Detailed information for compound 733689

Basic information

Technical information
  • TDR Targets ID: 733689
  • Name: CBKinase1_015890
  • MW: 433.501 | Formula: C23H20FN5OS
  • H donors: 1 H acceptors: 4 LogP: 4.32 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)n1c(SCC(=O)Nc2ccc(cc2)F)nnc1c1ccncc1
  • InChi: 1S/C23H20FN5OS/c1-2-16-3-9-20(10-4-16)29-22(17-11-13-25-14-12-17)27-28-23(29)31-15-21(30)26-19-7-5-18(24)6-8-19/h3-14H,2,15H2,1H3,(H,26,30)
  • InChiKey: NQKOXPMTPSEDET-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • CBKinase1_003490
  • T5387032

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ran 0.0022 0.0083 0.0082
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0063 0.2144
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0042 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0234
Echinococcus multilocularis mucolipin 3 0.0064 0.0387 0.0387
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0406 0.2864 0.5541
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0012 0.001 0.002
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0033 0.0032
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0012 0.001 0.0019
Brugia malayi beta-lactamase family protein 0.0079 0.0496 0.096
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0179 0.6861
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0285 0.1468
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0033 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0234
Brugia malayi RNA, U transporter 1 0.0087 0.055 0.1065
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0496 0.1224
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0066 0.0127
Brugia malayi TAR-binding protein 0.0406 0.2864 0.5542
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0044 0.0238 0.0459
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0102 0.0488
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0066 0.0234
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0472 0.4038
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0021 0.0019
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0185 0.0184
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0063 0.0282
Brugia malayi beta-lactamase family protein 0.0079 0.0496 0.096
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0017 0.0034
Loa Loa (eye worm) inositol-1 0.0036 0.0185 0.0356
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0229 0.1011
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0066 0.0065
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0179 0.0902
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1277 0.6766
Trypanosoma brucei unspecified product 0.0014 0.0021 0.0019
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.001 0.001
Echinococcus granulosus cpg binding protein 0.0033 0.0163 0.0162
Schistosoma mansoni hypothetical protein 0.0162 0.1099 0.1098
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0179 0.0902
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0142 0.0596
Schistosoma mansoni hypothetical protein 0.0326 0.2285 0.2285
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0496 1
Schistosoma mansoni hypothetical protein 0.0351 0.2467 0.2467
Schistosoma mansoni lamin 0.0081 0.0507 0.0507
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0256 0.1314
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0152 0.0645
Schistosoma mansoni tar DNA-binding protein 0.0406 0.2864 0.2863
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0179 0.2679
Loa Loa (eye worm) hypothetical protein 0.0079 0.0496 0.0959
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0081 0.0507 0.0981
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0179 0.0902
Mycobacterium ulcerans lipase LipD 0.0079 0.0496 0.4274
Loa Loa (eye worm) hypothetical protein 0.0076 0.0472 0.0913
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0472 0.0472
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0472 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1208 0.6396
Toxoplasma gondii hypothetical protein 0.0026 0.011 0.1092
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0496 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0066 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0234
Schistosoma mansoni mucolipin 0.0064 0.0387 0.0387
Echinococcus granulosus tar DNA binding protein 0.0406 0.2864 0.2863
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0285 0.1279
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0066 0.0234
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0083 0.0317
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0285 0.1279
Toxoplasma gondii ABC1 family protein 0.0079 0.0496 1
Schistosoma mansoni mucolipin 0.0059 0.0348 0.0347
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0001 0.0001
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0178 0.0177
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0083 0.0161
Schistosoma mansoni inositol monophosphatase 0.0036 0.0185 0.0184
Schistosoma mansoni hypothetical protein 0.002 0.0068 0.0067
Schistosoma mansoni ap endonuclease 0.002 0.0063 0.0062
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0179 0.0902
Schistosoma mansoni intermediate filament proteins 0.0081 0.0507 0.0507
Mycobacterium ulcerans hypothetical protein 0.0159 0.1076 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.017 0.0854
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0496 0.1224
Loa Loa (eye worm) hypothetical protein 0.0039 0.0204 0.0393
Onchocerca volvulus 0.0079 0.0496 0.1508
Leishmania major hypothetical protein, conserved 0.0015 0.003 0.0063
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0472 0.9447
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0066 0.0234
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0047 0.0046
Brugia malayi beta-lactamase 0.0079 0.0496 0.096
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0496 0.2596
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0102 0.0488
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0042 0.0042
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0229 0.1011
Echinococcus granulosus snurportin 1 0.0326 0.2285 0.2285
Mycobacterium ulcerans hypothetical protein 0.0079 0.0496 0.4274
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0256 0.1142
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.2115 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.011 0.1156
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0066 0.0065
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0229 0.1011
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.0033 0.0078
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0066 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0158 0.0787
Brugia malayi MH2 domain containing protein 0.0141 0.094 0.1818
Trypanosoma cruzi ISWI complex protein 0.0015 0.003 0.0063
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0017 0.0034
Echinococcus granulosus survival motor neuron protein 1 0.0723 0.5167 0.5167
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0101 0.0487
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0179 0.0902
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0063 0.0122
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0289 0.2018 0.3905
Entamoeba histolytica Ran family GTPase 0.0022 0.0083 0.2963
Schistosoma mansoni tar DNA-binding protein 0.0406 0.2864 0.2863
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0012 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0188 0.0947
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0142 0.0596
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.001 0.001
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.001 0.001
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0496 0.2596
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0152 0.0645
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0001 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0289 0.2018 0.2018
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0137 0.0263
Trichomonas vaginalis ran, putative 0.0022 0.0083 0.039
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.0033 0.0078
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0514 0.3646 0.7055
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.1882 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0066 0.0234
Brugia malayi RNA recognition motif domain containing protein 0.0406 0.2864 0.5542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0033 0.0121
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.001 0.001
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0083 0.0317
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0033 0.0121
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.001 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.1882 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0021 0.0019
Schistosoma mansoni cpg binding protein 0.0033 0.0163 0.0162
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0472 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0496 0.0495
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0101 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0256 0.1314
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.001 0.002
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0017 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0001 0.0001
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0083 0.0493
Leishmania major hypothetical protein, conserved 0.0079 0.0496 0.2285
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.017 0.0854
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0496 0.2285
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0188 0.0816
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0063 0.0062
Schistosoma mansoni lamin 0.0081 0.0507 0.0507
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0289 0.2018 0.2018
Brugia malayi MAP kinase sur-1 0.005 0.0285 0.0552
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0285 0.1279
Loa Loa (eye worm) intermediate filament protein 0.0081 0.0507 0.0981
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0959 0.4491
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0256 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0179 0.0902
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0179 0.0178
Schistosoma mansoni rotamase 0.0033 0.0158 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.017 0.0854
Brugia malayi CXXC zinc finger family protein 0.003 0.0137 0.0265
Trichomonas vaginalis importin beta-1, putative 0.0025 0.01 0.0478
Toxoplasma gondii hypothetical protein 0.0049 0.0274 0.4876
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0496 0.1224
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0126
Mycobacterium tuberculosis Conserved protein 0.0079 0.0496 0.1224
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0185 0.0184
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.001 0.001
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0094 0.0093
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0285 0.1468
Brugia malayi hypothetical protein 0.0723 0.5167 1
Leishmania major mitochondrial DNA polymerase beta 0.0303 0.2115 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0379 0.0379
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0496 0.0959
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0017 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0033 0.0121
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0496 0.0495
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.1882 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0193 0.0372
Brugia malayi nuclear receptor NHR-88 0.0011 0.0001 0.0001
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0179 0.0902
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0012 0.001 0.002
Brugia malayi Inositol-1 0.0036 0.0185 0.0358
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.001 0.001
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0185 0.1201
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.027 0.1882 0.3642
Schistosoma mansoni cpg binding protein 0.003 0.0137 0.0136
Schistosoma mansoni alpha-glucosidase 0.0138 0.0925 0.0924
Plasmodium falciparum importin beta, putative 0.0031 0.0142 0.1922
Brugia malayi G-protein alpha subunit 0.0012 0.001 0.002
Schistosoma mansoni bromodomain containing protein 0.0064 0.0386 0.0385
Loa Loa (eye worm) RNA binding protein 0.0406 0.2864 0.5541
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0234
Brugia malayi Importin beta-1 subunit 0.0031 0.0142 0.0274
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.001 0.001
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0285 0.1468
Brugia malayi hypothetical protein 0.0012 0.001 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0289 0.2018 0.2018
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0496 0.1224
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0066 0.0127
Mycobacterium ulcerans beta-lactamase 0.0079 0.0496 0.4274
Loa Loa (eye worm) hypothetical protein 0.0038 0.0193 0.0372
Trichomonas vaginalis rotamase, putative 0.0032 0.0152 0.0757
Loa Loa (eye worm) hypothetical protein 0.0351 0.2467 0.4774
Echinococcus granulosus mucolipin 3 0.0064 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.007 0.0427 0.0824
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0496 0.0495
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.017 0.0854
Loa Loa (eye worm) transcription factor SMAD2 0.0141 0.094 0.1817
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.001 0.001
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.01 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0138 0.0684
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0256 0.1142
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0063 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0234
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.027 0.1882 0.3643
Echinococcus multilocularis dna polymerase kappa 0.002 0.0066 0.0065
Echinococcus multilocularis expressed protein 0.0012 0.001 0.001
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0017 0.0034
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0047 0.0089
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0256 0.1142
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0285 0.1279
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0959 0.4491
Schistosoma mansoni hypothetical protein 0.0162 0.1099 0.1098
Onchocerca volvulus 0.0296 0.2069 0.6297
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0285 0.0284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0121 0.0592
Loa Loa (eye worm) hypothetical protein 0.0296 0.2069 0.4003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0188 0.0947
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0188 0.0947
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0017 0.0257
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0178 0.0177
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.006 0.0206
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.1076 0.2865
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0146 0.0723
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0012 0.001 0.001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0514 0.3646 0.7055
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0496 0.1224
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0496 0.0495
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0158 0.0305
Onchocerca volvulus 0.0079 0.0496 0.1508
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0179 0.0178
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0472 0.0472
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0068 0.013
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0285 0.5127
Brugia malayi RNA binding protein 0.0406 0.2864 0.5542
Schistosoma mansoni hypothetical protein 0.0015 0.003 0.0029
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0152 0.5762
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0101 0.0487
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0285 0.0284
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0229 0.1011
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0188 0.0816
Mycobacterium tuberculosis Conserved protein 0.0079 0.0496 0.1224
Trichomonas vaginalis rotamase, putative 0.0033 0.0158 0.0787
Brugia malayi follicle stimulating hormone receptor 0.0468 0.3315 0.6415
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0496 0.1224
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0066 0.0234
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0047 0.0046
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0066 0.225
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0179 0.0345
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0012 0.001 0.0019
Onchocerca volvulus 0.0093 0.0595 0.181
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0001 0.0001
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0185 0.0801
Echinococcus multilocularis snurportin 1 0.0326 0.2285 0.2285
Trypanosoma brucei unspecified product 0.002 0.0066 0.0234
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0157 0.0266
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0066 0.0234
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.011 0.1156
Brugia malayi ecdysteroid receptor 0.0011 0.0001 0.0001
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0285 0.0284
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.1882 1
Schistosoma mansoni zinc finger protein 0.0021 0.0073 0.0072
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0472 1
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0012 0.001 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0496 0.2285
Loa Loa (eye worm) runx1 0.0058 0.0342 0.0661
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0033 0.0078
Trypanosoma brucei glucosidase, putative 0.0036 0.0179 0.0774
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0256 0.0495
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0185 0.0801
Echinococcus granulosus lamin 0.0081 0.0507 0.0507
Onchocerca volvulus 0.0081 0.0507 0.1542
Schistosoma mansoni tar DNA-binding protein 0.0406 0.2864 0.2863
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0047 0.0046
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0066 0.0065
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0152 0.0645
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0256 0.1142
Loa Loa (eye worm) hypothetical protein 0.0079 0.0497 0.096
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0179 0.0774
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0256 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0185 0.0801
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0472 0.9379
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0179 0.0902
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.017 0.0854
Giardia lamblia GTOR 0.0046 0.0256 0.8704
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0012 0.001 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0256 0.1314
Echinococcus multilocularis expressed protein 0.0033 0.0158 0.0157
Schistosoma mansoni microtubule-associated protein tau 0.1389 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0347 0.6563
Onchocerca volvulus 0.0081 0.0507 0.1542
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0083 0.016
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0472 0.0472
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0042 0.0042
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.0033 0.0078
Schistosoma mansoni tar DNA-binding protein 0.0406 0.2864 0.2863
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0235 0.0454
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0094 0.0093
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0285 0.1279
Brugia malayi Bromodomain containing protein 0.0038 0.0195 0.0376
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0066 0.0007
Brugia malayi latrophilin 2 splice variant baaae 0.0351 0.2467 0.4774
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0472 0.9447
Brugia malayi intermediate filament protein 0.0081 0.0507 0.0982
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.001 0.002
Schistosoma mansoni DNA polymerase eta 0.002 0.0066 0.0065
Echinococcus multilocularis lamin dm0 0.0081 0.0507 0.0507
Brugia malayi nuclear hormone receptor 0.0011 0.0001 0.0001
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.011 0.1092
Schistosoma mansoni ran 0.0022 0.0083 0.0082
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1208 0.6396
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0496 0.096
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0012 0.001 0.002
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0285 0.0284
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0066 0.0126
Onchocerca volvulus 0.0079 0.0496 0.1508
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.1882 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0188 0.0816
Brugia malayi Latrophilin receptor protein 2 0.0162 0.1099 0.2127
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0162 0.1099 0.2127
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0472 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0185 0.0932
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.001 0.001
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0083 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0033 0.0121
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0496 0.2596
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.0033 0.0078
Echinococcus granulosus expressed protein 0.0033 0.0158 0.0157
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0033 0.0078
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0812 0.5814 0.5814
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0496 0.4274
Leishmania major GTP-binding protein, putative 0.0022 0.0083 0.0317
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0148 0.099 0.1917
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0496 0.4274
Loa Loa (eye worm) latrophilin receptor protein 2 0.0162 0.1099 0.2126
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0066 0.0296
Brugia malayi Calcitonin receptor-like protein seb-1 0.0514 0.3646 0.7056
Loa Loa (eye worm) hypothetical protein 0.0079 0.0496 0.0959
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0033 0.0064
Echinococcus multilocularis tar DNA binding protein 0.0406 0.2864 0.2863
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0033 0.0032
Echinococcus multilocularis survival motor neuron protein 1 0.0723 0.5167 0.5167
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0162 0.1099 0.1098
Brugia malayi Coelomocyte uptake defective protein 5 0.0064 0.0387 0.0749
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0289 0.2018 0.2018
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0468 0.3315 0.6415
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0472 0.9447
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0066 0.0234
Schistosoma mansoni hypothetical protein 0.0148 0.099 0.099
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0496 0.2596
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0234
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.001 0.002
Leishmania major importin beta-1 subunit, putative 0.0025 0.01 0.0396
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0162 0.1099 0.1098
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.017 0.2474
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1277 0.6766
Schistosoma mansoni zinc finger protein 0.0015 0.003 0.0029
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0179 0.6861
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0033 0.0062
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0179 0.0774
Onchocerca volvulus 0.0148 0.099 0.3013
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0021 0.0019
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0063 0.0062
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0285 0.1279
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.036 0.0359
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0496 0.2285
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0162 0.1099 0.1098
Schistosoma mansoni survival motor neuron protein 0.0148 0.099 0.099
Loa Loa (eye worm) hypothetical protein 0.0038 0.0195 0.0376
Brugia malayi hypothetical protein 0.0296 0.2069 0.4004
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.01 0.0478
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1208 0.6396
Loa Loa (eye worm) hypothetical protein 0.004 0.0212 0.0409
Echinococcus multilocularis GPCR, family 2 0.0162 0.1099 0.1098
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0285 0.055
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0256 0.1142
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0185 0.2973
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1087 0.1086
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0234
Echinococcus granulosus dna polymerase eta 0.002 0.0066 0.0065
Echinococcus multilocularis zinc finger protein 0.0021 0.0073 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.017 0.0854
Echinococcus multilocularis cpg binding protein 0.0033 0.0163 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0121 0.0592
Loa Loa (eye worm) hypothetical protein 0.0079 0.0496 0.0959
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0017 0.0034
Leishmania major DNA polymerase eta, putative 0.002 0.0066 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0207 0.1052
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0406 0.2864 0.2863
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0152 0.0645
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0204 0.0203
Echinococcus granulosus intermediate filament protein 0.0081 0.0507 0.0507
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0289 0.2018 0.3906
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0282 0.0619
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0066 0.0234
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0285 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0001 0.0001
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.001 0.001
Mycobacterium tuberculosis Conserved protein 0.0079 0.0496 0.1224
Loa Loa (eye worm) hypothetical protein 0.0162 0.1099 0.2126
Schistosoma mansoni cpg binding protein 0.0033 0.0163 0.0162
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0012 0.001 0.002
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0472 0.5
Echinococcus granulosus GPCR family 2 0.0162 0.1099 0.1098
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.001 0.001
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0083 0.0908
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0285 0.1468
Loa Loa (eye worm) hypothetical protein 0.0723 0.5167 1
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0066 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0188 0.0947
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0289 0.2018 0.2018
Loa Loa (eye worm) hypothetical protein 0.0079 0.0496 0.0959
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0496 0.2596
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0185 0.0932
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0282 0.0619
Brugia malayi hypothetical protein 0.0464 0.3285 0.6358
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0234
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0959 0.4491
Loa Loa (eye worm) beta-lactamase 0.0079 0.0496 0.0959
Entamoeba histolytica hypothetical protein 0.0025 0.01 0.3638
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0033 0.0032
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0063 0.0221
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.1087 0.1086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0188 0.0947
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0234
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0282 0.4449
Trypanosoma brucei protein kinase, putative 0.005 0.0285 0.1279
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0001 0.0001
Brugia malayi Bromodomain containing protein 0.0076 0.047 0.0909
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0303 0.2115 1
Trypanosoma cruzi ISWI complex protein 0.0015 0.003 0.0063
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0047 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.017 0.0854
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0158 0.0304
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0094 0.0093
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Echinococcus granulosus lamin dm0 0.0081 0.0507 0.0507
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0121 0.0592
Trypanosoma brucei ISWI complex protein 0.0015 0.003 0.0063
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0142 0.0141
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0326 0.2285 0.4422
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0185 0.2809
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0017 0.0034
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0152 0.2055
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0017 0.0048
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1208 0.6396
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.1087 0.2104
Schistosoma mansoni inositol monophosphatase 0.0036 0.0185 0.0184
Echinococcus granulosus importin subunit beta 1 0.0031 0.0142 0.0141
Giardia lamblia DINP protein human, muc B family 0.002 0.0066 0.0117
Loa Loa (eye worm) mucolipin 1 0.0064 0.0387 0.0748
Echinococcus multilocularis musashi 0.0081 0.0507 0.0507
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0496 0.1224
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0031
Brugia malayi steroid hormone receptor 0.0011 0.0001 0.0001
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0282 0.0281
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0012 0.001 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.1882 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0256 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0102 0.0488
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0063 0.0221
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.0273
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0066 0.0065
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0012 0.001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0464 0.3285 0.6358
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0507 0.36 1
Schistosoma mansoni lozenge 0.0058 0.0342 0.0342
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0234
Loa Loa (eye worm) hypothetical protein 0.0079 0.0496 0.0959
Onchocerca volvulus 0.0464 0.3285 1
Trichomonas vaginalis esterase, putative 0.0079 0.0496 0.2596
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0083 0.0317
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.001 0.001
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.2115 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0496 0.0959
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0256 0.0256
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1208 0.6396
Trypanosoma brucei unspecified product 0.0014 0.0021 0.0019
Schistosoma mansoni alpha-glucosidase 0.0138 0.0925 0.0924
Echinococcus granulosus dna polymerase kappa 0.002 0.0066 0.0065
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0256 0.0256
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0157 0.1209
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0256 0.1142
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0162 0.1099 0.1098
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0083 0.0465
Schistosoma mansoni importin beta-1 0.0031 0.0142 0.0141
Schistosoma mansoni alpha glucosidase 0.0036 0.0179 0.0178
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0204 0.0203
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0012 0.001 0.001
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0235 0.0453
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Onchocerca volvulus 0.003 0.0137 0.0414
Onchocerca volvulus 0.0012 0.001 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0001 0.0001
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0282 0.0281
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0081 0.0507 0.0981
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0285 0.0284
Loa Loa (eye worm) MH2 domain-containing protein 0.0141 0.094 0.1817
Loa Loa (eye worm) G protein alpha subunit 3 0.0012 0.001 0.0019
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0066 0.0026
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0185 0.7089
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1087 0.1086
Echinococcus multilocularis lamin 0.0081 0.0507 0.0507
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0017 0.0034
Mycobacterium leprae Probable lipase LipE 0.0079 0.0496 1
Schistosoma mansoni hypothetical protein 0.0162 0.1099 0.1098
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0017 0.0032
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0185 0.0932
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0066 0.0026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0289 0.2018 0.2018
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0472 0.4038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0102 0.0488
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.001 0.001
Onchocerca volvulus Glucosylceramidase homolog 0.0177 0.1208 0.3674
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0119 0.0581
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0012 0.001 0.002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0514 0.3646 0.7056
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0063 0.0221
Echinococcus multilocularis Protein lozenge 0.0058 0.0342 0.0342
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0063 0.0282
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0179 0.0902
Brugia malayi Probable ClpP-like protease 0.0076 0.0472 0.0914
Echinococcus multilocularis dna polymerase eta 0.002 0.0066 0.0065
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0179 0.0774
Plasmodium vivax importin-beta 2, putative 0.0031 0.0142 0.1816
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0019
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0079 0.0298
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.001 0.001
Echinococcus granulosus expressed protein 0.0012 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0001 0.0001
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0179 0.0347
Echinococcus granulosus zinc finger protein 0.0021 0.0073 0.0072
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0285 0.1279
Onchocerca volvulus 0.0012 0.001 0.0029
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0083 0.0465
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.036 0.0359
Loa Loa (eye worm) TAR-binding protein 0.0406 0.2864 0.5541
Brugia malayi Intermediate filament tail domain containing protein 0.0081 0.0507 0.0982
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.001 0.001
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0063 0.0121
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0185 0.0801
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1208 0.6396
Schistosoma mansoni ap endonuclease 0.002 0.0063 0.0062
Leishmania major DNA polymerase kappa, putative 0.002 0.0066 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0119 0.0581
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0066 0.0296
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.001 0.001
Onchocerca volvulus 0.0012 0.001 0.0029
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0083 0.0082
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0296 0.1333
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.1087 0.2103
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0042 0.0042
Echinococcus multilocularis microtubule associated protein 2 0.1389 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0289 0.2018 0.2018
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1208 0.6396
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.01 0.0478
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0142 0.1816
Schistosoma mansoni hypothetical protein 0.0162 0.1099 0.1098
Loa Loa (eye worm) hypothetical protein 0.0464 0.3285 0.6358
Brugia malayi PHD-finger family protein 0.0026 0.0111 0.0215

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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