Detailed information for compound 73272

Basic information

Technical information
  • TDR Targets ID: 73272
  • Name: 2,6-bis(3-carbamimidoylphenoxy)-N,N-dimethylp yridine-3-carboxamide
  • MW: 418.448 | Formula: C22H22N6O3
  • H donors: 2 H acceptors: 2 LogP: 1.97 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)c1ccc(nc1Oc1cccc(c1)C(=N)N)Oc1cccc(c1)C(=N)N)C
  • InChi: 1S/C22H22N6O3/c1-28(2)22(29)17-9-10-18(30-15-7-3-5-13(11-15)19(23)24)27-21(17)31-16-8-4-6-14(12-16)20(25)26/h3-12H,1-2H3,(H3,23,24)(H3,25,26)
  • InChiKey: YZZGIFYOGPXJKP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,6-bis(3-carbamimidoylphenoxy)-N,N-dimethyl-pyridine-3-carboxamide
  • 2,6-bis(3-carbamimidoylphenoxy)-N,N-dimethyl-3-pyridinecarboxamide
  • 2,6-bis(3-amidinophenoxy)-N,N-dimethyl-nicotinamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References
Bos taurus Trypsin I Starlite/ChEMBL References
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Brugia malayi Trypsin family protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Drosophila melanogaster CG17239 gene product from transcript CG17239-RB Trypsin I   246 aa 223 aa 34.5 %
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) Trypsin I   246 aa 287 aa 27.9 %
Onchocerca volvulus Trypsin I   246 aa 266 aa 22.2 %
Mycobacterium tuberculosis Membrane-associated serine protease Trypsin I   246 aa 203 aa 20.7 %
Drosophila melanogaster CG33465 gene product from transcript CG33465-RC Trypsin I   246 aa 235 aa 25.1 %
Schistosoma mansoni cercarial elastase (S01 family) Trypsin I   246 aa 241 aa 27.0 %
Onchocerca volvulus Trypsin I   246 aa 247 aa 21.1 %
Drosophila melanogaster CG30288 gene product from transcript CG30288-RC Trypsin I   246 aa 250 aa 29.6 %
Drosophila melanogaster CG13744 gene product from transcript CG13744-RA Trypsin I   246 aa 249 aa 31.3 %
Echinococcus multilocularis Mastin Trypsin I   246 aa 306 aa 23.2 %
Echinococcus granulosus transmembrane protease serine 3 Trypsin I   246 aa 233 aa 33.5 %
Drosophila melanogaster CG11313 gene product from transcript CG11313-RC Trypsin I   246 aa 223 aa 31.8 %
Schistosoma japonicum Enteropeptidase, putative Trypsin I   246 aa 264 aa 24.6 %
Echinococcus multilocularis glycoprotein Antigen 5 Trypsin I   246 aa 299 aa 21.7 %
Echinococcus granulosus Mastin Trypsin I   246 aa 306 aa 23.2 %
Echinococcus multilocularis transmembrane protease serine 3 Trypsin I   246 aa 233 aa 33.9 %
Drosophila melanogaster CG32277 gene product from transcript CG32277-RA Trypsin I   246 aa 267 aa 29.2 %
Drosophila melanogaster CG14990 gene product from transcript CG14990-RA Trypsin I   246 aa 238 aa 28.6 %
Drosophila melanogaster CG10405 gene product from transcript CG10405-RB Trypsin I   246 aa 251 aa 33.9 %
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family Trypsin I   246 aa 287 aa 27.5 %
Schistosoma mansoni aminopeptidase PILS (M01 family) Trypsin I   246 aa 301 aa 23.9 %
Drosophila melanogaster CG33458 gene product from transcript CG33458-RA Trypsin I   246 aa 248 aa 28.2 %
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Trypsin I   246 aa 304 aa 24.0 %
Drosophila melanogaster CG3505 gene product from transcript CG3505-RA Trypsin I   246 aa 235 aa 29.8 %
Schistosoma mansoni cercarial elastase (S01 family) Trypsin I   246 aa 241 aa 27.0 %
Drosophila melanogaster CG31220 gene product from transcript CG31220-RB Trypsin I   246 aa 227 aa 29.5 %
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Trypsin I   246 aa 262 aa 34.0 %
Drosophila melanogaster CG3916 gene product from transcript CG3916-RA Trypsin I   246 aa 269 aa 31.6 %
Drosophila melanogaster CG30323 gene product from transcript CG30323-RB Trypsin I   246 aa 208 aa 23.1 %
Schistosoma japonicum Cercarial protease precursor (EC 3.4.21.-) (Cercarial elastase), putative Trypsin I   246 aa 207 aa 24.6 %
Drosophila melanogaster CG31326 gene product from transcript CG31326-RA Trypsin I   246 aa 249 aa 24.5 %
Schistosoma mansoni cercarial elastase (S01 family) Trypsin I   246 aa 234 aa 26.9 %
Schistosoma japonicum Transmembrane protease, serine 9, putative Trypsin I   246 aa 250 aa 23.6 %
Drosophila melanogaster CG31267 gene product from transcript CG31267-RA Trypsin I   246 aa 234 aa 32.5 %
Echinococcus multilocularis enteropeptidase Trypsin I   246 aa 230 aa 27.0 %
Drosophila melanogaster Jonah 65Aii Trypsin I   246 aa 265 aa 34.3 %
Drosophila melanogaster Jonah 66Ci Trypsin I   246 aa 272 aa 30.5 %
Drosophila melanogaster Jonah 99Ci Trypsin I   246 aa 237 aa 32.9 %
Drosophila melanogaster CG4914 gene product from transcript CG4914-RA Trypsin I   246 aa 246 aa 38.2 %
Drosophila melanogaster CG4815 gene product from transcript CG4815-RA Trypsin I   246 aa 205 aa 27.8 %
Schistosoma japonicum ko:K09637 transmembrane protease, serine 6, putative Trypsin I   246 aa 242 aa 30.6 %
Schistosoma japonicum ko:K01346 pancreatic elastase II [EC3.4.21.71], putative Trypsin I   246 aa 305 aa 23.9 %
Drosophila melanogaster CG18180 gene product from transcript CG18180-RA Trypsin I   246 aa 233 aa 30.0 %
Drosophila melanogaster CG18420 gene product from transcript CG18420-RA Trypsin I   246 aa 243 aa 28.8 %
Drosophila melanogaster CG30083 gene product from transcript CG30083-RB Trypsin I   246 aa 209 aa 31.1 %
Echinococcus granulosus enteropeptidase Trypsin I   246 aa 230 aa 27.0 %
Brugia malayi Trypsin family protein Trypsin I   246 aa 270 aa 23.3 %
Loa Loa (eye worm) hypothetical protein Trypsin I   246 aa 217 aa 24.0 %
Drosophila melanogaster CG5909 gene product from transcript CG5909-RA Trypsin I   246 aa 261 aa 28.0 %
Drosophila melanogaster CG9673 gene product from transcript CG9673-RB Trypsin I   246 aa 260 aa 27.7 %
Neospora caninum glycine cleavage T-protein domain containing protein, putative Trypsin I   246 aa 203 aa 21.7 %
Drosophila melanogaster CG34436 gene product from transcript CG34436-RA Trypsin I   246 aa 208 aa 24.0 %
Drosophila melanogaster CG30287 gene product from transcript CG30287-RA Trypsin I   246 aa 259 aa 26.6 %
Echinococcus granulosus glycoprotein Antigen 5 Trypsin I   246 aa 299 aa 23.4 %
Drosophila melanogaster Jonah 65Aiii Trypsin I   246 aa 235 aa 34.9 %
Drosophila melanogaster CG9733 gene product from transcript CG9733-RB Trypsin I   246 aa 262 aa 30.1 %
Drosophila melanogaster Spatzle-Processing Enzyme Trypsin I   246 aa 272 aa 31.6 %
Onchocerca volvulus Trypsin I   246 aa 210 aa 21.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tachykinin peptides receptor 99D 0.0201 0.1948 0.6703
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Onchocerca volvulus 0.0201 0.1948 0.4383
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.011
Echinococcus multilocularis neuropeptides capa receptor 0.0201 0.1948 0.1946
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0626 0.2146
Brugia malayi beta-lactamase 0.0037 0.0168 0.0379
Onchocerca volvulus Huntingtin homolog 0.012 0.1066 0.2398
Echinococcus multilocularis fmrfamide receptor 0.0201 0.1948 0.1946
Loa Loa (eye worm) hypothetical protein 0.0183 0.1753 0.3943
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.011
Echinococcus granulosus tm gpcr rhodopsin 0.0201 0.1948 0.6703
Schistosoma mansoni neuropeptide F-like receptor 0.0201 0.1948 0.6703
Giardia lamblia Cathepsin B precursor 0.0098 0.0832 0.5
Schistosoma mansoni hypothetical protein 0.0201 0.1948 0.6703
Schistosoma mansoni opsin-like receptor 0.0201 0.1948 0.6703
Leishmania major cathepsin L-like protease 0.0079 0.0626 0.7517
Echinococcus granulosus neuropeptide FF receptor 2 0.0201 0.1948 0.6703
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Brugia malayi Serotonin receptor 0.0201 0.1948 0.4383
Schistosoma mansoni hypothetical protein 0.0201 0.1948 0.6703
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0256 0.0881
Brugia malayi hypothetical protein 0.0201 0.1948 0.4383
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0201 0.1948 0.4383
Leishmania major cathepsin L-like protease 0.0027 0.0066 0.0754
Echinococcus multilocularis Protein lozenge 0.0054 0.036 0.0356
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.029 0.2907 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0201 0.1948 0.1946
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0137 0.0308
Schistosoma mansoni peroxidasin 0.0025 0.0049 0.0168
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0168 0.0741
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.0049 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0201 0.1948 0.6703
Toxoplasma gondii cathepsin B 0.0098 0.0832 1
Onchocerca volvulus 0.0201 0.1948 0.4383
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.029 0.2907 1
Schistosoma mansoni peroxidasin 0.0025 0.0049 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0066 0.029
Schistosoma mansoni lipoxygenase 0.0114 0.1008 0.3467
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0137 0.0471
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Echinococcus granulosus g protein coupled receptor 0.0201 0.1948 0.6703
Schistosoma mansoni tar DNA-binding protein 0.0198 0.191 0.6569
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0201 0.1948 0.6703
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0168 0.0377
Leishmania major cysteine peptidase A (CPA) 0.0027 0.0066 0.0754
Leishmania major cathepsin L-like protease 0.0079 0.0626 0.7517
Onchocerca volvulus 0.0037 0.0168 0.0379
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0201 0.1948 0.4383
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0168 0.0379
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0626 0.7016
Loa Loa (eye worm) hypothetical protein 0.0037 0.0168 0.0379
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0201 0.1948 0.1946
Echinococcus granulosus 7tm_1 domain containing protein 0.0201 0.1948 0.6703
Mycobacterium ulcerans lipase LipD 0.0037 0.0168 0.5
Echinococcus multilocularis somatostatin receptor 0.0201 0.1948 0.1946
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0201 0.1948 0.6703
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0066 0.029
Loa Loa (eye worm) neuropeptide F receptor 0.0201 0.1948 0.4383
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0098 0.0832 0.2863
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0088 0.0304
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0201 0.1948 0.4383
Brugia malayi hypothetical protein 0.0201 0.1948 0.4383
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.011
Brugia malayi hypothetical protein 0.0432 0.4446 1
Brugia malayi sulfakinin receptor protein 0.0201 0.1948 0.4383
Loa Loa (eye worm) hypothetical protein 0.0034 0.0137 0.0308
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0168 0.0579
Echinococcus multilocularis cathepsin b 0.029 0.2907 0.2904
Brugia malayi RNA binding protein 0.0198 0.191 0.4295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0066 0.029
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0201 0.1948 0.1946
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0088 0.1026
Onchocerca volvulus 0.0027 0.0066 0.0148
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Leishmania major cathepsin L-like protease 0.0027 0.0066 0.0754
Echinococcus granulosus neuropeptides capa receptor 0.0201 0.1948 0.6703
Loa Loa (eye worm) G-protein coupled receptor 0.0201 0.1948 0.4383
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0142 0.0479
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0201 0.1948 0.6703
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0088 0.0085
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0201 0.1948 0.6703
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.011
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0201 0.1948 0.6703
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0626 0.7016
Brugia malayi hypothetical protein 0.0201 0.1948 0.4383
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.012 0.1067 0.3671
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0201 0.1948 0.4383
Echinococcus multilocularis rhodopsin orphan GPCR 0.0201 0.1948 0.1946
Brugia malayi putative neuropeptide receptor 0.0201 0.1948 0.4383
Brugia malayi cathepsin B-like cysteine proteinase 0.029 0.2907 0.6539
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0626 0.7016
Onchocerca volvulus 0.0201 0.1948 0.4383
Brugia malayi Kringle domain containing protein 0.0021 0.0003 0.0008
Loa Loa (eye worm) cathepsin B 0.0098 0.0832 0.1872
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.011
Leishmania major basic transcription factor 3a, putative 0.0034 0.0142 0.1676
Brugia malayi hypothetical protein 0.0201 0.1948 0.4383
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0066 0.0062
Brugia malayi Melatonin receptor type 1A 0.0201 0.1948 0.4383
Echinococcus granulosus g protein coupled receptor 0.0201 0.1948 0.6703
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0626 0.2146
Loa Loa (eye worm) fibroinase 0.0027 0.0066 0.0148
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0137 0.0471
Brugia malayi Tachykinin-like peptides receptor 99D 0.0201 0.1948 0.4383
Trypanosoma brucei cysteine peptidase C (CPC) 0.0098 0.0832 1
Brugia malayi Dopamine receptor protein 2 0.0201 0.1948 0.4383
Schistosoma mansoni alpha-1 adrenergic receptor 0.0201 0.1948 0.6703
Echinococcus multilocularis g-protein coupled receptor 0.0201 0.1948 0.1946
Brugia malayi N-terminal motif family protein 0.0183 0.1753 0.3943
Echinococcus multilocularis sex peptide receptor 0.0201 0.1948 0.1946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0066 0.029
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0137 0.0308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0066 0.029
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0168 0.0165
Schistosoma mansoni hypothetical protein 0.0201 0.1948 0.6703
Trichomonas vaginalis esterase, putative 0.0037 0.0168 0.0741
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0066 0.029
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.0049 0.011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0168 0.0379
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0198 0.191 0.4295
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.011
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Echinococcus granulosus biogenic amine 5HT receptor 0.0201 0.1948 0.6703
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0066 0.029
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0049 0.011
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0201 0.1948 0.4383
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0201 0.1948 0.1946
Echinococcus multilocularis g protein coupled receptor 0.0201 0.1948 0.1946
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0088 0.0304
Onchocerca volvulus Huntingtin homolog 0.012 0.1066 0.2398
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0922 0.2073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0626 0.7016
Schistosoma mansoni myosin xvIII 0.0201 0.1948 0.6703
Echinococcus granulosus geminin 0.0168 0.1589 0.5465
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Onchocerca volvulus 0.0029 0.0088 0.0199
Schistosoma mansoni hypothetical protein 0.0168 0.1589 0.5465
Onchocerca volvulus 0.0201 0.1948 0.4383
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0142 0.1676
Loa Loa (eye worm) G-protein coupled receptor 0.0201 0.1948 0.4383
Echinococcus multilocularis geminin 0.0168 0.1589 0.1586
Loa Loa (eye worm) hypothetical protein 0.0106 0.0922 0.2073
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0201 0.1948 0.6703
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0066 0.029
Entamoeba histolytica cysteine protease, putative 0.0027 0.0066 0.4631
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0168 0.0379
Plasmodium vivax vivapain-2 0.0027 0.0066 0.3789
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0201 0.1948 0.4383
Onchocerca volvulus 0.0027 0.0066 0.0148
Echinococcus multilocularis neuropeptide FF receptor 2 0.0201 0.1948 0.1946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0066 0.029
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0256 0.0576
Brugia malayi follicle stimulating hormone receptor 0.0201 0.1948 0.4383
Brugia malayi hypothetical protein 0.0201 0.1948 0.4383
Plasmodium vivax vivapain-2 0.0027 0.0066 0.3789
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0201 0.1948 0.6703
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0201 0.1948 0.1946
Loa Loa (eye worm) cysteine protease 0.0027 0.0066 0.0148
Echinococcus multilocularis neuropeptide Y receptor 0.0201 0.1948 0.1946
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0201 0.1948 0.1946
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0168 0.0568
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0201 0.1948 0.1946
Echinococcus multilocularis g protein coupled receptor 0.0201 0.1948 0.1946
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0626 0.7016
Onchocerca volvulus 0.0201 0.1948 0.4383
Echinococcus granulosus rhodopsin orphan GPCR 0.0201 0.1948 0.6703
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0088 0.0304
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0168 0.0741
Leishmania major cathepsin L-like protease 0.0027 0.0066 0.0754
Echinococcus multilocularis dro:myosuppressin receptor 0.0201 0.1948 0.1946
Echinococcus granulosus neuropeptide receptor A26 0.0201 0.1948 0.6703
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0049 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0201 0.1948 0.6703
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0168 0.0741
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0066 0.0062
Onchocerca volvulus 0.0037 0.0168 0.0379
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0558 0.1256
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0183 0.1753 0.3943
Brugia malayi Trypsin family protein 0.012 0.1067 0.24
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0027 0.0066 0.0148
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0201 0.1948 0.6703
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Echinococcus multilocularis allatostatin A receptor 0.0201 0.1948 0.1946
Echinococcus granulosus tm gpcr rhodopsin 0.0201 0.1948 0.6703
Brugia malayi G protein-coupled receptor F59B2.13 0.0201 0.1948 0.4383
Echinococcus multilocularis cathepsin b 0.029 0.2907 0.2904
Schistosoma mansoni neuropeptide receptor 0.0201 0.1948 0.6703
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Loa Loa (eye worm) melatonin receptor type 1A 0.0201 0.1948 0.4383
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0003 0.0012
Brugia malayi Cathepsin L-like precursor 0.0027 0.0066 0.0148
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Echinococcus multilocularis G-protein coupled receptor, putative 0.0201 0.1948 0.1946
Onchocerca volvulus Peroxidasin homolog 0.0025 0.0049 0.011
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Onchocerca volvulus 0.0027 0.0066 0.0148
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0066 0.029
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Loa Loa (eye worm) hypothetical protein 0.0027 0.0066 0.0148
Brugia malayi Cathepsin L-like precursor 0.0027 0.0066 0.0148
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0073 0.056 0.1918
Loa Loa (eye worm) blistered cuticle protein 3 0.0025 0.0049 0.011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0626 0.7016
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0142 1
Schistosoma mansoni amine GPCR 0.0201 0.1948 0.6703
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0201 0.1948 0.6703
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0201 0.1948 0.1946
Echinococcus multilocularis rhodopsin orphan GPCR 0.0201 0.1948 0.1946
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Echinococcus multilocularis neuropeptide s receptor 0.0201 0.1948 0.1946
Echinococcus granulosus dro:myosuppressin receptor 0.0201 0.1948 0.6703
Brugia malayi hypothetical protein 0.0201 0.1948 0.4383
Schistosoma mansoni hypothetical protein 0.0034 0.0137 0.0471
Brugia malayi Dopamine receptor protein 1 0.0201 0.1948 0.4383
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0168 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0201 0.1948 0.1946
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0098 0.0832 0.3663
Schistosoma mansoni biogenic amine receptor 0.0201 0.1948 0.6703
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Echinococcus granulosus g-protein coupled receptor 0.0201 0.1948 0.6703
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.011
Onchocerca volvulus Peroxidasin homolog 0.0025 0.0049 0.011
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Schistosoma mansoni opsin-like receptor 0.0201 0.1948 0.6703
Echinococcus granulosus cathepsin l cysteine peptidase 0.0027 0.0066 0.0227
Brugia malayi TAR-binding protein 0.0198 0.191 0.4295
Schistosoma mansoni biogenic amine (5HT) receptor 0.0201 0.1948 0.6703
Brugia malayi Dopamine receptor 0.0201 0.1948 0.4383
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Onchocerca volvulus 0.0201 0.1948 0.4383
Brugia malayi hypothetical protein 0.012 0.1066 0.2398
Loa Loa (eye worm) beta-lactamase 0.0037 0.0168 0.0379
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0256 0.0576
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0066 0.029
Mycobacterium ulcerans hypothetical protein 0.0037 0.0168 0.5
Onchocerca volvulus 0.0201 0.1948 0.4383
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.029 0.2907 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0201 0.1948 0.6703
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Echinococcus multilocularis orexin receptor type 2 0.0201 0.1948 0.1946
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Schistosoma mansoni biogenic amine (5HT) receptor 0.0201 0.1948 0.6703
Schistosoma mansoni hypothetical protein 0.0034 0.0137 0.0471
Echinococcus granulosus g protein coupled receptor 0.0201 0.1948 0.6703
Brugia malayi hypothetical protein 0.0201 0.1948 0.4383
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0626 0.2146
Brugia malayi neuropeptide F receptor 0.0201 0.1948 0.4383
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.1008 0.1005
Leishmania major cathepsin L-like protease 0.0027 0.0066 0.0754
Brugia malayi Pre-SET motif family protein 0.0203 0.1969 0.4429
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0201 0.1948 0.6703
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0168 0.0579
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0256 0.0881
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Echinococcus multilocularis serotonin receptor 0.0201 0.1948 0.1946
Loa Loa (eye worm) ctsf protein 0.0027 0.0066 0.0148
Schistosoma mansoni hypothetical protein 0.0021 0.0003 0.0012
Echinococcus granulosus somatostatin receptor 0.0201 0.1948 0.6703
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0098 0.0832 0.2854
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0137 0.0308
Toxoplasma gondii ABC1 family protein 0.0037 0.0168 0.199
Echinococcus granulosus neuropeptides capa receptor 0.0201 0.1948 0.6703
Brugia malayi hypothetical protein 0.0201 0.1948 0.4383
Schistosoma mansoni neuropeptide f receptor 76f 0.0201 0.1948 0.6703
Schistosoma mansoni amine GPCR 0.0201 0.1948 0.6703
Echinococcus multilocularis G protein coupled receptor 139 0.0201 0.1948 0.1946
Echinococcus multilocularis transcription factor btf3 0.0034 0.0142 0.0139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0201 0.1948 0.6703
Schistosoma mansoni amine GPCR 0.0201 0.1948 0.6703
Echinococcus granulosus neuropeptide Y receptor 0.0201 0.1948 0.6703
Schistosoma mansoni growth hormone secretagogue receptor 0.0201 0.1948 0.6703
Brugia malayi AKH receptor 0.0201 0.1948 0.4383
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0098 0.0832 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0066 0.029
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0168 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0201 0.1948 0.4383
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0142 0.0479
Onchocerca volvulus 0.0201 0.1948 0.4383
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0168 0.0568
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0003 0.0008
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0049 0.011
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0027 0.0066 0.4497
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0201 0.1948 0.4383
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0201 0.1948 0.6703
Loa Loa (eye worm) runx1 0.0054 0.036 0.0809
Brugia malayi Pre-SET motif family protein 0.0029 0.0088 0.0199
Schistosoma mansoni hypothetical protein 0.0201 0.1948 0.6703
Schistosoma mansoni histamine h1 receptor 0.0201 0.1948 0.6703
Schistosoma mansoni biogenic amine receptor 0.0201 0.1948 0.6703
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0256 0.0253
Echinococcus granulosus rhodopsin orphan GPCR 0.0201 0.1948 0.6703
Echinococcus granulosus cathepsin L cysteine proteinase 0.0027 0.0066 0.0227
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0922 0.2073
Schistosoma mansoni neuropeptide receptor 0.0201 0.1948 0.6703
Loa Loa (eye worm) hypothetical protein 0.012 0.1066 0.2398
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0088 0.0304
Schistosoma mansoni adenoreceptor 0.0201 0.1948 0.6703
Onchocerca volvulus 0.0201 0.1948 0.4383
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0201 0.1948 0.1946
Brugia malayi Cathepsin L-like precursor 0.0027 0.0066 0.0148
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0137 0.0133
Echinococcus multilocularis rhodopsin orphan GPCR 0.0201 0.1948 0.1946
Loa Loa (eye worm) hypothetical protein 0.012 0.1067 0.24
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0066 0.0148
Mycobacterium ulcerans beta-lactamase 0.0037 0.0168 0.5
Onchocerca volvulus 0.0231 0.2272 0.5111
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0066 0.029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0626 0.7016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0201 0.1948 0.6703
Mycobacterium leprae Probable lipase LipE 0.0037 0.0168 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0201 0.1948 0.1946
Schistosoma mansoni hypothetical protein 0.0034 0.0137 0.0471
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0626 0.7016
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0201 0.1948 0.6703
Loa Loa (eye worm) hypothetical protein 0.012 0.1066 0.2398
Loa Loa (eye worm) TAR-binding protein 0.0198 0.191 0.4295
Echinococcus granulosus fmrfamide receptor 0.0201 0.1948 0.6703
Onchocerca volvulus 0.0106 0.0923 0.2076
Schistosoma mansoni biogenic amine receptor 0.0201 0.1948 0.6703
Brugia malayi RE15519p 0.0201 0.1948 0.4383
Echinococcus granulosus orexin receptor type 2 0.0201 0.1948 0.6703
Echinococcus granulosus cathepsin b 0.029 0.2907 1
Echinococcus multilocularis tar DNA binding protein 0.0198 0.191 0.1907
Leishmania major cathepsin L-like protease 0.0027 0.0066 0.0754
Schistosoma mansoni neuropeptide receptor 0.0201 0.1948 0.6703
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Echinococcus granulosus allatostatin A receptor 0.0201 0.1948 0.6703
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0201 0.1948 0.1946
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0626 0.7016
Schistosoma mansoni hypothetical protein 0.0168 0.1589 0.5465
Echinococcus granulosus 7TM GPCR rhodopsin 0.0201 0.1948 0.6703
Echinococcus multilocularis rhodopsin orphan GPCR 0.0201 0.1948 0.1946
Echinococcus multilocularis rhodopsin orphan GPCR 0.0201 0.1948 0.1946
Brugia malayi G-protein coupled receptor 0.0201 0.1948 0.4383
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.011
Brugia malayi putative neuropeptide receptor NPR1 0.0201 0.1948 0.4383
Schistosoma mansoni hypothetical protein 0.0073 0.0558 0.1921
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0201 0.1948 0.4383
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.1008 0.3467
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0922 0.2073
Echinococcus multilocularis neuropeptide receptor A26 0.0201 0.1948 0.1946
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.011
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Brugia malayi neuropeptide F receptor 0.0201 0.1948 0.4383
Echinococcus granulosus rhodopsin orphan GPCR 0.0201 0.1948 0.6703
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0201 0.1948 0.4383
Brugia malayi G protein-coupled receptor 0.0201 0.1948 0.4383
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0077 0.0265
Brugia malayi Cathepsin L-like precursor 0.0027 0.0066 0.0148
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0201 0.1948 0.1946
Echinococcus granulosus peptide allatostatin:somatostatin 0.0201 0.1948 0.6703
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0066 0.0215
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0027 0.0066 0.4497
Schistosoma mansoni tar DNA-binding protein 0.0198 0.191 0.6569
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0066 0.0148
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0066 0.0062
Echinococcus multilocularis peroxidasin 0.0025 0.0049 0.0045
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0201 0.1948 0.6703
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.0049 0.011
Echinococcus multilocularis neuropeptides capa receptor 0.0201 0.1948 0.1946
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0201 0.1948 0.1946
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0066 0.0062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0256 0.0881
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0142 1
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.2296 1
Onchocerca volvulus 0.0201 0.1948 0.4383
Echinococcus granulosus GPCR family 2 0.0034 0.0137 0.0471
Brugia malayi beta-lactamase family protein 0.0037 0.0168 0.0379
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0626 0.7016
Onchocerca volvulus 0.0027 0.0066 0.0148
Onchocerca volvulus Peroxidase homolog 0.0025 0.0049 0.011
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1969 0.4429
Loa Loa (eye worm) neuropeptide F receptor 0.0201 0.1948 0.4383
Onchocerca volvulus Cathepsin F homolog 0.0027 0.0066 0.0148
Brugia malayi hypothetical protein 0.0201 0.1948 0.4383
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0201 0.1948 0.6703
Schistosoma mansoni tar DNA-binding protein 0.0198 0.191 0.6569
Onchocerca volvulus 0.0432 0.4446 1
Echinococcus granulosus cathepsin l1 0.0027 0.0066 0.0227
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Echinococcus granulosus tm gpcr rhodopsin 0.0201 0.1948 0.6703
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0201 0.1948 0.6703
Onchocerca volvulus 0.0201 0.1948 0.4383
Loa Loa (eye worm) hypothetical protein 0.0037 0.0168 0.0379
Echinococcus multilocularis serotonin receptor 0.0201 0.1948 0.1946
Toxoplasma gondii cathepsin CPL 0.0027 0.0066 0.0754
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0066 0.0227
Echinococcus multilocularis GPCR, family 2 0.0034 0.0137 0.0133
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0066 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0142 0.0627
Echinococcus granulosus rhodopsin orphan GPCR 0.0201 0.1948 0.6703
Echinococcus granulosus alpha 1A adrenergic receptor 0.0201 0.1948 0.6703
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Echinococcus granulosus neuropeptide receptor 0.0201 0.1948 0.6703
Brugia malayi larval opioid receptor 0.0201 0.1948 0.4383
Schistosoma mansoni neuropeptide receptor 0.0201 0.1948 0.6703
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0626 0.7016
Brugia malayi hypothetical protein 0.0201 0.1948 0.4383
Echinococcus granulosus neuropeptide Y receptor 0.0201 0.1948 0.6703
Loa Loa (eye worm) hypothetical protein 0.0037 0.0168 0.0379
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0168 0.0741
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0168 0.0741
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0066 0.029
Brugia malayi Peroxidasin 0.0025 0.0049 0.011
Echinococcus granulosus transcription factor btf3 0.0034 0.0142 0.049
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Leishmania major hypothetical protein, conserved 0.0037 0.0168 0.199
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0168 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0066 0.029
Onchocerca volvulus 0.0025 0.0049 0.011
Brugia malayi hypothetical protein 0.0025 0.0049 0.011
Loa Loa (eye worm) hypothetical protein 0.0073 0.0558 0.1256
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0066 0.029
Echinococcus multilocularis cysteine protease 0.0027 0.0066 0.0062
Echinococcus multilocularis neuropeptide receptor 0.0201 0.1948 0.1946
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0201 0.1948 0.6703
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0049 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0066 0.029
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0201 0.1948 0.6703
Onchocerca volvulus Dual oxidase homolog 0.0025 0.0049 0.011
Plasmodium vivax SET domain protein, putative 0.0029 0.0088 0.5155
Onchocerca volvulus 0.012 0.1067 0.24
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0066 0.029
Echinococcus granulosus neuropeptide receptor 0.0201 0.1948 0.6703
Plasmodium falciparum cysteine proteinase falcipain 3 0.0027 0.0066 0.4497
Onchocerca volvulus 0.0201 0.1948 0.4383
Schistosoma mansoni tar DNA-binding protein 0.0198 0.191 0.6569
Brugia malayi beta-lactamase family protein 0.0037 0.0168 0.0379
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0066 0.029
Loa Loa (eye worm) RNA binding protein 0.0198 0.191 0.4295
Schistosoma mansoni amine GPCR 0.0201 0.1948 0.6703
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0201 0.1948 0.1946
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Onchocerca volvulus 0.0027 0.0066 0.0148
Echinococcus granulosus peroxidasin 0.0025 0.0049 0.0168
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0201 0.1948 0.6703
Echinococcus granulosus rhodopsin orphan GPCR 0.0201 0.1948 0.6703
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0256 0.0881
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0066 0.029
Echinococcus multilocularis cysteine protease 0.0027 0.0066 0.0062
Brugia malayi Cathepsin L-like precursor 0.0027 0.0066 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0142 0.0627
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0137 0.0133
Loa Loa (eye worm) hypothetical protein 0.029 0.2907 0.6539
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0201 0.1948 0.1946
Schistosoma mansoni transcription factor btf3 0.0034 0.0142 0.049
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2272 1
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Echinococcus granulosus hypothetical protein 0.0201 0.1948 0.6703
Loa Loa (eye worm) hypothetical protein 0.0432 0.4446 1
Brugia malayi RNA recognition motif domain containing protein 0.0198 0.191 0.4295
Schistosoma mansoni amine GPCR 0.0201 0.1948 0.6703
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0201 0.1948 0.6703
Brugia malayi beta-NAC-like protein 0.0034 0.0142 0.032
Onchocerca volvulus 0.0027 0.0066 0.0148
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0066 0.029
Onchocerca volvulus 0.0201 0.1948 0.4383
Onchocerca volvulus 0.0201 0.1948 0.4383
Onchocerca volvulus Peroxidase homolog 0.0025 0.0049 0.011
Echinococcus multilocularis fmrfamide receptor 0.0201 0.1948 0.1946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0066 0.029
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0168 0.0379
Brugia malayi GnHR receptor homolog 0.0201 0.1948 0.4383
Echinococcus granulosus rhodopsin orphan GPCR 0.0201 0.1948 0.6703
Echinococcus multilocularis rhodopsin orphan GPCR 0.0201 0.1948 0.1946
Onchocerca volvulus 0.0201 0.1948 0.4383
Loa Loa (eye worm) hypothetical protein 0.012 0.1067 0.24
Loa Loa (eye worm) hypothetical protein 0.0037 0.0168 0.0379
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.0049 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0142 0.0627
Schistosoma mansoni tar DNA-binding protein 0.0198 0.191 0.6569
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0201 0.1948 0.6703
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.029 0.2907 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0199
Schistosoma mansoni neuropeptide F-like receptor 0.0201 0.1948 0.6703
Echinococcus granulosus biogenic amine 5HT receptor 0.0201 0.1948 0.6703
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.011
Onchocerca volvulus 0.0201 0.1948 0.4383
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0066 0.0148
Echinococcus granulosus tar DNA binding protein 0.0198 0.191 0.6569
Schistosoma mansoni hypothetical protein 0.0034 0.0137 0.0471
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Brugia malayi Cathepsin L-like precursor 0.0027 0.0066 0.0148
Brugia malayi ORL1-like opioid receptor 0.0201 0.1948 0.4383
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0066 0.029
Brugia malayi Serotonin receptor 0.0201 0.1948 0.4383
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0201 0.1948 0.6703
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0088 0.0085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0088 0.0304
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0201 0.1948 0.6703
Entamoeba histolytica hypothetical protein 0.0034 0.0142 1
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Loa Loa (eye worm) hypothetical protein 0.0432 0.4446 1
Echinococcus multilocularis g protein coupled receptor 0.0201 0.1948 0.1946
Brugia malayi Blistered cuticle protein 3 0.0025 0.0049 0.011
Echinococcus granulosus cathepsin b 0.029 0.2907 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0201 0.1948 0.4383
Schistosoma mansoni lipoxygenase 0.008 0.0636 0.219
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0066 0.4631
Loa Loa (eye worm) TYRA-2 protein 0.0201 0.1948 0.4383
Onchocerca volvulus 0.0201 0.1948 0.4383
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0201 0.1948 0.6703
Trypanosoma cruzi cruzipain precursor, putative 0.0079 0.0626 0.2146
Echinococcus multilocularis neuropeptide receptor 0.0201 0.1948 0.1946
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0168 0.0579
Onchocerca volvulus Chorion peroxidase homolog 0.0025 0.0049 0.011
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0066 0.0148
Onchocerca volvulus 0.0021 0.0003 0.0008
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.029 0.2907 1
Onchocerca volvulus 0.0037 0.0168 0.0379
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0066 0.4631
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0049 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0201 0.1948 0.1946
Echinococcus granulosus G protein coupled receptor 139 0.0201 0.1948 0.6703
Onchocerca volvulus 0.0027 0.0066 0.0148
Trypanosoma cruzi major cysteine proteinase, putative 0.0064 0.0464 0.1585
Schistosoma mansoni lozenge 0.0054 0.036 0.1237
Brugia malayi Protein kinase domain containing protein 0.0021 0.0003 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0066 0.029
Onchocerca volvulus 0.0025 0.0049 0.011
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0168 1
Echinococcus granulosus sex peptide receptor 0.0201 0.1948 0.6703
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0066 0.029
Echinococcus granulosus serotonin receptor 0.0201 0.1948 0.6703
Leishmania major cathepsin L-like protease 0.0079 0.0626 0.7517
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0256 0.0881
Giardia lamblia Cathepsin B precursor 0.0098 0.0832 0.5
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0142 0.032
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0201 0.1948 0.4383
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.012 0.1067 0.3671
Schistosoma mansoni opsin-like receptor 0.0201 0.1948 0.6703
Echinococcus granulosus neuropeptide s receptor 0.0201 0.1948 0.6703
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0142 0.8425
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0201 0.1948 0.6703
Loa Loa (eye worm) hypothetical protein 0.0201 0.1948 0.4383
Giardia lamblia Cathepsin B precursor 0.0098 0.0832 0.5
Brugia malayi G-protein coupled receptor 0.0201 0.1948 0.4383
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0256 0.0253
Onchocerca volvulus 0.0025 0.0049 0.011

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 32 nM Compound was tested for inhibition activity against Coagulation factor X ChEMBL. 10346927
Ki (binding) = 32 nM Compound was tested for inhibition activity against Coagulation factor X ChEMBL. 10346927
Ki (binding) = 780 nM Compound was tested for inhibition activity against bovine trypsin. ChEMBL. 10346927
Ki (binding) = 780 nM Compound was tested for inhibition activity against bovine trypsin. ChEMBL. 10346927
Ki (binding) > 5000 nM Compound was tested for inhibition activity against human thrombin (FIIa) ChEMBL. 10346927
Ki (binding) > 5000 nM Compound was tested for inhibition activity against human thrombin (FIIa) ChEMBL. 10346927

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.