Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0051 | 0.141 | 0.6652 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.141 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0051 | 0.141 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0693 | 0.3269 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.0864 | 0.4076 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.07 | 0.0093 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0693 | 0.0185 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0693 | 0.0185 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.141 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0069 | 0.2309 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.0989 | 0.2673 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0693 | 0.2407 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0056 | 0.0242 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.07 | 0.0093 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0693 | 0.3269 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0051 | 0.141 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.07 | 0.0093 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0051 | 0.141 | 0.6652 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1113 | 0.525 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 0.141 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0065 | 0.212 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1113 | 0.482 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0693 | 0.0185 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0051 | 0.141 | 0.5118 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1113 | 0.482 |
Onchocerca volvulus | 0.0036 | 0.0693 | 0.5 | |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.07 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0693 | 0.0185 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.07 | 0.0093 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.07 | 0.5 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.07 | 0.33 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0051 | 0.141 | 0.5 |
Onchocerca volvulus | 0.0036 | 0.0693 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.07 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0157 | 0.0739 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0157 | 0.0679 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0693 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1113 | 0.482 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0051 | 0.141 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0051 | 0.141 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0051 | 0.141 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0693 | 0.0185 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1113 | 0.525 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0051 | 0.141 | 0.6652 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0051 | 0.141 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.07 | 0.2432 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0051 | 0.141 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0051 | 0.141 | 0.4264 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0693 | 0.3001 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0693 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0693 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0693 | 0.2407 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0693 | 0.2407 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0693 | 0.2407 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.141 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2702 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0693 | 0.2407 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1113 | 0.525 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.0864 | 0.4076 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0693 | 0.2407 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0693 | 0.1553 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.07 | 0.33 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0051 | 0.141 | 0.6652 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.1113 | 0.3995 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0693 | 0.2407 |
Brugia malayi | Bromodomain containing protein | 0.0082 | 0.2928 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.07 | 0.303 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0693 | 0.1553 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 0.141 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1113 | 0.525 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0993 | 0.3541 |
Brugia malayi | Inositol-1 | 0.0036 | 0.07 | 0.1578 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0693 | 0.3001 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0693 | 0.0185 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0157 | 0.0739 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0051 | 0.141 | 0.6107 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1118 | 0.4014 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0693 | 0.1553 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.07 | 0.0093 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0693 | 0.0185 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0693 | 0.0185 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0693 | 0.1553 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1219 | 0.4395 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0693 | 0.0185 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.07 | 0.303 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.07 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0693 | 0.2407 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.07 | 0.0093 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0693 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.141 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0065 | 0.212 | 1 |
Onchocerca volvulus | 0.0036 | 0.0693 | 0.5 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.1113 | 0.3141 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.07 | 0.0093 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.