Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Lactobacillus casei | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium yoelii | thymidylate synthase, putative | Dihydrofolate reductase | 163 aa | 139 aa | 21.6 % |
Babesia bovis | dihydrofolate reductase/thymidilate synthase | Dihydrofolate reductase | 163 aa | 133 aa | 27.1 % |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Dihydrofolate reductase | 163 aa | 138 aa | 29.7 % |
Onchocerca volvulus | Putative dihydrofolate reductase | Dihydrofolate reductase | 163 aa | 173 aa | 27.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dihydrofolate reductase | 0.0208 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0208 | 1 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1789 | 0.1789 |
Echinococcus granulosus | dihydrofolate reductase | 0.0208 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0049 | 0.1789 | 0.1789 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0208 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0208 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0049 | 0.1789 | 0.1789 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Brugia malayi | Dihydrofolate reductase | 0.0208 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3378 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3378 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0208 | 1 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3378 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0208 | 1 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0079 | 0.3378 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0208 | 1 | 0.5 |
Echinococcus granulosus | expressed conserved protein | 0.0049 | 0.1789 | 0.1789 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1789 | 0.1789 |
Onchocerca volvulus | Putative nachr subunit | 0.0014 | 0 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3378 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3378 | 0.5 |
Echinococcus multilocularis | expressed conserved protein | 0.0049 | 0.1789 | 0.1789 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.00000025 M | Compound was evaluated for growth inhibition in L1210 murine leukemia cells | ChEMBL. | 3091834 |
IC50 (functional) | = 0.00000025 M | Compound was evaluated for growth inhibition in L1210 murine leukemia cells | ChEMBL. | 3091834 |
IC50 (binding) | = 0.0000015 M | Compound was evaluated for the inhibition of dihydrofolate reductase (DHFR)derived from Lactobacillus casei | ChEMBL. | 3091834 |
IC50 (binding) | = 0.0000015 M | Compound was evaluated for the inhibition of dihydrofolate reductase (DHFR)derived from Lactobacillus casei | ChEMBL. | 3091834 |
IC50 (binding) | > 0.0005 M | Compound was evaluated for the inhibition of thymidylate synthase (TS) derived from Lactobacillus casei | ChEMBL. | 3091834 |
IC50 (binding) | > 0.0005 M | Compound was evaluated for the inhibition of thymidylate synthase (TS) derived from Lactobacillus casei | ChEMBL. | 3091834 |
IC50 (functional) | = 1 ng ml-1 | Compound was evaluated for growth inhibition in Lactobacillus casei ATCC 7469 | ChEMBL. | 3091834 |
IC50 (functional) | = 2 ng ml-1 | Compound was evaluated for growth inhibition in Streptococcus faecium ATCC 8043 | ChEMBL. | 3091834 |
IC50 (functional) | = 530 ng ml-1 | Compound was evaluated for growth inhibition in Streptococcus faecium MTX-resistant | ChEMBL. | 3091834 |
IC50 (functional) | > 10000 ng ml-1 | Compound was evaluated for growth inhibition in Lactobacillus casei MTX-resistant | ChEMBL. | 3091834 |
Ki (functional) | > 0.00000001 M | Compound was evaluated for inhibitory activity against DHFR in L1210 cells | ChEMBL. | 3091834 |
Ki (functional) | > 0.00000001 M | Compound was evaluated for inhibitory activity against DHFR in L1210 cells | ChEMBL. | 3091834 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 3091834 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.