca volvulus 0.0031 0.0225 0.0951
Brugia malayi Cathepsin L-like precursor 0.0027 0.0185 0.0618
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0089 0.0299
Loa Loa (eye worm) hypothetical protein 0.0037 0.0286 0.0956
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0081
Echinococcus granulosus transcription factor btf3 0.0035 0.026 0.087
Toxoplasma gondii histone deacetylase SIR2 0.0016 0.0065 0.0445
Plasmodium vivax vivapain-2 0.0027 0.0185 0.6138
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0024 0.0081
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0089 0.0279
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0073 0.0671 0.2244
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0207 0.0207
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0024 0.0081
Schistosoma mansoni hypothetical protein 0.0031 0.0225 0.0751
Mycobacterium ulcerans hypothetical protein 0.0037 0.0286 1
Brugia malayi transcriptional regulator, Sir2 family protein 0.0108 0.1041 0.3481
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0185 0.0782
Onchocerca volvulus 0.0037 0.0286 0.121
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0255 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0185 0.0687
Echinococcus multilocularis transcription factor btf3 0.0035 0.026 0.026
Schistosoma mansoni neuropeptide receptor 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.012 0.0408
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0286 0.1119
Echinococcus granulosus g protein coupled receptor 0.0031 0.0225 0.0751
Brugia malayi Cathepsin L-like precursor 0.0027 0.0185 0.0618
Loa Loa (eye worm) cysteine protease 0.0027 0.0185 0.0618
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0293 0.2991 1
Brugia malayi Dopamine receptor protein 1 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0185 0.0618
Echinococcus multilocularis cathepsin b 0.0293 0.2991 0.2991
Echinococcus multilocularis G-protein coupled receptor, putative 0.0031 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0031 0.0225 0.0751
Echinococcus multilocularis somatostatin receptor 0.0031 0.0225 0.0225
Brugia malayi hypothetical protein 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0021 0.012 0.04
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0031 0.0225 0.0751
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.1041 0.3481
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0225 0.0751
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0065 0.0174
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Loa Loa (eye worm) sirtuin 4 0.0016 0.0065 0.0217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0185 0.0687
Plasmodium vivax vivapain-1 0.0018 0.0089 0.2488
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0031 0.0225 0.0225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0185 0.0687
Brugia malayi G-protein coupled receptor 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0107 0.103 0.3444
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0185 0.0687
Loa Loa (eye worm) hypothetical protein 0.0037 0.0286 0.0956
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0255 0.0852
Echinococcus granulosus neuropeptide receptor 0.0031 0.0225 0.0751
Schistosoma mansoni hypothetical protein 0.0034 0.0255 0.0852
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0108 0.1041 0.3427
Brugia malayi beta-lactamase family protein 0.0037 0.0286 0.0956
Loa Loa (eye worm) RNA binding protein 0.02 0.2006 0.6706
Schistosoma mansoni hypothetical protein 0.0031 0.0225 0.0751
Brugia malayi cathepsin B-like cysteine proteinase 0.0293 0.2991 1
Loa Loa (eye worm) ICD-1 protein 0.0035 0.026 0.087
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0031 0.0225 0.0751
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0185 0.0687
Schistosoma mansoni amine GPCR 0.0031 0.0225 0.0751
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0016 0.0065 0.1728
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Echinococcus granulosus cathepsin L cysteine proteinase 0.0027 0.0185 0.0618
Plasmodium vivax vivapain-3 0.0018 0.0089 0.2488
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Echinococcus granulosus dro:myosuppressin receptor 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0081
Onchocerca volvulus 0.0027 0.0185 0.0782
Brugia malayi hypothetical protein 0.0031 0.0225 0.0751
Echinococcus granulosus hypothetical protein 0.0031 0.0225 0.0751
Schistosoma mansoni biogenic amine receptor 0.0031 0.0225 0.0751
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0185 0.158
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0031 0.0225 0.0751
Brugia malayi Cathepsin L-like precursor 0.0027 0.0185 0.0618
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0065 0.0174
Echinococcus multilocularis geminin 0.017 0.1688 0.1688
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0207 0.1993
Echinococcus granulosus cathepsin l1 0.0027 0.0185 0.0618
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0225 0.0751
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0089 0.2762
Toxoplasma gondii histone deacetylase SIR2-like 0.0016 0.0065 0.0445
Echinococcus multilocularis cathepsin L 0.0018 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0185 0.0687
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0225 0.0751
Schistosoma mansoni amine GPCR 0.0031 0.0225 0.0751
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0286 0.0952
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0089 0.022
Plasmodium vivax SET domain protein, putative 0.0029 0.0207 0.6986
Plasmodium vivax vivapain-2 0.0027 0.0185 0.6138
Brugia malayi RE15519p 0.0031 0.0225 0.0751
Brugia malayi Cathepsin L-like precursor 0.0027 0.0185 0.0618
Entamoeba histolytica cysteine protease, putative 0.0018 0.0089 0.0641
Schistosoma mansoni ap endonuclease 0.0018 0.0089 0.0299
Brugia malayi cathepsin F-like cysteine proteinase 0.0012 0.0024 0.0081
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0016 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0217
Schistosoma mansoni neuropeptide f receptor 76f 0.0031 0.0225 0.0751
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0031 0.0225 0.0751
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0031 0.0225 0.0751
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0089 0.0641
Entamoeba histolytica cysteine protease, putative 0.0018 0.0089 0.0641
Schistosoma mansoni tar DNA-binding protein 0.02 0.2006 0.6706
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0031 0.0225 0.0751
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0185 0.0687
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0225 0.0751
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0738 0.69
Brugia malayi Cathepsin L-like precursor 0.0021 0.012 0.04
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0012 0.0024 0.0081
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0089 0.0641
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0185 0.0687
Brugia malayi hypothetical protein 0.0031 0.0225 0.0751
Entamoeba histolytica cysteine protease, putative 0.0018 0.0089 0.0641
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0089 0.022
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0031 0.0225 0.0225
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0031 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Schistosoma mansoni hypothetical protein 0.0034 0.0255 0.0852
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0031 0.0225 0.0751
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0016 0.0065 0.0138
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.1041 0.3481
Echinococcus granulosus 7tm_1 domain containing protein 0.0031 0.0225 0.0751
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0225 0.0225
Schistosoma mansoni hypothetical protein 0.0073 0.0671 0.2244
Trypanosoma cruzi cruzipain precursor, putative 0.008 0.0738 0.2408
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0027 0.0185 0.0618
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2364 1
Echinococcus multilocularis neuropeptide Y receptor 0.0031 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0081
Entamoeba histolytica cysteine protease, putative 0.0018 0.0089 0.0641
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0089 0.0299
Echinococcus multilocularis cysteine protease 0.0027 0.0185 0.0185
Schistosoma mansoni opsin-like receptor 0.0031 0.0225 0.0751
Onchocerca volvulus 0.0031 0.0225 0.0951
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.026 0.1009
Brugia malayi cathepsin L precursor 0.0012 0.0024 0.0081
Brugia malayi neuropeptide F receptor 0.0031 0.0225 0.0751
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0185 0.0687
Brugia malayi beta-NAC-like protein 0.0035 0.026 0.087
Echinococcus multilocularis cathepsin L 0.0012 0.0024 0.0024
Entamoeba histolytica cysteine protease, putative 0.0018 0.0089 0.0641
Schistosoma mansoni tar DNA-binding protein 0.02 0.2006 0.6706
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0089 0.5
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0012 0.0024 0.0081
Echinococcus multilocularis cathepsin b 0.0293 0.2991 0.2991
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0089 0.025
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.1041 0.4347
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0286 0.2264
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Schistosoma mansoni neuropeptide F-like receptor 0.0031 0.0225 0.0751
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0286 0.0952
Brugia malayi cathepsin Z-like cysteine proteinase 0.0012 0.0024 0.0081
Brugia malayi cathepsin Z-like cysteine proteinase 0.0012 0.0024 0.0081
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0024 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0207 0.0692
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0225 0.0751
Onchocerca volvulus 0.0029 0.0207 0.0876
Loa Loa (eye worm) hypothetical protein 0.0037 0.0286 0.0956
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0089 0.0278
Leishmania major hypothetical protein, conserved 0.0037 0.0286 0.2264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0185 0.0687
Brugia malayi hypothetical protein 0.0031 0.0225 0.0751
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0065 0.0217
Loa Loa (eye worm) hypothetical protein 0.0293 0.2991 1
Trichomonas vaginalis esterase, putative 0.0037 0.0286 0.1119
Schistosoma mansoni cathepsin S (C01 family) 0.0012 0.0024 0.0081
Onchocerca volvulus 0.0027 0.0185 0.0782
Echinococcus multilocularis orexin receptor type 2 0.0031 0.0225 0.0225
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0225 0.0225
Brugia malayi Cathepsin L-like cysteine proteinase 0.0021 0.012 0.04
Echinococcus granulosus g-protein coupled receptor 0.0031 0.0225 0.0751
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0065 0.0217
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0225 0.0225
Loa Loa (eye worm) transcriptional regulator 0.0108 0.1041 0.3481
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0081
Echinococcus multilocularis fmrfamide receptor 0.0031 0.0225 0.0225
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0065 0.0217
Leishmania major cathepsin L-like protease 0.0027 0.0185 0.1228
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0027 0.0185 0.6805
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0286 0.1119
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0225 0.0751
Echinococcus multilocularis g-protein coupled receptor 0.0031 0.0225 0.0225
Brugia malayi TAR-binding protein 0.02 0.2006 0.6706
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0099 0.0942 0.3922
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0031 0.0225 0.0225
Onchocerca volvulus 0.0031 0.0225 0.0951
Schistosoma mansoni opsin-like receptor 0.0031 0.0225 0.0751
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0089 0.0641
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0225 0.0751
Brugia malayi sulfakinin receptor protein 0.0031 0.0225 0.0751
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.026 0.902
Mycobacterium leprae Probable lipase LipE 0.0037 0.0286 0.5
Leishmania major silent information regulator 2, putative 0.0108 0.1041 1
Brugia malayi Dopamine receptor 0.0031 0.0225 0.0751
Onchocerca volvulus 0.0027 0.0185 0.0782
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0286 0.1119
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.1041 0.4347
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2064 0.6901
Loa Loa (eye worm) melatonin receptor type 1A 0.0031 0.0225 0.0751
Brugia malayi NAD-dependent deacetylase SIRT1 0.0016 0.0065 0.0217
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Echinococcus multilocularis allatostatin A receptor 0.0031 0.0225 0.0225
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0225 0.0225
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0286 0.0956
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0024 0.0081
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.103 0.3444
Brugia malayi neuropeptide F receptor 0.0031 0.0225 0.0751
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0738 0.69
Brugia malayi Pre-SET motif family protein 0.0029 0.0207 0.0692
Leishmania major cysteine peptidase A (CPA) 0.0027 0.0185 0.1228
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.026 0.1009
Onchocerca volvulus 0.0031 0.0225 0.0951
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Onchocerca volvulus 0.0031 0.0225 0.0951
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0225 0.0751
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0738 0.69
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0031 0.0225 0.0225
Brugia malayi RNA recognition motif domain containing protein 0.02 0.2006 0.6706
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0185 0.0687
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0185 0.0618
Brugia malayi fibroinase precursor 0.0012 0.0024 0.0081
Schistosoma mansoni amine GPCR 0.0031 0.0225 0.0751
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0185 0.0687
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0031 0.0225 0.0751
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0225 0.0225
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0031 0.0225 0.0751
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0089 0.0641
Echinococcus granulosus neuropeptide Y receptor 0.0031 0.0225 0.0751
Schistosoma mansoni alpha-1 adrenergic receptor 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Schistosoma mansoni opsin-like receptor 0.0031 0.0225 0.0751
Brugia malayi hypothetical protein 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0021 0.012 0.04
Trypanosoma cruzi major cysteine proteinase, putative 0.0065 0.0578 0.1866
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0196 0.0654
Brugia malayi hypothetical protein 0.0031 0.0225 0.0751
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0738 0.69
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0185 0.0687
Loa Loa (eye worm) TYRA-2 protein 0.0031 0.0225 0.0751
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0089 0.022
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0671 0.2244
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0065 0.0174
Echinococcus multilocularis tar DNA binding protein 0.02 0.2006 0.2006
Schistosoma mansoni cathepsin C 0.0012 0.0024 0.0081
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Trypanosoma cruzi cysteine peptidase, putative 0.008 0.0738 0.2408
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0031 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0031 0.0225 0.0751
Echinococcus granulosus g protein coupled receptor 0.0031 0.0225 0.0751
Leishmania major cathepsin L-like protease 0.008 0.0738 0.69
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0225 0.0751
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.026 0.0796
Entamoeba histolytica cysteine proteinase 2 0.0018 0.0089 0.0641
Schistosoma mansoni hypothetical protein 0.017 0.1688 0.5645
Schistosoma mansoni neuropeptide F-like receptor 0.0031 0.0225 0.0751
Giardia lamblia Transcriptional regulator, Sir2 family 0.0016 0.0065 0.0401
Loa Loa (eye worm) ctsf protein 0.0027 0.0185 0.0618
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0031 0.0225 0.0225
Schistosoma mansoni amine GPCR 0.0031 0.0225 0.0751
Echinococcus multilocularis dro:myosuppressin receptor 0.0031 0.0225 0.0225
Echinococcus multilocularis chromatin regulatory protein sir2 0.0108 0.1041 0.1041
Echinococcus granulosus neuropeptides capa receptor 0.0031 0.0225 0.0751
Entamoeba histolytica cysteine protease, putative 0.0018 0.0089 0.0641
Onchocerca volvulus 0.0031 0.0225 0.0951
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0089 0.0641
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0012 0.0024 0.0081
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0225 0.0225
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0099 0.0942 0.3093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0738 0.69
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0185 0.0185
Echinococcus granulosus fmrfamide receptor 0.0031 0.0225 0.0751
Echinococcus granulosus tar DNA binding protein 0.02 0.2006 0.6706
Onchocerca volvulus 0.0031 0.0225 0.0951
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0185 0.0687
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0089 0.0299
Schistosoma mansoni amine GPCR 0.0031 0.0225 0.0751
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.0065 0.0401
Schistosoma mansoni biogenic amine receptor 0.0031 0.0225 0.0751
Echinococcus granulosus biogenic amine 5HT receptor 0.0031 0.0225 0.0751
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0286 0.0882
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0207 0.0692
Brugia malayi Pre-SET motif family protein 0.0205 0.2064 0.6901
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0185 0.0185
Brugia malayi Cathepsin L-like precursor 0.0027 0.0185 0.0618
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Mycobacterium tuberculosis Conserved protein 0.0037 0.0286 0.0952
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0738 0.69
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0738 0.69
Plasmodium falciparum cysteine proteinase falcipain 3 0.0027 0.0185 0.6805
Entamoeba histolytica cysteine protease, putative 0.0018 0.0089 0.0641
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0293 0.2991 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0016 0.0065 0.0217
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0016 0.0065 0.0401
Brugia malayi AKH receptor 0.0031 0.0225 0.0751
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0065 0.1559
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0185 0.1851 0.7831
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0027 0.0185 0.0618
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0185 0.0687
Mycobacterium tuberculosis Conserved protein 0.0037 0.0286 0.0952
Echinococcus granulosus geminin 0.017 0.1688 0.5645
Brugia malayi N-terminal motif family protein 0.0185 0.1851 0.6188
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0185 0.0185
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0185 0.0782
Loa Loa (eye worm) G-protein coupled receptor 0.0031 0.0225 0.0751
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0089 0.0249
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0031 0.0225 0.0751
Toxoplasma gondii NAC domain-containing protein 0.0035 0.026 0.2573
Onchocerca volvulus Neuropeptide F receptor homolog 0.0031 0.0225 0.0951
Loa Loa (eye worm) hypothetical protein 0.0021 0.012 0.04
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0089 0.022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Brugia malayi cathepsin L-like cysteine proteinase 0.0012 0.0024 0.0081
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0099 0.0942 0.8983
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0089 0.022
Echinococcus multilocularis cysteine protease 0.0027 0.0185 0.0185
Onchocerca volvulus Cathepsin F homolog 0.0027 0.0185 0.0782
Echinococcus multilocularis neuropeptide Y receptor 0.0031 0.0225 0.0225
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0225 0.0751
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0255 0.0852
Brugia malayi hypothetical protein 0.0031 0.0225 0.0751
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0031 0.0225 0.0225
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0089 0.0299
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0089 0.0299
Echinococcus granulosus neuropeptides capa receptor 0.0031 0.0225 0.0751
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0751
Schistosoma mansoni tar DNA-binding protein 0.02 0.2006 0.6706
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0738 0.69
Echinococcus granulosus alpha 1A adrenergic receptor 0.0031 0.0225 0.0751
Brugia malayi Dopamine receptor protein 2 0.0031 0.0225 0.0751
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0108 0.1041 0.3427
Echinococcus granulosus G protein coupled receptor 139 0.0031 0.0225 0.0751
Brugia malayi Cathepsin L-like precursor 0.0021 0.012 0.04
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0255 0.0852
Echinococcus granulosus orexin receptor type 2 0.0031 0.0225 0.0751
Giardia lamblia Sirtuin type 2 0.0016 0.0065 0.0401
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0024 0.0081
Brugia malayi Serotonin receptor 0.0031 0.0225 0.0751

Activities

Activity type Activity value Assay description Source Reference
ILS (functional) NT 0 % Percent increase in life span (ILS) was measured on P388 cells which were inoculated intraperitoneally in CD2F1 mice ChEMBL. 2821258

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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