TDR Targets

Basic information

Technical information

TDR Targets ID: 733635
Name: T5398939
MW: 434.941 | Formula: C23H19ClN4OS
H donors: 0 H acceptors: 4 LogP: 5.36 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccc(cc1)n1c(SCC(=O)c2ccc(cc2)Cl)nnc1c1ccncc1
InChi: 1S/C23H19ClN4OS/c1-2-16-3-9-20(10-4-16)28-22(18-11-13-25-14-12-18)26-27-23(28)30-15-21(29)17-5-7-19(24)8-6-17/h3-14H,2,15H2,1H3
InChiKey: BHKKUUIBLZJPTB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

CBKinase1_015865
CBKinase1_003465

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.005	0.1003	0.0876
Loa Loa (eye worm)	PDE1B protein	0.005	0.1003	0.1001
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0164	0.0162
Echinococcus granulosus	tm gpcr rhodopsin	0.0016	0.0164	0.0162
Echinococcus granulosus	neuropeptides capa receptor	0.0016	0.0164	0.0162
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0465	0.0463
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0967	0.1105
Entamoeba histolytica	hypothetical protein	0.0116	0.2629	0.9951
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Schistosoma mansoni	chitinase	0.0017	0.0181	0.0042
Brugia malayi	G protein-coupled receptor	0.0016	0.0164	0.0188
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Schistosoma mansoni	hypothetical protein	0.0026	0.0396	0.026
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Echinococcus multilocularis	g-protein coupled receptor	0.0016	0.0164	0.0162
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0164	0.0162
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0116	0.2629	0.2627
Trypanosoma brucei	PAB1-binding protein , putative	0.0058	0.1183	1
Echinococcus multilocularis	somatostatin receptor	0.0016	0.0164	0.0162
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0016	0.0164	0.0162
Echinococcus granulosus	orexin receptor type 2	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0164	0.0162
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.005	0.1003	0.215
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3598	0.3596
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0465	0.0531
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.005	0.1003	0.0876
Schistosoma mansoni	cpg binding protein	0.0029	0.0465	0.033
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0139	0.0159
Echinococcus granulosus	serotonin receptor	0.0016	0.0164	0.0162
Brugia malayi	G protein-coupled receptor F59B2.13	0.0016	0.0164	0.0188
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0172	0.4004	1
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.005	0.1003	0.1001
Echinococcus multilocularis	serotonin receptor	0.0016	0.0164	0.0162
Echinococcus multilocularis	cpg binding protein	0.003	0.0506	0.0503
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0016	0.0164	0.0162
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.005	0.1003	0.0876
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0172	0.4004	0.3683
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0139	0.0137
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Brugia malayi	hypothetical protein	0.0016	0.0164	0.0188
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.1003	0.0521
Schistosoma mansoni	amine GPCR	0.0016	0.0164	0.0025
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0172	0.4004	0.4003
Echinococcus granulosus	g protein coupled receptor	0.0016	0.0164	0.0162
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.005	0.1003	0.1146
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.005	0.1003	0.215
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.005	0.1003	0.1001
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0026	0.0396	0.0393
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.005	0.1003	0.1146
Echinococcus granulosus	tar DNA binding protein	0.0197	0.4625	0.4624
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Echinococcus granulosus	Glycoside hydrolase chitinase domain containing protein 1	0.0017	0.0181	0.0179
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0164	0.0025
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0016	0.0164	0.0188
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0059	0.122	0.2717
Schistosoma mansoni	cpg binding protein	0.003	0.0506	0.0371
Entamoeba histolytica	hypothetical protein	0.0116	0.2629	0.9951
Loa Loa (eye worm)	neuropeptide F receptor	0.0016	0.0164	0.0162
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.1512
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Trichomonas vaginalis	set domain proteins, putative	0.0237	0.5618	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.1003	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Schistosoma mansoni	hypothetical protein	0.0016	0.0164	0.0025
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0172	0.4004	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.1512
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0181	0.0179
Echinococcus multilocularis	neuropeptide Y receptor	0.0016	0.0164	0.0162
Loa Loa (eye worm)	cuticular endochitinase	0.0116	0.2641	0.2639
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.005	0.1003	0.1512
Brugia malayi	endochitinase	0.0116	0.2641	0.3017
Schistosoma mansoni	histamine h1 receptor	0.0016	0.0164	0.0025
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0164	0.0162
Echinococcus multilocularis	fmrfamide receptor	0.0016	0.0164	0.0162
Brugia malayi	follicle stimulating hormone receptor	0.0016	0.0164	0.0188
Echinococcus granulosus	allatostatin A receptor	0.0016	0.0164	0.0162
Brugia malayi	Dopamine receptor protein 1	0.0016	0.0164	0.0188
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0509	0.0374
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0208	0.4909	0.4907
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0414	1	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.1512
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0363	0.8753	0.8753
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0172	0.4004	0.5
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.1003	0.0521
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.005	0.1003	0.1146
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0139	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.005	0.1003	0.1001
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Leishmania major	chitinase	0.0116	0.2641	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.1003	0.0521
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0164	0.0162
Trypanosoma cruzi	PAB1-binding protein , putative	0.0058	0.1183	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0016	0.0164	0.0162
Echinococcus multilocularis	dnaJ subfamily B	0.0408	0.9852	0.9852
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.1512
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0016	0.0164	0.0162
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.1512
Loa Loa (eye worm)	TYRA-2 protein	0.0016	0.0164	0.0162
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.1003	0.0521
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0016	0.0164	0.0162
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.005	0.1003	0.0876
Brugia malayi	hypothetical protein	0.0016	0.0164	0.0188
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0016	0.0164	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Brugia malayi	Glycosyl hydrolases family 18 protein	0.0017	0.0181	0.0207
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0466	0.0463
Echinococcus granulosus	somatostatin receptor	0.0016	0.0164	0.0162
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.1126	0.0651
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0112	0.2541	1
Schistosoma mansoni	cpg binding protein	0.003	0.0506	0.0371
Loa Loa (eye worm)	chitinase I	0.0116	0.2641	0.2639
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0172	0.4004	1
Schistosoma mansoni	biogenic amine receptor	0.0016	0.0164	0.0025
Schistosoma mansoni	neuropeptide F-like receptor	0.0016	0.0164	0.0025
Echinococcus granulosus	dnaJ subfamily B	0.0408	0.9852	0.9852
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0172	0.4004	0.4003
Schistosoma mansoni	opsin-like receptor	0.0016	0.0164	0.0025
Brugia malayi	Dopamine receptor protein 2	0.0016	0.0164	0.0188
Brugia malayi	hypothetical protein	0.0016	0.0164	0.0188
Schistosoma mansoni	amine GPCR	0.0016	0.0164	0.0025
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.005	0.1003	0.1001
Brugia malayi	G-protein coupled receptor	0.0016	0.0164	0.0188
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0112	0.2541	0.4744
Brugia malayi	Melatonin receptor type 1A	0.0016	0.0164	0.0188
Loa Loa (eye worm)	transcription factor SMAD2	0.0137	0.3148	0.3146
Onchocerca volvulus	Putative endochitinase	0.0116	0.2641	0.4541
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.1003	0.0521
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0164	0.0162
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0016	0.0164	0.0025
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Echinococcus multilocularis	neuropeptides capa receptor	0.0016	0.0164	0.0162
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0509	0.0374
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.1512
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.005	0.1003	0.1001
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0584	0.0581
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.1512
Echinococcus granulosus	tm gpcr rhodopsin	0.0016	0.0164	0.0162
Loa Loa (eye worm)	neuropeptide F receptor	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0059	0.122	0.2717
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0016	0.0164	0.0162
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.005	0.1003	0.1001
Brugia malayi	ORL1-like opioid receptor	0.0016	0.0164	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Schistosoma mansoni	biogenic amine receptor	0.0016	0.0164	0.0025
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0172	0.4004	0.5
Brugia malayi	hypothetical protein	0.0116	0.2629	0.3004
Schistosoma mansoni	myosin xvIII	0.0016	0.0164	0.0025
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.005	0.1003	0.0876
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.1003	0.0521
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0016	0.0164	0.0025
Brugia malayi	putative neuropeptide receptor	0.0016	0.0164	0.0188
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0016	0.0164	0.0188
Echinococcus granulosus	peptidase Clp S14 family	0.0112	0.2541	0.2539
Brugia malayi	Endochitinase	0.0017	0.0181	0.0207
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0016	0.0164	0.0162
Brugia malayi	Pre-SET motif family protein	0.0208	0.4909	0.5608
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0016	0.0164	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Loa Loa (eye worm)	melatonin receptor type 1A	0.0016	0.0164	0.0162
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0016	0.0164	0.0162
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0016	0.0164	0.0025
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0016	0.0164	0.0025
Echinococcus granulosus	fmrfamide receptor	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0967	0.0964
Plasmodium falciparum	ataxin-2 like protein, putative	0.0058	0.1183	0.2619
Schistosoma mansoni	amine GPCR	0.0016	0.0164	0.0025
Plasmodium vivax	SET domain protein, putative	0.003	0.0509	0.0856
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0414	1	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0116	0.2629	0.2627
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.1003	0.0521
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0363	0.8753	0.8753
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0164	0.0025
Brugia malayi	RNA binding protein	0.0197	0.4625	0.5284
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0164	0.0025
Brugia malayi	RE15519p	0.0016	0.0164	0.0188
Loa Loa (eye worm)	hypothetical protein	0.005	0.1003	0.1001
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Echinococcus granulosus	sex peptide receptor	0.0016	0.0164	0.0162
Echinococcus multilocularis	neuropeptide s receptor	0.0016	0.0164	0.0162
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0016	0.0164	0.0162
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0172	0.4004	0.3683
Schistosoma mansoni	hypothetical protein	0.0016	0.0164	0.0025
Schistosoma mansoni	hypothetical protein	0.0116	0.2629	0.2525
Echinococcus multilocularis	allatostatin A receptor	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Onchocerca volvulus		0.0029	0.0465	0.0552
Schistosoma mansoni	tar DNA-binding protein	0.0197	0.4625	0.4549
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0016	0.0164	0.0025
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0139	0.0137
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0164	0.0162
Echinococcus granulosus	neuropeptide receptor	0.0016	0.0164	0.0162
Schistosoma mansoni	hypothetical protein	0.0033	0.0584	0.0451
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0016	0.0164	0.0162
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.1512
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0164	0.0025
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0509	0.0506
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0016	0.0164	0.0188
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0016	0.0164	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.1003	0.0521
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0016	0.0164	0.0162
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Echinococcus multilocularis	sex peptide receptor	0.0016	0.0164	0.0162
Brugia malayi	Dopamine receptor	0.0016	0.0164	0.0188
Brugia malayi	larval opioid receptor	0.0016	0.0164	0.0188
Entamoeba histolytica	chitinase, putative	0.0116	0.2641	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0164	0.0162
Echinococcus granulosus	neuropeptide receptor	0.0016	0.0164	0.0162
Brugia malayi	endochitinase	0.0116	0.2641	0.3017
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0016	0.0164	0.0188
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.005	0.1003	0.0876
Schistosoma mansoni	opsin-like receptor	0.0016	0.0164	0.0025
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0016	0.0164	0.0025
Echinococcus granulosus	biogenic amine 5HT receptor	0.0016	0.0164	0.0162
Schistosoma mansoni	tar DNA-binding protein	0.0197	0.4625	0.4549
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0164	0.0162
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.005	0.1003	0.0876
Echinococcus multilocularis	dro:myosuppressin receptor	0.0016	0.0164	0.0162
Echinococcus granulosus	cpg binding protein	0.003	0.0506	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Schistosoma mansoni	neuropeptide f receptor 76f	0.0016	0.0164	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0172	0.4004	0.4003
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.1003	0.0521
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.005	0.1003	0.1001
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0164	0.0025
Brugia malayi	neuropeptide F receptor	0.0016	0.0164	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Onchocerca volvulus	Putative endochitinase	0.0017	0.0181	0.0031
Brugia malayi	hypothetical protein	0.0016	0.0164	0.0188
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.1512
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.005	0.1003	0.0876
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.1003	0.1512
Brugia malayi	hypothetical protein	0.0016	0.0164	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Echinococcus multilocularis	tar DNA binding protein	0.0197	0.4625	0.4624
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0181	0.0179
Echinococcus multilocularis	Glycoside hydrolase, chitinase domain containing protein 1	0.0017	0.0181	0.0179
Echinococcus multilocularis	serotonin receptor	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0414	1	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.1003	0.0521
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.005	0.1003	0.1001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0164	0.0162
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0164	0.0025
Schistosoma mansoni	adenoreceptor	0.0016	0.0164	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Echinococcus granulosus	g protein coupled receptor	0.0016	0.0164	0.0162
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0016	0.0164	0.0162
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0164	0.0162
Brugia malayi	RNA recognition motif domain containing protein	0.0197	0.4625	0.5284
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.005	0.1003	0.1146
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.005	0.1003	0.1001
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.005	0.1003	0.1512
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0139	0.0137
Schistosoma mansoni	tar DNA-binding protein	0.0197	0.4625	0.4549
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.215
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0016	0.0164	0.0162
Brugia malayi	hypothetical protein	0.0017	0.0181	0.0207
Brugia malayi	Pre-SET motif family protein	0.003	0.0509	0.0581
Brugia malayi	GnHR receptor homolog	0.0016	0.0164	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0016	0.0164	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1183	0.118
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Trypanosoma cruzi	PAB1-binding protein , putative	0.0058	0.1183	1
Brugia malayi	neuropeptide F receptor	0.0016	0.0164	0.0188
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.1512
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Echinococcus multilocularis	neuropeptide Y receptor	0.0016	0.0164	0.0162
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Plasmodium falciparum	phosphodiesterase gamma, putative	0.005	0.1003	0.215
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0112	0.2541	0.2539
Loa Loa (eye worm)	RNA binding protein	0.0197	0.4625	0.4624
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0363	0.8753	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0139	0.0137
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.1003	0.1512
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0509	0.0374
Loa Loa (eye worm)	TAR-binding protein	0.0197	0.4625	0.4624
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0164	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0164	0.0025
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0016	0.0164	0.0025
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0414	1	1
Schistosoma mansoni	transcription factor LCR-F1	0.0116	0.2629	0.2525
Onchocerca volvulus		0.003	0.0509	0.0631
Plasmodium falciparum	phosphodiesterase delta, putative	0.005	0.1003	0.215
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Brugia malayi	MH2 domain containing protein	0.0137	0.3148	0.3596
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.1003	0.0521
Echinococcus multilocularis	g protein coupled receptor	0.0016	0.0164	0.0162
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0363	0.8753	0.8753
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.215
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0016	0.0164	0.0025
Brugia malayi	hypothetical protein	0.0016	0.0164	0.0188
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.215
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Brugia malayi	hypothetical protein	0.0016	0.0164	0.0188
Schistosoma mansoni	amine GPCR	0.0016	0.0164	0.0025
Plasmodium vivax	phosphodiesterase gamma, putative	0.005	0.1003	0.215
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.215
Onchocerca volvulus	Putative endochitinase	0.0116	0.2641	0.4541
Echinococcus granulosus	hypothetical protein	0.0016	0.0164	0.0162
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.1003	0.0521
Echinococcus granulosus	g protein coupled receptor	0.0016	0.0164	0.0162
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.1003	0.0521
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0164	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0139	0.0137
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.1003	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0414	1	1
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.005	0.1003	0.1001
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Schistosoma mansoni	opsin-like receptor	0.0016	0.0164	0.0025
Leishmania major	hypothetical protein, conserved	0.0058	0.1183	0.1096
Brugia malayi	putative neuropeptide receptor NPR1	0.0016	0.0164	0.0188
Loa Loa (eye worm)	microfilarial chitinase	0.0099	0.2216	0.2214
Echinococcus multilocularis	neuropeptides capa receptor	0.0016	0.0164	0.0162
Brugia malayi	hypothetical protein	0.0016	0.0164	0.0188
Brugia malayi	hypothetical protein	0.0016	0.0164	0.0188
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0172	0.4004	0.5
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0172	0.4004	1
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.005	0.1003	0.1001
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0509	0.0506
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Onchocerca volvulus	Putative chitinase	0.0017	0.0181	0.0031
Echinococcus granulosus	neuropeptides capa receptor	0.0016	0.0164	0.0162
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0164	0.0162
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0016	0.0164	0.0162
Schistosoma mansoni	tar DNA-binding protein	0.0197	0.4625	0.4549
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.005	0.1003	0.1001
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.005	0.1003	0.1001
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Onchocerca volvulus	Putative endochitinase	0.0116	0.2641	0.4541
Mycobacterium ulcerans	chitinase/cellulase	0.0099	0.2216	0.5323
Loa Loa (eye worm)	hypothetical protein	0.0099	0.2216	0.2214
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Schistosoma mansoni	amine GPCR	0.0016	0.0164	0.0025
Brugia malayi	Serotonin receptor	0.0016	0.0164	0.0188
Echinococcus multilocularis	g protein coupled receptor	0.0016	0.0164	0.0162
Brugia malayi	hypothetical protein	0.0155	0.3598	0.4111
Echinococcus granulosus	tm gpcr rhodopsin	0.0016	0.0164	0.0162
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0016	0.0164	0.0162
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.005	0.1003	0.1001
Echinococcus granulosus	neuropeptide s receptor	0.0016	0.0164	0.0162
Brugia malayi	TAR-binding protein	0.0197	0.4625	0.5284
Brugia malayi	AKH receptor	0.0016	0.0164	0.0188
Brugia malayi	G-protein coupled receptor	0.0016	0.0164	0.0188
Brugia malayi	hypothetical protein	0.0058	0.1183	0.1351
Echinococcus multilocularis	orexin receptor type 2	0.0016	0.0164	0.0162
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0164	0.0025
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0172	0.4004	1
Entamoeba histolytica	hypothetical protein	0.0116	0.2629	0.9951
Echinococcus multilocularis	g protein coupled receptor	0.0016	0.0164	0.0162
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.1287	0.1164
Loa Loa (eye worm)	hypothetical protein	0.003	0.0509	0.0506
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0414	1	1
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0026	0.0396	0.0393
Plasmodium vivax	ataxin-2 like protein, putative	0.0058	0.1183	0.2619
Echinococcus multilocularis	G protein coupled receptor 139	0.0016	0.0164	0.0162
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0164	0.0025
Schistosoma mansoni	hypothetical protein	0.0016	0.0164	0.0025
Echinococcus granulosus	g-protein coupled receptor	0.0016	0.0164	0.0162
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0016	0.0164	0.0188
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0139	0.0137
Toxoplasma gondii	LsmAD domain-containing protein	0.0058	0.1183	0.071
Schistosoma mansoni	peptidase Clp (S14 family)	0.0172	0.4004	0.392
Echinococcus granulosus	7tm_1 domain containing protein	0.0016	0.0164	0.0162
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0509	0.0374
Brugia malayi	Probable ClpP-like protease	0.0172	0.4004	0.4575
Loa Loa (eye worm)	hypothetical protein	0.005	0.1003	0.1001
Brugia malayi	hypothetical protein	0.0017	0.0181	0.0207
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0016	0.0164	0.0162
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.005	0.1003	0.1146
Echinococcus granulosus	7TM GPCR rhodopsin	0.0016	0.0164	0.0162
Echinococcus multilocularis	neuropeptide receptor A26	0.0016	0.0164	0.0162
Schistosoma mansoni	neuropeptide F-like receptor	0.0016	0.0164	0.0025
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0016	0.0164	0.0025
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.1512
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0164	0.0162
Toxoplasma gondii	hypothetical protein	0.0059	0.122	0.0749
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Schistosoma mansoni	biogenic amine receptor	0.0016	0.0164	0.0025
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0112	0.2541	1
Echinococcus granulosus	GPCR family 2	0.0015	0.0139	0.0137
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.1003	0.0521
Echinococcus multilocularis	neuropeptide receptor	0.0016	0.0164	0.0162
Entamoeba histolytica	hypothetical protein	0.0116	0.2629	0.9951
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Echinococcus granulosus	G protein coupled receptor 139	0.0016	0.0164	0.0162
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.1003	0.0521
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0016	0.0164	0.0162
Echinococcus granulosus	neuropeptide receptor A26	0.0016	0.0164	0.0162
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Echinococcus granulosus	neuropeptide FF receptor 2	0.0016	0.0164	0.0162
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0016	0.0164	0.0162
Onchocerca volvulus		0.0237	0.5618	1
Brugia malayi	Serotonin receptor	0.0016	0.0164	0.0188
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.005	0.1003	0.1146
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.1512
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.1512
Echinococcus granulosus	biogenic amine 5HT receptor	0.0016	0.0164	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Loa Loa (eye worm)	glycosyl hydrolase family 18 protein	0.0017	0.0181	0.0179
Echinococcus granulosus	dro:myosuppressin receptor	0.0016	0.0164	0.0162
Plasmodium falciparum	ataxin-2 like protein, putative	0.0058	0.1183	0.2619
Schistosoma mansoni	hypothetical protein	0.0016	0.0164	0.0025
Brugia malayi	hypothetical protein	0.0016	0.0164	0.0188
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0016	0.0164	0.0162
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0016	0.0164	0.0025
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.005	0.1003	0.0876
Brugia malayi	hypothetical protein	0.0037	0.0677	0.0774
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0197	0.4625	0.4624
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0164	0.0025
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0016	0.0164	0.0162
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0414	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0016	0.0164	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Schistosoma mansoni	growth hormone secretagogue receptor	0.0016	0.0164	0.0025
Onchocerca volvulus	Putative endochitinase	0.0116	0.2641	0.4541
Echinococcus granulosus	neuropeptide Y receptor	0.0016	0.0164	0.0162
Onchocerca volvulus		0.0155	0.3598	0.6296
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.1003	0.1512
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.1003	0.1512
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Loa Loa (eye worm)	G-protein coupled receptor	0.0016	0.0164	0.0162
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0967	0.0964
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0164	0.0025
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0139	0.0159
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.1512
Mycobacterium ulcerans	chitinase/cellulase	0.0099	0.2216	0.5323
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0162
Brugia malayi	Glycosyl hydrolases family 18 protein	0.0017	0.0181	0.0207
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.005	0.1003	0.215
Brugia malayi	Endochitinase	0.0116	0.2641	0.3017
Schistosoma mansoni	hypothetical protein	0.0408	0.9852	0.985
Onchocerca volvulus	Putative endochitinase	0.0116	0.2641	0.4541
Echinococcus granulosus	neuropeptide Y receptor	0.0016	0.0164	0.0162
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0584	0.0667
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0016	0.0164	0.0025
Schistosoma mansoni	tar DNA-binding protein	0.0197	0.4625	0.4549
Loa Loa (eye worm)	G-protein coupled receptor	0.0016	0.0164	0.0162
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0016	0.0164	0.0162
Brugia malayi	sulfakinin receptor protein	0.0016	0.0164	0.0188
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.005	0.1003	0.1512
Echinococcus multilocularis	neuropeptide receptor	0.0016	0.0164	0.0162
Echinococcus multilocularis	fmrfamide receptor	0.0016	0.0164	0.0162
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0172	0.4004	1
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.005	0.1003	0.0876
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0967	0.1105
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0016	0.0164	0.0025
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0509	0.0506
Loa Loa (eye worm)	MH2 domain-containing protein	0.0137	0.3148	0.3146
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0016	0.0164	0.0162

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 733635