Detailed information for compound 733825

Basic information

Technical information
  • TDR Targets ID: 733825
  • Name: Oprea1_179919
  • MW: 396.463 | Formula: C20H20N4O3S
  • H donors: 2 H acceptors: 5 LogP: 3.03 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1c(SCC(=O)Nc2ccc(cc2)C(=O)O)nnc1c1ccc(cc1)C
  • InChi: 1S/C20H20N4O3S/c1-3-24-18(14-6-4-13(2)5-7-14)22-23-20(24)28-12-17(25)21-16-10-8-15(9-11-16)19(26)27/h4-11H,3,12H2,1-2H3,(H,21,25)(H,26,27)
  • InChiKey: OGKXAPIZKHOTAE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • CBKinase1_003413
  • STK114918
  • CBKinase1_015813

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans carboxylesterase, LipT 0.0023 0.0168 0.2242
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0081 0.03
Brugia malayi CXXC zinc finger family protein 0.0028 0.0282 0.0202
Schistosoma mansoni lamin 0.0055 0.0848 0.314
Echinococcus granulosus survival motor neuron protein 1 0.0478 1 1
Loa Loa (eye worm) carboxylesterase 0.0023 0.0168 0.0117
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0346 0.128
Echinococcus granulosus dna polymerase kappa 0.0019 0.0081 0.0043
Loa Loa (eye worm) hypothetical protein 0.0037 0.0469 0.042
Echinococcus granulosus mitogen activated protein kinase 3 0.0102 0.1867 0.1836
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0081 0.0433
Brugia malayi RNA binding protein 0.0124 0.2353 0.229
Schistosoma mansoni hypothetical protein 0.0021 0.0115 0.0427
Brugia malayi Carboxylesterase family protein 0.0023 0.0168 0.0088
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0467 0.0431
Brugia malayi Pre-SET motif family protein 0.0031 0.0346 0.0267
Echinococcus multilocularis GPCR, family 2 0.0063 0.1027 0.0992
Mycobacterium ulcerans lipase LipD 0.0037 0.0469 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0446 0.0409
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0714 0.2645
Mycobacterium tuberculosis Conserved protein 0.0037 0.0469 0.0826
Leishmania major DNA polymerase eta, putative 0.0019 0.0081 0.0433
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0166
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0081 0.0043
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0469 0.0826
Schistosoma mansoni alpha-glucosidase 0.014 0.27 1
Onchocerca volvulus 0.0031 0.0346 0.0372
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0469 0.0826
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0451 0.076
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.1867 0.3675
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0081 0.0433
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0467 0.0801
Echinococcus multilocularis tar DNA binding protein 0.0124 0.2353 0.2324
Loa Loa (eye worm) hypothetical protein 0.0037 0.0469 0.042
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0081 0.0043
Echinococcus granulosus intermediate filament protein 0.0055 0.0848 0.0813
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0451 0.0414
Brugia malayi Carboxylesterase family protein 0.0137 0.2619 0.2559
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0081 0.0433
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0469 0.2511
Echinococcus granulosus mitogen activated protein kinase 0.0102 0.1867 0.1836
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0191 0.0154
Brugia malayi Carboxylesterase family protein 0.0023 0.0168 0.0088
Brugia malayi Latrophilin receptor protein 2 0.0063 0.1027 0.0953
Onchocerca volvulus 0.0037 0.0469 0.0631
Schistosoma mansoni alpha-glucosidase 0.014 0.27 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0905 0.3675
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0081 0.0433
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0467 0.2504
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0469 1
Onchocerca volvulus 0.0028 0.0282 0.0238
Loa Loa (eye worm) hypothetical protein 0.0037 0.0469 0.042
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.319 0.3155
Brugia malayi Inositol-1 0.0037 0.0467 0.039
Onchocerca volvulus 0.0094 0.1705 0.322
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0469 0.0826
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0081 0.0433
Loa Loa (eye worm) hypothetical protein 0.0023 0.0168 0.0117
Brugia malayi Bromodomain containing protein 0.0077 0.1325 0.1254
Loa Loa (eye worm) mucolipin 1 0.0065 0.1078 0.1033
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0102 0.1867 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.1027 0.0992
Echinococcus multilocularis acetylcholinesterase 0.0137 0.2619 0.2591
Loa Loa (eye worm) TAR-binding protein 0.0124 0.2353 0.2313
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0102 0.1867 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0168 0.0117
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0023 0.0168 0.0185
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0081 0.0433
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0081 0.0433
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0081 0.0433
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0238 0.0201
Schistosoma mansoni BC026374 protein (S09 family) 0.0023 0.0168 0.0622
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0301 0.0251
Trypanosoma brucei protein kinase, putative 0.0102 0.1867 1
Loa Loa (eye worm) hypothetical protein 0.0199 0.3959 0.3928
Onchocerca volvulus 0.0055 0.0848 0.1424
Echinococcus granulosus cpg binding protein 0.0032 0.0358 0.0321
Loa Loa (eye worm) hypothetical protein 0.0054 0.0826 0.0779
Echinococcus granulosus dna polymerase eta 0.0019 0.0081 0.0043
Loa Loa (eye worm) hypothetical protein 0.0071 0.1198 0.1152
Brugia malayi beta-lactamase family protein 0.0037 0.0469 0.0391
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0467 0.0431
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0102 0.1867 1
Schistosoma mansoni hypothetical protein 0.0136 0.2602 0.9637
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0081 0.03
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0081 0.0433
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0469 1
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0301 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0081 0.0433
Onchocerca volvulus 0.0244 0.4943 1
Echinococcus granulosus para nitrobenzyl esterase 0.0023 0.0168 0.013
Mycobacterium tuberculosis Carboxylesterase LipT 0.0023 0.0168 0.0185
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0469 0.0826
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0451 0.0414
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0191 0.0154
Loa Loa (eye worm) hypothetical protein 0.0023 0.0168 0.0117
Schistosoma mansoni zinc finger protein 0.0021 0.0127 0.0472
Echinococcus multilocularis BC026374 protein (S09 family) 0.0023 0.0168 0.013
Loa Loa (eye worm) hypothetical protein 0.0037 0.0469 0.042
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0081 0.0433
Echinococcus granulosus tar DNA binding protein 0.0124 0.2353 0.2324
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0467 0.0795
Schistosoma mansoni hypothetical protein 0.0063 0.1027 0.3803
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2353 0.8715
Schistosoma mansoni cellular tumor antigen P53 0.005 0.074 0.274
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0081 0.0433
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0451 0.2413
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0282 0.0232
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.003
Echinococcus multilocularis para nitrobenzyl esterase 0.0023 0.0168 0.013
Schistosoma mansoni inositol monophosphatase 0.0037 0.0467 0.1732
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0102 0.1867 0.1826
Loa Loa (eye worm) hypothetical protein 0.0023 0.0168 0.0117
Leishmania major hypothetical protein, conserved 0.0037 0.0469 0.2511
Echinococcus granulosus mucolipin 3 0.0065 0.1078 0.1045
Loa Loa (eye worm) hypothetical protein 0.0023 0.0168 0.0117
Echinococcus granulosus acetylcholinesterase 0.0137 0.2619 0.2591
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.319 0.3164
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0451 0.076
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0081 0.0433
Loa Loa (eye worm) carboxylesterase 0.0137 0.2619 0.2581
Brugia malayi PHD-finger family protein 0.0027 0.0243 0.0163
Trichomonas vaginalis set domain proteins, putative 0.0244 0.4943 1
Schistosoma mansoni hypothetical protein 0.0063 0.1027 0.3803
Schistosoma mansoni lamin 0.0055 0.0848 0.314
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0102 0.1867 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.1777 0.171
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0469 0.0798
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.4777 1
Toxoplasma gondii ABC1 family protein 0.0037 0.0469 0.081
Mycobacterium leprae Probable lipase LipE 0.0037 0.0469 1
Schistosoma mansoni hypothetical protein 0.0098 0.1777 0.6581
Trypanosoma brucei unspecified product 0.0019 0.0081 0.0433
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0137 0.2619 0.9702
Echinococcus multilocularis carboxylesterase 5A 0.0137 0.2619 0.2591
Brugia malayi beta-lactamase 0.0037 0.0469 0.0391
Schistosoma mansoni survival motor neuron protein 0.0098 0.1777 0.6581
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0115 0.0064
Mycobacterium ulcerans hypothetical protein 0.0037 0.0469 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0994 0.096
Schistosoma mansoni cpg binding protein 0.0032 0.0358 0.1326
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0102 0.1867 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0238 0.0188
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2353 0.8715
Echinococcus granulosus BC026374 protein S09 family 0.0023 0.0168 0.013
Echinococcus multilocularis dna polymerase eta 0.0019 0.0081 0.0043
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0469 0.0433
Schistosoma mansoni cpg binding protein 0.0032 0.0358 0.1326
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0168 0.0622
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0469 0.042
Brugia malayi Coelomocyte uptake defective protein 5 0.0065 0.1078 0.1006
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0102 0.1867 1
Brugia malayi Carboxylesterase family protein 0.0137 0.2619 0.2559
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.1027 0.0992
Echinococcus granulosus zinc finger protein 0.0021 0.0127 0.009
Loa Loa (eye worm) carboxylesterase 0.0023 0.0168 0.0117
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0469 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0168 0.0622
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0994 0.096
Brugia malayi MAP kinase sur-1 0.0102 0.1867 0.1801
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0992 0.3677
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0469 0.2511
Onchocerca volvulus 0.0037 0.0469 0.0631
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2353 0.8715
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0848 0.0801
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0168 0.0622
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0451 0.076
Trichomonas vaginalis spcc417.12 protein, putative 0.0023 0.0168 0.0179
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0081 0.0433
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.3959 0.3928
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.1027 0.098
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0469 0.1737
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0714 0.0679
Echinococcus multilocularis lamin 0.0055 0.0848 0.0813
Echinococcus multilocularis survival motor neuron protein 1 0.0478 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.1027 0.0953
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0451 0.9563
Schistosoma mansoni hypothetical protein 0.0063 0.1027 0.3803
Schistosoma mansoni neuroligin 3 (S09 family) 0.0023 0.0168 0.0622
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.4304 0.4275
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.319 0.3164
Loa Loa (eye worm) hypothetical protein 0.0044 0.0626 0.0578
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.1867 0.3675
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.1867 0.6917
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0081 0.0433
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0848 0.0773
Loa Loa (eye worm) hypothetical protein 0.0037 0.0469 0.042
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0451 0.076
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0451 0.076
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0451 0.0373
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.3959 0.391
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0451 0.076
Echinococcus multilocularis acetylcholinesterase 0.0137 0.2619 0.2591
Schistosoma mansoni hypothetical protein 0.0063 0.1027 0.3803
Echinococcus granulosus lamin dm0 0.0055 0.0848 0.0813
Loa Loa (eye worm) hypothetical protein 0.0478 1 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0467 0.2504
Loa Loa (eye worm) acetylcholinesterase 1 0.0137 0.2619 0.2581
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0023 0.0168 0.013
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0467 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0451 0.069
Echinococcus multilocularis cpg binding protein 0.0032 0.0358 0.0321
Mycobacterium tuberculosis Conserved protein 0.0037 0.0469 0.0826
Schistosoma mansoni alpha glucosidase 0.0036 0.0451 0.1669
Echinococcus granulosus GPCR family 2 0.0063 0.1027 0.0992
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0081 0.0433
Loa Loa (eye worm) hypothetical protein 0.0023 0.0168 0.0117
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0469 0.0798
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0469 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0102 0.1867 0.1836
Schistosoma mansoni cpg binding protein 0.0028 0.0282 0.1044
Brugia malayi intermediate filament protein 0.0055 0.0848 0.0773
Echinococcus multilocularis lamin dm0 0.0055 0.0848 0.0813
Echinococcus multilocularis musashi 0.0055 0.0848 0.0813
Loa Loa (eye worm) hypothetical protein 0.0037 0.0469 0.042
Loa Loa (eye worm) hypothetical protein 0.0048 0.0714 0.0666
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0467 0.2504
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0451 0.9563
Trypanosoma brucei glucosidase, putative 0.0036 0.0451 0.2413
Brugia malayi Carboxylesterase family protein 0.0023 0.0168 0.0088
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0081 0.0433
Brugia malayi Pre-SET motif family protein 0.0214 0.4304 0.4258
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.319 0.3164
Giardia lamblia Kinase, CMGC MAPK 0.0102 0.1867 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0469 0.2511
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0451 0.0401
Schistosoma mansoni inositol monophosphatase 0.0037 0.0467 0.1732
Echinococcus granulosus tumor protein p63 0.0338 0.6981 0.697
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0446 0.0409
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0469 0.1737
Schistosoma mansoni intermediate filament proteins 0.0055 0.0848 0.314
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0081 0.0043
Schistosoma mansoni bromodomain containing protein 0.0065 0.1072 0.397
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0308 0.0271
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0346 0.128
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0038 0.014
Echinococcus granulosus neuroligin 0.0023 0.0168 0.013
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2353 0.8715
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0467 0.5
Schistosoma mansoni gliotactin 0.0023 0.0168 0.0622
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0081 0.003
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0469 0.0798
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0238 0.0201
Loa Loa (eye worm) hypothetical protein 0.0063 0.1027 0.098
Echinococcus granulosus carboxylesterase 5A 0.0137 0.2619 0.2591
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0467 0.0795
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0023 0.0168 0.013
Echinococcus multilocularis zinc finger protein 0.0021 0.0127 0.009
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0451 0.2413
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0451 0.076
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0384 0.0645
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.1027 0.0992
Loa Loa (eye worm) hypothetical protein 0.0055 0.0848 0.0801
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0848 0.0801
Loa Loa (eye worm) hypothetical protein 0.0038 0.0498 0.045
Brugia malayi TAR-binding protein 0.0124 0.2353 0.229
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0469 0.0798
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0166
Brugia malayi beta-lactamase family protein 0.0037 0.0469 0.0391
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0451 0.076
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0451 0.076
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.1027 0.0992
Schistosoma mansoni mucolipin 0.006 0.0961 0.3559
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.319 0.3134
Schistosoma mansoni mucolipin 0.0065 0.1078 0.3995
Loa Loa (eye worm) inositol-1 0.0037 0.0467 0.0418
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0469 0.0826
Loa Loa (eye worm) beta-lactamase 0.0037 0.0469 0.042
Schistosoma mansoni acetylcholinesterase 0.0023 0.0168 0.0622
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0467 0.0795
Onchocerca volvulus 0.0055 0.0848 0.1424
Loa Loa (eye worm) hypothetical protein 0.0137 0.2619 0.2581
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0467 0.2504
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0102 0.1867 1
Onchocerca volvulus 0.005 0.074 0.1198
Loa Loa (eye worm) hypothetical protein 0.0041 0.055 0.0501
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.2353 0.229
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0102 0.1867 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0023 0.0168 0.0185
Loa Loa (eye worm) hypothetical protein 0.0137 0.2619 0.2581
Echinococcus multilocularis neuroligin 0.0023 0.0168 0.013
Trichomonas vaginalis esterase, putative 0.0037 0.0469 0.0798
Onchocerca volvulus 0.0098 0.1777 0.3369
Echinococcus multilocularis tumor protein p63 0.0338 0.6981 0.697
Mycobacterium tuberculosis Conserved protein 0.0037 0.0469 0.0826
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0469 0.0798
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0346 0.0309
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0469 0.0391
Loa Loa (eye worm) hypothetical protein 0.0136 0.2602 0.2564
Leishmania major DNA polymerase kappa, putative 0.0019 0.0081 0.0433
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0714 0.2645
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0081 0.0433
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.3959 0.391
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0469 0.0433
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0467 0.9964
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.2602 0.2541
Brugia malayi Bromodomain containing protein 0.0038 0.0497 0.0419
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.1867 0.3675
Schistosoma mansoni DNA polymerase eta 0.0019 0.0081 0.03
Onchocerca volvulus 0.0037 0.0469 0.0631
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2353 0.8715
Loa Loa (eye worm) hypothetical protein 0.0023 0.0168 0.0117
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.1867 0.3675
Mycobacterium ulcerans beta-lactamase 0.0037 0.0469 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0451 0.2413
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0038 0.014
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.2353 0.2313
Loa Loa (eye worm) hypothetical protein 0.005 0.074 0.0692
Loa Loa (eye worm) RNA binding protein 0.0124 0.2353 0.2313
Echinococcus multilocularis mucolipin 3 0.0065 0.1078 0.1045
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0714 0.0679
Echinococcus granulosus lamin 0.0055 0.0848 0.0813
Echinococcus granulosus acetylcholinesterase 0.0137 0.2619 0.2591
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0081 0.0433
Echinococcus multilocularis mitogen activated protein kinase 0.0102 0.1867 0.1836
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0081 0.0433
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0469 0.0826
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0469 0.0826
Brugia malayi hypothetical protein 0.0023 0.0168 0.0088
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0023 0.0168 0.0179
Brugia malayi Carboxylesterase family protein 0.0023 0.0168 0.0088
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0191 0.0709

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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